LOCUS       NM_027544               1525 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus gametogenetin binding protein 1 (Ggnbp1), transcript
            variant 1, mRNA.
ACCESSION   NM_027544 XM_981720
VERSION     NM_027544.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1525)
  AUTHORS   Ge,T., Yuan,L., Xu,L., Yang,F., Xu,W., Niu,C., Li,G., Zhou,H. and
            Zheng,Y.
  TITLE     Coiled-coil domain containing 159 is required for spermatid head
            and tail assembly in micedagger
  JOURNAL   Biol Reprod 110 (5), 877-894 (2024)
   PUBMED   38236177
REFERENCE   2  (bases 1 to 1525)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1525)
  AUTHORS   Han,T., Wang,L., Tang,W., Zhang,Z., Khawar,M.B., Li,G., Jiang,H.
            and Liu,C.
  TITLE     GGNBP1 ensures proper spermiogenesis in response to stress in mice
  JOURNAL   Biochem Biophys Res Commun 525 (3), 706-713 (2020)
   PUBMED   32139124
  REMARK    GeneRIF: GGNBP1 ensures proper spermiogenesis in response to stress
            in mice.
REFERENCE   4  (bases 1 to 1525)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 1525)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1525)
  AUTHORS   Brower,C.S., Veiga,L., Jones,R.H. and Varshavsky,A.
  TITLE     Mouse Dfa is a repressor of TATA-box promoters and interacts with
            the Abt1 activator of basal transcription
  JOURNAL   J Biol Chem 285 (22), 17218-17234 (2010)
   PUBMED   20356838
REFERENCE   7  (bases 1 to 1525)
  AUTHORS   Aihara,T., Nakamura,N., Honda,S. and Hirose,S.
  TITLE     A novel potential role for gametogenetin-binding protein 1 (GGNBP1)
            in mitochondrial morphogenesis during spermatogenesis in mice
  JOURNAL   Biol Reprod 80 (4), 762-770 (2009)
   PUBMED   19208545
  REMARK    GeneRIF: GGNBP1 is involved in spermatogenesis by modifying
            mitochondrial dynamics and morphology.
REFERENCE   8  (bases 1 to 1525)
  AUTHORS   Zhao,Q., Zhou,Y., Cao,Z., Zhu,H., Huang,P. and Lu,B.
  TITLE     Germ-cell specific protein gametogenetin protein 2 (GGN2),
            expression in the testis, and association with intracellular
            membrane
  JOURNAL   Mol Reprod Dev 72 (1), 31-39 (2005)
   PUBMED   15892049
REFERENCE   9  (bases 1 to 1525)
  AUTHORS   Zhou,Y., Zhao,Q., Bishop,C.E., Huang,P. and Lu,B.
  TITLE     Identification and characterization of a novel testicular germ
            cell-specific gene Ggnbp1
  JOURNAL   Mol Reprod Dev 70 (3), 301-307 (2005)
   PUBMED   15625700
  REMARK    GeneRIF: A testicular germ cell-specific protein interacting with
            GGN1. The protein seems to associate with the membrane system in
            the germ cell.
REFERENCE   10 (bases 1 to 1525)
  AUTHORS   Zhang,J., Wang,Y., Zhou,Y., Cao,Z., Huang,P. and Lu,B.
  TITLE     Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are
            potential interaction partners of testicular germ cell-specific
            protein GGN1
  JOURNAL   FEBS Lett 579 (2), 559-566 (2005)
   PUBMED   15642376
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY141192.1, AK077129.1 and BB018101.1.
            
            On Sep 15, 2007 this sequence version replaced NM_027544.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY141192.1, AB250379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AY141192.1         1-117
            118-1517            AK077129.1         1-1400
            1518-1525           BB018101.1         205-212
FEATURES             Location/Qualifiers
     source          1..1525
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 13.6 cM"
     gene            1..1525
                     /gene="Ggnbp1"
                     /gene_synonym="0610031G08Rik; mdf"
                     /note="gametogenetin binding protein 1"
                     /db_xref="GeneID:70772"
                     /db_xref="MGI:MGI:3055306"
     exon            1..688
                     /gene="Ggnbp1"
                     /gene_synonym="0610031G08Rik; mdf"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1313
                     /gene="Ggnbp1"
                     /gene_synonym="0610031G08Rik; mdf"
                     /note="isoform a is encoded by transcript variant 1;
                     gametogenin binding protein 1; deubiquitinating enzyme
                     Usp15"
                     /codon_start=1
                     /product="gametogenetin-binding protein 1 isoform a"
                     /protein_id="NP_081820.2"
                     /db_xref="CCDS:CCDS28559.1"
                     /db_xref="GeneID:70772"
                     /db_xref="MGI:MGI:3055306"
                     /translation="MAAPARTPRSRILGCSSMLRFLRNLVGSKGGSKSTNKPLTRSQP
                     SSSWEQDVVSPMMGHQGGRGRKEPRAKVHSAASSNGKREPPPRVLSAAPSNPRHDAFE
                     LGTGDSGSQTLTSKDVPKLRAQGVEVTSVPLRGTWEVLEQLPEKKGEEEEPVGEVSGA
                     SDREHFGQALETEQGCLQWVPGPLALTPGAFIKEEEDEHCPIEFGDLKPSSCKVGSTP
                     WNYLLGLYKQLQKSAMAKAQRPAAPQLALKDGLPHEEKGEREEAVDESCPKWCAPRAS
                     SDESCPKWCAPRASTYQSPLQKKFRSTDTVGFVESELKKILSVQREARLWKVGNPEGR
                     ELLTQPDITLEEAGMVDGQHLLLEEMDEMGNWPPPD"
     exon            689..813
                     /gene="Ggnbp1"
                     /gene_synonym="0610031G08Rik; mdf"
                     /inference="alignment:Splign:2.1.0"
     exon            814..908
                     /gene="Ggnbp1"
                     /gene_synonym="0610031G08Rik; mdf"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1119
                     /gene="Ggnbp1"
                     /gene_synonym="0610031G08Rik; mdf"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1259
                     /gene="Ggnbp1"
                     /gene_synonym="0610031G08Rik; mdf"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1525
                     /gene="Ggnbp1"
                     /gene_synonym="0610031G08Rik; mdf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1501..1506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ggnbp1"
                     /gene_synonym="0610031G08Rik; mdf"
                     /note="hexamer: AATAAA"
     polyA_site      1524
                     /gene="Ggnbp1"
                     /gene_synonym="0610031G08Rik; mdf"
                     /note="major polyA site"
ORIGIN      
        1 cctggctagc tccctctacc cctctacccg ctttccttcc agtagacccc cccccaccag
       61 cctccagtta tagcctcccc ccacccccac ctcctctttg ccttctagaa cttctggaag
      121 tttccaactg gaggtttctg ctagcagttg gtcctgggct ggctgccatg gcttctccct
      181 gagtcggggt cccactcagg atggcagccc cggcgcggac ccctcggtca cggatcttag
      241 gctgctcctc catgctgcgc tttctccgaa acctggtggg gagtaagggc ggttctaaga
      301 gcactaacaa gcccctgacc aggagccagc ccagctcctc atgggagcaa gatgttgtct
      361 ccccaatgat gggccaccag ggaggtcgtg ggaggaagga gccccgggcc aaggtccact
      421 ctgcagcttc ctctaatggg aagagggagc ccccgcccag ggttctctct gcagctccct
      481 ccaacccgag gcatgatgcc tttgagctgg gcactgggga ctcagggtcc cagaccctca
      541 cctccaagga tgtcccgaag ctaagggccc agggtgttga ggtaacatca gttcctctca
      601 gaggaacctg ggaggttctg gagcagctac ctgagaagaa aggagaggag gaggagccag
      661 taggggaggt ctccggggcc tcagacaggg agcattttgg ccaggccctg gagacagaac
      721 aaggatgctt acagtgggtt ccgggaccac tggcgctcac ccctggggcc ttcatcaagg
      781 aggaagagga tgaacactgc ccaattgagt ttggagacct caagccgtcc tcttgcaagg
      841 tggggtccac cccgtggaac tatctccttg gcttgtacaa gcagctccag aagtcagcca
      901 tggccaaggc tcagagacca gctgcgcctc agttggctct caaggatggc ttgccccacg
      961 aggagaaagg ggagagagaa gaagcggtgg atgagagctg tcccaagtgg tgtgcccctc
     1021 gcgcctctag cgacgagagc tgtcccaagt ggtgtgcccc gcgtgcctcc acctaccagt
     1081 cgccgctgca aaagaagttt aggtctacag atacagtggg ttttgtggag tcggagctga
     1141 agaagattct gtcagtgcaa cgagaggctc gcctctggaa ggtgggcaac cccgagggcc
     1201 gggagctgct gacccagcca gacatcacac tggaggaggc tggcatggtg gacggccagc
     1261 acctgctcct ggaggagatg gacgagatgg gaaactggcc ccctccagat tgaggcccgt
     1321 gccggcagga gcccaccgtg cccacactcc tgggacccca gtctggcgtg tgcctcttct
     1381 tgggacacat gcaaggagtc cctggggccc tgggttttgg gatgagtagc atcctgtgtg
     1441 tgtgcggttg gcctgcctgg cactgtccct acccgtcaga ctcctgcaga tgacgttatt
     1501 aataaaagct tagtttggca ttcac
//
