LOCUS       NM_031871               2457 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus GH3 domain containing (Ghdc), transcript variant 1,
            mRNA.
ACCESSION   NM_031871
VERSION     NM_031871.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2457)
  AUTHORS   Cui,Y., Li,M., Walton,K.D., Sun,K., Hanover,J.A., Furth,P.A. and
            Hennighausen,L.
  TITLE     The Stat3/5 locus encodes novel endoplasmic reticulum and
            helicase-like proteins that are preferentially expressed in normal
            and neoplastic mammary tissue
  JOURNAL   Genomics 78 (3), 129-134 (2001)
   PUBMED   11735219
REFERENCE   2  (bases 1 to 2457)
  AUTHORS   Miyoshi,K., Cui,Y., Riedlinger,G., Robinson,P., Lehoczky,J.,
            Zon,L., Oka,T., Dewar,K. and Hennighausen,L.
  TITLE     Structure of the mouse Stat 3/5 locus: evolution from Drosophila to
            zebrafish to mouse
  JOURNAL   Genomics 71 (2), 150-155 (2001)
   PUBMED   11161808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591466.8.
            
            On Mar 18, 2023 this sequence version replaced NM_031871.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF316996.1, AK143922.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AL591466.8         224968-225035
            69-349              AL591466.8         225564-225844
            350-471             AL591466.8         226137-226258
            472-973             AL591466.8         226385-226886
            974-1166            AL591466.8         227337-227529
            1167-1238           AL591466.8         227625-227696
            1239-1372           AL591466.8         227767-227900
            1373-1458           AL591466.8         228545-228630
            1459-2457           AL591466.8         228890-229888
FEATURES             Location/Qualifiers
     source          1..2457
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.6 cM"
     gene            1..2457
                     /gene="Ghdc"
                     /gene_synonym="D11Lgp1e"
                     /note="GH3 domain containing"
                     /db_xref="GeneID:80860"
                     /db_xref="MGI:MGI:1931556"
     exon            1..68
                     /gene="Ghdc"
                     /gene_synonym="D11Lgp1e"
                     /inference="alignment:Splign:2.1.0"
     exon            69..349
                     /gene="Ghdc"
                     /gene_synonym="D11Lgp1e"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1680
                     /gene="Ghdc"
                     /gene_synonym="D11Lgp1e"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; D11lgp1; GH3 domain-containing protein"
                     /codon_start=1
                     /product="GH3 domain-containing protein isoform 1
                     precursor"
                     /protein_id="NP_114077.1"
                     /db_xref="CCDS:CCDS25437.1"
                     /db_xref="GeneID:80860"
                     /db_xref="MGI:MGI:1931556"
                     /translation="MLLLWLLLLLLLLVPLLAILWQQRSRGARPCWLISLQHRVAWGM
                     LGWAAAWQQWRLDRSTLNVGQSQQQALMWCLKKAQGSCCLPREDTDMRTFRNHLPLTQ
                     TSHTQEQESEETLPSPASPQYHGDASLQATLLGLITLNKAYPEALAPGSTACVTPTSP
                     WPCSVPWLGHALGRVSPDGAKDPRTLLLEALISPGLRVLEARTAVELLDVFVGLEADG
                     EELAEAIAAGILGTLLPKRAAELKEALEQGPRGLARRLWPKLQVVVTLDSGGQAEAVA
                     ALRVLWCQGLAFFSPAYAASGGVVALNLWPERPQGSYLLPPGVPFIELLPIKEGTQEE
                     AASTLLLTDAQREKEYELVLTNHTSLTRCRLGDVVQVVGTYNQCPVVRFTCRLGQTLN
                     VRGEVTDETVFSVALAQAVGQWPGAKLLDHVCVESRVLDSCEGSAPHYEVFVELRGLR
                     NLSEENRDKLDNCLQEASAQYKSLRFRGSVGPAKVHLVRPGSFRVLREALAAFSSSSC
                     RPPEMPRVIRLRHLAQLLQKRVIS"
     exon            350..471
                     /gene="Ghdc"
                     /gene_synonym="D11Lgp1e"
                     /inference="alignment:Splign:2.1.0"
     exon            472..973
                     /gene="Ghdc"
                     /gene_synonym="D11Lgp1e"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1166
                     /gene="Ghdc"
                     /gene_synonym="D11Lgp1e"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1238
                     /gene="Ghdc"
                     /gene_synonym="D11Lgp1e"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1372
                     /gene="Ghdc"
                     /gene_synonym="D11Lgp1e"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1458
                     /gene="Ghdc"
                     /gene_synonym="D11Lgp1e"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..2457
                     /gene="Ghdc"
                     /gene_synonym="D11Lgp1e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2430..2435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ghdc"
                     /gene_synonym="D11Lgp1e"
                     /note="hexamer: AATAAA"
     regulatory      2440..2445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ghdc"
                     /gene_synonym="D11Lgp1e"
                     /note="hexamer: AATATA"
     polyA_site      2451
                     /gene="Ghdc"
                     /gene_synonym="D11Lgp1e"
                     /note="major polyA site"
     polyA_site      2457
                     /gene="Ghdc"
                     /gene_synonym="D11Lgp1e"
ORIGIN      
        1 atcacttcaa ctttcaggac tgcgaccaga cacactgagg gaccctgagg ggtcccgggg
       61 tgctgaaaga gctccttgga gatgcttctg ctgtggctgc tgctgctgct gctcctcctc
      121 gtgcccctgc tggccatact ctggcagcag aggtctcggg gtgccaggcc atgctggctg
      181 atcagtctcc aacaccgagt ggcctggggg atgctgggct gggcagccgc ctggcagcag
      241 tggagactag accggagcac gttgaatgtg ggccagagcc agcagcaggc cctcatgtgg
      301 tgtctgaaga aagcccaggg ctcctgctgt ctccccaggg aggacacaga tatgagaacc
      361 ttccggaatc atcttccact gacccaaacc agccacactc aggagcaaga aagtgaagag
      421 acgctcccat cccctgcctc cccccagtac catggagacg cctctttgca ggccaccctg
      481 ctgggtctaa taaccctaaa caaggcctac ccagaagcgc tggctccagg aagtactgcc
      541 tgtgtgaccc ctacatcgcc atggccctgc tctgtcccct ggcttgggca cgccctgggc
      601 cgggtaagcc ccgatggagc caaggacccc cggaccctgc tgctggaggc attgatatcc
      661 ccggggctga gggtacttga ggcaaggact gcagtggagc tcctggatgt ctttgtgggc
      721 ttggaggctg atggtgaaga actggctgag gccatagcag ctgggattct gggaacgctt
      781 ctccccaaac gagccgctga gctgaaggag gccctagagc agggaccccg aggattggcc
      841 cgccggctct ggccaaagct gcaggtggtg gtgactctgg actcaggagg acaggcagaa
      901 gctgtggctg cccttagggt cctgtggtgc caagggctag ccttcttctc tcctgcttat
      961 gctgcctcag gaggagtggt ggccctaaac ctgtggccag agcgacccca aggatcctat
     1021 cttctgcccc ctggagtccc ctttattgag ctgcttccaa tcaaggaagg aacccaagag
     1081 gaggcagcct ccactctcct ccttactgat gcccaaaggg agaaggagta tgagttggtg
     1141 ctgacgaacc acaccagcct gaccaggtgc cgcctgggtg acgtggtcca ggtggttggt
     1201 acctacaatc agtgtcctgt ggtcaggttc acctgcaggc tggggcaaac cctgaatgtt
     1261 cgaggagaag ttactgatga gactgtattc tctgtggccc tggcccaagc agtggggcag
     1321 tggccagggg ccaagctgtt ggaccatgtc tgtgtggaga gcagagttct ggactcctgt
     1381 gagggttctg ccccacacta cgaagtgttt gtagagctga gggggttgag gaatctgtcg
     1441 gaggaaaatc gagacaagct tgacaactgc ctgcaggaag cctccgcaca gtacaagtcc
     1501 ttgcgattcc ggggcagtgt gggtcctgcc aaagtccatc tggtgaggcc agggagcttc
     1561 agggttctcc gggaagcact ggcagccttc tcctcctcct cctgccgccc tcctgaaatg
     1621 cctcgggtca tcaggctcag gcacctggcc cagctcctgc agaagagggt gatatcctaa
     1681 ccaaggcagc cagccttcct gtttctgcct cactctttcc tctggaacat ctctggatgt
     1741 tgagtcctgg accagatgtc acataacagt ggtctgattg ggtccaattg gactcattgg
     1801 caagttttaa gatgccggct tggagcacac agctgaaccc atcatcgatg gtctcccgtc
     1861 agcctatcct tcgtgagact gctggtcctt ctcatgtgct tggccaaggt acagcaaggg
     1921 ctgaaagtgt aggcagtgct cctggagcag atgaagaaac ctcaggctca ggggtggtga
     1981 gatggctcag caggtaagag cactgactgc tcttccaaag gtcctgagtt caaatcccag
     2041 caaccatatg gtgcctcaca accatccgca atgagatccg atgccctctt ctggtgtgtc
     2101 tgaagacaac tacagtgtac ctacatataa caataaataa atctgaaaga aagaaagaga
     2161 gagagagaga gagaaagaga gagaaagaaa gagagagaaa gaaagaaaga aagaaagaaa
     2221 gaaagaaaga aagaaagaaa gaaagaaaga aagaaaacct cagcctcatt gtttcgtggt
     2281 ctagggtgtg tcttgcacaa ccacctgaag ggctgaggct gtggcccaca gtggcccagt
     2341 gttcagtgct cttcttacca gatcccccca tccctccatc ctcctctccc ctgcttactc
     2401 tatcattctg ttccctggat caacccccaa ataaaattaa atatatataa atattaa
//
