LOCUS       NM_001359425            3788 bp    mRNA    linear   ROD 09-FEB-2024
DEFINITION  Mus musculus gamma-glutamyltransferase 5 (Ggt5), transcript variant
            2, mRNA.
ACCESSION   NM_001359425 XM_006513649
VERSION     NM_001359425.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3788)
  AUTHORS   Gallman,A.E., Wolfreys,F.D., Nguyen,D.N., Sandy,M., Xu,Y., An,J.,
            Li,Z., Marson,A., Lu,E. and Cyster,J.G.
  TITLE     Abcc1 and Ggt5 support lymphocyte guidance through export and
            catabolism of S-geranylgeranyl-l-glutathione
  JOURNAL   Sci Immunol 6 (60) (2021)
   PUBMED   34088745
  REMARK    GeneRIF: Abcc1 and Ggt5 support lymphocyte guidance through export
            and catabolism of S-geranylgeranyl-l-glutathione.
REFERENCE   2  (bases 1 to 3788)
  AUTHORS   Li,W., Wu,Z.Q., Zhang,S., Cao,R., Zhao,J., Sun,Z.J. and Zou,W.
  TITLE     Augmented expression of gamma-glutamyl transferase 5 (GGT5) impairs
            testicular steroidogenesis by deregulating local oxidative stress
  JOURNAL   Cell Tissue Res 366 (2), 467-481 (2016)
   PUBMED   27397680
  REMARK    GeneRIF: GGT5/oxidative stress cascade plays a central role during
            luteinizing hormone-stimulated steroidogenesis.
REFERENCE   3  (bases 1 to 3788)
  AUTHORS   Lefebvre,J., Clarkson,M., Massa,F., Bradford,S.T., Charlet,A.,
            Buske,F., Lacas-Gervais,S., Schulz,H., Gimpel,C., Hata,Y.,
            Schaefer,F. and Schedl,A.
  TITLE     Alternatively spliced isoforms of WT1 control podocyte-specific
            gene expression
  JOURNAL   Kidney Int 88 (2), 321-331 (2015)
   PUBMED   25993318
REFERENCE   4  (bases 1 to 3788)
  AUTHORS   Endoh-Yamagami,S., Karkar,K.M., May,S.R., Cobos,I., Thwin,M.T.,
            Long,J.E., Ashique,A.M., Zarbalis,K., Rubenstein,J.L. and
            Peterson,A.S.
  TITLE     A mutation in the pericentrin gene causes abnormal interneuron
            migration to the olfactory bulb in mice
  JOURNAL   Dev Biol 340 (1), 41-53 (2010)
   PUBMED   20096683
REFERENCE   5  (bases 1 to 3788)
  AUTHORS   Chavez,J., Young,H.W., Corry,D.B. and Lieberman,M.W.
  TITLE     Interactions between leukotriene C4 and interleukin 13 signaling
            pathways in a mouse model of airway disease
  JOURNAL   Arch Pathol Lab Med 130 (4), 440-446 (2006)
   PUBMED   16594735
REFERENCE   6  (bases 1 to 3788)
  AUTHORS   Han,B., Luo,G., Shi,Z.Z., Barrios,R., Atwood,D., Liu,W.,
            Habib,G.M., Sifers,R.N., Corry,D.B. and Lieberman,M.W.
  TITLE     Gamma-glutamyl leukotrienase, a novel endothelial membrane protein,
            is specifically responsible for leukotriene D(4) formation in vivo
  JOURNAL   Am J Pathol 161 (2), 481-490 (2002)
   PUBMED   12163373
  REMARK    GeneRIF: plays an important role in inflammatory processes
REFERENCE   7  (bases 1 to 3788)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   8  (bases 1 to 3788)
  AUTHORS   Shi,Z.Z., Han,B., Habib,G.M., Matzuk,M.M. and Lieberman,M.W.
  TITLE     Disruption of gamma-glutamyl leukotrienase results in disruption of
            leukotriene D(4) synthesis in vivo and attenuation of the acute
            inflammatory response
  JOURNAL   Mol Cell Biol 21 (16), 5389-5395 (2001)
   PUBMED   11463821
REFERENCE   9  (bases 1 to 3788)
  AUTHORS   Habib,G.M. and Lieberman,M.W.
  TITLE     Cleavage of leukotriene D4 in mice with targeted disruption of a
            membrane-bound dipeptidase gene
  JOURNAL   Adv Exp Med Biol 469, 295-300 (1999)
   PUBMED   10667344
REFERENCE   10 (bases 1 to 3788)
  AUTHORS   Carter,B.Z., Shi,Z.Z., Barrios,R. and Lieberman,M.W.
  TITLE     gamma-glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene
            family member, is expressed primarily in spleen
  JOURNAL   J Biol Chem 273 (43), 28277-28285 (1998)
   PUBMED   9774450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052183.1, DV051227.1 and AK049084.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by
            NM_001359425.2.
            
            On Jan 4, 2018 this sequence version replaced XM_006513649.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089585.1, SRR3224854.1649.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-502               AK052183.1         2-503
            503-1520            AK052183.1         1085-2102
            1521-1521           DV051227.1         581-581
            1522-3556           AK052183.1         2104-4138
            3557-3788           AK049084.1         4143-4374
FEATURES             Location/Qualifiers
     source          1..3788
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.55 cM"
     gene            1..3788
                     /gene="Ggt5"
                     /gene_synonym="GGL; GGT-REL; Ggtla1"
                     /note="gamma-glutamyltransferase 5"
                     /db_xref="GeneID:23887"
                     /db_xref="MGI:MGI:1346063"
     exon            1..502
                     /gene="Ggt5"
                     /gene_synonym="GGL; GGT-REL; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..649
                     /gene="Ggt5"
                     /gene_synonym="GGL; GGT-REL; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
     CDS             565..1470
                     /gene="Ggt5"
                     /gene_synonym="GGL; GGT-REL; Ggtla1"
                     /EC_number="2.3.2.2"
                     /EC_number="3.4.19.13"
                     /EC_number="3.4.19.14"
                     /note="isoform 2 is encoded by transcript variant 2;
                     gamma-glutamyltranspeptidase 5; gamma-glutamyl
                     leukotrienase; leukotriene-C4 hydrolase;
                     gamma-glutamyltransferase-like activity 1; glutathione
                     hydrolase 5 proenzyme"
                     /codon_start=1
                     /product="glutathione hydrolase 5 proenzyme isoform 2"
                     /protein_id="NP_001346354.1"
                     /db_xref="GeneID:23887"
                     /db_xref="MGI:MGI:1346063"
                     /translation="MPLGNYTLYSPPPPAGGAILSFILNVLKGFNFSAETVARPGGEV
                     NMYHHLVETLKFAVGQRWRLWDPSSHPGIQNISRDLLREDLAQRIRQQIDGRGDHHQL
                     SHYNLTGVRGNRMGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGILLNNELLDL
                     CWRHMPTSPITPPPVPGERPPSSMVPSILVNKGQGSKLVIGGAGGELIISAVAQTIMN
                     KLWLGFDLTEAIASPILHVNSKGHVEYEPKFNQEVQKGLQDRGQIQSQSQRPVFLNAV
                     QAVFQEGPCVYAASDLRKAGKASGY"
     exon            650..786
                     /gene="Ggt5"
                     /gene_synonym="GGL; GGT-REL; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
     exon            787..980
                     /gene="Ggt5"
                     /gene_synonym="GGL; GGT-REL; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1087
                     /gene="Ggt5"
                     /gene_synonym="GGL; GGT-REL; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1206
                     /gene="Ggt5"
                     /gene_synonym="GGL; GGT-REL; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1317
                     /gene="Ggt5"
                     /gene_synonym="GGL; GGT-REL; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..3788
                     /gene="Ggt5"
                     /gene_synonym="GGL; GGT-REL; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttctgcct ctggaggaga gtgtagcagc agcctggcca cagcctgccg tctgtctatc
       61 cataaaccca ggctggctgg cttcctgttt ctcctctgta acctgcctgg ccacctatct
      121 gtaaggctgt ccgtcatcct ttctgtccag ttgtctggcc tgtgtggctg tctgtcttga
      181 cccatcgatc tttcccctct gtccaatagc ctgagatcac cctgtgtagc ttcttttccc
      241 ttcagtttgt cagtcagttt gtctgtctct gtctgtccac tgccctgtgt gtccagttgc
      301 ctccctctct gtccctgggc cactgagcca tggcttgggg tcacagggcc acggtctgcc
      361 tggtcctgct gggtgtaggt ctaggtctgg ttatcgttgt gttggctgcg gtcctttctc
      421 ctcgtcaagc ctcttgtggt cccggtgcct tcacgcgtgc tgcggtagcg gctgactcca
      481 agatctgctc ggatattgga cggaagcctg ctgacagttc aggacttggc tgccttccag
      541 cctgaagtgg tggaacccct ggagatgccc ctaggaaact ataccctgta ctcgccgccg
      601 ccgcctgcag ggggcgctat tcttagcttc attctcaatg tgctgaaagg gttcaacttc
      661 tctgcagaga cggtggcgcg gcctggaggg gaagtgaaca tgtaccatca ccttgtagag
      721 actctcaagt tcgccgtagg gcagaggtgg cggctatggg acccttccag tcacccgggg
      781 atacagaaca tctcccggga cctcctccgg gaagatctag cccagcgcat ccgccagcag
      841 attgacggcc gtggtgacca ccaccagctc agccattaca acctgactgg ggtcaggggc
      901 aaccggatgg gcacctctca tgtgtctgtg ttgggagaag atggcagtgc tgtggcagcc
      961 accagcacca tcaacacacc ctttggggcg atggtgtact ccccacggac aggcatcctc
     1021 ctgaacaacg agcttctaga cttatgctgg agacacatgc caacatcccc gatcacccct
     1081 ccacctgttc caggtgagcg gccaccatct tccatggtac cttccatctt ggtcaacaaa
     1141 ggccagggat cgaagctggt gatcggtggg gcaggtggag agctgatcat ctctgccgtg
     1201 gcccagacta tcatgaacaa gctgtggctt ggctttgacc tgacagaagc tatcgcatct
     1261 cctattctac acgtcaacag caagggccat gtggagtatg agcccaaatt caaccaggag
     1321 gtacagaagg ggctacagga ccgaggccag attcagagcc agagccagcg gccagttttc
     1381 ctgaatgcgg tccaggctgt gtttcaggaa gggccctgcg tctatgcagc gtctgacctg
     1441 aggaaggctg gaaaggcttc aggatactaa gtcagctctg cccagagctg ggatctggcc
     1501 cactacgaat gctgtgactc acatgggtga tgctgtatgc ctaagcactc caggacctgg
     1561 atcccttgct gtgaggtcaa cctgggactg aaaaagaaca aggatcagct cagcaggatg
     1621 aatgactgga gagagaagga ctgacttgtc cttgatccca tcccaacacc tcctgtggcc
     1681 ctgccttggt tcttctagcc ttgccttggc ctcatgccca ccctcttaaa tggtgtacct
     1741 gccagtccaa gattaaagag gagccacagc gtgaactgat ttggtggttc taagcaggta
     1801 aagagaccct cagagagtcc ccagtgatac atagcacaac acagattcct atggtccttc
     1861 gggactcgac atcagggttc agagatgggc cagccttatg gatgaggctc aatgggcaga
     1921 ggcaagcaca ccattcacct ctactctgct ccagctacaa tatctttggg ggatctgtga
     1981 tgtgtctgct cccacctcac cccatcttgc ttgctggtgg gaagacagga gcatggctta
     2041 ttgtacttgt ccctaactct tgtgatgttt ttctgcacgc aggaagaggt tgggtaaagc
     2101 aaagctcggg tcttaatact ccatgttctt gagacaaggg cccatgcttg gcagtgctga
     2161 catctgagat gacattatct tttgtcgcat ggagctgtcc ccacatcaca cacccttgac
     2221 acaatagcat cccctcacgt atccccagat gcaacaacaa actgtcactg gacagggcta
     2281 cgccacccct ggctgagaac tgcctctctg gagcagtggg aaactgtcag agatggcttt
     2341 gcaggctacc cagtaggatg ctcctcgggg atgtctccct agagggacct gagcatctga
     2401 ctcctacgag tatcaggtac ctctgtgtca cctcaagtgc ctgtgggagt tgcgctacta
     2461 catacagggt attacaacaa cctgtgtggc ttatgcatct caaagaatgc tggttcaatt
     2521 gttaagagct cttttctttt cttttttctt tctttttctt tttttttttt tctttttttc
     2581 ctttttggct aggacctagg ttttgattcc aggctcctac ataaccatct ctaactccag
     2641 ttccaaggga tctgatggcc ctttctgacc tccataggca ccaaggatac aatataatat
     2701 gcatgcctac atgcaggcag aacactcaca tataaaatta aatgaataga tctaacttta
     2761 aaatttgttt gaaaaaaatg atgacttaca actctgaaaa agaggaagcc tgagataaag
     2821 gtgcgtgcag attctatgct tagcgatggt tcatttcctc acagcccgtc atgtggtgga
     2881 agaagctagg tgacttgcta gggtctatta aaggatgcta accctcactg tctaagaaag
     2941 attggttcca ggacctcccc caaagaagac gtgatttctg tggatgctca tggcctttat
     3001 ataaaatgta gctgtatttg catcagctcc ttggaaaacc aagagctgga agctaatggg
     3061 gcattaagtg aggttcaggt gatatcttct ggtgttcctg atgacagttt cctcatcttc
     3121 attgtgatgt tgtggtaagg gatggacacc cccccacaca cacacacctt ggtttgagat
     3181 cataaaactc tctgctccct tctaacacag tttcccactg ttcctgcttt tctgtgccta
     3241 gccccaggat ctttcctgat ttataactgc acgattcaag ctactgaatc ttgctccacg
     3301 tgccccttct atctcctact acatctgtgg gaacccaact caagtgcttt tgatcaaaga
     3361 ggggtggcta catcttttgg ctagctctcg ccatgtgata atgtcagtgt gctttccgta
     3421 tcagatcaaa gaggtaacct aagacctcca tgacaagttc tgttcttgag agattatttt
     3481 tcctagtata ctaattgggt tctaagagga acttaatgat tctgctatga ccacatacct
     3541 ctgatgtatt gtgcccagaa aaaaaaaatg gtggtttggg tttccccctg agccttatag
     3601 aatagcaact gatgttatat atctgagaga ggcaaccgta tcttcttcct gctaattcat
     3661 ctcttgatgt atagtgaaat aaatttgatc ctcaagcttt agaaagaaag agctggctgt
     3721 gtacaatgtc gccaggcaac caattaaatg ttaagaagaa taaataaatg ataggcaatt
     3781 taacgttt
//
