LOCUS       NM_001358852            2333 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus gametogenetin (Ggn), transcript variant 4, mRNA.
ACCESSION   NM_001358852 XM_006539945
VERSION     NM_001358852.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2333)
  AUTHORS   Guo,K., He,Y., Liu,L., Liang,Z., Li,X., Cai,L., Lan,Z.J., Zhou,J.,
            Wang,H. and Lei,Z.
  TITLE     Ablation of Ggnbp2 impairs meiotic DNA double-strand break repair
            during spermatogenesis in mice
  JOURNAL   J Cell Mol Med 22 (10), 4863-4874 (2018)
   PUBMED   30055035
  REMARK    GeneRIF: these data suggest that GGNBP2, likely mediated by its
            interaction with GGN1, plays a role in DNA double-strand break
            repair during meiotic progression of spermatocytes.
REFERENCE   2  (bases 1 to 2333)
  AUTHORS   Jamsai,D., O'Connor,A.E., Deboer,K.D., Clark,B.J., Smith,S.J.,
            Browne,C.M., Bensley,J.G., Merriman,J.A., Yuen,W.S., Koopman,P.,
            Jones,K.T. and O'Bryan,M.K.
  TITLE     Loss of GGN leads to pre-implantation embryonic lethality and
            compromised male meiotic DNA double strand break repair in the
            mouse
  JOURNAL   PLoS One 8 (2), e56955 (2013)
   PUBMED   23451117
  REMARK    GeneRIF: Results suggest that GGN plays a role in male meiotic DSB
            repair and is absolutely required for the survival of
            pre-implantation embryos.
REFERENCE   3  (bases 1 to 2333)
  AUTHORS   Jamsai,D., Bianco,D.M., Smith,S.J., Merriner,D.J., Ly-Huynh,J.D.,
            Herlihy,A., Niranjan,B., Gibbs,G.M. and O'Bryan,M.K.
  TITLE     Characterization of gametogenetin 1 (GGN1) and its potential role
            in male fertility through the interaction with the ion channel
            regulator, cysteine-rich secretory protein 2 (CRISP2) in the sperm
            tail
  JOURNAL   Reproduction 135 (6), 751-759 (2008)
   PUBMED   18502891
REFERENCE   4  (bases 1 to 2333)
  AUTHORS   Zhao,Q., Zhou,Y., Cao,Z., Zhu,H., Huang,P. and Lu,B.
  TITLE     Germ-cell specific protein gametogenetin protein 2 (GGN2),
            expression in the testis, and association with intracellular
            membrane
  JOURNAL   Mol Reprod Dev 72 (1), 31-39 (2005)
   PUBMED   15892049
REFERENCE   5  (bases 1 to 2333)
  AUTHORS   Zhang,J., Wang,Y., Zhou,Y., Cao,Z., Huang,P. and Lu,B.
  TITLE     Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are
            potential interaction partners of testicular germ cell-specific
            protein GGN1
  JOURNAL   FEBS Lett 579 (2), 559-566 (2005)
   PUBMED   15642376
REFERENCE   6  (bases 1 to 2333)
  AUTHORS   Hansson,A.S., Johannesson,M., Svensson,L., Nandakumar,K.S.,
            Heinegard,D. and Holmdahl,R.
  TITLE     Relapsing polychondritis, induced in mice with matrilin 1, is an
            antibody- and complement-dependent disease
  JOURNAL   Am J Pathol 164 (3), 959-966 (2004)
   PUBMED   14982849
REFERENCE   7  (bases 1 to 2333)
  AUTHORS   Lu,B. and Bishop,C.E.
  TITLE     Mouse GGN1 and GGN3, two germ cell-specific proteins from the
            single gene Ggn, interact with mouse POG and play a role in
            spermatogenesis
  JOURNAL   J Biol Chem 278 (18), 16289-16296 (2003)
   PUBMED   12574169
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164564.3.
            
            On Dec 12, 2017 this sequence version replaced XM_006539945.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF538032.1, SRR11927932.2715987.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               AC164564.3         88075-88306         c
            233-2155            AC164564.3         85416-87338         c
            2156-2333           AC164564.3         84583-84760         c
FEATURES             Location/Qualifiers
     source          1..2333
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.94 cM"
     gene            1..2333
                     /gene="Ggn"
                     /note="gametogenetin"
                     /db_xref="GeneID:243897"
                     /db_xref="MGI:MGI:2181461"
     exon            1..232
                     /gene="Ggn"
                     /inference="alignment:Splign:2.1.0"
     exon            233..2155
                     /gene="Ggn"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..2273
                     /gene="Ggn"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="gametogenetin isoform 4"
                     /protein_id="NP_001345781.1"
                     /db_xref="CCDS:CCDS90196.1"
                     /db_xref="GeneID:243897"
                     /db_xref="MGI:MGI:2181461"
                     /translation="MGNVQSEPSAGGGSRKEQASDRASDSRRTPLVEPEVTPSSPAMR
                     LARGLGVWFPGSSGPPGLLIPPEPQASSSPLPLTLELPSPVTPPPEEAAAVSTPPPPP
                     VGTLLPAPSKWRKPTGTSVPRIRGLLEASHRGQGDPPSLRPLPPLPRQLTEKDPVLRA
                     PAPPPTPLEPRKQLPPAPSTCDPQPLSRRITLASSATSPTESQVRHSSEGQAAGGAHG
                     GVPPQAGEGEMARSATSESGLSLLCKVTFKSGPHLSPTSASGPLAAKASPGAGGGGLF
                     ASSGAISYAEVLKQGPQPPGATRPLGEVPPGATRPLGEVPRAAQETEGGDGDGEGCSG
                     PPSVPAPLARALPPPPYTTFPGSKPKFDWVSPPDGTERHFRFNGAVGGIGAPRRRTTT
                     LSGPWGSPPPRSGQTHPSSGPRRPTPALLAPPMFIFPAPNNGEPVRPVPPSPQQIPPL
                     PPPPPTPPATPPPAPPPTPQPPALPRTPILVARPPTPGPGHLESALAPTPPSTLSPTA
                     AADQVPAATPATVTSQVPATATAELSPPMPQPKTRTRRNKGPRAARGVIREEGTSGDG
                     PREPNTAPVTDSSSGGGGGGSNGTSTAGASNKGTARHWPPFEVLNSCPCKCYCRHQRR
                     HRRLPRNVSAWLSTPTNHLSEPPWVATVKLAGSLVAGLEHYDLQATHST"
     exon            2156..2333
                     /gene="Ggn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2313..2318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ggn"
                     /note="hexamer: AATAAA"
     polyA_site      2333
                     /gene="Ggn"
                     /note="major polyA site"
ORIGIN      
        1 gtatttttct aagggtgatc caggtttgaa gggctgcact caagctggct tgcagggggc
       61 agggcctcga gctcggggcg gggcctagat ctcgggggtc gtcctcgctg tctcgcccac
      121 ttgccttcac ccgcacaccc gttcttttcg gttattttct gctacggccg ttccccgccc
      181 tgccttgggc ccacggggca gtgatctgat ctttggtcgg ctggaggagt cgtccccgac
      241 cttcttcaaa aatggggaac gtgcagtcgg agccgtccgc gggcgggggt tcccgaaaag
      301 agcaggcctc agaccgcgcc tccgactccc gcaggacgcc tctagtggag cccgaggtga
      361 ccccctcatc ccctgccatg cgcctggctc gagggctggg cgtctggttc cctggcagtt
      421 ccgggccccc gggactcctg atacccccgg agccccaggc ctcatcctcg cccctgcccc
      481 tgaccttaga actgccctcg ccagtgacac cccctccaga ggaggcggct gcggtctcca
      541 caccaccccc gccccccgtg gggaccctgc tgcctgcgcc atctaagtgg cgaaaaccca
      601 cgggcacttc agtgcctcgg atccgcggtc ttctggaggc gagccatcgt ggtcagggtg
      661 accctccaag cctccgcccg ctgccaccgc tgccccggca actgaccgaa aaagacccgg
      721 tcctgagggc cccagcccca cctccgacgc ccctggaacc tcggaaacaa ctaccgccag
      781 caccatcaac ttgcgatccg cagcccctga gccgcagaat cactctggcc tcgtcggcca
      841 caagccccac agaaagtcag gtcagacaca gcagcgaggg tcaggcggcc gggggagccc
      901 acggaggggt acctccccaa gctggagagg gcgaaatggc tcggtctgct acttccgagt
      961 ctggcctgag tctgctgtgt aaagtcacct tcaagtcggg gccccatttg tcccccacat
     1021 cggcctcggg tcccttagca gccaaagcct cacccggggc cggtggtggc ggactgtttg
     1081 cctcttctgg ggccatctcc tatgctgagg tcctgaagca agggccccaa cctcctggag
     1141 ccactcgtcc cttgggagag gtccctcctg gagccactcg tcccttggga gaggtccctc
     1201 gtgcagctca ggaaaccgag ggtggtgacg gagatggcga agggtgttct ggtccccctt
     1261 cggtgcctgc tccccttgcc cgggctctac cgccgccccc ttacaccacc ttcccaggtt
     1321 caaagcccaa attcgactgg gtgagccctc ctgatggcac tgaacggcat ttccgattca
     1381 atggggctgt cgggggaatc ggggcacccc gacggcgcac gaccacgctc tcagggcctt
     1441 ggggatcccc tccacccagg tcaggtcaga cacatccatc ttcagggcct cggaggccca
     1501 cacctgcctt gttggcacca cccatgttca tcttcccagc gccaaacaat ggcgagcctg
     1561 ttcgcccagt gcctccaagt ccacagcaga tacctcctct gccgccacca ccacccacgc
     1621 caccagccac gccaccaccg gcgccaccac ccacaccaca gccaccagcg ctcccaagga
     1681 cgccgatact ggtggcccgt ccgccgaccc caggccctgg ccacttagag tcagccttgg
     1741 ctcccacccc tccctccact ttatccccaa ctgcagctgc cgaccaggtc ccagctgcaa
     1801 ctccagccac agtcacatcc caagttccag caaccgccac cgctgagctg tcaccgccaa
     1861 tgccccaacc caagactcgt acacgcagga acaaaggtcc ccgagcggcc cggggtgtta
     1921 tccgtgaaga agggacttct ggagatggcc ctcgagaacc gaatacggct ccggtgactg
     1981 acagcagcag tggagggggt ggcggtggta gcaacggaac ctccacagct ggggcctcta
     2041 acaagggaac agcaaggcac tggccgcctt tcgaggtgct taattcctgt ccctgcaagt
     2101 gctactgccg ccatcaacgt cgtcaccgtc ggctgccacg caacgtgtct gcctggctga
     2161 gcacacctac caaccacctg agcgagccac cgtgggtggc cactgtcaag ctggctggct
     2221 ccctagtagc gggcctggag cactacgact tgcaggccac ccattctacc tgagtgcgac
     2281 tgcccaaccc cctcggcctc accctcctcg ccaataaagt acccagtcta caa
//
