LOCUS       NM_001003685            1598 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus growth hormone releasing hormone receptor (Ghrhr),
            mRNA.
ACCESSION   NM_001003685 XM_132546
VERSION     NM_001003685.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1598)
  AUTHORS   Gusmao,D.O., de Sousa,L.M.M., de Sousa,M.E., Rusew,S.J.R.,
            List,E.O., Kopchick,J.J., Gomes,A.F., Campideli-Santana,A.C.,
            Szawka,R.E. and Donato,J. Jr.
  TITLE     Characterization and Regulation of the Neonatal Growth Hormone
            Surge
  JOURNAL   Endocrinology 165 (12) (2024)
   PUBMED   39446366
REFERENCE   2  (bases 1 to 1598)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1598)
  AUTHORS   Gonigam,R.L., Weis,K.E., Ge,X., Yao,B., Zhang,Q. and Raetzman,L.T.
  TITLE     Characterization of Somatotrope Cell Expansion in Response to GHRH
            in the Neonatal Mouse Pituitary
  JOURNAL   Endocrinology 164 (10) (2023)
   PUBMED   37616545
REFERENCE   4  (bases 1 to 1598)
  AUTHORS   Du,L., Ho,B.M., Zhou,L., Yip,Y.W.Y., He,J.N., Wei,Y., Tham,C.C.,
            Chan,S.O., Schally,A.V., Pang,C.P., Li,J. and Chu,W.K.
  TITLE     Growth hormone releasing hormone signaling promotes Th17 cell
            differentiation and autoimmune inflammation
  JOURNAL   Nat Commun 14 (1), 3298 (2023)
   PUBMED   37280225
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1598)
  AUTHORS   Zhao,L., Jia,D., Tan,Z. and Jiang,H.
  TITLE     Association of growth hormone deficiency with an increased number
            of preadipocytes in subcutaneous fat
  JOURNAL   Front Endocrinol (Lausanne) 14, 1199589 (2023)
   PUBMED   37305046
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1598)
  AUTHORS   Lin,C., Lin,S.C., Chang,C.P. and Rosenfeld,M.G.
  TITLE     Pit-1-dependent expression of the receptor for growth hormone
            releasing factor mediates pituitary cell growth
  JOURNAL   Nature 360 (6406), 765-768 (1992)
   PUBMED   1334535
REFERENCE   7  (bases 1 to 1598)
  AUTHORS   Wilson,D.B. and Wyatt,D.P.
  TITLE     Adrenocorticotropic cell distribution in adult and embryonic
            pituitaries of the little (lit) mutant mouse
  JOURNAL   Anat Embryol (Berl) 186 (4), 347-353 (1992)
   PUBMED   1329576
REFERENCE   8  (bases 1 to 1598)
  AUTHORS   Wilson,D.B. and Wyatt,D.P.
  TITLE     Histopathology of the pituitary gland in neonatal little (lit)
            mutant mice
  JOURNAL   Histol Histopathol 7 (3), 451-455 (1992)
   PUBMED   1504465
REFERENCE   9  (bases 1 to 1598)
  AUTHORS   Beamer,W.H. and Eicher,E.M.
  TITLE     Stimulation of growth in the little mouse
  JOURNAL   J Endocrinol 71 (1), 37-45 (1976)
   PUBMED   978118
REFERENCE   10 (bases 1 to 1598)
  AUTHORS   Eicher,E.M. and Beamer,W.G.
  TITLE     Inherited ateliotic dwarfism in mice. Characteristics of the
            mutation, little, on chromosome 6
  JOURNAL   J Hered 67 (2), 87-91 (1976)
   PUBMED   1270792
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB618094.1, AK030504.1, AC083946.5 and BB027246.1.
            
            On May 21, 2010 this sequence version replaced NM_001003685.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030504.1, BC120774.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-554               BB618094.1         3-556
            555-994             AK030504.1         509-948
            995-1028            AC083946.5         142959-142992
            1029-1506           AK030504.1         982-1459
            1507-1507           AC083946.5         146644-146644
            1508-1584           AK030504.1         1461-1537
            1585-1598           BB027246.1         262-275
FEATURES             Location/Qualifiers
     source          1..1598
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.38 cM"
     gene            1..1598
                     /gene="Ghrhr"
                     /gene_synonym="Ghrfr; lit; little"
                     /note="growth hormone releasing hormone receptor"
                     /db_xref="GeneID:14602"
                     /db_xref="MGI:MGI:95710"
     exon            1..147
                     /gene="Ghrhr"
                     /gene_synonym="Ghrfr; lit; little"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1362
                     /gene="Ghrhr"
                     /gene_synonym="Ghrfr; lit; little"
                     /note="GRFR; GRF receptor; GHRH receptor; growth
                     hormone-releasing factor receptor"
                     /codon_start=1
                     /product="growth hormone-releasing hormone receptor
                     precursor"
                     /protein_id="NP_001003685.2"
                     /db_xref="CCDS:CCDS20165.1"
                     /db_xref="GeneID:14602"
                     /db_xref="MGI:MGI:95710"
                     /translation="MDGLMWATRILCLLSLCGVTLGHLHLECDFITQLRDDELACLQA
                     AEGTNNTSLGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDTGFVKRDCTITGWS
                     NPFPPYPVACPVPLELLTKEKSYFSTVKIIYTTGHSISIVALCVAIAILVALRRLHCP
                     RNYIHTQLFATFILKASAVFLKDAAIFQGDSTDHCSMSTVLCKVSVAISHLATMTNFS
                     WLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTECWDLD
                     NSSPCWWIIKGPIVLSVGVNFGLFLNIICILLRKLEPAQGGLHTRAQYWRLSKSTLLL
                     IPLFGIHYIIFNFLPDSAGLDIRVPLELGLGSFQGFIVAVLYCFLNQEVRTEISRKWY
                     GHDPELLPARRTCTEWTTPPRSRLKVLTSEC"
     exon            148..250
                     /gene="Ghrhr"
                     /gene_synonym="Ghrfr; lit; little"
                     /inference="alignment:Splign:2.1.0"
     exon            251..358
                     /gene="Ghrhr"
                     /gene_synonym="Ghrfr; lit; little"
                     /inference="alignment:Splign:2.1.0"
     exon            359..456
                     /gene="Ghrhr"
                     /gene_synonym="Ghrfr; lit; little"
                     /inference="alignment:Splign:2.1.0"
     exon            457..554
                     /gene="Ghrhr"
                     /gene_synonym="Ghrfr; lit; little"
                     /inference="alignment:Splign:2.1.0"
     exon            555..687
                     /gene="Ghrhr"
                     /gene_synonym="Ghrfr; lit; little"
                     /inference="alignment:Splign:2.1.0"
     exon            688..841
                     /gene="Ghrhr"
                     /gene_synonym="Ghrfr; lit; little"
                     /inference="alignment:Splign:2.1.0"
     exon            842..902
                     /gene="Ghrhr"
                     /gene_synonym="Ghrfr; lit; little"
                     /inference="alignment:Splign:2.1.0"
     exon            903..972
                     /gene="Ghrhr"
                     /gene_synonym="Ghrfr; lit; little"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1064
                     /gene="Ghrhr"
                     /gene_synonym="Ghrfr; lit; little"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1194
                     /gene="Ghrhr"
                     /gene_synonym="Ghrfr; lit; little"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1236
                     /gene="Ghrhr"
                     /gene_synonym="Ghrfr; lit; little"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1598
                     /gene="Ghrhr"
                     /gene_synonym="Ghrfr; lit; little"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctactggga aggtgaggca gcagagatgc agctaggtgg catcaccaga gacagcctgg
       61 gagggaaggc tgactgcaga caccattgcc atggatggcc tgatgtgggc tacccgtatc
      121 ctctgcttgc tgagcctgtg cggagttaca ctgggtcacc tccacctaga atgtgacttc
      181 atcactcagc tgagagacga tgagcttgca tgtcttcagg cggcagaggg gaccaacaac
      241 acctccctgg gatgccctgg gacctgggat gggctgctgt gctggccccc gacaggctct
      301 ggccagtggg tctctctccc ctgccctgaa ttcttctctc acttcggctc agacacaggg
      361 tttgtgaaga gggactgcac catcactggc tggtctaatc ccttcccacc ataccctgtg
      421 gcttgccctg tgcccttgga actgttaacc aaggagaaat cgtacttctc cacggtgaag
      481 atcatctaca ccacgggcca cagcatctcc attgtagccc tctgcgtggc tattgccatc
      541 ctggttgccc tcaggaggct ccactgcccc aggaactaca tccacacgca gctgtttgcc
      601 accttcatcc tcaaggccag tgctgtgttc ttgaaggatg ccgccatctt ccagggggat
      661 agcacggacc actgcagcat gtccactgtc ctgtgcaagg tctctgtggc catctcacat
      721 ttggccacca tgaccaactt cagctggctg ttggcagaag ctgtctacct gagctgcctg
      781 ttggcctcca catcccccag gtccaaacca gctttttggt ggctggtcct ggctggctgg
      841 gggctccccg tgctatgcac tggtacgtgg gtgggctgca aactggcttt tgaggacact
      901 gagtgctggg acttagacaa cagctccccc tgctggtgga tcatcaaagg acccatagtc
      961 ctctctgttg gggtgaactt tgggctgttt ctcaatataa tttgtatcct gctgaggaag
     1021 ctggagcctg cacaaggcgg cctacacaca cgggctcagt actggcggct ttccaagtca
     1081 acacttctcc ttataccgct gtttggaatt cattacatca tcttcaactt cctgcctgac
     1141 agtgctggcc ttgacatccg tgtacccctg gagctggggt tggggtcctt tcagggcttc
     1201 attgttgctg tcctctactg cttcctcaat caagaggtga ggacagagat ttcacgcaaa
     1261 tggtatggcc acgaccctga acttctgcca gctcgacgga cctgcactga gtggaccaca
     1321 cctccccgat cgagattgaa ggtgctgacc tctgagtgct aggccagcca tcatcacaag
     1381 ggccaagccc caaaccctgt gctcaaactg tcatggcacc acgggcaatg cggtcctccc
     1441 taccgttctc cttccccttc tctgcatctg ctttctccag gtccccgtat atcaaccttc
     1501 gactttctca gttcctgcat ctgctcccat ctgttctttc ttcccatcta gggctattgc
     1561 ccaaggccca gagaaaccaa taaacttgta cacgagtg
//
