LOCUS       NM_205844               2075 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus GDNF family receptor alpha like (Gfral), transcript
            variant 1, mRNA.
ACCESSION   NM_205844
VERSION     NM_205844.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2075)
  AUTHORS   Hes,C., Gui,L.T., Bay,A., Alvarez,F., Katz,P., Paul,T.,
            Bozadjieva-Kramer,N., Seeley,R.J., Piccirillo,C.A. and
            Sabatini,P.V.
  TITLE     GDNF family receptor alpha-like (GFRAL) expression is restricted to
            the caudal brainstem
  JOURNAL   Mol Metab 91, 102070 (2025)
   PUBMED   39608751
REFERENCE   2  (bases 1 to 2075)
  AUTHORS   Igual-Gil,C., Bishop,C.A., Jahnert,M., Johann,K., Coleman,V.,
            Baum,V., Kruse,M., Pfeiffer,A.F.H., Pivovarova-Ramich,O., Ost,M.,
            Kleinert,M. and Klaus,S.
  TITLE     GDF15 is required for maintaining subcutaneous adipose tissue lipid
            metabolic signature
  JOURNAL   Sci Rep 14 (1), 26989 (2024)
   PUBMED   39505926
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2075)
  AUTHORS   Baur,K., San,S., Holzl-Wenig,G., Mandl,C., Hellwig,A. and
            Ciccolini,F.
  TITLE     GDF15 controls primary cilia morphology and function thereby
            affecting progenitor proliferation
  JOURNAL   Life Sci Alliance 7 (7), e202302384 (2024)
   PUBMED   38719753
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2075)
  AUTHORS   Shah,F.A., Bahudhanapati,H., Jiang,M., Tabary,M., van der Geest,R.,
            Tolman,N.J., Kochin,M., Xiong,Z., Al-Yousif,N., Sayed,K.,
            Benos,P.V., Raffensperger,K., Evankovich,J., Neal,M.D.,
            Snyder,M.E., Eickelberg,O., Ray,P., Dela Cruz,C., Bon,J.,
            McVerry,B.J., Straub,A.C., Jurczak,M.J., Suber,T.L., Zhang,Y.,
            Chen,K., Kitsios,G.D., Lee,J.S., Alder,J.K. and Bain,W.G.
  TITLE     Lung Epithelium Releases Growth Differentiation Factor 15 in
            Response to Pathogen-mediated Injury
  JOURNAL   Am J Respir Cell Mol Biol 70 (5), 379-391 (2024)
   PUBMED   38301257
REFERENCE   5  (bases 1 to 2075)
  AUTHORS   Lu,J.F., Zhu,M.Q., Xia,B., Zhang,N.N., Liu,X.P., Liu,H.,
            Zhang,R.X., Xiao,J.Y., Yang,H., Zhang,Y.Q., Li,X.M. and Wu,J.W.
  TITLE     GDF15 is a major determinant of ketogenic diet-induced weight loss
  JOURNAL   Cell Metab 35 (12), 2165-2182 (2023)
   PUBMED   38056430
  REMARK    Erratum:[Cell Metab. 2024 Feb 6;36(2):454-456. doi:
            10.1016/j.cmet.2024.01.004. PMID: 38325339]
REFERENCE   6  (bases 1 to 2075)
  AUTHORS   Yang,L., Chang,C.C., Sun,Z., Madsen,D., Zhu,H., Padkjaer,S.B.,
            Wu,X., Huang,T., Hultman,K., Paulsen,S.J., Wang,J., Bugge,A.,
            Frantzen,J.B., Norgaard,P., Jeppesen,J.F., Yang,Z., Secher,A.,
            Chen,H., Li,X., John,L.M., Shan,B., He,Z., Gao,X., Su,J.,
            Hansen,K.T., Yang,W. and Jorgensen,S.B.
  TITLE     GFRAL is the receptor for GDF15 and is required for the
            anti-obesity effects of the ligand
  JOURNAL   Nat Med 23 (10), 1158-1166 (2017)
   PUBMED   28846099
REFERENCE   7  (bases 1 to 2075)
  AUTHORS   Emmerson,P.J., Wang,F., Du,Y., Liu,Q., Pickard,R.T., Gonciarz,M.D.,
            Coskun,T., Hamang,M.J., Sindelar,D.K., Ballman,K.K., Foltz,L.A.,
            Muppidi,A., Alsina-Fernandez,J., Barnard,G.C., Tang,J.X., Liu,X.,
            Mao,X., Siegel,R., Sloan,J.H., Mitchell,P.J., Zhang,B.B.,
            Gimeno,R.E., Shan,B. and Wu,X.
  TITLE     The metabolic effects of GDF15 are mediated by the orphan receptor
            GFRAL
  JOURNAL   Nat Med 23 (10), 1215-1219 (2017)
   PUBMED   28846098
REFERENCE   8  (bases 1 to 2075)
  AUTHORS   Mullican,S.E., Lin-Schmidt,X., Chin,C.N., Chavez,J.A., Furman,J.L.,
            Armstrong,A.A., Beck,S.C., South,V.J., Dinh,T.Q., Cash-Mason,T.D.,
            Cavanaugh,C.R., Nelson,S., Huang,C., Hunter,M.J. and Rangwala,S.M.
  TITLE     GFRAL is the receptor for GDF15 and the ligand promotes weight loss
            in mice and nonhuman primates
  JOURNAL   Nat Med 23 (10), 1150-1157 (2017)
   PUBMED   28846097
REFERENCE   9  (bases 1 to 2075)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   10 (bases 1 to 2075)
  AUTHORS   Li,Z., Wang,B., Wu,X., Cheng,S.Y., Paraoan,L. and Zhou,J.
  TITLE     Identification, expression and functional characterization of the
            GRAL gene
  JOURNAL   J Neurochem 95 (2), 361-376 (2005)
   PUBMED   16086688
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079244.29.
            
            On Feb 25, 2022 this sequence version replaced NM_205844.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY457637.2 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164135
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AC079244.29        1722-1938
            218-352             AC079244.29        6711-6845
            353-505             AC079244.29        9889-10041
            506-565             AC079244.29        16386-16445
            566-896             AC079244.29        18021-18351
            897-1147            AC079244.29        21926-22176
            1148-1240           AC079244.29        47289-47381
            1241-1313           AC079244.29        48263-48335
            1314-2075           AC079244.29        50511-51272
FEATURES             Location/Qualifiers
     source          1..2075
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 42.48 cM"
     gene            1..2075
                     /gene="Gfral"
                     /gene_synonym="Gral"
                     /note="GDNF family receptor alpha like"
                     /db_xref="GeneID:404194"
                     /db_xref="MGI:MGI:3607786"
     exon            1..217
                     /gene="Gfral"
                     /gene_synonym="Gral"
                     /inference="alignment:Splign:2.1.0"
     exon            218..352
                     /gene="Gfral"
                     /gene_synonym="Gral"
                     /inference="alignment:Splign:2.1.0"
     exon            353..505
                     /gene="Gfral"
                     /gene_synonym="Gral"
                     /inference="alignment:Splign:2.1.0"
     exon            506..565
                     /gene="Gfral"
                     /gene_synonym="Gral"
                     /inference="alignment:Splign:2.1.0"
     exon            566..896
                     /gene="Gfral"
                     /gene_synonym="Gral"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1147
                     /gene="Gfral"
                     /gene_synonym="Gral"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1240
                     /gene="Gfral"
                     /gene_synonym="Gral"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1313
                     /gene="Gfral"
                     /gene_synonym="Gral"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..2075
                     /gene="Gfral"
                     /gene_synonym="Gral"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2055..2060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gfral"
                     /gene_synonym="Gral"
                     /note="hexamer: AATAAA"
     polyA_site      2075
                     /gene="Gfral"
                     /gene_synonym="Gral"
                     /note="major polyA site"
ORIGIN      
        1 aacaattgaa tttgaataca attaggaaag ttcacagctc aaaacaaact ggtgaggaac
       61 agctgacacc agaagctgac tctaattggc tggctcttag gaagcaaaac ctttacacag
      121 aaacttcagt tgggatgttg gttggtgtca gttcatccgc ctttctccca gggagaccat
      181 cttgagttgt ccaacatgct agtgttcatt ttcctggctg ttacgttaag ctcagaaaat
      241 gaatcctctt cccaaacaaa tgattgtgca catttaatac agaaatgctt gattgatgca
      301 aatggctgtg agcagtcatg gagatcaatg gaagacacct gccttactcc aggtgactcc
      361 tgcaagataa ataattcact acattgtaac ctgagtatcc aggctttggt ggaaaaaaat
      421 ttccaattta aagagtgtct ttgtatggat gacctccact gtacagtaaa caaacttttt
      481 ggaaaaaagt gcaccaataa gacagataac atggaaaagg acaataaaga taaatggaat
      541 ctaactacta ctcctttcta tcatggattc aaacagatgc agtcttgttt ggaggtgaca
      601 gaggcgtgtg taggggatgt ggtttgtaat gcacagttgg ccctttacct taaagcatgc
      661 tcagcaaatg gaaatctgtg tgatgtgaaa cactgccaag cagccatacg gttcttctat
      721 caaaatatgc cttttaacac tgcccagatg ttggcttttt gtgactgtgc tcaatctgat
      781 ataccctgtc agcaatccaa agaaactctt cacagcaagc catgtgcact gaatatagtt
      841 ccacccccca cttgcctcag tgtaattcac acttgccgaa atgatgaatt atgcaggaca
      901 cactaccgaa cattccagac agaatgctgg ccccacataa ctgggaagtg ccatgaagat
      961 gagacctgca ttagcatgtt aggcaagcaa gaccttactt gttctgggag tgagagctgc
     1021 agggctgcct tcctaggaac ctttgggaca gtcctgcaag taccctgtgc ttgcaggggc
     1081 gttacacagg ctgaagaaca cgtgtgcatg attttccagc acatgcttca tagcaaatcg
     1141 tgtttcaatt acccaactcc taatgtcaaa gacatttcct catatgaaaa aaagaattca
     1201 aaagaaatta ctctgactgg attcaattct ttcttcaatg gagaactact ctatgttgtt
     1261 gtgtgcatgg cagttacctg tggaattctt ttcttggtga tgctcaagtt aaggatacaa
     1321 agtgaaaaaa gagatccctc atccatcgaa atagctggag gtgtcatcat tcagtgagct
     1381 gcagatcact taccaaccac atgtctgtgt gactaaccaa tggaaaatta catttgccaa
     1441 taacgcaatt taagatggat ttgacaatat ttagtcatta tatgtaacag tgactggtac
     1501 agtaatatac cacaatgatc acagatctgt ttttgttttt gtttttaatg tttgagtaaa
     1561 tacttgttgt ggtgtcataa ctagttgata acattttctt taaagacaac aggtgtcatg
     1621 taaaatgtga caaatttgct ggaagactat caatccacat atcaacttct atcttatgga
     1681 actaatcata attagtgtgt gcagttttct gaacaaggtt atagttttcc attaagttgg
     1741 taaaattaaa atgctaagta gaatattgag tatacttgtt atttatatat tcttacttag
     1801 tgtccaatca ttaaacaaat tggtaacatt gaacatattt agttagatga ctgcttatga
     1861 aaataagaac tgacatctta caaattttat aatttaaata gtattgaatt ttacttttta
     1921 tttggtatgt taagattcat aatatataaa gcagctacat tggttgagaa aagtcaatgg
     1981 ttactccagt aatgatatac tttgtgaatt tatttatttt tgctaattaa tgatcctgaa
     2041 tgtaatcatg atgaaataaa aaagacatac ttaaa
//
