LOCUS       NM_010285                531 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus growth hormone releasing hormone (Ghrh), transcript
            variant 1, mRNA.
ACCESSION   NM_010285
VERSION     NM_010285.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 531)
  AUTHORS   Gusmao,D.O., de Sousa,L.M.M., de Sousa,M.E., Rusew,S.J.R.,
            List,E.O., Kopchick,J.J., Gomes,A.F., Campideli-Santana,A.C.,
            Szawka,R.E. and Donato,J. Jr.
  TITLE     Characterization and Regulation of the Neonatal Growth Hormone
            Surge
  JOURNAL   Endocrinology 165 (12) (2024)
   PUBMED   39446366
REFERENCE   2  (bases 1 to 531)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 531)
  AUTHORS   Lasher,A.T. and Sun,L.Y.
  TITLE     Distinct physiological characteristics and altered glucagon
            signaling in GHRH knockout mice: Implications for longevity
  JOURNAL   Aging Cell 22 (12), e13985 (2023)
   PUBMED   37667562
  REMARK    GeneRIF: Distinct physiological characteristics and altered
            glucagon signaling in GHRH knockout mice: Implications for
            longevity.
REFERENCE   4  (bases 1 to 531)
  AUTHORS   Recinella,L., Libero,M.L., Veschi,S., Piro,A., Marconi,G.D.,
            Diomede,F., Chiavaroli,A., Orlando,G., Ferrante,C., Florio,R.,
            Lamolinara,A., Cai,R., Sha,W., Schally,A.V., Salvatori,R.,
            Brunetti,L. and Leone,S.
  TITLE     Effects of GHRH Deficiency and GHRH Antagonism on Emotional
            Disorders in Mice
  JOURNAL   Cells 12 (22), 2615 (2023)
   PUBMED   37998350
  REMARK    GeneRIF: Effects of GHRH Deficiency and GHRH Antagonism on
            Emotional Disorders in Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 531)
  AUTHORS   Gusmao,D.O., de Sousa,M.E., Tavares,M.R. and Donato,J.
  TITLE     Increased GH Secretion and Body Growth in Mice Carrying Ablation of
            IGF-1 Receptor in GH-releasing Hormone Cells
  JOURNAL   Endocrinology 163 (11) (2022)
   PUBMED   36099517
REFERENCE   6  (bases 1 to 531)
  AUTHORS   Lin,C., Lin,S.C., Chang,C.P. and Rosenfeld,M.G.
  TITLE     Pit-1-dependent expression of the receptor for growth hormone
            releasing factor mediates pituitary cell growth
  JOURNAL   Nature 360 (6406), 765-768 (1992)
   PUBMED   1334535
REFERENCE   7  (bases 1 to 531)
  AUTHORS   Asa,S.L., Kovacs,K., Stefaneanu,L., Horvath,E., Billestrup,N.,
            Gonzalez-Manchon,C. and Vale,W.
  TITLE     Pituitary adenomas in mice transgenic for growth hormone-releasing
            hormone
  JOURNAL   Endocrinology 131 (5), 2083-2089 (1992)
   PUBMED   1425411
REFERENCE   8  (bases 1 to 531)
  AUTHORS   Kamps,M.P., Murre,C., Sun,X.H. and Baltimore,D.
  TITLE     A new homeobox gene contributes the DNA binding domain of the
            t(1;19) translocation protein in pre-B ALL
  JOURNAL   Cell 60 (4), 547-555 (1990)
   PUBMED   1967983
REFERENCE   9  (bases 1 to 531)
  AUTHORS   Stefaneanu,L., Kovacs,K., Horvath,E., Asa,S.L., Losinski,N.E.,
            Billestrup,N., Price,J. and Vale,W.
  TITLE     Adenohypophysial changes in mice transgenic for human growth
            hormone-releasing factor: a histological, immunocytochemical, and
            electron microscopic investigation
  JOURNAL   Endocrinology 125 (5), 2710-2718 (1989)
   PUBMED   2507296
REFERENCE   10 (bases 1 to 531)
  AUTHORS   Frohman,M.A., Downs,T.R., Chomczynski,P. and Frohman,L.A.
  TITLE     Cloning and characterization of mouse growth hormone-releasing
            hormone (GRH) complementary DNA: increased GRH messenger RNA levels
            in the growth hormone-deficient lit/lit mouse
  JOURNAL   Mol Endocrinol 3 (10), 1529-1536 (1989)
   PUBMED   2481813
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK018816.1 and BY705613.1.
            
            On Jul 25, 2016 this sequence version replaced NM_010285.2.
            
            Summary: This gene encodes a hormone that has stimulatory effects
            on pituitary growth hormone synthesis and release, and somatotrope
            expansion. The encoded preproprotein undergoes proteolytic
            processing to generate the mature peptide that is secreted by
            hypothalamus. Mice lacking the encoded protein are deficient in the
            growth hormone, live longer and exhibit growth retardation,
            enhanced insulin sensitivity and increased xenobiotic metabolism.
            [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein. Both variants 1 and
            2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY705613.1, AK005392.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-516               AK018816.1         2-517
            517-531             BY705613.1         515-529
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 78.25 cM"
     gene            1..531
                     /gene="Ghrh"
                     /gene_synonym="Ghrf; GRF"
                     /note="growth hormone releasing hormone"
                     /db_xref="GeneID:14601"
                     /db_xref="MGI:MGI:95709"
     exon            1..84
                     /gene="Ghrh"
                     /gene_synonym="Ghrf; GRF"
                     /inference="alignment:Splign:2.1.0"
     exon            85..184
                     /gene="Ghrh"
                     /gene_synonym="Ghrf; GRF"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..416
                     /gene="Ghrh"
                     /gene_synonym="Ghrf; GRF"
                     /note="somatoliberin; growth hormone-releasing factor"
                     /codon_start=1
                     /product="somatoliberin preproprotein"
                     /protein_id="NP_034415.1"
                     /db_xref="CCDS:CCDS16976.1"
                     /db_xref="GeneID:14601"
                     /db_xref="MGI:MGI:95709"
                     /translation="MLLWVLFVILILTSGSHCSLPPSPPFRMQRHVDAIFTTNYRKLL
                     SQLYARKVIQDIMNKQGERIQEQRARLSRQEDSMWTEDKQMTLESILQGFPRMKPSAD
                     A"
     exon            185..286
                     /gene="Ghrh"
                     /gene_synonym="Ghrf; GRF"
                     /inference="alignment:Splign:2.1.0"
     exon            287..377
                     /gene="Ghrh"
                     /gene_synonym="Ghrf; GRF"
                     /inference="alignment:Splign:2.1.0"
     exon            378..517
                     /gene="Ghrh"
                     /gene_synonym="Ghrf; GRF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      493..498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ghrh"
                     /gene_synonym="Ghrf; GRF"
                     /note="hexamer: AATAAA"
     polyA_site      517
                     /gene="Ghrh"
                     /gene_synonym="Ghrf; GRF"
                     /note="major polyA site"
ORIGIN      
        1 actggtgatc caggccggct ctccaggtcg caggtctctc ctggttgcgg ctccctgctc
       61 atctggctcc cacaacatca cagagtccca cccaggagtg aaggatgctg ctctgggtgc
      121 tctttgtgat cctcatcctc accagtggct cccactgctc actgcccccc tcacctccct
      181 tcaggatgca gcgacacgta gatgccatct tcaccaccaa ctacaggaaa ctcctgagcc
      241 agctgtatgc ccggaaagtg atccaggaca tcatgaacaa gcaaggggag aggatccagg
      301 aacaaagggc caggctcagc cgccaggaag acagcatgtg gacagaggac aagcagatga
      361 ccctggagag catcttgcag ggattcccaa ggatgaagcc ttcagcggac gcttgagccc
      421 cccgagcccc aaacacaact gtaccctgtt acttctgctt cagctctgac cttttccgtc
      481 ctctgtaaat acaataaaac ccccattctc atctgcaaaa aaaaaaaaaa a
//
