LOCUS       NM_001379540            2099 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus gamma-glutamyltransferase 1 (Ggt1), transcript variant
            6, mRNA.
ACCESSION   NM_001379540 XM_030244884
VERSION     NM_001379540.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2099)
  AUTHORS   Yang,Y., Li,Q., Ling,Y., Leng,L., Ma,Y., Xue,L., Lu,G., Ding,Y.,
            Li,J. and Tao,S.
  TITLE     m6A eraser FTO modulates autophagy by targeting SQSTM1/P62 in the
            prevention of canagliflozin against renal fibrosis
  JOURNAL   Front Immunol 13, 1094556 (2023)
   PUBMED   36685533
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2099)
  AUTHORS   Mendiola,A.S., Ryu,J.K., Bardehle,S., Meyer-Franke,A., Ang,K.K.,
            Wilson,C., Baeten,K.M., Hanspers,K., Merlini,M., Thomas,S.,
            Petersen,M.A., Williams,A., Thomas,R., Rafalski,V.A.,
            Meza-Acevedo,R., Tognatta,R., Yan,Z., Pfaff,S.J., Machado,M.R.,
            Bedard,C., Rios Coronado,P.E., Jiang,X., Wang,J., Pleiss,M.A.,
            Green,A.J., Zamvil,S.S., Pico,A.R., Bruneau,B.G., Arkin,M.R. and
            Akassoglou,K.
  TITLE     Transcriptional profiling and therapeutic targeting of oxidative
            stress in neuroinflammation
  JOURNAL   Nat Immunol 21 (5), 513-524 (2020)
   PUBMED   32284594
  REMARK    Erratum:[Nat Immunol. 2020 Sep;21(9):1135. doi:
            10.1038/s41590-020-0754-x.. PMID: 32661365]
REFERENCE   3  (bases 1 to 2099)
  AUTHORS   Shimamura,Y., Takeuchi,I., Terada,H. and Makino,K.
  TITLE     Therapeutic Effect of GGsTop, Selective Gamma-glutamyl
            Transpeptidase Inhibitor, on a Mouse Model of
            5-Fluorouracil-induced Oral Mucositis
  JOURNAL   Anticancer Res 39 (1), 201-206 (2019)
   PUBMED   30591459
  REMARK    GeneRIF: GGsTop is a newly-discovered gamma-glutamyl transpeptidase
            (GGT) inhibitor...GGsTop treated Oral mucositis (OM) quickly and
            safely. GGsTop is highly valuable for use as a treatment for OM
REFERENCE   4  (bases 1 to 2099)
  AUTHORS   Long,Y., Jia,D., Wei,L., Yang,Y., Tian,H. and Chen,T.
  TITLE     Liver-Specific Overexpression of Gamma-Glutamyltransferase
            Ameliorates Insulin Sensitivity of Male C57BL/6 Mice
  JOURNAL   J Diabetes Res 2017, 2654520 (2017)
   PUBMED   28660214
  REMARK    GeneRIF: the present study developed a liver-specific
            GGT-overexpressing mice model and found that GGT elevation in short
            term had no effects on glucose metabolism but could increase
            insulin sensitivity through enhancing the activity of insulin
            signaling pathway.
REFERENCE   5  (bases 1 to 2099)
  AUTHORS   Kaminski,M.M., Tosic,J., Kresbach,C., Engel,H., Klockenbusch,J.,
            Muller,A.L., Pichler,R., Grahammer,F., Kretz,O., Huber,T.B.,
            Walz,G., Arnold,S.J. and Lienkamp,S.S.
  TITLE     Direct reprogramming of fibroblasts into renal tubular epithelial
            cells by defined transcription factors
  JOURNAL   Nat Cell Biol 18 (12), 1269-1280 (2016)
   PUBMED   27820600
REFERENCE   6  (bases 1 to 2099)
  AUTHORS   Lieberman,M.W., Barrios,R., Carter,B.Z., Habib,G.M., Lebovitz,R.M.,
            Rajagopalan,S., Sepulveda,A.R., Shi,Z.Z. and Wan,D.F.
  TITLE     gamma-Glutamyl transpeptidase. What does the organization and
            expression of a multipromoter gene tell us about its functions?
  JOURNAL   Am J Pathol 147 (5), 1175-1185 (1995)
   PUBMED   7485380
  REMARK    Review article
REFERENCE   7  (bases 1 to 2099)
  AUTHORS   Carter,B.Z., Habib,G.M., Sepulveda,A.R., Barrios,R., Wan,D.F.,
            Lebovitz,R.M. and Lieberman,M.W.
  TITLE     Type VI RNA is the major gamma-glutamyl transpeptidase RNA in the
            mouse small intestine
  JOURNAL   J Biol Chem 269 (40), 24581-24585 (1994)
   PUBMED   7523374
REFERENCE   8  (bases 1 to 2099)
  AUTHORS   Rajagopalan,S., Wan,D.F., Habib,G.M., Sepulveda,A.R., McLeod,M.R.,
            Lebovitz,R.M. and Lieberman,M.W.
  TITLE     Six mRNAs with different 5' ends are encoded by a single
            gamma-glutamyltransferase gene in mouse
  JOURNAL   Proc Natl Acad Sci U S A 90 (13), 6179-6183 (1993)
   PUBMED   8101000
REFERENCE   9  (bases 1 to 2099)
  AUTHORS   Gattone,V.H. 2nd, Andrews,G.K., Niu,F.W., Chadwick,L.J., Klein,R.M.
            and Calvet,J.P.
  TITLE     Defective epidermal growth factor gene expression in mice with
            polycystic kidney disease
  JOURNAL   Dev Biol 138 (1), 225-230 (1990)
   PUBMED   1968405
REFERENCE   10 (bases 1 to 2099)
  AUTHORS   Curto,K.A., Sweeney,W.E., Avner,E.D., Piesco,N.P. and Curthoys,N.P.
  TITLE     Immunocytochemical localization of gamma-glutamyltranspeptidase
            during fetal development of mouse kidney
  JOURNAL   J Histochem Cytochem 36 (2), 159-166 (1988)
   PUBMED   2891746
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087540.34.
            
            On Apr 9, 2020 this sequence version replaced XM_030244884.1.
            
            Summary: This gene encodes gamma-glutamyl transpeptidase, a
            plasmamembrane-associated enzyme that cleaves the peptide bond
            between gamma-glutamyl and cysteinyl glycine moieties of
            glutathione. The encoded protein is autocatalytically processed to
            generate an enzymatically active heterodimer comprised of heavy and
            light chains. Mice lacking the encoded protein grow slowly, develop
            cataracts and have elevated levels of glutathione in plasma and
            urine. Transgenic overexpression of the encoded protein in mice
            enhances osteoclastic bone resorption. The mutant alleles termed
            'Dwarf grey' and 'Dwarf grey Bayer' in mice are associated with
            deletions in this gene. A gamma-glutamyl transpeptidase paralog is
            located adjacent to this gene. Alternative splicing results in
            multiple transcript variants. Additional transcripts using
            alternate promoters and differing in 5' UTRs have been described.
            [provided by RefSeq, Apr 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189676.88534.1,
                                           SRR7652917.726429.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC087540.34        28892-28975
            85-222              AC087540.34        30943-31080
            223-387             AC087540.34        31564-31728
            388-518             AC087540.34        33282-33412
            519-605             AC087540.34        33548-33634
            606-798             AC087540.34        36061-36253
            799-956             AC087540.34        36558-36715
            957-1106            AC087540.34        37836-37985
            1107-1243           AC087540.34        38629-38765
            1244-1431           AC087540.34        42152-42339
            1432-1559           AC087540.34        42490-42617
            1560-1672           AC087540.34        42719-42831
            1673-1786           AC087540.34        42923-43036
            1787-2099           AC087540.34        43213-43525
FEATURES             Location/Qualifiers
     source          1..2099
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.55 cM"
     gene            1..2099
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /note="gamma-glutamyltransferase 1"
                     /db_xref="GeneID:14598"
                     /db_xref="MGI:MGI:95706"
     exon            1..84
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            85..222
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            223..387
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1933
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /EC_number="2.3.2.2"
                     /EC_number="3.4.19.13"
                     /EC_number="3.4.19.14"
                     /note="gamma-glutamyltranspeptidase 1; leukotriene-C4
                     hydrolase; glutathione hydrolase 1 proenzyme"
                     /codon_start=1
                     /product="glutathione hydrolase 1 proenzyme precursor"
                     /protein_id="NP_001366469.1"
                     /db_xref="GeneID:14598"
                     /db_xref="MGI:MGI:95706"
                     /translation="MKNRFLVLGLVAVVLVFVIIGLCIWLPYTSGKPDHVYSRAAVAT
                     DAKRCSEIGRDILQEGGSVVDAAIASLLCMGLMNAHSMGIGGGLFFTIYNSTTGKVEV
                     INAREVAPRLANTTMFNNSKDSEEGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSI
                     QLARHGFPVGKGLAIALDKKRDVIEKTPALCEVFCRQGKVLQEGETVTMPKLADTLQI
                     LAQEGAKAFYNGSLTAQIVKDIQEAGGIMTVEDLNNYRAELIEHPMSIGLGDATLYVP
                     SAPLSGPVLILILNILKGYNFSPKSVATPEQKALTYHRIVEAFRFAYAKRTMLGDPKF
                     VDVSQVIRNMSSEFYATQLRARITDETTHPAAYYEPEFYLQDDGGTAHLSAVSEDGSA
                     VAATSTINLYFGSKVLSRVSGILFNDEMDDFSSPNFINQFRVAPSPANFIKPGKQPLS
                     SMCPSIILDKDGQVRMVVGASGGTQITTSVALAIINSLWFGYDVKRAVEEPRLHNQLL
                     PNTTTVEKDIDQVVTAGLKIRHHHTEVTPTFIAVVQAVVRASGGWAAASDSRKGGEPA
                     GY"
     exon            388..518
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            519..605
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            606..798
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            799..956
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1106
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1243
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1431
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1559
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1672
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1786
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..2099
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2099
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /note="major polyA site"
ORIGIN      
        1 ctcacacccc actcagaagc cttcagatgc ccttctggga tgctgggcac cccttagctg
       61 acctcttgcc ccccctggga ttaggagtgc caggaggtag cctgctctag cagttcaggg
      121 aagatcggtc tctgcagagt gtggagagag ttcctgccca tccatacagc tgtttttcaa
      181 aagccacctc cccaagaaag gtttgggggc tcctactgga agagccatga agaatcggtt
      241 tctggtgctg ggcctggtgg ctgtggttct ggtatttgtc atcatcggcc tctgtatctg
      301 gttgccctac acctctggga agcccgacca cgtgtactcc agggcggcgg tggccaccga
      361 cgccaagcgc tgctcagaga ttggacggga tatcctacag gaaggtggtt ccgtggtgga
      421 tgcagccatc gcaagcctgc tgtgtatggg gctcatgaat gcccacagta tgggcatcgg
      481 gggcggcctg ttcttcacca tctacaacag caccacagga aaagttgagg ttatcaatgc
      541 ccgtgaggta gctcccaggt tggccaatac caccatgttc aacaactcca aggactctga
      601 agaaggtggc ctttcagtgg ctgtccctgg tgaaatccgt ggttatgagc tggcacacca
      661 acgacacggc cggctcccct gggctcgcct cttccaaccc agcatccagc tggctcgcca
      721 cggcttccct gtgggcaagg gtttggcaat agccctggac aaaaaacggg acgtcattga
      781 gaagacccct gccttgtgcg aggtgttctg ccgccaaggg aaggtgcttc aagaaggaga
      841 gacggtgact atgccgaagc tggctgacac attgcagata ctggcccagg agggcgccaa
      901 ggccttctac aatgggagcc tcacagccca gattgtgaaa gacatccagg aggctggtgg
      961 cattatgacg gttgaggacc tcaacaacta ccgtgctgag ctgattgagc atccgatgag
     1021 catcggcctc ggtgatgcga ccctgtacgt gcccagtgcc ccactcagcg ggcccgtgct
     1081 gattctcatc ttgaacatcc tcaaaggata caacttctct ccgaagagcg tagcgacccc
     1141 tgaacagaag gcactgacgt atcaccgtat cgtggaggcc tttcggtttg cctatgccaa
     1201 gaggaccatg ctcggtgacc caaagtttgt cgatgtgtct caggtgatcc gcaacatgag
     1261 ctctgagttc tacgccaccc agctccgagc ccgcatcact gatgaaacca cccacccagc
     1321 cgcctactat gagcctgaat tctaccttca ggatgatgga ggcaccgctc acctgtctgc
     1381 ggtttcagag gatggcagtg ctgtggctgc cactagtacc atcaacctct actttggctc
     1441 caaggtcctg tctcgggtca gtggcatcct gtttaatgat gagatggatg acttcagctc
     1501 gcccaacttc atcaaccagt tcagggtagc cccctcacca gccaacttca tcaagccagg
     1561 taagcagcct ctttcatcca tgtgtccctc aatcatcctg gataaggacg gccaggttcg
     1621 catggtggtc ggagcctcag ggggtaccca gatcaccaca tctgttgcac tggccatcat
     1681 caacagcctg tggttcggat acgatgtgaa gagagctgtg gaggagcccc ggctgcacaa
     1741 ccagctttta cctaatacca caacggtaga gaaagacatt gatcaggtgg tgactgcagg
     1801 cctgaagatt cggcaccacc atacagaagt cacgcccacc ttcatcgctg tagttcaggc
     1861 tgtcgttcga gcatcaggtg gttgggcagc tgcctcagac tccagaaaag gcggggaacc
     1921 tgctggctac tgagtgcccg gaagaggcaa gattgacccg cagccaaggg acgagaatgg
     1981 gaacaggagc aagagtggga cgttggagaa catgccgcct ctgggtggga cagagggagc
     2041 gcaataaatg gaggccaccg ccaagctgcg ggaagccttt gcgggctgaa ctttccata
//
