LOCUS       NM_020014               1457 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus glial cell line derived neurotrophic factor family
            receptor alpha 4 (Gfra4), transcript variant 2, mRNA.
ACCESSION   NM_020014
VERSION     NM_020014.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1457)
  AUTHORS   Catela,C., Shin,M.M., Lee,D.H., Liu,J.P. and Dasen,J.S.
  TITLE     Hox Proteins Coordinate Motor Neuron Differentiation and
            Connectivity Programs through Ret/Gfralpha Genes
  JOURNAL   Cell Rep 14 (8), 1901-1915 (2016)
   PUBMED   26904955
REFERENCE   2  (bases 1 to 1457)
  AUTHORS   Patel,A., Harker,N., Moreira-Santos,L., Ferreira,M., Alden,K.,
            Timmis,J., Foster,K., Garefalaki,A., Pachnis,P., Andrews,P.,
            Enomoto,H., Milbrandt,J., Pachnis,V., Coles,M.C., Kioussis,D. and
            Veiga-Fernandes,H.
  TITLE     Differential RET signaling pathways drive development of the
            enteric lymphoid and nervous systems
  JOURNAL   Sci Signal 5 (235), ra55 (2012)
   PUBMED   22855506
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1457)
  AUTHORS   Lindfors,P.H., Lindahl,M., Rossi,J., Saarma,M. and Airaksinen,M.S.
  TITLE     Ablation of persephin receptor glial cell line-derived neurotrophic
            factor family receptor alpha4 impairs thyroid calcitonin production
            in young mice
  JOURNAL   Endocrinology 147 (5), 2237-2244 (2006)
   PUBMED   16497798
  REMARK    GeneRIF: GFRalpha4 signaling has a role in regulating calcitonin
            production in thyroid C cells of young mice
REFERENCE   4  (bases 1 to 1457)
  AUTHORS   Yang,J., Lindahl,M., Lindholm,P., Virtanen,H., Coffey,E.,
            Runeberg-Roos,P. and Saarma,M.
  TITLE     PSPN/GFRalpha4 has a significantly weaker capacity than
            GDNF/GFRalpha1 to recruit RET to rafts, but promotes neuronal
            survival and neurite outgrowth
  JOURNAL   FEBS Lett 569 (1-3), 267-271 (2004)
   PUBMED   15225646
REFERENCE   5  (bases 1 to 1457)
  AUTHORS   Masure,S., Cik,M., Hoefnagel,E., Nosrat,C.A., Van der Linden,I.,
            Scott,R., Van Gompel,P., Lesage,A.S., Verhasselt,P., Ibanez,C.F.
            and Gordon,R.D.
  TITLE     Mammalian GFRalpha -4, a divergent member of the GFRalpha family of
            coreceptors for glial cell line-derived neurotrophic factor family
            ligands, is a receptor for the neurotrophic factor persephin
  JOURNAL   J Biol Chem 275 (50), 39427-39434 (2000)
   PUBMED   10958791
REFERENCE   6  (bases 1 to 1457)
  AUTHORS   Rossi,J., Tomac,A., Saarma,M. and Airaksinen,M.S.
  TITLE     Distinct roles for GFRalpha1 and GFRalpha2 signalling in different
            cranial parasympathetic ganglia in vivo
  JOURNAL   Eur J Neurosci 12 (11), 3944-3952 (2000)
   PUBMED   11069590
REFERENCE   7  (bases 1 to 1457)
  AUTHORS   Lindahl,M., Timmusk,T., Rossi,J., Saarma,M. and Airaksinen,M.S.
  TITLE     Expression and alternative splicing of mouse Gfra4 suggest roles in
            endocrine cell development
  JOURNAL   Mol Cell Neurosci 15 (6), 522-533 (2000)
   PUBMED   10860579
REFERENCE   8  (bases 1 to 1457)
  AUTHORS   Fundin,B.T., Mikaels,A., Westphal,H. and Ernfors,P.
  TITLE     A rapid and dynamic regulation of GDNF-family ligands and receptors
            correlate with the developmental dependency of cutaneous sensory
            innervation
  JOURNAL   Development 126 (12), 2597-2610 (1999)
   PUBMED   10331972
REFERENCE   9  (bases 1 to 1457)
  AUTHORS   Gunn,T.M., Miller,K.A., He,L., Hyman,R.W., Davis,R.W., Azarani,A.,
            Schlossman,S.F., Duke-Cohan,J.S. and Barsh,G.S.
  TITLE     The mouse mahogany locus encodes a transmembrane form of human
            attractin
  JOURNAL   Nature 398 (6723), 152-156 (1999)
   PUBMED   10086356
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ276516.1, AK090192.1 and
            AI553572.1.
            
            On Aug 21, 2012 this sequence version replaced NM_020014.1.
            
            Summary: This gene encodes a transmembrane protein that functions
            as the receptor for persephin, a member of the glial cell line
            derived neurotrophic factors. The encoded protein undergoes
            proteolytic processing to generate a
            glycosylphosphatidylinositol-anchored cell surface coreceptor that
            forms a complex with the receptor tyrosine kinase Ret. A complete
            lack of the encoded protein impairs production of thyroid
            calcitonin and increases the rate of bone formation in young mice.
            [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longest isoform (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141874.1, AJ276516.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849381,
                                           SAMN01164133 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-909               AJ276516.1         1-909
            910-1446            AK090192.1         548-1084
            1447-1457           AI553572.1         1-11                c
FEATURES             Location/Qualifiers
     source          1..1457
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.26 cM"
     gene            1..1457
                     /gene="Gfra4"
                     /gene_synonym="G630015H18Rik"
                     /note="glial cell line derived neurotrophic factor family
                     receptor alpha 4"
                     /db_xref="GeneID:14588"
                     /db_xref="MGI:MGI:1341873"
     CDS             1..909
                     /gene="Gfra4"
                     /gene_synonym="G630015H18Rik"
                     /note="isoform 2 is encoded by transcript variant 2; GDNF
                     family receptor alpha-4; GDNFR-alpha-4; persephin
                     receptor; GFR alpha-4"
                     /codon_start=1
                     /product="GDNF family receptor alpha-4 isoform 2"
                     /protein_id="NP_064398.1"
                     /db_xref="CCDS:CCDS16752.1"
                     /db_xref="GeneID:14588"
                     /db_xref="MGI:MGI:1341873"
                     /translation="MLRRAHLMDERPGQAIFLGLGSQRGSASFTDGNRCVDAAEACTA
                     DERCQQLRSEYVARCLGRAAPGGRPGPGGCVRSRCRRALRRFFARGPPALTHALLFCG
                     CEGSACAERRRQTFAPACAFSGPGLVPPSCLEPLERCERSRLCRPRLLAFQASCAPAP
                     GSRDRCPEEGGPRCLRVYAGLIGTVVTPNYLDNVSARVAPWCGCAASGNRREECEAFR
                     KLFTRNPCLDGAIQAFDSLQPSVLQDQTAGCCFPRARHEWPEKSWRQKQSLFCPNAQG
                     VLAVCTHCPGSPGPALIRNMNRGRHS"
     exon            1..73
                     /gene="Gfra4"
                     /gene_synonym="G630015H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            74..437
                     /gene="Gfra4"
                     /gene_synonym="G630015H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            438..547
                     /gene="Gfra4"
                     /gene_synonym="G630015H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            548..682
                     /gene="Gfra4"
                     /gene_synonym="G630015H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            683..759
                     /gene="Gfra4"
                     /gene_synonym="G630015H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            760..1453
                     /gene="Gfra4"
                     /gene_synonym="G630015H18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1428..1433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gfra4"
                     /gene_synonym="G630015H18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1449
                     /gene="Gfra4"
                     /gene_synonym="G630015H18Rik"
                     /note="major polyA site"
ORIGIN      
        1 atgttgagaa gagcacattt gatggatgag aggccaggtc aggcgatttt cctgggtctg
       61 ggaagccaga gagggtctgc gagctttacc gacgggaatc gctgcgtgga cgcggccgag
      121 gcgtgtacag cagacgagcg gtgccagcag ctgcgctctg agtacgtggc acgatgcctg
      181 ggccgggcag cgcccggggg caggccggga cccgggggct gcgtgcgctc ccgctgccgc
      241 cgagccctgc gccgcttctt cgcgcgtggg cctccggcgc tcacgcatgc gctgctcttc
      301 tgcggctgcg aaggctccgc gtgcgccgag cgccggcgcc agactttcgc gcccgcctgc
      361 gcgttctccg gcccggggtt ggtgccgccc tcttgcctgg agcccctgga gcgctgcgag
      421 cgcagccgcc tgtgccggcc ccgtctcctt gccttccagg cctcatgcgc tcccgcgccc
      481 ggctcccgcg accgctgccc ggaggagggg ggcccgcgtt gtctgcgcgt ctacgcaggc
      541 ctcataggca ccgtggtcac ccccaactac ctggacaacg tgagcgcgcg cgttgcgccc
      601 tggtgcggct gtgcggccag tggaaaccgg cgcgaagaat gcgaagcctt ccgcaagctc
      661 tttacaagga acccctgctt ggatggtgcc atacaagcct ttgacagctt gcagccatca
      721 gttctgcagg accagactgc tgggtgctgt ttcccgcggg caaggcacga gtggcctgag
      781 aagagctgga ggcagaaaca gtccttgttt tgtcctaacg cccaaggtgt cctggctgta
      841 tgcactcact gccctggctc tccaggccct gctctgatta ggaacatgaa ccgtggacga
      901 cacagctgac tgccatgtct cccgatgact gctcactgag ctgaaactcc cttgccctca
      961 ggtctgctgc cctttgcagg cctggacccc tgtgtggctg tcctctggat tgggggctgg
     1021 aggctagggt ctgactgaaa agcctgtgtt cccgtcagta ggcatcttgt ccattttctt
     1081 ccccatccta gagctgagca cccatagatg aggcctcatt gggtcccctg ggcttacaga
     1141 gcaggacaga gactagcccc cgctcctaga atttggaact gtccttttcc aagatgacaa
     1201 ggcactaagg agatcatatg aacaggctga cagacaaggc tgcctaaata ccctcccagt
     1261 tagccattac tcaccattaa gcttacccgt gtcacagcac tgacgtggct tgtcacctat
     1321 gacacagtgt gtagacatta aggagagact gaggtccctc ctgctcagca ccccactggc
     1381 ttcccaggat ctccctgcca tggtttcccc agcacctgca gtggctcaat aaacccatgt
     1441 gcactgagac caaaaaa
//
