LOCUS       NM_001411816            1436 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus GDP-L-fucose synthase (Gfus), transcript variant 4,
            mRNA.
ACCESSION   NM_001411816 XM_006520750
VERSION     NM_001411816.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1436)
  AUTHORS   Wang,L., Yu,S., Chan,E.R., Chen,K.Y., Liu,C., Che,D., Awadallah,A.,
            Myers,J., Askew,D., Huang,A.Y., Maillard,I., Huang,D., Xin,W. and
            Zhou,L.
  TITLE     Notch-Regulated Dendritic Cells Restrain Inflammation-Associated
            Colorectal Carcinogenesis
  JOURNAL   Cancer Immunol Res 9 (3), 348-361 (2021)
   PUBMED   33441309
REFERENCE   2  (bases 1 to 1436)
  AUTHORS   Kizuka,Y., Nakano,M., Yamaguchi,Y., Nakajima,K., Oka,R., Sato,K.,
            Ren,C.T., Hsu,T.L., Wong,C.H. and Taniguchi,N.
  TITLE     An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by
            Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3
  JOURNAL   Cell Chem Biol 24 (12), 1467-1478 (2017)
   PUBMED   29033318
REFERENCE   3  (bases 1 to 1436)
  AUTHORS   Wang,Y., Huang,D., Chen,K.Y., Cui,M., Wang,W., Huang,X.,
            Awadellah,A., Li,Q., Friedman,A., Xin,W.W., Di Martino,L.,
            Cominelli,F., Miron,A., Chan,R., Fox,J.G., Xu,Y., Shen,X.,
            Kalady,M.F., Markowitz,S., Maillard,I., Lowe,J.B., Xin,W. and
            Zhou,L.
  TITLE     Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma
  JOURNAL   Gastroenterology 152 (1), 193-205 (2017)
   PUBMED   27639802
REFERENCE   4  (bases 1 to 1436)
  AUTHORS   Yao,D., Huang,Y., Huang,X., Wang,W., Yan,Q., Wei,L., Xin,W.,
            Gerson,S., Stanley,P., Lowe,J.B. and Zhou,L.
  TITLE     Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and
            myeloid homeostasis through modulation of Notch receptor ligand
            interactions
  JOURNAL   Blood 117 (21), 5652-5662 (2011)
   PUBMED   21464368
REFERENCE   5  (bases 1 to 1436)
  AUTHORS   Myers,J., Huang,Y., Wei,L., Yan,Q., Huang,A. and Zhou,L.
  TITLE     Fucose-deficient hematopoietic stem cells have decreased
            self-renewal and aberrant marrow niche occupancy
  JOURNAL   Transfusion 50 (12), 2660-2669 (2010)
   PUBMED   20573072
  REMARK    GeneRIF: Fucosylation-modified Notch receptor may represent a novel
            extrinsic regulator for hematopoietic stem cells (HSC) engraftment
            and HSC niche maintenance.
REFERENCE   6  (bases 1 to 1436)
  AUTHORS   Smith,P.L., Myers,J.T., Rogers,C.E., Zhou,L., Petryniak,B.,
            Becker,D.J., Homeister,J.W. and Lowe,J.B.
  TITLE     Conditional control of selectin ligand expression and global
            fucosylation events in mice with a targeted mutation at the FX
            locus
  JOURNAL   J Cell Biol 158 (4), 801-815 (2002)
   PUBMED   12186857
REFERENCE   7  (bases 1 to 1436)
  AUTHORS   Dyson,P.J., de Smet,C., Knight,A.M., Simon-Chazottes,D.,
            Guenet,J.L. and Boon,T.
  TITLE     Mapping of the genes encoding tum- transplantation antigens P91A,
            P35B, and P198
  JOURNAL   Immunogenetics 35 (5), 316-323 (1992)
   PUBMED   1348494
REFERENCE   8  (bases 1 to 1436)
  AUTHORS   Szikora,J.P., Van Pel,A., Brichard,V., Andre,M., Van Baren,N.,
            Henry,P., De Plaen,E. and Boon,T.
  TITLE     Structure of the gene of tum- transplantation antigen P35B:
            presence of a point mutation in the antigenic allele
  JOURNAL   EMBO J 9 (4), 1041-1050 (1990)
   PUBMED   2108859
REFERENCE   9  (bases 1 to 1436)
  AUTHORS   Lurquin,C., Van Pel,A., Mariame,B., De Plaen,E., Szikora,J.P.,
            Janssens,C., Reddehase,M.J., Lejeune,J. and Boon,T.
  TITLE     Structure of the gene of tum- transplantation antigen P91A: the
            mutated exon encodes a peptide recognized with Ld by cytolytic T
            cells
  JOURNAL   Cell 58 (2), 293-303 (1989)
   PUBMED   2568889
REFERENCE   10 (bases 1 to 1436)
  AUTHORS   Uyttenhove,C., Van Snick,J. and Boon,T.
  TITLE     Immunogenic variants obtained by mutagenesis of mouse mastocytoma
            P815. I. Rejection by syngeneic mice
  JOURNAL   J Exp Med 152 (5), 1175-1183 (1980)
   PUBMED   6776226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116520.14.
            
            On Sep 2, 2022 this sequence version replaced XM_006520750.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.346790.1,
                                           SRR14777530.955712.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC116520.14        118498-118609       c
            113-270             AC116520.14        117737-117894       c
            271-385             AC116520.14        117274-117388       c
            386-514             AC116520.14        115812-115940       c
            515-644             AC116520.14        115588-115717       c
            645-812             AC116520.14        115135-115302       c
            813-877             AC116520.14        114974-115038       c
            878-944             AC116520.14        114638-114704       c
            945-1024            AC116520.14        114428-114507       c
            1025-1124           AC116520.14        114130-114229       c
            1125-1436           AC116520.14        113528-113839       c
FEATURES             Location/Qualifiers
     source          1..1436
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 35.1 cM"
     gene            1..1436
                     /gene="Gfus"
                     /gene_synonym="FX; Tsta3; Tstap35b"
                     /note="GDP-L-fucose synthase"
                     /db_xref="GeneID:22122"
                     /db_xref="MGI:MGI:98857"
     exon            1..112
                     /gene="Gfus"
                     /gene_synonym="FX; Tsta3; Tstap35b"
                     /inference="alignment:Splign:2.1.0"
     exon            113..270
                     /gene="Gfus"
                     /gene_synonym="FX; Tsta3; Tstap35b"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1180
                     /gene="Gfus"
                     /gene_synonym="FX; Tsta3; Tstap35b"
                     /EC_number="1.1.1.271"
                     /note="isoform 2 is encoded by transcript variant 4;
                     GDP-L-fucose synthetase; protein FX; tum-P35B antigen;
                     transplantation antigen P35B; red cell NADP(H)-binding
                     protein;
                     GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase;
                     GDP-fucose synthase; tissue specific transplantation
                     antigen P35B"
                     /codon_start=1
                     /product="GDP-L-fucose synthase isoform 2"
                     /protein_id="NP_001398745.1"
                     /db_xref="GeneID:22122"
                     /db_xref="MGI:MGI:98857"
                     /translation="MGEPHGSMRILVTGGSGLVGRAIQKVVADGAGLPGEEWVFVSSK
                     DADLTDAAQTQALFQKVQPTHVIHLAAMVGGLFRNIKYNLDFWRKNVHINDNVLHSAF
                     EVGARKVVSCLSTCIFPDKTTYPIDETMIHNGPPHSSNFGYSYAKRMIDVQNRCCLLV
                     LPRPLWRGEDGPWEPTSSSTAVPSPPSSLPMSLGLMTTSTSKMATCYPASSIRCTWPR
                     VSAAIRHTPGPGSDSALTVWGTGKPRRQFIYSLDLARLFIWVLREYSEVEPIILSVGE
                     EDEVSIKEAAEAVVEAMDFNGEVTFDSTKSDGQYKKTASNGKLRSYLPDFRFTPFKQA
                     VKETCTWFTDNYEQARK"
     exon            271..385
                     /gene="Gfus"
                     /gene_synonym="FX; Tsta3; Tstap35b"
                     /inference="alignment:Splign:2.1.0"
     exon            386..514
                     /gene="Gfus"
                     /gene_synonym="FX; Tsta3; Tstap35b"
                     /inference="alignment:Splign:2.1.0"
     exon            515..644
                     /gene="Gfus"
                     /gene_synonym="FX; Tsta3; Tstap35b"
                     /inference="alignment:Splign:2.1.0"
     exon            645..812
                     /gene="Gfus"
                     /gene_synonym="FX; Tsta3; Tstap35b"
                     /inference="alignment:Splign:2.1.0"
     exon            813..877
                     /gene="Gfus"
                     /gene_synonym="FX; Tsta3; Tstap35b"
                     /inference="alignment:Splign:2.1.0"
     exon            878..944
                     /gene="Gfus"
                     /gene_synonym="FX; Tsta3; Tstap35b"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1024
                     /gene="Gfus"
                     /gene_synonym="FX; Tsta3; Tstap35b"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1124
                     /gene="Gfus"
                     /gene_synonym="FX; Tsta3; Tstap35b"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1436
                     /gene="Gfus"
                     /gene_synonym="FX; Tsta3; Tstap35b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1417..1422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gfus"
                     /gene_synonym="FX; Tsta3; Tstap35b"
                     /note="hexamer: AATAAA"
     polyA_site      1436
                     /gene="Gfus"
                     /gene_synonym="FX; Tsta3; Tstap35b"
                     /note="major polyA site"
ORIGIN      
        1 aattgtgcac cggaagtagc tcttgggctg gtggaaccca tcgcaggtga gatttacagt
       61 tggattcggc gcagcaaacc ggggatctcg caggctggtc agggccgtaa gagtgcagac
      121 cataatgggc gaaccccatg gatccatgag gatcctagtg acagggggct ctggactggt
      181 gggtagagcc atccagaagg tggttgcaga tggggccggc ttacctggag aggaatgggt
      241 gtttgtctcc tccaaagatg cagatctgac ggatgcagcc caaacccaag cactcttcca
      301 gaaagtacag cccacccacg tcatccatct cgctgcaatg gtaggcggcc ttttccggaa
      361 tatcaaatac aacttggatt tctggcggaa aaacgtgcac atcaatgaca acgtcctgca
      421 ttcggccttc gaggtgggcg ctcgcaaggt ggtctcctgc ctgtccacct gcatcttccc
      481 tgacaagacc acctatccta ttgacgagac aatgatccac aacgggccgc ctcacagcag
      541 caatttcggg tactcatacg ccaagaggat gattgacgtg cagaacaggt gctgcctctt
      601 ggtcttgccc aggcctctct ggagagggga ggacggaccc tgggagccta cttccagcag
      661 cacggctgta ccttcaccgc cgtcatccct accaatgtct ttgggcctta tgacaacttc
      721 aacatcgaag atggccacgt gctacccggc ctcatccata aggtgcacct ggccaagagt
      781 gagtgcagcc atccggcaca cgcctggccc aggtagtgac tcggccctga cggtgtgggg
      841 tacagggaag ccgcggaggc agttcatcta ctcactggac ctcgcccggc tcttcatctg
      901 ggtcctacgg gagtacagtg aggtggagcc catcatcctc tcagtgggtg aggaagatga
      961 agtgtccatc aaggaggcag ctgaggctgt agtggaggcc atggacttca atggggaagt
     1021 cacttttgat tcaacaaagt cagatgggca atataagaag acagccagca atggcaagtt
     1081 gcggtcctac ttgcccgact tccgtttcac acccttcaag caggctgtga aggaaacctg
     1141 cacttggttc accgacaact atgagcaggc ccggaagtaa ggcgcggggc aagcaagtgc
     1201 tcgcctggcg atgcccagtc agtggtcacc acccccagtt ctcgccaaga actgaggaca
     1261 gtatccagcc acctgagcca tatgctgacc tctttgccag gatcctccat gctgctgtcc
     1321 agtagggccc atgtccatcc ttggggaaag gccagaccaa cattttgctt gtctgcttct
     1381 gcccaacctc catgtgtccc tgctggacta gaaaccaata aaatggattt tcatga
//
