LOCUS       NM_153144               3002 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus gametogenetin binding protein 2 (Ggnbp2), transcript
            variant 3, mRNA.
ACCESSION   NM_153144
VERSION     NM_153144.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3002)
  AUTHORS   Guo,K., Cao,Y., Zhao,Z., Zhao,J., Liu,L. and Wang,H.
  TITLE     GGNBP2 regulates histone ubiquitination and methylation in
            spermatogenesis
  JOURNAL   Epigenetics 19 (1), 2381849 (2024)
   PUBMED   39109527
  REMARK    GeneRIF: GGNBP2 regulates histone ubiquitination and methylation in
            spermatogenesis.
REFERENCE   2  (bases 1 to 3002)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3002)
  AUTHORS   Chee,J.M., Lanoue,L., Clary,D., Higgins,K., Bower,L., Flenniken,A.,
            Guo,R., Adams,D.J., Bosch,F., Braun,R.E., Brown,S.D.M., Chin,H.G.,
            Dickinson,M.E., Hsu,C.W., Dobbie,M., Gao,X., Galande,S.,
            Grobler,A., Heaney,J.D., Herault,Y., de Angelis,M.H., Mammano,F.,
            Nutter,L.M.J., Parkinson,H., Qin,C., Shiroishi,T., Sedlacek,R.,
            Seong,J.K., Xu,Y., Brooks,B., McKerlie,C., Lloyd,K.C.K.,
            Westerberg,H. and Moshiri,A.
  CONSRTM   International Mouse Phenotyping Consortium
  TITLE     Genome-wide screening reveals the genetic basis of mammalian
            embryonic eye development
  JOURNAL   BMC Biol 21 (1), 22 (2023)
   PUBMED   36737727
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3002)
  AUTHORS   Wang,Q., Wu,L., Cao,R., Gao,J., Chai,D., Qin,Y., Ma,L., Wu,S.,
            Tao,Y., Ma,J. and Wang,Z.W.
  TITLE     Fbxo45 promotes the malignant development of esophageal squamous
            cell carcinoma by targeting GGNBP2 for ubiquitination and
            degradation
  JOURNAL   Oncogene 41 (43), 4795-4807 (2022)
   PUBMED   36127399
  REMARK    GeneRIF: Fbxo45 promotes the malignant development of esophageal
            squamous cell carcinoma by targeting GGNBP2 for ubiquitination and
            degradation.
REFERENCE   5  (bases 1 to 3002)
  AUTHORS   Guo,K., He,Y., Liu,L., Liang,Z., Li,X., Cai,L., Lan,Z.J., Zhou,J.,
            Wang,H. and Lei,Z.
  TITLE     Ablation of Ggnbp2 impairs meiotic DNA double-strand break repair
            during spermatogenesis in mice
  JOURNAL   J Cell Mol Med 22 (10), 4863-4874 (2018)
   PUBMED   30055035
  REMARK    GeneRIF: these data suggest that GGNBP2, likely mediated by its
            interaction with GGN1, plays a role in DNA double-strand break
            repair during meiotic progression of spermatocytes.
REFERENCE   6  (bases 1 to 3002)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   7  (bases 1 to 3002)
  AUTHORS   Zhang,J., Wang,Y., Zhou,Y., Cao,Z., Huang,P. and Lu,B.
  TITLE     Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are
            potential interaction partners of testicular germ cell-specific
            protein GGN1
  JOURNAL   FEBS Lett 579 (2), 559-566 (2005)
   PUBMED   15642376
  REMARK    GeneRIF: Ggnbp2 is mainly expressed in the testis. Its protein
            product interacted with GGN1 and could be involved in intracellular
            trafficking.
REFERENCE   8  (bases 1 to 3002)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3002)
  AUTHORS   Ohbayashi,T., Oikawa,K., Iwata,R., Kameta,A., Evine,K., Isobe,T.,
            Matsuda,Y., Mimura,J., Fujii-Kuriyama,Y., Kuroda,M. and Mukai,K.
  TITLE     Dioxin induces a novel nuclear factor, DIF-3, that is implicated in
            spermatogenesis
  JOURNAL   FEBS Lett 508 (3), 341-344 (2001)
   PUBMED   11728448
REFERENCE   10 (bases 1 to 3002)
  AUTHORS   Kerr,S.M., Taggart,M.H., Lee,M. and Cooke,H.J.
  TITLE     Ott, a mouse X-linked multigene family expressed specifically
            during meiosis
  JOURNAL   Hum Mol Genet 5 (8), 1139-1148 (1996)
   PUBMED   8842733
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645623.13, AB064543.1, AY633741.1 and BE982217.1.
            
            On Jun 7, 2018 this sequence version replaced NM_153144.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY633741.1, ERR3363658.3309647.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AL645623.13        29734-29785         c
            53-301              AB064543.1         1-249
            302-2634            AY633741.1         250-2582
            2635-3002           BE982217.1         18-385              c
FEATURES             Location/Qualifiers
     source          1..3002
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.34 cM"
     gene            1..3002
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
                     /note="gametogenetin binding protein 2"
                     /db_xref="GeneID:217039"
                     /db_xref="MGI:MGI:2387356"
     exon            1..153
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
                     /inference="alignment:Splign:2.1.0"
     exon            154..349
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..2353
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
                     /note="isoform 3 is encoded by transcript variant 3;
                     gametogenin binding protein 2; zinc finger protein 403;
                     dioxin inducible factor 3"
                     /codon_start=1
                     /product="gametogenetin-binding protein 2 isoform 3"
                     /protein_id="NP_694784.2"
                     /db_xref="CCDS:CCDS36262.1"
                     /db_xref="GeneID:217039"
                     /db_xref="MGI:MGI:2387356"
                     /translation="MARLVAVCRDGEEEFPFERRQIPLYIDDTLTMVMEFPDNVLNLD
                     GHQNNGAQLKQFIQRHSMLKQQDLSIAMVVTSREVLSALSQLVPCVGCRRSVERLFSQ
                     LVESGNPALEPLTVGPKGVLSLTRSCMTDAKKLYTLFYVHGSKLNDMIDAIPKSKKNK
                     RCQLHSLDTHKPKPLGGCWMDVWELMSQECRDEVVLIDSSCLLETLETYLRKHRFCTD
                     CKNKVLRAYNILIGELDCSKEKGYCAALYEGLRCCPHERHIHVCCETDFIAHLLGRAE
                     PEFAGGYERRERHAKTIDIAQEEVLTCLGIHLYERLHRIWQKLRAEEQTWQMLFYLGV
                     DALRKSFEMTVEKVQGISRLEQLCEEFSEEERVRELKQEKKRQKRKNRRKNKCVCDTP
                     ASLHTADEKAVSREKETDFIENSCNACGSAEDGETCVEVMVTSENTSCTCPSSGNLLG
                     SPKIKKGMSPHCNGSDCGYSSSMEGSETGSREGSDVACTEGICNHDEHGEDSCVHHCE
                     DKEDDGDSCVECWANSEENNIKGKNKKKKKKSKMLKCDEHIQKLGSCITDPGNRETSG
                     NTMHTVFHRDKTKDAHPESCCSTEKGGQPLPWFEHRKSVPQFTEPTEMSFGPDSGKGA
                     KSLVELLDESECTSDEEIFISQDEIQSFMANNQSFYSNREQYRQHLKEKFNKYCRLND
                     HKRPVCSGWLTTAGAN"
     exon            350..430
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
                     /inference="alignment:Splign:2.1.0"
     exon            431..684
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
                     /inference="alignment:Splign:2.1.0"
     exon            685..783
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
                     /inference="alignment:Splign:2.1.0"
     exon            784..897
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1107
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1282
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1477
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1625
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1751
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1900
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2149
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..3002
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2757..2762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
                     /note="hexamer: AATAAA"
     polyA_site      2781
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
                     /note="major polyA site"
     regulatory      2982..2987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
                     /note="hexamer: AATAAA"
     polyA_site      3002
                     /gene="Ggnbp2"
                     /gene_synonym="D330017P12Rik; DIF-3; Zfp403"
ORIGIN      
        1 acactccccg tggcgcgagc ggctgactga gcctggagag gaaacggcaa tcgcagccgc
       61 gctcccgccc aggccggccc tgacgcgggc ctcgtcagcc ggtaacgggg agcagaggtg
      121 ggggtcaggg aggcgtcctc gaagtcagtg aaggcaggag ctgggaggag gcagcagcag
      181 cggcggcggc aggagcagcg gcggcggcag cagctgggag gaggtggtga cggtggcaac
      241 ggcagcgtcg gggacgatgg cgcgactggt ggcagtgtgc agggacgggg aggaggagtt
      301 ccccttcgag aggaggcaga tccccctcta catagacgac accctgacga tggtgatgga
      361 atttcctgac aatgttttaa atcttgatgg gcatcagaat aatggtgcac aactaaagca
      421 gtttattcag cgacacagta tgcttaagca acaagattta agtattgcca tggtggtaac
      481 atcacgcgaa gtcttgagtg cactttctca gcttgtccca tgtgttggtt gtcgtcgaag
      541 tgtggaacgc ctcttttctc aacttgtaga gtctggaaat cctgcccttg aacccctgac
      601 agtagggccc aagggagtac tatctctgac tcggagctgc atgactgatg caaaaaagct
      661 ttatacatta ttttatgtac atgggtccaa actaaatgat atgatagatg ctattccaaa
      721 aagtaagaag aacaagagat gtcagttaca ctctttagat acacacaaac ctaaacctct
      781 gggaggatgt tggatggatg tttgggaact catgtcccag gaatgcaggg atgaagtagt
      841 tttaattgac tctagttgtc ttttagaaac actagaaaca tatcttcgaa agcacaggtt
      901 ttgcactgat tgcaaaaata aagtcctccg agcatacaat atcctcattg gtgaacttga
      961 ctgcagcaaa gagaagggct actgtgctgc cctgtatgaa ggattgcggt gctgtccaca
     1021 tgagcgacac atacatgttt gctgtgaaac agacttcatt gcacatctct tgggtcgtgc
     1081 tgagccagag ttcgcaggag ggtatgagcg aagagaaaga catgctaaga caatagatat
     1141 agctcaagaa gaagttttga cctgcttggg gattcatctt tatgaacgac tgcatcggat
     1201 ctggcaaaaa ctacgggctg aagagcagac gtggcagatg ctcttttatc tcggtgttga
     1261 cgctttacgt aagagctttg agatgactgt ggaaaaagtg cagggtatta gccgcttgga
     1321 acaactttgt gaggaatttt cagaggaaga acgagttaga gaactcaagc aagaaaagaa
     1381 acgccaaaaa cggaagaaca gacgaaaaaa taagtgtgtg tgtgacactc ctgcttcctt
     1441 acacaccgca gacgagaaag cagtgagccg agagaaggaa acagacttca ttgaaaacag
     1501 ctgcaacgcc tgtggcagtg ctgaagatgg cgagacttgt gtagaagtaa tggttaccag
     1561 tgaaaacaca tcatgtacct gtccgagcag tggcaatctt ttggggtccc ctaaaataaa
     1621 gaaaggtatg tctccacact gtaatggtag tgactgtgga tattcatcta gcatggaagg
     1681 aagtgaaaca ggttctcgag aaggttcaga tgttgcctgc accgagggaa tttgtaacca
     1741 tgatgaacat ggtgaagatt cctgtgttca ccactgtgaa gacaaagaag atgatggtga
     1801 cagttgtgtt gaatgttggg caaattctga agaaaataac ataaaaggaa aaaataaaaa
     1861 gaagaaaaag aaaagcaaga tgttgaaatg cgatgaacat atccaaaaac ttggaagctg
     1921 tattacagat ccaggtaatc gagagacctc aggaaacact atgcacacag tgtttcaccg
     1981 tgacaagacc aaagatgcac atcctgagag ttgttgcagc actgagaagg gtgggcagcc
     2041 attgccttgg tttgagcata ggaaaagcgt accacagttc acagaaccta cagaaatgtc
     2101 atttggtcct gactctggaa aaggtgccaa gagcttagtt gaacttcttg atgagtctga
     2161 atgtacttca gatgaggaaa tctttatctc acaagatgaa atacagtcat ttatggctaa
     2221 taaccagtct ttctacagca atagagaaca ataccgacag catctgaagg agaaatttaa
     2281 taaatactgc cgcttaaatg atcacaagag gcccgtttgt agtggctggc tgacaacggc
     2341 tggagcaaat taaataaata aaatagctct gtctttcaat gaaacactca agatgactac
     2401 tgcgccttct cttttaaaaa ctcctaattt agtgacttct ggcaaaattt taccttaaat
     2461 cttaaatcaa tgtgattcct tgttttggga gacggtggag gtaacctcat tcgtttgttc
     2521 tttcttcagg cttgtgtctt tagtttcgtg gctgcgcagg cctgcctatg atttaagcca
     2581 tctcttcatt aaacgtttct cttcctgtga gacttactaa agcaacttag tggcaaaagt
     2641 aatgttgtac ttacacctct gtacagaaat gacagtgagc tggatatatg gtttacagta
     2701 gacatccact tgcaaagcat ctggacagaa tgttaaaggc aatgtgcaaa atttaaaata
     2761 aagagtattt attaatacgc atagtagaat gtggtgtaca tgtttctact caccgtggtg
     2821 gtactttagt atttgccact cgtgaacttt gtatctaacc attgttgatg gagagagcat
     2881 gaagagcaaa tgagggtaga gattcagact gcccaagact gaattcttcc tttgatgaga
     2941 cttgataact gagaaaagca gttctagtct tgttcttaaa gaataaatgc atttaaacac
     3001 tg
//
