LOCUS       NM_008117                903 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus growth hormone (Gh), mRNA.
ACCESSION   NM_008117
VERSION     NM_008117.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 903)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   2  (bases 1 to 903)
  AUTHORS   Zhang,J., Hu,G., Lu,Y., Ren,H., Huang,Y., Wen,Y., Ji,B., Wang,D.,
            Wang,H., Liu,H., Ma,N., Zhang,L., Pan,G., Qu,Y., Wang,H., Zhang,W.,
            Miao,Z. and Yao,H.
  TITLE     CTCF mutation at R567 causes developmental disorders via 3D genome
            rearrangement and abnormal neurodevelopment
  JOURNAL   Nat Commun 15 (1), 5524 (2024)
   PUBMED   38951485
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 903)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 903)
  AUTHORS   Sarver,D.C., Garcia-Diaz,J., Saqib,M., Riddle,R.C. and Wong,G.W.
  TITLE     Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and
            impairs skeletal acquisition
  JOURNAL   Elife 12, 90949 (2024)
   PUBMED   38241182
  REMARK    GeneRIF: Tmem263 deletion disrupts the GH/IGF-1 axis and causes
            dwarfism and impairs skeletal acquisition.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 903)
  AUTHORS   Dos Santos,W.O., Juliano,V.A.L., Chaves,F.M., Vieira,H.R.,
            Frazao,R., List,E.O., Kopchick,J.J., Munhoz,C.D. and Donato,J. Jr.
  TITLE     Growth Hormone Action in Somatostatin Neurons Regulates Anxiety and
            Fear Memory
  JOURNAL   J Neurosci 43 (40), 6816-6829 (2023)
   PUBMED   37625855
  REMARK    GeneRIF: Growth Hormone Action in Somatostatin Neurons Regulates
            Anxiety and Fear Memory.
REFERENCE   6  (bases 1 to 903)
  AUTHORS   Lin,C., Lin,S.C., Chang,C.P. and Rosenfeld,M.G.
  TITLE     Pit-1-dependent expression of the receptor for growth hormone
            releasing factor mediates pituitary cell growth
  JOURNAL   Nature 360 (6406), 765-768 (1992)
   PUBMED   1334535
REFERENCE   7  (bases 1 to 903)
  AUTHORS   Remmers,E.F., Goldmuntz,E.A., Cash,J.M., Crofford,L.J.,
            Misiewicz-Poltorak,B., Zha,H. and Wilder,R.L.
  TITLE     Genetic map of nine polymorphic loci comprising a single linkage
            group on rat chromosome 10: evidence for linkage conservation with
            human chromosome 17 and mouse chromosome 11
  JOURNAL   Genomics 14 (3), 618-623 (1992)
   PUBMED   1358809
REFERENCE   8  (bases 1 to 903)
  AUTHORS   Tornell,J., Carlsson,B., Pohjanen,P., Wennbo,H., Rymo,L. and
            Isaksson,O.
  TITLE     High frequency of mammary adenocarcinomas in metallothionein
            promoter-human growth hormone transgenic mice created from two
            different strains of mice
  JOURNAL   J Steroid Biochem Mol Biol 43 (1-3), 237-242 (1992)
   PUBMED   1525063
REFERENCE   9  (bases 1 to 903)
  AUTHORS   Wilson,D.B. and Wyatt,D.P.
  TITLE     Adrenocorticotropic cell distribution in adult and embryonic
            pituitaries of the little (lit) mutant mouse
  JOURNAL   Anat Embryol (Berl) 186 (4), 347-353 (1992)
   PUBMED   1329576
REFERENCE   10 (bases 1 to 903)
  AUTHORS   Frankel,W.N., Lee,B.K., Stoye,J.P., Coffin,J.M. and Eicher,E.M.
  TITLE     Characterization of the endogenous nonecotropic murine leukemia
            viruses of NZB/B1NJ and SM/J inbred strains
  JOURNAL   Mamm Genome 2 (2), 110-122 (1992)
   PUBMED   1311971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL604045.7, AK030419.1, AK019954.1 and BB024006.1.
            
            On Feb 13, 2013 this sequence version replaced NM_008117.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061157.1, AK019954.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AL604045.7         83915-83945         c
            32-86               AK030419.1         2-56
            87-893              AK019954.1         2-808
            894-903             BB024006.1         285-294
FEATURES             Location/Qualifiers
     source          1..903
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 68.89 cM"
     gene            1..903
                     /gene="Gh"
                     /gene_synonym="Gh1; Ghb1"
                     /note="growth hormone"
                     /db_xref="GeneID:14599"
                     /db_xref="MGI:MGI:95707"
     exon            1..157
                     /gene="Gh"
                     /gene_synonym="Gh1; Ghb1"
                     /inference="alignment:Splign:2.1.0"
     exon            158..318
                     /gene="Gh"
                     /gene_synonym="Gh1; Ghb1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..435
                     /gene="Gh"
                     /gene_synonym="Gh1; Ghb1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..597
                     /gene="Gh"
                     /gene_synonym="Gh1; Ghb1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..903
                     /gene="Gh"
                     /gene_synonym="Gh1; Ghb1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      875..880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gh"
                     /gene_synonym="Gh1; Ghb1"
                     /note="hexamer: AATAAA"
     polyA_site      896
                     /gene="Gh"
                     /gene_synonym="Gh1; Ghb1"
                     /note="major polyA site"
ORIGIN      
        1 gaataaatgt atagggggaa aggcaggagc cttggggtcg aggaaaacag gtagggtata
       61 aaaagggcac gcaagggacc aagtccagca tcctagagtc cagattccaa actgctcaga
      121 gtcctgtgga cagatcactg cttggcaatg gctacagact ctcggacctc ctggctcctg
      181 accgtcagcc tgctctgcct gctctggcct caggaggcta gtgcttttcc cgccatgccc
      241 ttgtccagtc tgttttctaa tgctgtgctc cgagcccagc acctgcacca gctggctgct
      301 gacacctaca aagagttcga gcgtgcctac attcccgagg gacagcgcta ttccattcag
      361 aatgcccagg ctgctttctg cttctcagag accatcccgg cccccacagg caaggaggag
      421 gcccagcaga gaaccgacat ggaattgctt cgcttctcgc tgctgctcat ccagtcatgg
      481 ctggggcccg tgcagttcct cagcaggatt ttcaccaaca gcctgatgtt cggcacctcg
      541 gaccgtgtct atgagaaact gaaggacctg gaagagggca tccaggctct gatgcaggag
      601 ctggaagatg gcagcccccg tgttgggcag atcctcaagc aaacctatga caagtttgac
      661 gccaacatgc gcagcgacga cgcgctgctc aaaaactatg ggctgctctc ctgcttcaag
      721 aaggacctgc acaaagcgga gacctacctg cgggtcatga agtgtcgccg ctttgtggaa
      781 agcagctgtg ccttctagcc actcaccagt gtctctgctg cactctcctg tgcctccctg
      841 ccccctggca actgccaccc ctgcgctttg tcctaataaa attaagatgc atcatatcac
      901 ccg
//
