LOCUS       NM_001379537            2230 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus gamma-glutamyltransferase 1 (Ggt1), transcript variant
            3, mRNA.
ACCESSION   NM_001379537 XM_006513230
VERSION     NM_001379537.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2230)
  AUTHORS   Yang,Y., Li,Q., Ling,Y., Leng,L., Ma,Y., Xue,L., Lu,G., Ding,Y.,
            Li,J. and Tao,S.
  TITLE     m6A eraser FTO modulates autophagy by targeting SQSTM1/P62 in the
            prevention of canagliflozin against renal fibrosis
  JOURNAL   Front Immunol 13, 1094556 (2023)
   PUBMED   36685533
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2230)
  AUTHORS   Mendiola,A.S., Ryu,J.K., Bardehle,S., Meyer-Franke,A., Ang,K.K.,
            Wilson,C., Baeten,K.M., Hanspers,K., Merlini,M., Thomas,S.,
            Petersen,M.A., Williams,A., Thomas,R., Rafalski,V.A.,
            Meza-Acevedo,R., Tognatta,R., Yan,Z., Pfaff,S.J., Machado,M.R.,
            Bedard,C., Rios Coronado,P.E., Jiang,X., Wang,J., Pleiss,M.A.,
            Green,A.J., Zamvil,S.S., Pico,A.R., Bruneau,B.G., Arkin,M.R. and
            Akassoglou,K.
  TITLE     Transcriptional profiling and therapeutic targeting of oxidative
            stress in neuroinflammation
  JOURNAL   Nat Immunol 21 (5), 513-524 (2020)
   PUBMED   32284594
  REMARK    Erratum:[Nat Immunol. 2020 Sep;21(9):1135. doi:
            10.1038/s41590-020-0754-x.. PMID: 32661365]
REFERENCE   3  (bases 1 to 2230)
  AUTHORS   Shimamura,Y., Takeuchi,I., Terada,H. and Makino,K.
  TITLE     Therapeutic Effect of GGsTop, Selective Gamma-glutamyl
            Transpeptidase Inhibitor, on a Mouse Model of
            5-Fluorouracil-induced Oral Mucositis
  JOURNAL   Anticancer Res 39 (1), 201-206 (2019)
   PUBMED   30591459
  REMARK    GeneRIF: GGsTop is a newly-discovered gamma-glutamyl transpeptidase
            (GGT) inhibitor...GGsTop treated Oral mucositis (OM) quickly and
            safely. GGsTop is highly valuable for use as a treatment for OM
REFERENCE   4  (bases 1 to 2230)
  AUTHORS   Long,Y., Jia,D., Wei,L., Yang,Y., Tian,H. and Chen,T.
  TITLE     Liver-Specific Overexpression of Gamma-Glutamyltransferase
            Ameliorates Insulin Sensitivity of Male C57BL/6 Mice
  JOURNAL   J Diabetes Res 2017, 2654520 (2017)
   PUBMED   28660214
  REMARK    GeneRIF: the present study developed a liver-specific
            GGT-overexpressing mice model and found that GGT elevation in short
            term had no effects on glucose metabolism but could increase
            insulin sensitivity through enhancing the activity of insulin
            signaling pathway.
REFERENCE   5  (bases 1 to 2230)
  AUTHORS   Kaminski,M.M., Tosic,J., Kresbach,C., Engel,H., Klockenbusch,J.,
            Muller,A.L., Pichler,R., Grahammer,F., Kretz,O., Huber,T.B.,
            Walz,G., Arnold,S.J. and Lienkamp,S.S.
  TITLE     Direct reprogramming of fibroblasts into renal tubular epithelial
            cells by defined transcription factors
  JOURNAL   Nat Cell Biol 18 (12), 1269-1280 (2016)
   PUBMED   27820600
REFERENCE   6  (bases 1 to 2230)
  AUTHORS   Lieberman,M.W., Barrios,R., Carter,B.Z., Habib,G.M., Lebovitz,R.M.,
            Rajagopalan,S., Sepulveda,A.R., Shi,Z.Z. and Wan,D.F.
  TITLE     gamma-Glutamyl transpeptidase. What does the organization and
            expression of a multipromoter gene tell us about its functions?
  JOURNAL   Am J Pathol 147 (5), 1175-1185 (1995)
   PUBMED   7485380
  REMARK    Review article
REFERENCE   7  (bases 1 to 2230)
  AUTHORS   Carter,B.Z., Habib,G.M., Sepulveda,A.R., Barrios,R., Wan,D.F.,
            Lebovitz,R.M. and Lieberman,M.W.
  TITLE     Type VI RNA is the major gamma-glutamyl transpeptidase RNA in the
            mouse small intestine
  JOURNAL   J Biol Chem 269 (40), 24581-24585 (1994)
   PUBMED   7523374
REFERENCE   8  (bases 1 to 2230)
  AUTHORS   Rajagopalan,S., Wan,D.F., Habib,G.M., Sepulveda,A.R., McLeod,M.R.,
            Lebovitz,R.M. and Lieberman,M.W.
  TITLE     Six mRNAs with different 5' ends are encoded by a single
            gamma-glutamyltransferase gene in mouse
  JOURNAL   Proc Natl Acad Sci U S A 90 (13), 6179-6183 (1993)
   PUBMED   8101000
REFERENCE   9  (bases 1 to 2230)
  AUTHORS   Gattone,V.H. 2nd, Andrews,G.K., Niu,F.W., Chadwick,L.J., Klein,R.M.
            and Calvet,J.P.
  TITLE     Defective epidermal growth factor gene expression in mice with
            polycystic kidney disease
  JOURNAL   Dev Biol 138 (1), 225-230 (1990)
   PUBMED   1968405
REFERENCE   10 (bases 1 to 2230)
  AUTHORS   Curto,K.A., Sweeney,W.E., Avner,E.D., Piesco,N.P. and Curthoys,N.P.
  TITLE     Immunocytochemical localization of gamma-glutamyltranspeptidase
            during fetal development of mouse kidney
  JOURNAL   J Histochem Cytochem 36 (2), 159-166 (1988)
   PUBMED   2891746
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087540.34.
            
            On Apr 9, 2020 this sequence version replaced XM_006513230.4.
            
            Summary: This gene encodes gamma-glutamyl transpeptidase, a
            plasmamembrane-associated enzyme that cleaves the peptide bond
            between gamma-glutamyl and cysteinyl glycine moieties of
            glutathione. The encoded protein is autocatalytically processed to
            generate an enzymatically active heterodimer comprised of heavy and
            light chains. Mice lacking the encoded protein grow slowly, develop
            cataracts and have elevated levels of glutathione in plasma and
            urine. Transgenic overexpression of the encoded protein in mice
            enhances osteoclastic bone resorption. The mutant alleles termed
            'Dwarf grey' and 'Dwarf grey Bayer' in mice are associated with
            deletions in this gene. A gamma-glutamyl transpeptidase paralog is
            located adjacent to this gene. Alternative splicing results in
            multiple transcript variants. Additional transcripts using
            alternate promoters and differing in 5' UTRs have been described.
            [provided by RefSeq, Apr 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.188830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AC087540.34        21464-21590
            128-212             AC087540.34        22153-22237
            213-350             AC087540.34        30943-31080
            351-518             AC087540.34        31561-31728
            519-649             AC087540.34        33282-33412
            650-736             AC087540.34        33548-33634
            737-929             AC087540.34        36061-36253
            930-1087            AC087540.34        36558-36715
            1088-1237           AC087540.34        37836-37985
            1238-1374           AC087540.34        38629-38765
            1375-1562           AC087540.34        42152-42339
            1563-1690           AC087540.34        42490-42617
            1691-1803           AC087540.34        42719-42831
            1804-1917           AC087540.34        42923-43036
            1918-2230           AC087540.34        43213-43525
FEATURES             Location/Qualifiers
     source          1..2230
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.55 cM"
     gene            1..2230
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /note="gamma-glutamyltransferase 1"
                     /db_xref="GeneID:14598"
                     /db_xref="MGI:MGI:95706"
     exon            1..127
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            128..212
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            213..350
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            351..518
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..2064
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /EC_number="2.3.2.2"
                     /EC_number="3.4.19.13"
                     /EC_number="3.4.19.14"
                     /note="gamma-glutamyltranspeptidase 1; leukotriene-C4
                     hydrolase; glutathione hydrolase 1 proenzyme"
                     /codon_start=1
                     /product="glutathione hydrolase 1 proenzyme precursor"
                     /protein_id="NP_001366466.1"
                     /db_xref="GeneID:14598"
                     /db_xref="MGI:MGI:95706"
                     /translation="MKNRFLVLGLVAVVLVFVIIGLCIWLPYTSGKPDHVYSRAAVAT
                     DAKRCSEIGRDILQEGGSVVDAAIASLLCMGLMNAHSMGIGGGLFFTIYNSTTGKVEV
                     INAREVAPRLANTTMFNNSKDSEEGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSI
                     QLARHGFPVGKGLAIALDKKRDVIEKTPALCEVFCRQGKVLQEGETVTMPKLADTLQI
                     LAQEGAKAFYNGSLTAQIVKDIQEAGGIMTVEDLNNYRAELIEHPMSIGLGDATLYVP
                     SAPLSGPVLILILNILKGYNFSPKSVATPEQKALTYHRIVEAFRFAYAKRTMLGDPKF
                     VDVSQVIRNMSSEFYATQLRARITDETTHPAAYYEPEFYLQDDGGTAHLSAVSEDGSA
                     VAATSTINLYFGSKVLSRVSGILFNDEMDDFSSPNFINQFRVAPSPANFIKPGKQPLS
                     SMCPSIILDKDGQVRMVVGASGGTQITTSVALAIINSLWFGYDVKRAVEEPRLHNQLL
                     PNTTTVEKDIDQVVTAGLKIRHHHTEVTPTFIAVVQAVVRASGGWAAASDSRKGGEPA
                     GY"
     exon            519..649
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            650..736
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            737..929
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1087
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1237
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1374
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1562
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1690
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1803
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1917
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2230
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2230
                     /gene="Ggt1"
                     /gene_synonym="CD224; dwg; GGT; GGT 1; GGT-1; Ggtp"
                     /note="major polyA site"
ORIGIN      
        1 agttgcttag ctcaggttag gacttgttga ccttgggcat ctgacacagc gggtggctca
       61 gacttggact ctatgtgcaa tgtgatatag ctcagcatgg aagatgtaaa gaggaaggga
      121 gctctggatg ctgaatgctc ccaggaatta acaagctgac catcccggag gcccacgcgc
      181 ttggctaagt acaggctcca ctcacaccaa aggagtgcca ggaggtagcc tgctctagca
      241 gttcagggaa gatcggtctc tgcagagtgt ggagagagtt cctgcccatc catacagctg
      301 tttttcaaaa gccacctccc caagaaaggt ttgggggctc ctactggaag cagagccatg
      361 aagaatcggt ttctggtgct gggcctggtg gctgtggttc tggtatttgt catcatcggc
      421 ctctgtatct ggttgcccta cacctctggg aagcccgacc acgtgtactc cagggcggcg
      481 gtggccaccg acgccaagcg ctgctcagag attggacggg atatcctaca ggaaggtggt
      541 tccgtggtgg atgcagccat cgcaagcctg ctgtgtatgg ggctcatgaa tgcccacagt
      601 atgggcatcg ggggcggcct gttcttcacc atctacaaca gcaccacagg aaaagttgag
      661 gttatcaatg cccgtgaggt agctcccagg ttggccaata ccaccatgtt caacaactcc
      721 aaggactctg aagaaggtgg cctttcagtg gctgtccctg gtgaaatccg tggttatgag
      781 ctggcacacc aacgacacgg ccggctcccc tgggctcgcc tcttccaacc cagcatccag
      841 ctggctcgcc acggcttccc tgtgggcaag ggtttggcaa tagccctgga caaaaaacgg
      901 gacgtcattg agaagacccc tgccttgtgc gaggtgttct gccgccaagg gaaggtgctt
      961 caagaaggag agacggtgac tatgccgaag ctggctgaca cattgcagat actggcccag
     1021 gagggcgcca aggccttcta caatgggagc ctcacagccc agattgtgaa agacatccag
     1081 gaggctggtg gcattatgac ggttgaggac ctcaacaact accgtgctga gctgattgag
     1141 catccgatga gcatcggcct cggtgatgcg accctgtacg tgcccagtgc cccactcagc
     1201 gggcccgtgc tgattctcat cttgaacatc ctcaaaggat acaacttctc tccgaagagc
     1261 gtagcgaccc ctgaacagaa ggcactgacg tatcaccgta tcgtggaggc ctttcggttt
     1321 gcctatgcca agaggaccat gctcggtgac ccaaagtttg tcgatgtgtc tcaggtgatc
     1381 cgcaacatga gctctgagtt ctacgccacc cagctccgag cccgcatcac tgatgaaacc
     1441 acccacccag ccgcctacta tgagcctgaa ttctaccttc aggatgatgg aggcaccgct
     1501 cacctgtctg cggtttcaga ggatggcagt gctgtggctg ccactagtac catcaacctc
     1561 tactttggct ccaaggtcct gtctcgggtc agtggcatcc tgtttaatga tgagatggat
     1621 gacttcagct cgcccaactt catcaaccag ttcagggtag ccccctcacc agccaacttc
     1681 atcaagccag gtaagcagcc tctttcatcc atgtgtccct caatcatcct ggataaggac
     1741 ggccaggttc gcatggtggt cggagcctca gggggtaccc agatcaccac atctgttgca
     1801 ctggccatca tcaacagcct gtggttcgga tacgatgtga agagagctgt ggaggagccc
     1861 cggctgcaca accagctttt acctaatacc acaacggtag agaaagacat tgatcaggtg
     1921 gtgactgcag gcctgaagat tcggcaccac catacagaag tcacgcccac cttcatcgct
     1981 gtagttcagg ctgtcgttcg agcatcaggt ggttgggcag ctgcctcaga ctccagaaaa
     2041 ggcggggaac ctgctggcta ctgagtgccc ggaagaggca agattgaccc gcagccaagg
     2101 gacgagaatg ggaacaggag caagagtggg acgttggaga acatgccgcc tctgggtggg
     2161 acagagggag cgcaataaat ggaggccacc gccaagctgc gggaagcctt tgcgggctga
     2221 actttccata
//
