LOCUS       NM_173048               3650 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus golgi associated, gamma adaptin ear containing, ARF
            binding protein 3 (Gga3), transcript variant 1, mRNA.
ACCESSION   NM_173048
VERSION     NM_173048.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3650)
  AUTHORS   Lomoio,S., Willen,R., Kim,W., Ho,K.Z., Robinson,E.K.,
            Prokopenko,D., Kennedy,M.E., Tanzi,R.E. and Tesco,G.
  TITLE     Gga3 deletion and a GGA3 rare variant associated with late onset
            Alzheimer's disease trigger BACE1 accumulation in axonal swellings
  JOURNAL   Sci Transl Med 12 (570) (2020)
   PUBMED   33208500
  REMARK    GeneRIF: Gga3 deletion and a GGA3 rare variant associated with late
            onset Alzheimer's disease trigger BACE1 accumulation in axonal
            swellings.
REFERENCE   2  (bases 1 to 3650)
  AUTHORS   Kim,W., Ma,L., Lomoio,S., Willen,R., Lombardo,S., Dong,J.,
            Haydon,P.G. and Tesco,G.
  TITLE     BACE1 elevation engendered by GGA3 deletion increases beta-amyloid
            pathology in association with APP elevation and decreased CHL1
            processing in 5XFAD mice
  JOURNAL   Mol Neurodegener 13 (1), 6 (2018)
   PUBMED   29391027
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3650)
  AUTHORS   Walker,K.R., Modgil,A., Albrecht,D., Lomoio,S., Haydon,P.G.,
            Moss,S.J. and Tesco,G.
  TITLE     Genetic Deletion of the Clathrin Adaptor GGA3 Reduces Anxiety and
            Alters GABAergic Transmission
  JOURNAL   PLoS One 11 (5), e0155799 (2016)
   PUBMED   27192432
  REMARK    GeneRIF: GGA3 plays a key role in GABAergic transmission. GGA3
            deletion results in decreased anxiety-like behaviors and increased
            BACE1 levels.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3650)
  AUTHORS   Kizuka,Y., Kitazume,S., Fujinawa,R., Saito,T., Iwata,N.,
            Saido,T.C., Nakano,M., Yamaguchi,Y., Hashimoto,Y., Staufenbiel,M.,
            Hatsuta,H., Murayama,S., Manya,H., Endo,T. and Taniguchi,N.
  TITLE     An aberrant sugar modification of BACE1 blocks its lysosomal
            targeting in Alzheimer's disease
  JOURNAL   EMBO Mol Med 7 (2), 175-189 (2015)
   PUBMED   25592972
REFERENCE   5  (bases 1 to 3650)
  AUTHORS   Zhang,J., Neal,J., Lian,G., Hu,J., Lu,J. and Sheen,V.
  TITLE     Filamin A regulates neuronal migration through brefeldin
            A-inhibited guanine exchange factor 2-dependent Arf1 activation
  JOURNAL   J Neurosci 33 (40), 15735-15746 (2013)
   PUBMED   24089482
REFERENCE   6  (bases 1 to 3650)
  AUTHORS   Walker,K.R., Kang,E.L., Whalen,M.J., Shen,Y. and Tesco,G.
  TITLE     Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1
  JOURNAL   J Neurosci 32 (30), 10423-10437 (2012)
   PUBMED   22836275
  REMARK    GeneRIF: depletion of GGA1 and GGA3 engender a rapid and robust
            elevation of BACE1 in the acute phase after brain injury. However,
            the efficient disposal of the acutely accumulated BACE1 solely
            depends on GGA3 levels in the subacute phase of injury
REFERENCE   7  (bases 1 to 3650)
  AUTHORS   Govero,J., Doray,B., Bai,H. and Kornfeld,S.
  TITLE     Analysis of Gga null mice demonstrates a non-redundant role for
            mammalian GGA2 during development
  JOURNAL   PLoS One 7 (1), e30184 (2012)
   PUBMED   22291915
REFERENCE   8  (bases 1 to 3650)
  AUTHORS   Kang,E.L., Cameron,A.N., Piazza,F., Walker,K.R. and Tesco,G.
  TITLE     Ubiquitin regulates GGA3-mediated degradation of BACE1
  JOURNAL   J Biol Chem 285 (31), 24108-24119 (2010)
   PUBMED   20484053
  REMARK    GeneRIF: GGA3 tightly and inversely regulate BACE1 levels via
            interaction with ubiquitin sorting machinery
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645470.20.
            
            On Dec 22, 2022 this sequence version replaced NM_173048.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122212.2, BC024266.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AL645470.20        20939-20996
            59-143              AL645470.20        29831-29915
            144-219             AL645470.20        30043-30118
            220-318             AL645470.20        32294-32392
            319-442             AL645470.20        33071-33194
            443-546             AL645470.20        33458-33561
            547-627             AL645470.20        33857-33937
            628-765             AL645470.20        34291-34428
            766-847             AL645470.20        35688-35769
            848-964             AL645470.20        35852-35968
            965-1198            AL645470.20        36279-36512
            1199-1266           AL645470.20        36821-36888
            1267-1577           AL645470.20        37108-37418
            1578-1783           AL645470.20        37623-37828
            1784-1953           AL645470.20        38339-38508
            1954-2064           AL645470.20        38628-38738
            2065-3650           AL645470.20        38984-40569
FEATURES             Location/Qualifiers
     source          1..3650
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.89 cM"
     gene            1..3650
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /note="golgi associated, gamma adaptin ear containing, ARF
                     binding protein 3"
                     /db_xref="GeneID:260302"
                     /db_xref="MGI:MGI:2384159"
     exon            1..58
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..2175
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ADP-ribosylation factor-binding protein GGA3;
                     golgi-localized, gamma ear-containing, ARF-binding protein
                     3"
                     /codon_start=1
                     /product="ADP-ribosylation factor-binding protein GGA3
                     isoform 1"
                     /protein_id="NP_766636.2"
                     /db_xref="CCDS:CCDS25641.1"
                     /db_xref="GeneID:260302"
                     /db_xref="MGI:MGI:2384159"
                     /translation="MAEAEGESLESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQ
                     IAVRLLAHKIQSPQEWEAVQALTVLEACMKNCGRRLHNEVGKFRFLNELIKVVSPKYL
                     GDRVSEKVKTKVIELLFSWTLALPEEAKIKDAYHMLKRQGIVQSDPPIPMDRTLIPSP
                     PPRPKNPVFDDEEKSKLLARLLKSKNPDDLQEANRLIKSMVKEDEARIQKVTKRLHTL
                     EEVNNNVKLLHEMLLHYSQEYSSDADKELMKELFDRCENKRRTLFKLASETEDNDNSL
                     GDILQASDNLSRVINSYKTIIEGQIVNGEVTTSTMPDSEGNSHCGNQGALIDLAELDA
                     PSNSSPALAPPTSGIPILPPPPQTSGPPRSRSSSQAEAPPGSDSTNNALSLLDEELLC
                     LGLTDPAPTAPKESPGSSQWHLFQNEPPSDLDFFSPRPVPAASCPSDGPQLPPPVSTS
                     SMSQAPLPAAFPAPVVPASAPTHSTGSFMFSSGPAPALAPKAEPKGPEYPSSSTSHRL
                     DALDQLLEEAKVTSGLVKPVSCFSPGPTASPLLPASAPARPLLPFSTGPGSPLFQSQG
                     SPQKGPELSLASVHVPLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVV
                     SMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPMK
                     EKVRLRYKLTFALGEQLSTELGEVDQFPPVEQWGNL"
     exon            59..143
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /inference="alignment:Splign:2.1.0"
     exon            144..219
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /inference="alignment:Splign:2.1.0"
     exon            220..318
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /inference="alignment:Splign:2.1.0"
     exon            319..442
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /inference="alignment:Splign:2.1.0"
     exon            443..546
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /inference="alignment:Splign:2.1.0"
     exon            547..627
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /inference="alignment:Splign:2.1.0"
     exon            628..765
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /inference="alignment:Splign:2.1.0"
     exon            766..847
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /inference="alignment:Splign:2.1.0"
     exon            848..964
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1198
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1266
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1577
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1783
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1953
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2064
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..3650
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3523..3528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /note="hexamer: ATTAAA"
     polyA_site      3542
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /note="major polyA site"
     regulatory      3631..3636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
                     /note="hexamer: AATAAA"
     polyA_site      3650
                     /gene="Gga3"
                     /gene_synonym="C230037M19Rik; mKIAA0154"
ORIGIN      
        1 ggaccgggcg gctgcaatat ggcggaggcg gaaggggaga gcctggagtc ctggctgaat
       61 aaagctacca atccttccaa ccgccaggaa gactgggaat atatcattgg tttctgtgat
      121 cagatcaaca aagagcttga agggccccag attgctgtgc gactcctggc ccacaagatc
      181 cagtctccac aggaatggga ggcagtgcag gccctcacgg tgctggaggc gtgtatgaag
      241 aactgtggca ggagacttca taatgaagtg gggaagttcc ggtttttgaa tgaattaatc
      301 aaagtcgtct ctccaaagta cttgggagac agggtgtctg aaaaggtgaa gactaaggtc
      361 atcgagttgc tttttagctg gacactggcc ttgccggaag aagcaaagat caaagatgcc
      421 taccatatgt tgaagagaca aggcatagtg cagtcggacc cccccatccc catggataga
      481 acgctgatcc cctctccccc acctcggccc aaaaaccccg tttttgatga tgaggagaaa
      541 tccaagcttt tagccaggct gctgaagagc aagaacccag atgacctgca agaggccaac
      601 agactcatca agtccatggt gaaggaagat gaggctcgca tccagaaagt gaccaagcgt
      661 ctacacacac tggaggaggt taacaacaat gtcaagctgc tccacgagat gctgcttcac
      721 tacagccaag agtactcgtc agacgccgac aaggagctca tgaaggagct ctttgatcgt
      781 tgtgagaata agaggcggac gctgtttaaa ctagccagcg agacagagga caatgacaac
      841 agtttggggg acatcctgca ggccagtgac aacctgtcca gggtcatcaa ctcttacaaa
      901 actattattg aagggcagat cgtcaatggt gaggtgacca cctcaaccat gcctgactct
      961 gaaggaaaca gtcactgtgg taaccaaggc gccctcattg accttgctga gttggacgcc
     1021 cccagcaact cgtctccggc attggcccca cccacctcag gcatccccat cctccctcca
     1081 cccccccaaa cctccgggcc tccacgaagc cgttcatcca gccaggctga ggctccccca
     1141 gggtctgaca gcacgaacaa tgccctctcc ttgctggatg aggagctcct ctgcttaggc
     1201 cttactgacc ccgcccccac tgctcccaaa gagtcacctg gaagtagtca gtggcacctg
     1261 ttccagaatg aaccaccatc agatctggac ttcttcagtc ccaggccagt gcctgcggcc
     1321 tcctgcccct cagatggacc ccagctccct cccccagttt ctacctcaag tatgtcccaa
     1381 gctccactgc ctgctgcctt cccagctcct gtggtcccag ccagtgcacc aacccacagc
     1441 actggctcct tcatgttctc ttctggacct gccccagcct tggctccaaa ggctgagccc
     1501 aaaggtccag aataccccag ctccagcacc tcgcaccgcc tagatgccct tgatcagctt
     1561 ctggaagagg ccaaagtaac ctcaggcttg gtgaaacctg tttcttgctt ctctcctggg
     1621 cccactgcct ccccgctgct gcctgcctct gccccagcca gacctctcct gcccttctcc
     1681 actgggcccg gaagccctct cttccagtcc caaggcagcc ctcagaaagg cccagagctc
     1741 tccttggcca gtgtccatgt gcccctggaa tcgatcaagc ctagcagtgc ccttcccgtg
     1801 acagcctatg ataaaaatgg cttccgcatc cttttccact ttgctaagga gtgtccgcca
     1861 ggacggcctg atgtgctggt ggtggtggtt tccatgctga atacggctcc gttgccagtc
     1921 aagagcatag tgctgcaggc tgcagtgccc aagtcaatga aagtgaagtt gcagccaccc
     1981 tctgggacag aactttcccc atttagtcct atccagccac ctgcagccat cacccaggtc
     2041 atgctgctgg ccaatccaat gaaggaaaag gtgcggcttc gatataaact gacctttgct
     2101 ttgggggagc agctgagcac agaactgggt gaagtggacc agtttcctcc tgtggagcag
     2161 tgggggaacc tatgacccca gcatatgttg ccatctctac ttggaaggca agcagccctg
     2221 agacaggctc tagctagtcc agccactgta caccctgaac agcgtttata gcttggtgtg
     2281 gatcggagcc ctggacactt ctgtcaggaa ccaagctgct gctttggtca cctcttcctg
     2341 ggcccctaaa aggacctgtc ttatctacct gtgtgacttg aagtagccgt actgtgtggg
     2401 tgatgagtcc cctgtggctt cattggccac tctgggatgg tggactctgg gcccagagta
     2461 ggatttcctt tttttactgg cattccttga tatcagggag agggctctga acggtgcctc
     2521 tccagcccct gtaagaactg catctttaca ctcgaagagg catggcttag gagactgtac
     2581 ctccccttgg cggtccctgg ttctttgctg ataggcactg ctgctccctg aactaaagtg
     2641 ggcagcagtg gcccagagtg agaactgtgg agtactgtag tcttcacttt ctgcaagcag
     2701 cagcatcctg cagtggctac tgagtgagtg atgtgcttac agtggcaggt tgtgtcctat
     2761 ggacatccta gcaggacggg gagcttggcc ggatagcctc actagggaca ggaaggaaaa
     2821 cggaagtgcc aatgtttccc ttcagaggca ggtactgtgg ctttctggga aaggcgtacc
     2881 tcctgcagtg ggaataggcc gtcctactca ctacctcttg cttggcatga aataaactgc
     2941 tgtgctcccc ataagccttt caggggagga cacctcctgc cactctgcat cctgctttgg
     3001 tcactccttc tccctgccac acagtatgtg gtgtggcacc tatggctgga cccaggaagt
     3061 ctcagggtca cacacattgc actagacttt tatgctgcac ccaacaccct cttttcccca
     3121 gctaaagagg ggcactgtca gcgacatgtt gggtctggag atgagaggtc tgtgattaaa
     3181 ctgagtttcc agaccctatt gcttctacag tgctgtgcct cagccagcat aacccagttg
     3241 ctccaggcca gagacgttta ggctgatcgg gaactcggct gccatactag tctactgggc
     3301 cctgctgtcc gtatgctgtc gccactacat ctttggagct ctgtctagag gtcatctggc
     3361 ctacctccca gctattgtcc ttagctagca ggttttacag tttccttagg acaggtttaa
     3421 aagagataat cattttcact gatgatggaa taaatccaag agctttccag agactggtta
     3481 cttcggtgct ggaacatcta tgggatcact gtcaatacgg tcattaaaga tttaaattat
     3541 gagtgttgct cactactact gaggtcactg cttcagtcag tacagctgta ctggttgtac
     3601 cacctcctgc ccttgttttg ctgcatgtga aataaaacca tttcaccctg
//
