LOCUS       NM_010282               5113 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus geranylgeranyl diphosphate synthase 1 (Ggps1),
            transcript variant 5, mRNA.
ACCESSION   NM_010282 XM_904706 XM_918946 XM_918968
VERSION     NM_010282.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5113)
  AUTHORS   Shao,X., Wang,K., Wu,J., Ma,X., Zhao,Y., Xu,T., Dai,C., Zhang,F.,
            Wang,Y., Ren,X., Lu,K., Yin,Z., Guo,B., Cao,C., Xu,X. and Xue,B.
  TITLE     Deficiency of geranylgeranyl biphosphate synthase in kidney tubules
            causes cystic kidney disease
  JOURNAL   FASEB J 38 (17), e23875 (2024)
   PUBMED   39229897
  REMARK    GeneRIF: Deficiency of geranylgeranyl biphosphate synthase in
            kidney tubules causes cystic kidney disease.
REFERENCE   2  (bases 1 to 5113)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5113)
  AUTHORS   Wang,L., Lin,Q., Wei,B., Guo,Y., Li,Q., Wang,Z., Wu,L., Zhang,Y.,
            Yin,J. and Wan,B.
  TITLE     CircUBR1 knockdown relieves ventilator-induced lung injury through
            regulating miR-20a-5p/GGPPS1 pathway
  JOURNAL   Cell Signal 112, 110920 (2023)
   PUBMED   37827345
  REMARK    GeneRIF: CircUBR1 knockdown relieves ventilator-induced lung injury
            through regulating miR-20a-5p/GGPPS1 pathway.
REFERENCE   4  (bases 1 to 5113)
  AUTHORS   Edwards,W., Greco,T.M., Miner,G.E., Barker,N.K., Herring,L.,
            Cohen,S., Cristea,I.M. and Conlon,F.L.
  TITLE     Quantitative proteomic profiling identifies global protein network
            dynamics in murine embryonic heart development
  JOURNAL   Dev Cell 58 (12), 1087-1105 (2023)
   PUBMED   37148880
REFERENCE   5  (bases 1 to 5113)
  AUTHORS   Shen,N., Gong,T., Wang,J.D., Meng,F.L., Qiao,L., Yang,R.L., Xue,B.,
            Pan,F.Y., Zhou,X.J., Chen,H.Q., Ning,W. and Li,C.J.
  TITLE     Cigarette smoke-induced pulmonary inflammatory responses are
            mediated by EGR-1/GGPPS/MAPK signaling
  JOURNAL   Am J Pathol 178 (1), 110-118 (2011)
   PUBMED   21224049
  REMARK    GeneRIF: these results reveal a new EGR-1/GGPPS/MAPK signaling
            pathway that controls cigarette smoke-induced pulmonary
            inflammation.
REFERENCE   6  (bases 1 to 5113)
  AUTHORS   Yoshida,T., Asanuma,M., Grossmann,L., Fuse,M., Shibata,T.,
            Yonekawa,T., Tanaka,T., Ueno,K., Yasuda,T., Saito,Y. and Tatsuno,I.
  TITLE     Geranylgeranyl-pyrophosphate (GGPP) synthase is down-regulated
            during differentiation of osteoblastic cell line MC3T3-E1
  JOURNAL   FEBS Lett 580 (22), 5203-5207 (2006)
   PUBMED   16978613
  REMARK    GeneRIF: GGPP is critical for the cell-to-cell contact-induced
            differentiation, in which the down-regulation of GGPPS might be
            involved.
REFERENCE   7  (bases 1 to 5113)
  AUTHORS   Bommel,H., Xie,G., Rossoll,W., Wiese,S., Jablonka,S., Boehm,T. and
            Sendtner,M.
  TITLE     Missense mutation in the tubulin-specific chaperone E (Tbce) gene
            in the mouse mutant progressive motor neuronopathy, a model of
            human motoneuron disease
  JOURNAL   J Cell Biol 159 (4), 563-569 (2002)
   PUBMED   12446740
REFERENCE   8  (bases 1 to 5113)
  AUTHORS   Martin,N., Jaubert,J., Glaser,P., Szatanik,M. and Guenet,J.L.
  TITLE     Genetic and physical delineation of the region overlapping the
            progressive motor neuropathy (pmn) locus on mouse chromosome 13
  JOURNAL   Genomics 75 (1-3), 9-16 (2001)
   PUBMED   11472062
REFERENCE   9  (bases 1 to 5113)
  AUTHORS   Vicent,D., Maratos-Flier,E. and Kahn,C.R.
  TITLE     The branch point enzyme of the mevalonate pathway for protein
            prenylation is overexpressed in the ob/ob mouse and induced by
            adipogenesis
  JOURNAL   Mol Cell Biol 20 (6), 2158-2166 (2000)
   PUBMED   10688662
REFERENCE   10 (bases 1 to 5113)
  AUTHORS   Kainou,T., Kawamura,K., Tanaka,K., Matsuda,H. and Kawamukai,M.
  TITLE     Identification of the GGPS1 genes encoding geranylgeranyl
            diphosphate synthases from mouse and human
  JOURNAL   Biochim Biophys Acta 1437 (3), 333-340 (1999)
   PUBMED   10101267
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY273432.1, BC069913.1 and CT025604.10.
            
            On Sep 13, 2016 this sequence version replaced NM_010282.2.
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069913.1, SRR9219382.135844.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                BY273432.1         1-87
            88-2458             BC069913.1         1-2371
            2459-5113           CT025604.10        6394-9048           c
FEATURES             Location/Qualifiers
     source          1..5113
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 5.29 cM"
     gene            1..5113
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik; GGPPS"
                     /note="geranylgeranyl diphosphate synthase 1"
                     /db_xref="GeneID:14593"
                     /db_xref="MGI:MGI:1341724"
     exon            1..283
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik; GGPPS"
                     /inference="alignment:Splign:2.1.0"
     exon            284..376
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik; GGPPS"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..1209
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik; GGPPS"
                     /EC_number="2.5.1.1"
                     /EC_number="2.5.1.10"
                     /EC_number="2.5.1.29"
                     /note="isoform 1 is encoded by transcript variant 5;
                     geranylgeranyl pyrophosphate synthetase; geranylgeranyl
                     pyrophosphate synthase; GGPPSase; GGPP synthetase;
                     geranyltranstransferase; farnesyltranstransferase;
                     dimethylallyltranstransferase; farnesyl diphosphate
                     synthase; (2E,6E)-farnesyl diphosphate synthase; GGPP
                     synthase"
                     /codon_start=1
                     /product="geranylgeranyl pyrophosphate synthase isoform 1"
                     /protein_id="NP_034412.1"
                     /db_xref="CCDS:CCDS26248.1"
                     /db_xref="GeneID:14593"
                     /db_xref="MGI:MGI:1341724"
                     /translation="MEKTKEKAERILLEPYRYLLQLPGKQVRSKLSQAFNHWLKVPED
                     KLQIIIEVTEMLHNASLLIDDIEDSSKLRRGFPVAHSIYGVPSVINSANYVYFLGLEK
                     VLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDTYTCPTEEEYKAMVLQKTGGLFGLAV
                     GLMQLFSDYKEDLKPLLDTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTI
                     HAIWSRPESTQVQNILRQRTENIDIKKYCVQYLEDVGSFAYTRHTLRELEAKAYKQIE
                     ACGGNPSLVALVKHLSKMFTEENK"
     exon            377..447
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik; GGPPS"
                     /inference="alignment:Splign:2.1.0"
     exon            448..5113
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik; GGPPS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3234..3239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik; GGPPS"
                     /note="hexamer: AATAAA"
     polyA_site      3256
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik; GGPPS"
                     /note="major polyA site"
     regulatory      4220..4225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik; GGPPS"
                     /note="hexamer: AATAAA"
     regulatory      4225..4230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik; GGPPS"
                     /note="hexamer: AATAAA"
     regulatory      4239..4244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik; GGPPS"
                     /note="hexamer: TATAAA"
     polyA_site      4240
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik; GGPPS"
     polyA_site      4244
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik; GGPPS"
     polyA_site      4256
                     /gene="Ggps1"
                     /gene_synonym="1810026C22Rik; 9530089B04Rik; GGPPS"
ORIGIN      
        1 tgcgttcgac gagagagggg aggggaagga ggcgcggcca tgaggcagag gggaggtggc
       61 atacgacgcc tgcgcagtgt gatagggatg gcgtattttc ttgcactgag tgctgcggcg
      121 tcgctggccg ctgaggaggg cagagatttc tgtgtgaaat agtgggaggg ctccaaggaa
      181 gcctcttgaa gagccgcagt cagaacaata aattgagaag tcgatgtggg cactgctagt
      241 ctcgtaccgg cggcggcttc aagtctgaga tcatcgtgga accgtcagct ttgaaattta
      301 taaaacatgg agaaaactaa agagaaagct gagaggattc ttctagagcc ctataggtac
      361 ttacttcagt taccaggtaa acaggtgaga agcaaacttt cacaggcatt taatcactgg
      421 ctgaaagttc cagaagacaa gctacagatt atcattgaag tgactgaaat gttgcataat
      481 gccagtttac tcattgatga tattgaagac agttcaaagc tccgacgtgg tttcccagtg
      541 gctcacagca tctatggtgt cccatctgtc attaattctg ccaattacgt ctacttcctt
      601 ggactggaaa aagtcttaac ccttgatcac ccggatgcgg tgaagctttt cacacgccag
      661 cttctggaac ttcatcaggg acaaggcctc gatatttact ggagggacac ctacacttgt
      721 ccaactgaag aagaatataa agccatggtg ttgcagaaga caggtggttt gtttggatta
      781 gcagtaggtc ttatgcagct gttctctgat tacaaagaag atctaaagcc actgcttgac
      841 acacttgggc tctttttcca gattagagat gattatgcca atctacactc caaagaatac
      901 agtgaaaaca aaagtttctg tgaagacttg acagaaggga agttctcatt ccccactatc
      961 catgccattt ggtcaaggcc agaaagcacc caggtacaga acatcctgcg ccagagaaca
     1021 gagaatatag atattaaaaa gtattgtgtg cagtacctgg aggatgtagg ttcttttgca
     1081 tacactcgac acactcttag agagcttgaa gctaaagcct acaaacaaat tgaggcctgt
     1141 ggtgggaacc cttcactagt ggctttagtc aagcacttaa gtaagatgtt cacagaagaa
     1201 aataaataat actatccttt ctggattaga ctcagtagct tctttcagtt gaaaatgagg
     1261 agtggcttca tcccatttat cttttctttt tttttttttt aagatttatt tattatatgt
     1321 aagtgtagct gtcttcagac actccagaag atggagtcag atctcattac ggatggttgt
     1381 gagccaccat gtggttgctg ggatttgaac tccagacctt cagaaagcca ccatcagaag
     1441 agcagttggg tgctcttacc tactgagcca tctcaccagc cccaccattt atcttttcaa
     1501 gtactagact ccaataattg agtaaatgag ggtgacgtgt gtaaaagtgt tatgttatca
     1561 aaatcccttt gcataaaaat acaaaattga gggctggaga gatggcttag cagttaaaaa
     1621 gctgcttttc cagagaaccc cggttcaatt tccagggccc acagtgaagt tcaccaacac
     1681 ctgtaactcc atttccagat catcttctgg acttttcagg caccaggcac acacataggt
     1741 atacaaacat gcacaatatt cagacacata agatatttaa tttttatttt tttaaaaaca
     1801 aagttgaaac tatcaggaat cacataacgt aggtcataaa tgtcagacac taagtgtgac
     1861 agctcttcct acgaccccac gtgctctggg cttgtcaata aaaaagactg atcttccaag
     1921 aaactatctg ctttctaact atatgacatg gagggttctc agtccataga tgacaattca
     1981 aaacaagtct ctttagctaa ctgactaaaa agaccaaaga actgctgttt ttccctaaat
     2041 gataatgcca agagtacctc agttttgtct ctgaagacct gtgtcaaagt ctgaaaagac
     2101 agaaagaatg cacaggcact cttccaccca acttgtttgt ttcaatgctt gacaccccac
     2161 aaattgtcct ttttaacaaa agaggctcca cttagtgaag ttcaattcac aacctggttc
     2221 cattgttttt ttctggtttg tttgtgtttt ttcttgtaac atttttctac cccaaactga
     2281 ttagtatctg tgattaatgt ttctttgaag gaagaaaata atagaaaagg tgtttgtgga
     2341 gtacatgagt aatgccagca ttccattggt agagtcagga agatcagaag ctcaaggtta
     2401 tactcagcta tatataagtt tgtgaccagt ctgaactaca ggggacattg catcaaaaga
     2461 aaagaaaaag aaaaaactga tatatatttt ttttaatttc ttgagacagg tttcactcac
     2521 tatgcagttc tagctggcct agaactcaag ggtccatcag cttggcttct gcctctttga
     2581 gagctaggat caaatgtgtg tcctaccatg cctggcaaag actctgtaag tcaatttatt
     2641 tccttgccta attaaattaa ttttggcctg gtacttaata gtgaattaag gaccttttta
     2701 gagtcatttt gtctatccaa taatcaaaat ctcgttcttt atttggtcta tggttcccaa
     2761 atgttaattc agaagagacc caggaagctg gagagatggc tcagaggtta agaacactgg
     2821 ctgctcttcc agaggaccct ggttcagttc ccagcaccca catggcagtt cacaactgtc
     2881 tgtaacttca gttccagaag atctaatacc atctcacaga catacatgta agcaaaatac
     2941 aaatacacat taaaaaaaaa ttatctgaag agacccagaa catgagtagc tgagttcatt
     3001 taataaaatg actttatttg cttagatttg tgctacaata atgcttttcc tgcctaagaa
     3061 agtcttgaga tatcctcttc gagaaatgtt ggattttgct gtgtcaaaga catacttttt
     3121 gtttgtttgt tttgttttgt tttttgagac agagacatac tttttaaaca atataaattt
     3181 tctaatttat gcagcttcag aaaaacatta agtttttata tcaaatctgc aagaataaag
     3241 gtcagttgta ttgccataat gtttttttct ttcctttgat gtctaaacta ttgttgacct
     3301 cactattttc cttcagcctt ttccttcctg ggccagccag tgctgctagg gaatggattc
     3361 ctgtctgctc ttgtagccac tgctgccttg ttgagcaact cctgtcctgg gtagcctgta
     3421 tcattggctc ttcttccttt cctagcagaa aaggagattc ctcaactagc aatggaatgt
     3481 cccttattat ctttttctgt tctccaccta tcaaatgtgg aatctcctac ctttctttct
     3541 tcaaattttt tacttcaaat ctgcctttaa gtagtcagcc ttttatttcc aaaaatgtaa
     3601 accagatgag atggcacatg cctgtagtat tagttcttag gggaaataga gattaaaagt
     3661 tgagggtcct gattggctac atagtgggct agaactagcc tggattttgt tagaatttgc
     3721 cctgcagcct taggcgaaag gagctcttga gctctagagg ccttgtaaca tcccaggctg
     3781 taattctcag gcatcctaaa gctcatttta agctatgtga taagaaacag gggaaagaca
     3841 cgtatattta tacaacttta atcccagcac tcaagtggca gaagccggca gatctcttat
     3901 catctggtat acagagaaag ttccagacag agcagcatag tggactgact gtctgtgtgt
     3961 gtgtgtctct ctctctcaaa aaaaaagctt caaatacaaa aaaaaaaggg ctcaaaataa
     4021 tgaaccctac agtagtatga gttcatgtat aatagagtta gcattttgct tcctcaaccc
     4081 taacacccca cttggctaaa cacaatcact ctgcttatct taattcatct ttttatattt
     4141 acattcaata tgttgagaat gagctataat gtgaaggcat tgtttgacca tgtactactt
     4201 ggttaaaaaa aaatacaaaa ataaaataaa atcactgata taaatttcaa tgttaatttg
     4261 ctcaactccg ctccgtacag tatttcctaa cacttaattg gcactgacac agaagtggct
     4321 agttgtttgt cattcttttt tttttatgta tgtatgtatg tatgtatgta tgtatgtatg
     4381 tatgtatgta tgttgtttgt ttgtttaatg tagcccttgt tgggctagaa cctgatttgt
     4441 agatctgagc tcaactcaga gatctttgtc agagtgcagg gattaaacac atgtgccatc
     4501 actcccagca aaggctattc tatgcaacac tactttagaa gaatcaccaa ctttgtattg
     4561 tttatcactg tacttaaaaa gaaggctgtg tttgaagaaa taatctatga aacaaggtcg
     4621 ttgaacctct tttgggtgaa ggtcttagtc actgttctat tgttgtgaag agataccatg
     4681 gccaaagcaa ttcttataaa tgaaagcatt taatttgggg atctgcttac agtttcagtc
     4741 agtctgttat cagctagtag gaacatagtg tcactcatgg ccctggagta gtggcttaga
     4801 actgtgtcct gatctgtagg cagcagattc ggtctggcat gaggttctaa aacctcaaag
     4861 tccactccag tgacacactt cctccaacaa ggccacacct ccaaattcta attttgtcaa
     4921 agaattgcac tccctggtga ctaaggattc agatatatga gcctagaggg tcattcttat
     4981 ttaaaccacc acagtgaggt agttcagtac taatggtaag ctgttagatg gtgtggaaat
     5041 ttttttgaaa cttgccagtt gcttaataga aattgtaaat tgggaataaa catttcagca
     5101 gtgttttaaa gag
//
