LOCUS       NP_659035                662 aa            linear   ROD 04-JUN-2024
DEFINITION  glutathione hydrolase 7 isoform 2 [Mus musculus].
ACCESSION   NP_659035 XP_981655
VERSION     NP_659035.2
DBSOURCE    REFSEQ: accession NM_144786.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 662)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 662)
  AUTHORS   Clotman,F., Jacquemin,P., Plumb-Rudewiez,N., Pierreux,C.E., Van der
            Smissen,P., Dietz,H.C., Courtoy,P.J., Rousseau,G.G. and
            Lemaigre,F.P.
  TITLE     Control of liver cell fate decision by a gradient of TGF beta
            signaling modulated by Onecut transcription factors
  JOURNAL   Genes Dev 19 (16), 1849-1854 (2005)
   PUBMED   16103213
REFERENCE   3  (residues 1 to 662)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   4  (residues 1 to 662)
  AUTHORS   Ehringer,M.A., Thompson,J., Conroy,O., Xu,Y., Yang,F., Canniff,J.,
            Beeson,M., Gordon,L., Bennett,B., Johnson,T.E. and Sikela,J.M.
  TITLE     High-throughput sequence identification of gene coding variants
            within alcohol-related QTLs
  JOURNAL   Mamm Genome 12 (8), 657-663 (2001)
   PUBMED   11471062
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY127251.1, AK032051.1 and AK177521.1.
            
            On Mar 14, 2009 this sequence version replaced NP_659035.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (2)
            has the same N- and C-termini but is shorter compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032051.1, BC005772.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..662
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.26 cM"
     Protein         1..662
                     /product="glutathione hydrolase 7 isoform 2"
                     /EC_number="2.3.2.2"
                     /EC_number="3.4.19.13"
                     /note="gamma-glutamyltransferase-like 3; mFLJ00311
                     protein; GGT 7; gamma-glutamyltranspeptidase 7;
                     glutathione hydrolase 7"
                     /calculated_mol_wt=70121
     Site            17
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99MZ4; propagated from
                     UniProtKB/Swiss-Prot (Q99JP7.2)"
     Region          26..90
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JP7.2)"
     Site            72
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UJ14; propagated from
                     UniProtKB/Swiss-Prot (Q99JP7.2)"
     Site            79
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q99JP7.2)"
     Site            83
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q99JP7.2)"
     Site            107..127
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JP7.2)"
     Region          155..654
                     /region_name="G_glu_transpept"
                     /note="Gamma-glutamyltranspeptidase; pfam01019"
                     /db_xref="CDD:425991"
     Site            198
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99JP7.2)"
     Site            267
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99JP7.2)"
     Site            283
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99JP7.2)"
     Site            330
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99JP7.2)"
     Site            353
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99JP7.2)"
     Site            394
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99JP7.2)"
     Site            519
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99JP7.2)"
     Site            523
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99JP7.2)"
     Site            586
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99JP7.2)"
     CDS             1..662
                     /gene="Ggt7"
                     /gene_synonym="1110017C11Rik; 6330563L03Rik; Ggtl3"
                     /coded_by="NM_144786.2:50..2038"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS16949.1"
                     /db_xref="GeneID:207182"
                     /db_xref="MGI:MGI:1913385"
ORIGIN      
        1 maaeneasqe salgayspvd ymsitsfprl pedepapaap lrgrkdedaf lgdpdtdpds
       61 flksarlqrl pssssemgsq dgsplretrk dpfsaaaaec scrqdgltvi vtacltfatg
      121 vtvalvmqiy fgdpqifqqg avvtdassct algmevlskq gssvdaavaa alclgivaph
      181 ssglggggvm lvhdirrnes hlidfresap galreealqr swdtkpgllv gvpgmvkglh
      241 eahqlygrlp wsqvlafaaa vaqdgfnvth dlahalaeql ppnasdrfld tflplghppl
      301 pgsllrrpdl aevldilgts gpaafynggn ltlemvaeaq haggviteed fsnysaltek
      361 pvcgvyrghl vlspppphtg palisalnil egfnltslvs reqalhwvae tlkialalas
      421 rlgdpvydst itesmddmls kveaanfrgh isdsqaapap llpvyeldga ptaaqvlvmg
      481 pddfivamvs slnrpfgsgl ltpsgillns qmldfswpnr tanhsapsle nsvqpgkrpl
      541 sfllptvvrp aeglcgtyla lgangaargl sgltqvllnv ltlnrnlsds largrlhpdl
      601 qsnllqvdse fteeeiefle arghhvekvd vlswvhgsrr tntfiigvkd prspdaagat
      661 il
//
