LOCUS       NM_028758               4891 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus golgi associated, gamma adaptin ear containing, ARF
            binding protein 2 (Gga2), mRNA.
ACCESSION   NM_028758 XM_133801
VERSION     NM_028758.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4891)
  AUTHORS   Tolvanen,T.A., Dash,S.N., Polianskyte-Prause,Z., Dumont,V. and
            Lehtonen,S.
  TITLE     Lack of CD2AP disrupts Glut4 trafficking and attenuates glucose
            uptake in podocytes
  JOURNAL   J Cell Sci 128 (24), 4588-4600 (2015)
   PUBMED   26546360
REFERENCE   2  (bases 1 to 4891)
  AUTHORS   Doray,B., Govero,J. and Kornfeld,S.
  TITLE     Impact of genetic background on neonatal lethality of Gga2
            gene-trap mice
  JOURNAL   G3 (Bethesda) 4 (5), 885-890 (2014)
   PUBMED   24637350
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4891)
  AUTHORS   Doray,B., Misra,S., Qian,Y., Brett,T.J. and Kornfeld,S.
  TITLE     Do GGA adaptors bind internal DXXLL motifs?
  JOURNAL   Traffic 13 (10), 1315-1325 (2012)
   PUBMED   22762444
  REMARK    GeneRIF: GGA2 binds to the internal DXXLL motif of the LRP9
REFERENCE   4  (bases 1 to 4891)
  AUTHORS   Govero,J., Doray,B., Bai,H. and Kornfeld,S.
  TITLE     Analysis of Gga null mice demonstrates a non-redundant role for
            mammalian GGA2 during development
  JOURNAL   PLoS One 7 (1), e30184 (2012)
   PUBMED   22291915
REFERENCE   5  (bases 1 to 4891)
  AUTHORS   del Castillo,F.J., Cohen-Salmon,M., Charollais,A., Caille,D.,
            Lampe,P.D., Chavrier,P., Meda,P. and Petit,C.
  TITLE     Consortin, a trans-Golgi network cargo receptor for the plasma
            membrane targeting and recycling of connexins
  JOURNAL   Hum Mol Genet 19 (2), 262-275 (2010)
   PUBMED   19864490
REFERENCE   6  (bases 1 to 4891)
  AUTHORS   Van Dyck,F., Braem,C.V., Chen,Z., Declercq,J., Deckers,R.,
            Kim,B.M., Ito,S., Wu,M.K., Cohen,D.E., Dewerchin,M., Derua,R.,
            Waelkens,E., Fiette,L., Roebroek,A., Schuit,F., Van de Ven,W.J. and
            Shivdasani,R.A.
  TITLE     Loss of the PlagL2 transcription factor affects lacteal uptake of
            chylomicrons
  JOURNAL   Cell Metab 6 (5), 406-413 (2007)
   PUBMED   17983586
REFERENCE   7  (bases 1 to 4891)
  AUTHORS   Li,L.V. and Kandror,K.V.
  TITLE     Golgi-localized, gamma-ear-containing, Arf-binding protein adaptors
            mediate insulin-responsive trafficking of glucose transporter 4 in
            3T3-L1 adipocytes
  JOURNAL   Mol Endocrinol 19 (8), 2145-2153 (2005)
   PUBMED   15774496
REFERENCE   8  (bases 1 to 4891)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 4891)
  AUTHORS   Fowles,L.F., Bennetts,J.S., Berkman,J.L., Williams,E., Koopman,P.,
            Teasdale,R.D. and Wicking,C.
  TITLE     Genomic screen for genes involved in mammalian craniofacial
            development
  JOURNAL   Genesis 35 (2), 73-87 (2003)
   PUBMED   12533789
REFERENCE   10 (bases 1 to 4891)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY291970.1, AK143691.1 and AC126941.3.
            
            On Mar 15, 2007 this sequence version replaced NM_028758.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143691.1, AK129280.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BY291970.1         1-12
            13-2693             AK143691.1         1-2681
            2694-4891           AC126941.3         27790-29987
FEATURES             Location/Qualifiers
     source          1..4891
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 65.21 cM"
     gene            1..4891
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /note="golgi associated, gamma adaptin ear containing, ARF
                     binding protein 2"
                     /db_xref="GeneID:74105"
                     /db_xref="MGI:MGI:1921355"
     exon            1..210
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1922
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /note="gamma-adaptin-related protein 2; golgi-localized,
                     gamma ear-containing, ARF-binding protein 2"
                     /codon_start=1
                     /product="ADP-ribosylation factor-binding protein GGA2"
                     /protein_id="NP_083034.1"
                     /db_xref="CCDS:CCDS40116.1"
                     /db_xref="GeneID:74105"
                     /db_xref="MGI:MGI:1921355"
                     /translation="MAATAVAAGTGSPAGTESAEGGPGAAAALELWLNKATDPSMAEQ
                     DWSAIQKFCEQVNTDPSGPTHAPWLLAHKIQSPQEKEALYALTVLEICMNHCGEKFHS
                     EVAKFRFLNELIKVLSPKYLGAWATEKVKGRVIEILFSWTVWFPEDIKIRDAYQMLKK
                     QGIIKQDPKLPMDKILPPPSPWPKSIFDADEEKSKLLTRLLKSNHPEDLQAANRLIKN
                     LVKEEQEKSEKVSRRVSAVEEVRSHVRVLREMLSMYRRPGHALPDQQALQVVYERCEK
                     LRPTLFRLASDTTDDDDALAEILQANDLLTQGVRLYKQVVEGRVSAGNAVPAAVGAIP
                     APRAFPNPEPCGLNCPLIDLETPSLLHQDLAALGINDVPTRNQVVIPSCCNDKKQPGA
                     ITLMGGGIQSLSADRNLLDLFSPQPSPGLNYVPQKSIPKEVPPGTKASPGWSWEAGPL
                     ASSTASQNTPLAHVFVPLESVKPSSLPPIVVYDRNGFRILLHFSQTGAPGHPDVKVLL
                     LTMMSTATQPVWDVMFQVAVPKSMRVKLQPASSSKLPAFSPLMPPAVISQTLLLDNPH
                     KEPIRLRYKLTFNQGGQPFSEVGEVKDFPDLAVLSTA"
     exon            211..295
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /inference="alignment:Splign:2.1.0"
     exon            296..371
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /inference="alignment:Splign:2.1.0"
     exon            372..470
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /inference="alignment:Splign:2.1.0"
     exon            471..594
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /inference="alignment:Splign:2.1.0"
     exon            595..695
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /inference="alignment:Splign:2.1.0"
     exon            696..776
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /inference="alignment:Splign:2.1.0"
     exon            777..914
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /inference="alignment:Splign:2.1.0"
     exon            915..996
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1122
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1212
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1241
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1372
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1530
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1700
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1811
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..4891
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2830..2835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /note="hexamer: AATAAA"
     polyA_site      2848
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /note="major polyA site"
     regulatory      4873..4878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
                     /note="hexamer: AATAAA"
     polyA_site      4891
                     /gene="Gga2"
                     /gene_synonym="1200007E24Rik; mKIAA1080"
ORIGIN      
        1 acgtgcctct cagtgtctgc cgcgtcggca gctggagcga aggctaggcg gcggcggtgg
       61 ctgcagcttt tgggcaggag tgactgcggc cgcagcgctg ggctgggcag atggcagcga
      121 cggcagtggc agcggggacc ggatccccgg cagggaccga gtcggcggag ggcggccctg
      181 gggcagcggc ggcgctggag ctgtggctca acaaagccac agacccaagc atggcggagc
      241 aggattggtc agccatccag aagttctgtg agcaggtgaa caccgacccc agtggcccga
      301 cacatgcacc ctggctactg gcccacaaga ttcagtctcc acaggagaag gaagcccttt
      361 atgccctgac ggtgctggag atatgcatga accactgtgg ggagaagttc cacagtgaag
      421 tggccaagtt ccgcttcctg aacgagctga tcaaagtatt gtccccaaag tacctagggg
      481 cctgggctac ggagaaggtt aaaggaagag ttattgaaat cctctttagc tggaccgtct
      541 ggtttccgga agacatcaag atccgagatg cttatcagat gctgaagaag caaggaatca
      601 taaagcaaga tcccaaacta ccgatggata aaatcttgcc cccaccgtct ccctggccga
      661 agagcatctt tgatgctgat gaggagaagt caaagcttct gacaagactt ctcaagagta
      721 accaccctga ggatcttcag gctgcaaacc ggctgatcaa gaatttggtc aaggaagaac
      781 aagagaagtc tgaaaaggtg tccaggcgag tcagtgcagt agaggaagtc cgcagccacg
      841 tgagggtgct tcgggagatg ctgagcatgt accgaaggcc aggtcatgcc ctgcccgacc
      901 agcaggccct gcaggttgtg tatgaaagat gtgagaagct gaggcccacc ctgttccggc
      961 ttgcaagcga caccactgat gacgacgatg ctctggcgga gattcttcaa gcaaatgacc
     1021 ttctcacaca gggggttcgg ctgtacaaac aggtggtgga gggccgagtt agtgctggga
     1081 acgcagtgcc tgccgcagtg ggagccattc ccgcccccag agcattcccg aatccagaac
     1141 cctgtgggtt gaactgtcca ctcattgacc tggagacgcc atctttgctt catcaggacc
     1201 tggcagcctt aggaatcaac gatgttccca ctaggaacca ggttgttatt ccgagttgct
     1261 gtaatgacaa gaagcagccg ggtgccatca cactcatggg gggtggaatc cagagtcttt
     1321 ctgcagaccg gaacctgctg gatctcttct cgccacagcc atctccagga ctgaattatg
     1381 ttccacaaaa aagcatcccc aaggaggtgc caccaggtac caaggcctct ccaggttggt
     1441 cctgggaggc tgggccattg gcttcttcca cagcctcaca gaatacacct ctggctcatg
     1501 tgtttgtccc tttggagtct gtgaaaccca gcagcttgcc gcccattgtc gtgtatgacc
     1561 ggaatggctt ccgaattctg ctgcacttct cccagactgg ggcccctggc cacccggatg
     1621 tgaaggtgtt gttgttgacc atgatgagca ctgccaccca acctgtctgg gatgtcatgt
     1681 ttcaggtggc tgtcccaaag tcaatgcgag tgaagctgca gccggcatcc agctccaagc
     1741 tccctgcatt cagtcctttg atgcctccag cagtgatatc tcagacgctg ttgctcgaca
     1801 acccacacaa agaacctatc cggttgcggt ataagctgac tttcaaccaa ggtgggcagc
     1861 cgttcagtga agtaggagag gtgaaagact ttccagacct ggctgtcttg agcaccgcct
     1921 gacttttcaa ccaagactct tcagtcacgc ttaggccagc gtccttttac tgtctggtcg
     1981 ggacttgttg taatgtagtg cagagtgcca aggattctct cctgatgtta ggccttgatt
     2041 gccaatgtgt ctgttgatca tgtatgtgtg ggtgcgtgtg tgttactggg gtgctggggg
     2101 aggagggaga gctgggcttg ggatttgggc agtatggggg atgctgacca cctctgagat
     2161 catctctgct gcactcatac ctgcttctgc atgttggttg acaatgttgc ccctgcctcg
     2221 agttggagtt ttataagcca aagttttttc catgtattgt taatcttttc attcatccac
     2281 tctgtgcctt gtcagccttt gaaagtctta gttgctccca ggctgctatt ctcagggacc
     2341 ttagaaaggg acctggttgg tcttgcgaca gagagtgtct tctggggcac actcttccaa
     2401 gaatggcctt gtcttcattt ttcattagca aatgctgctt gcagatattc agtaagacct
     2461 tctaaatgga atgtttgttg tactggttca ggcaaggggc ttgccatgaa accaggagac
     2521 cacacttgtt gggccaatca tgtccttcac tacagtgcct tagatactcc cttagacgga
     2581 ccctcttgag gccttgctca ggccttgggt tctgtgggtt gggcagcctg tctgggccct
     2641 tactcaggac ccacaatgtc atcttcattc tttctgttca caaacatctc agagctcttt
     2701 cattgtgacc ctgtgttcgt tgttgtgaat catagttaag gggggccagc cctgagccct
     2761 cacaatccaa ggtggggagc tgcgatgcag gtagagagcc atgtggtgac taagtacaga
     2821 acatcattga ataaatactg tgttcagatc tgcctggtgt tgagtccaca ggggatgcat
     2881 ttagagggga caggctggcg gggaatggtt ttctgtcaac aagtgaggac atgatgagca
     2941 gtgttctgac gagctgaagg agctggagaa gaggggtggg tgtttgcctc aggtgtcccc
     3001 agaaaggaaa ctcaagctac tggttgactc gagagcacct actatgtgct gggttctttg
     3061 gcatgcatgc ttcaacaagt tctgcttggc tgggtccatg ggagaaggaa ccctgaggtc
     3121 tgaaatgggt gctgagggct ggaaagtcct ggcatccagt cttgcgggtt ctgcctcaga
     3181 aactggaggg ccatctctca attatgacat gttcatctag ttggatatcc aacaataatt
     3241 ttctttaggt gtatattaat attgataatt tcagtagatt tttaggatag cttctggctg
     3301 ctgtttttgt ttgtttttga gacagtcact gtagccctgg ctggcctgga attcaccatg
     3361 tagaccaagc tggcctcaca ctcacagtga tccactgcct ctgcctcctg agtgctggga
     3421 ttaaaggtct gcgctacaat gactgacttt aaaaaaaaaa aaaataggtc tcatgtagcc
     3481 caagctgacc tcaaactcac tgtggaaact gaaagagagt gaccttcaac ttctgatcct
     3541 cctgcctcca actcatgtgt accaagtcct gacaagatgg aaccccaagc ctgtgcatgc
     3601 taggcaagca cttgtccaac tgagctgcat ccccagcccc ctggtttttt gttgtctcaa
     3661 gctatagtcc aacctgacct ggaactcaaa taccatgttc aaagaaacat gatatagtag
     3721 ccaatataca ctacacactt gtggaaacag gctagagcag ggcatccaag gttttttgcc
     3781 tttaagttcc caggaacacg ctcctcacag ccctgttccc agatgcagct tcaatatcac
     3841 agttgccaat gcactgtcag tcacaggagg gagccgggcg ggcatggtgg tgcacgcctt
     3901 taatcccagc actctggagg cagaggcagg cagatttctg agtttgaggc cagcctggtc
     3961 tacagagtga gttctaggac agccagggct acacagagaa accctgtctc tggaaaccaa
     4021 aacaaacaac aacaacaaaa acagttacag gaggaaaagg ggaaatgcca aggctttctg
     4081 gaaacttccc atgatgtctg ccttcacatc ttgtcctgta tgggtatttg gccacaccta
     4141 gctgcaaacc acactgggaa ggtatggatg ttgtgtgcag tgcaacacag tataaacttg
     4201 gggtctagtt accatggaag gagagattcg atagtatggt acaaaattag caagcagtct
     4261 tccctctact gtgagagaag cctgctttca aactattgct aagtgaaaat gcaggttatt
     4321 cttctttgtt gttctggcca tcaaatttat ggctttaagg ttactactgc tgtgataaaa
     4381 caccttgtgg aggaaagagt ttattggctt acatttccac ctcacaggaa ggcagggcag
     4441 aaactcaaac agggcaggaa catggaggca ggagctgatg cagaggtcgt ggaggggtgc
     4501 tgcttactgc cttgctcctt gtggtttgct cagcttgtct tacagaagcc aggaccacca
     4561 tcttgggaat ggtcccacca tagtgggctt gacccctctc tccattaatc actatttaag
     4621 aaaatgccct acagacttgc atgcagactc atcttatgga ggcatttctt tattacagtt
     4681 cccacctctc agacgactgt gtcaagttta cataaaacta accaagctac atccttatcc
     4741 ccttgttcta gctttaaacc aaacatttcc ccccagatat ttggatatac acataactgg
     4801 ccatggttgg gtcttggaat tacaggtggg ttcttttcaa cttcatttcc gtttactgaa
     4861 atttctaaac caaataaagc tgaatttctt a
//
