LOCUS       NM_010281               1340 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus gamma-glutamyl hydrolase (Ggh), mRNA.
ACCESSION   NM_010281 XM_989632
VERSION     NM_010281.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1340)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1340)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (bases 1 to 1340)
  AUTHORS   Uematsu,R., Furukawa,J., Nakagawa,H., Shinohara,Y., Deguchi,K.,
            Monde,K. and Nishimura,S.
  TITLE     High throughput quantitative glycomics and glycoform-focused
            proteomics of murine dermis and epidermis
  JOURNAL   Mol Cell Proteomics 4 (12), 1977-1989 (2005)
   PUBMED   16170054
REFERENCE   4  (bases 1 to 1340)
  AUTHORS   Masumoto,N., Chen,J. and Sirotnak,F.M.
  TITLE     Regulation of transcription of the murine gamma-glutamyl hydrolase
            gene. Delineation of core promoter A and the role of LYF-1, E2F and
            ETS-1 in determining tumor-specific expression
  JOURNAL   Gene 291 (1-2), 169-176 (2002)
   PUBMED   12095690
REFERENCE   5  (bases 1 to 1340)
  AUTHORS   Masumoto,N., Esaki,T. and Sirotnak,F.M.
  TITLE     Additional organizational features of the murine gamma-glutamyl
            hydrolase gene. Two remotely situated exons within the complement
            C3 gene locus encode an alternate 5' end and proximal ORF under the
            control of a bidirectional promoter
  JOURNAL   Gene 268 (1-2), 183-194 (2001)
   PUBMED   11368914
REFERENCE   6  (bases 1 to 1340)
  AUTHORS   Esaki,T., Masumoto,N., Hayes,P., Chen,J. and Sirotnak,F.M.
  TITLE     Organization and structure of the mouse gamma-glutamyl hydrolase
            gene and the functional identification of its promoter
  JOURNAL   Gene 234 (1), 93-100 (1999)
   PUBMED   10393243
REFERENCE   7  (bases 1 to 1340)
  AUTHORS   Esaki,T., Roy,K., Yao,R., Galivan,J. and Sirotnak,F.M.
  TITLE     Cloning of mouse gamma-glutamyl hydrolase in the form of two cDNA
            variants with different 5' ends and encoding alternate leader
            peptide sequences
  JOURNAL   Gene 219 (1-2), 37-44 (1998)
   PUBMED   9756990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732527.6, BE859353.1, BB610405.1, AI846732.1, CO044650.1 and
            AI840300.1.
            
            On or before May 1, 2008 this sequence version replaced
            XM_989632.2, NM_010281.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF051102.1, AK089996.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AL732527.6         12274-12380         c
            108-444             BE859353.1         1-337
            445-628             BB610405.1         333-516
            629-834             AI846732.1         185-390
            835-1323            CO044650.1         21-509              c
            1324-1340           AI840300.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1340
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 7.79 cM"
     gene            1..1340
                     /gene="Ggh"
                     /gene_synonym="gamma-GH"
                     /note="gamma-glutamyl hydrolase"
                     /db_xref="GeneID:14590"
                     /db_xref="MGI:MGI:1329035"
     exon            1..231
                     /gene="Ggh"
                     /gene_synonym="gamma-GH"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1076
                     /gene="Ggh"
                     /gene_synonym="gamma-GH"
                     /EC_number="3.4.19.9"
                     /note="GH; FGPH; conjugase; folylpolyglutamate hydrolase;
                     gamma-Glu-x carboxypeptidase"
                     /codon_start=1
                     /product="gamma-glutamyl hydrolase precursor"
                     /protein_id="NP_034411.2"
                     /db_xref="CCDS:CCDS51126.1"
                     /db_xref="GeneID:14590"
                     /db_xref="MGI:MGI:1329035"
                     /translation="MANLGYLLCLLGLLLCGLSSPGMSRPYNHGSERPIIGVVMQECF
                     GKMAKLGNYYIAASYVKYIESAGARVVPIRPDLSDAEYEELFRSINGVLLPGGGANLT
                     DSGYSRVAKIFFSKALESFDNGDHFPVWGTCLGFEELSVLVSGENLLTSTDTKSKKLP
                     LNFTEGARKSRMFKHFPTELLDSLALENLTANFHKWSLSVKNFTENEKLKKFFNILTT
                     NTDGKTEFISSMEGFKYPVYAVQWHPEKAAFEWKNLGGISHAPNAVKTSFYLAEFLVS
                     EARKNSHHFENVVKETASLIYKFNPIYTGNISSFQQAYMFD"
     exon            232..343
                     /gene="Ggh"
                     /gene_synonym="gamma-GH"
                     /inference="alignment:Splign:2.1.0"
     exon            344..394
                     /gene="Ggh"
                     /gene_synonym="gamma-GH"
                     /inference="alignment:Splign:2.1.0"
     exon            395..479
                     /gene="Ggh"
                     /gene_synonym="gamma-GH"
                     /inference="alignment:Splign:2.1.0"
     exon            480..618
                     /gene="Ggh"
                     /gene_synonym="gamma-GH"
                     /inference="alignment:Splign:2.1.0"
     exon            619..725
                     /gene="Ggh"
                     /gene_synonym="gamma-GH"
                     /inference="alignment:Splign:2.1.0"
     exon            726..816
                     /gene="Ggh"
                     /gene_synonym="gamma-GH"
                     /inference="alignment:Splign:2.1.0"
     exon            817..954
                     /gene="Ggh"
                     /gene_synonym="gamma-GH"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1326
                     /gene="Ggh"
                     /gene_synonym="gamma-GH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1305..1310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ggh"
                     /gene_synonym="gamma-GH"
                     /note="hexamer: AATACA"
     polyA_site      1324
                     /gene="Ggh"
                     /gene_synonym="gamma-GH"
                     /note="major polyA site"
ORIGIN      
        1 gcgccctcga gcttggcacc gcccaggccg cgagaccgcg ccccaacctg gccgccgggc
       61 gcgcgcctgg ctgaagaacc tttttaagtg ggggcggagg ccggattgcg attgcgatcg
      121 cgatggcgaa cctgggctac ctgctgtgct tgttgggttt gctactatgc gggctttcaa
      181 gtcccgggat gtccagaccc tacaaccatg gctccgagag gcccatcatc ggagtagtaa
      241 tgcaagaatg ttttgggaaa atggcgaagt tgggaaacta ctacattgct gcatcctatg
      301 tgaagtatat agagtctgca ggtgcacgag ttgtgcccat aaggcccgat cttagtgatg
      361 cagagtatga agaacttttt agatctatta atggagttct ccttcctgga ggaggtgcta
      421 acctaacaga ttcaggttat tcccgagtgg ccaaaatatt tttcagcaag gctctagaga
      481 gctttgataa tggagaccat tttcctgtgt ggggaacatg ccttggattt gaggagcttt
      541 ctgtcctggt tagtggagag aacttactaa cgagtacaga cactaagtca aagaaattgc
      601 ccttgaactt cactgaaggt gcaaggaaga gcagaatgtt caaacatttt cctactgaat
      661 tattggattc attagcatta gaaaatctga ccgcaaattt tcacaaatgg agcctctctg
      721 tgaagaattt tacagaaaat gaaaagttaa agaagttttt caatatatta acaaccaata
      781 cagatggcaa aactgagttc atttcatcca tggaaggatt taagtatcca gtgtatgctg
      841 tccagtggca tcctgagaaa gcagcatttg agtggaagaa tctgggcggc atttctcatg
      901 caccaaatgc tgtgaagact tcattctact tagcagaatt tttagtttct gaagctcgga
      961 agaacagtca ccactttgag aacgtggtta aggagacggc atccttgatt tacaagttca
     1021 atccaattta tactggaaat atttcttcat ttcagcaagc ttatatgttt gactgaaatt
     1081 cttcaatatg gtaacccagc agctttgagt aattctgtga ttgaattgct aacacagctc
     1141 agggcagtat gagaaagcca cacagatatc tttgctgtgt gcctggttct gattcctggc
     1201 ttaatacatg attgttttta tcagatttga taacctgaca atgaaaaata taaaaaatca
     1261 gagtgttttt catgaaaatg ccttcttatg tctgaagatt ctaaaataca agtttttgaa
     1321 aatataaaaa aaaaaaaaaa
//
