LOCUS       NP_995316                393 aa            linear   ROD 18-MAR-2025
DEFINITION  GDNF family receptor alpha-like precursor [Mus musculus].
ACCESSION   NP_995316
VERSION     NP_995316.2
DBSOURCE    REFSEQ: accession NM_205844.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 393)
  AUTHORS   Hes,C., Gui,L.T., Bay,A., Alvarez,F., Katz,P., Paul,T.,
            Bozadjieva-Kramer,N., Seeley,R.J., Piccirillo,C.A. and
            Sabatini,P.V.
  TITLE     GDNF family receptor alpha-like (GFRAL) expression is restricted to
            the caudal brainstem
  JOURNAL   Mol Metab 91, 102070 (2025)
   PUBMED   39608751
REFERENCE   2  (residues 1 to 393)
  AUTHORS   Igual-Gil,C., Bishop,C.A., Jahnert,M., Johann,K., Coleman,V.,
            Baum,V., Kruse,M., Pfeiffer,A.F.H., Pivovarova-Ramich,O., Ost,M.,
            Kleinert,M. and Klaus,S.
  TITLE     GDF15 is required for maintaining subcutaneous adipose tissue lipid
            metabolic signature
  JOURNAL   Sci Rep 14 (1), 26989 (2024)
   PUBMED   39505926
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 393)
  AUTHORS   Sun,Q., van de Lisdonk,D., Ferrer,M., Gegenhuber,B., Wu,M.,
            Park,Y., Tuveson,D.A., Tollkuhn,J., Janowitz,T. and Li,B.
  TITLE     Area postrema neurons mediate interleukin-6 function in cancer
            cachexia
  JOURNAL   Nat Commun 15 (1), 4682 (2024)
   PUBMED   38824130
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 393)
  AUTHORS   Baur,K., San,S., Holzl-Wenig,G., Mandl,C., Hellwig,A. and
            Ciccolini,F.
  TITLE     GDF15 controls primary cilia morphology and function thereby
            affecting progenitor proliferation
  JOURNAL   Life Sci Alliance 7 (7), e202302384 (2024)
   PUBMED   38719753
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 393)
  AUTHORS   Shah,F.A., Bahudhanapati,H., Jiang,M., Tabary,M., van der Geest,R.,
            Tolman,N.J., Kochin,M., Xiong,Z., Al-Yousif,N., Sayed,K.,
            Benos,P.V., Raffensperger,K., Evankovich,J., Neal,M.D.,
            Snyder,M.E., Eickelberg,O., Ray,P., Dela Cruz,C., Bon,J.,
            McVerry,B.J., Straub,A.C., Jurczak,M.J., Suber,T.L., Zhang,Y.,
            Chen,K., Kitsios,G.D., Lee,J.S., Alder,J.K. and Bain,W.G.
  TITLE     Lung Epithelium Releases Growth Differentiation Factor 15 in
            Response to Pathogen-mediated Injury
  JOURNAL   Am J Respir Cell Mol Biol 70 (5), 379-391 (2024)
   PUBMED   38301257
REFERENCE   6  (residues 1 to 393)
  AUTHORS   Yang,L., Chang,C.C., Sun,Z., Madsen,D., Zhu,H., Padkjaer,S.B.,
            Wu,X., Huang,T., Hultman,K., Paulsen,S.J., Wang,J., Bugge,A.,
            Frantzen,J.B., Norgaard,P., Jeppesen,J.F., Yang,Z., Secher,A.,
            Chen,H., Li,X., John,L.M., Shan,B., He,Z., Gao,X., Su,J.,
            Hansen,K.T., Yang,W. and Jorgensen,S.B.
  TITLE     GFRAL is the receptor for GDF15 and is required for the
            anti-obesity effects of the ligand
  JOURNAL   Nat Med 23 (10), 1158-1166 (2017)
   PUBMED   28846099
REFERENCE   7  (residues 1 to 393)
  AUTHORS   Emmerson,P.J., Wang,F., Du,Y., Liu,Q., Pickard,R.T., Gonciarz,M.D.,
            Coskun,T., Hamang,M.J., Sindelar,D.K., Ballman,K.K., Foltz,L.A.,
            Muppidi,A., Alsina-Fernandez,J., Barnard,G.C., Tang,J.X., Liu,X.,
            Mao,X., Siegel,R., Sloan,J.H., Mitchell,P.J., Zhang,B.B.,
            Gimeno,R.E., Shan,B. and Wu,X.
  TITLE     The metabolic effects of GDF15 are mediated by the orphan receptor
            GFRAL
  JOURNAL   Nat Med 23 (10), 1215-1219 (2017)
   PUBMED   28846098
REFERENCE   8  (residues 1 to 393)
  AUTHORS   Mullican,S.E., Lin-Schmidt,X., Chin,C.N., Chavez,J.A., Furman,J.L.,
            Armstrong,A.A., Beck,S.C., South,V.J., Dinh,T.Q., Cash-Mason,T.D.,
            Cavanaugh,C.R., Nelson,S., Huang,C., Hunter,M.J. and Rangwala,S.M.
  TITLE     GFRAL is the receptor for GDF15 and the ligand promotes weight loss
            in mice and nonhuman primates
  JOURNAL   Nat Med 23 (10), 1150-1157 (2017)
   PUBMED   28846097
REFERENCE   9  (residues 1 to 393)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   10 (residues 1 to 393)
  AUTHORS   Li,Z., Wang,B., Wu,X., Cheng,S.Y., Paraoan,L. and Zhou,J.
  TITLE     Identification, expression and functional characterization of the
            GRAL gene
  JOURNAL   J Neurochem 95 (2), 361-376 (2005)
   PUBMED   16086688
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079244.29.
            
            On Jun 16, 2004 this sequence version replaced NP_995316.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY457637.2 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164135
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..393
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 42.48 cM"
     Protein         1..393
                     /product="GDNF family receptor alpha-like precursor"
                     /note="GDNF receptor alpha-like"
                     /calculated_mol_wt=41908
     sig_peptide     1..19
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6SJE0.2)"
                     /calculated_mol_wt=2074
     mat_peptide     20..393
                     /product="GDNF family receptor alpha-like.
                     /id=PRO_0000240125"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6SJE0.2)"
                     /calculated_mol_wt=41908
     Site            59
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6SJE0.2)"
     Site            65
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6SJE0.2)"
     Site            101
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6SJE0.2)"
     Site            115
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6SJE0.2)"
     Region          131..210
                     /region_name="GDNF"
                     /note="GDNF/GAS1 domain; pfam02351"
                     /db_xref="CDD:460537"
     Region          149..228
                     /region_name="Required for interaction with GDF15.
                     /evidence=ECO:0000250|UniProtKB:Q6UXV0"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6SJE0.2)"
     Region          220..316
                     /region_name="GDNF"
                     /note="GDNF/GAS1 domain; pfam02351"
                     /db_xref="CDD:460537"
     Site            350..370
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6SJE0.2)"
     CDS             1..393
                     /gene="Gfral"
                     /gene_synonym="Gral"
                     /coded_by="NM_205844.4:196..1377"
                     /db_xref="CCDS:CCDS40694.1"
                     /db_xref="GeneID:404194"
                     /db_xref="MGI:MGI:3607786"
ORIGIN      
        1 mlvfiflavt lssenesssq tndcahliqk clidangceq swrsmedtcl tpgdsckinn
       61 slhcnlsiqa lveknfqfke clcmddlhct vnklfgkkct nktdnmekdn kdkwnltttp
      121 fyhgfkqmqs clevteacvg dvvcnaqlal ylkacsangn lcdvkhcqaa irffyqnmpf
      181 ntaqmlafcd caqsdipcqq sketlhskpc alnivppptc lsvihtcrnd elcrthyrtf
      241 qtecwphitg kchedetcis mlgkqdltcs gsescraafl gtfgtvlqvp cacrgvtqae
      301 ehvcmifqhm lhskscfnyp tpnvkdissy ekknskeitl tgfnsffnge llyvvvcmav
      361 tcgilflvml klriqsekrd pssieiaggv iiq
//
