LOCUS       NM_026637               1362 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus gamma-glutamyl cyclotransferase (Ggct), mRNA.
ACCESSION   NM_026637
VERSION     NM_026637.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1362)
  AUTHORS   Mori,M., Ii,H., Fujita,M., Nose,K., Shimada,A., Shiraki,R.,
            Sone,Y., Moyama,C., Taniguchi,K. and Nakata,S.
  TITLE     Desert Hedgehog Down-regulation Mediates Inhibition of
            Proliferation by gamma-Glutamylcyclotransferase Knockdown in Murine
            Glioblastoma Stem Cells
  JOURNAL   Cancer Genomics Proteomics 21 (5), 474-484 (2024)
   PUBMED   39191500
  REMARK    GeneRIF: Desert Hedgehog Down-regulation Mediates Inhibition of
            Proliferation by gamma-Glutamylcyclotransferase Knockdown in Murine
            Glioblastoma Stem Cells.
REFERENCE   2  (bases 1 to 1362)
  AUTHORS   Bejarano,E., Whitcomb,E.A., Pfeiffer,R.L., Rose,K.L., Asensio,M.J.,
            Rodriguez-Navarro,J.A., Ponce-Mora,A., Canto,A., Almansa,I.,
            Schey,K.L., Jones,B.W., Taylor,A. and Rowan,S.
  TITLE     Unbalanced redox status network as an early pathological event in
            congenital cataracts
  JOURNAL   Redox Biol 66, 102869 (2023)
   PUBMED   37677999
REFERENCE   3  (bases 1 to 1362)
  AUTHORS   He,Z., Sun,X., Wang,S., Bai,D., Zhao,X., Han,Y., Hao,P. and
            Liu,X.S.
  TITLE     Ggct (gamma-glutamyl cyclotransferase) plays an important role in
            erythrocyte antioxidant defense and red blood cell survival
  JOURNAL   Br J Haematol 195 (2), 267-275 (2021)
   PUBMED   34409610
  REMARK    GeneRIF: Ggct (gamma-glutamyl cyclotransferase) plays an important
            role in erythrocyte antioxidant defense and red blood cell
            survival.
REFERENCE   4  (bases 1 to 1362)
  AUTHORS   He,Z., Wang,S., Shao,Y., Zhang,J., Wu,X., Chen,Y., Hu,J., Zhang,F.
            and Liu,X.S.
  TITLE     Ras Downstream Effector GGCT Alleviates Oncogenic Stress
  JOURNAL   iScience 19, 256-266 (2019)
   PUBMED   31400748
REFERENCE   5  (bases 1 to 1362)
  AUTHORS   Oakley,A.J., Yamada,T., Liu,D., Coggan,M., Clark,A.G. and
            Board,P.G.
  TITLE     The identification and structural characterization of C7orf24 as
            gamma-glutamyl cyclotransferase. An essential enzyme in the
            gamma-glutamyl cycle
  JOURNAL   J Biol Chem 283 (32), 22031-22042 (2008)
   PUBMED   18515354
  REMARK    Erratum:[J Biol Chem. 2008 Nov 14;283(46):32152]
REFERENCE   6  (bases 1 to 1362)
  AUTHORS   Dush,M.K. and Martin,G.R.
  TITLE     Analysis of mouse Evx genes: Evx-1 displays graded expression in
            the primitive streak
  JOURNAL   Dev Biol 151 (1), 273-287 (1992)
   PUBMED   1349539
REFERENCE   7  (bases 1 to 1362)
  AUTHORS   Johnson,K.R., Cook,S.A. and Davisson,M.T.
  TITLE     Chromosomal localization of the murine gene and two related
            sequences encoding high-mobility-group I and Y proteins
  JOURNAL   Genomics 12 (3), 503-509 (1992)
   PUBMED   1559701
REFERENCE   8  (bases 1 to 1362)
  AUTHORS   Nadeau,J.H., Bedigian,H.G., Bouchard,G., Denial,T., Kosowsky,M.,
            Norberg,R., Pugh,S., Sargeant,E., Turner,R. and Paigen,B.
  TITLE     Multilocus markers for mouse genome analysis: PCR amplification
            based on single primers of arbitrary nucleotide sequence
  JOURNAL   Mamm Genome 3 (2), 55-64 (1992)
   PUBMED   1617215
REFERENCE   9  (bases 1 to 1362)
  AUTHORS   Thaete,L.G., Nesbitt,M.N. and Malkinson,A.M.
  TITLE     Genetic analysis of the distribution of corticosterone-containing
            cells in mouse adrenal cortex
  JOURNAL   Proc Soc Exp Biol Med 194 (2), 97-102 (1990)
   PUBMED   2349252
REFERENCE   10 (bases 1 to 1362)
  AUTHORS   Ramagli,L.S., Womack,J.E. and Rodriguez,L.V.
  TITLE     Genetic analysis of nonhistone chromosomal protein inheritance in
            recombinant inbred mouse strains using two-dimensional
            electrophoresis
  JOURNAL   Biochem Genet 28 (3-4), 123-136 (1990)
   PUBMED   2383242
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK079465.1.
            
            On Apr 5, 2007 this sequence version replaced NM_026637.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079465.1, AK028830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1362              AK079465.1         3-1364
FEATURES             Location/Qualifiers
     source          1..1362
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.26 cM"
     gene            1..1362
                     /gene="Ggct"
                     /gene_synonym="A030007L17Rik; Gctg; Ggc"
                     /note="gamma-glutamyl cyclotransferase"
                     /db_xref="GeneID:110175"
                     /db_xref="MGI:MGI:95700"
     exon            1..173
                     /gene="Ggct"
                     /gene_synonym="A030007L17Rik; Gctg; Ggc"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..599
                     /gene="Ggct"
                     /gene_synonym="A030007L17Rik; Gctg; Ggc"
                     /EC_number="4.3.2.9"
                     /codon_start=1
                     /product="gamma-glutamylcyclotransferase"
                     /protein_id="NP_080913.1"
                     /db_xref="CCDS:CCDS20161.1"
                     /db_xref="GeneID:110175"
                     /db_xref="MGI:MGI:95700"
                     /translation="MASSDCEGHAGQEGETFLYFAYGSNLLTERIHLRNPSAVFCCVA
                     RLQDFKLDFGNFQGKMSERWHGGIATIFQSPGDEVWGVVWRMNKSNISSLDEQEGVKS
                     GVYVVIEIKVSTREGKEITCRSYLMTNYESAPPSPQYKKVICMGAKENGLPQEYQEKL
                     KAIEPNEYKGKISDEMEDIIKKGESKLS"
     exon            174..319
                     /gene="Ggct"
                     /gene_synonym="A030007L17Rik; Gctg; Ggc"
                     /inference="alignment:Splign:2.1.0"
     exon            320..455
                     /gene="Ggct"
                     /gene_synonym="A030007L17Rik; Gctg; Ggc"
                     /inference="alignment:Splign:2.1.0"
     exon            456..1362
                     /gene="Ggct"
                     /gene_synonym="A030007L17Rik; Gctg; Ggc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      773..778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ggct"
                     /gene_synonym="A030007L17Rik; Gctg; Ggc"
                     /note="hexamer: ATTAAA"
     polyA_site      810
                     /gene="Ggct"
                     /gene_synonym="A030007L17Rik; Gctg; Ggc"
                     /note="major polyA site"
     regulatory      958..963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ggct"
                     /gene_synonym="A030007L17Rik; Gctg; Ggc"
                     /note="hexamer: AATATA"
     polyA_site      992
                     /gene="Ggct"
                     /gene_synonym="A030007L17Rik; Gctg; Ggc"
ORIGIN      
        1 gtgcttgacg ctgctggcgt ggataagtgg acatggcgag ctccgactgt gagggccatg
       61 cgggccagga gggggagaca ttcctgtact tcgcctacgg cagcaatctc ctgaccgaga
      121 ggatccacct gcgaaacccc tcggccgtgt tctgctgcgt ggcgcgcctg caggacttta
      181 agctcgactt cggcaatttc caaggcaaaa tgagtgagag gtggcacgga ggtatagcta
      241 ccatttttca aagtcctggc gacgaagtgt ggggagtggt atggagaatg aacaaaagca
      301 atataagttc cctggatgag caagaaggag ttaaaagtgg agtctatgtt gtaatagaaa
      361 ttaaagtttc aactcgagaa gggaaggaaa taacctgccg aagttacctg atgacgaact
      421 acgagagcgc gcccccatca ccacagtata agaaggttat ctgcatgggt gcgaaagaaa
      481 acggtttgcc acaggaatat caagagaaat taaaagcaat agaaccaaat gagtataaag
      541 gaaagatctc cgacgaaatg gaagacatca tcaaaaaggg agagtcaaaa ctgtcataac
      601 agactctgaa gctatgtgtg ctagtatgaa gtgcttttaa cgtttgcgaa caggagtctg
      661 gaccttcttg gttctgacct tgattttcaa cagtgctggg aagggcttct cacataggtg
      721 attctttatt tttaactgta acaaagaact ggaatgggga tgggcttaga ccattaaagg
      781 gaccagggga tcctggcatg tgcaagtggt gatggccgtg ggttctcctg tggacactgc
      841 tatagccccc cactgtgtgg acgacctccg tggagggtag gtctgtagct caggggcgca
      901 ctgctgcgct tggtctgctt tctgcttgta tccgatcggc ttgtaagaag taagcaaaat
      961 atagagggta ggtggtaagg ctttgagaag tacaaagatg gtacactgtc ctttgagggg
     1021 cgactgcttt catgactcta aggggtttct cagcaagagc tccacctcac tgtgctctgc
     1081 tcagaccaca cagagcagcc tcagctcata gagtctgtgt taactggtat tgtggactct
     1141 ggagccaagc tggccttgaa cctgtgacca tcttgcctca gcttctcata tagctggctg
     1201 ggattatagt cttgtgctac tggggctagc tgagcctccc actttccagt tgtgggactt
     1261 gagcttctct ggctcactgg accttagttg cttcacctgt ataaataggg aaaatcaaaa
     1321 acgtgaattt gaagatttca tgagtaaaca tgtgataagc tt
//
