LOCUS       NM_010280               1997 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus glial cell line derived neurotrophic factor family
            receptor alpha 3 (Gfra3), mRNA.
ACCESSION   NM_010280 XM_907931
VERSION     NM_010280.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1997)
  AUTHORS   Hall,S., Liu,S., Liang,I., Schulz,S., Ezran,C., Tan,M. and Kuo,C.S.
  TITLE     Cellular and molecular characterization of peripheral glia in the
            lung and other organs
  JOURNAL   PLoS One 19 (12), e0310303 (2024)
   PUBMED   39621665
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1997)
  AUTHORS   Yang,C., Yamaki,S., Jung,T., Kim,B., Huyhn,R. and McKemy,D.D.
  TITLE     Endogenous Inflammatory Mediators Produced by Injury Activate TRPV1
            and TRPA1 Nociceptors to Induce Sexually Dimorphic Cold Pain That
            Is Dependent on TRPM8 and GFRalpha3
  JOURNAL   J Neurosci 43 (15), 2803-2814 (2023)
   PUBMED   36898840
  REMARK    GeneRIF: Endogenous Inflammatory Mediators Produced by Injury
            Activate TRPV1 and TRPA1 Nociceptors to Induce Sexually Dimorphic
            Cold Pain That Is Dependent on TRPM8 and GFRalpha3.
REFERENCE   3  (bases 1 to 1997)
  AUTHORS   Perera,S.N., Williams,R.M., Lyne,R., Stubbs,O., Buehler,D.P.,
            Sauka-Spengler,T., Noda,M., Micklem,G., Southard-Smith,E.M. and
            Baker,C.V.H.
  TITLE     Insights into olfactory ensheathing cell development from a
            laser-microdissection and transcriptome-profiling approach
  JOURNAL   Glia 68 (12), 2550-2584 (2020)
   PUBMED   32857879
REFERENCE   4  (bases 1 to 1997)
  AUTHORS   Hauser,B.R., Aure,M.H., Kelly,M.C., Hoffman,M.P. and Chibly,A.M.
  CONSRTM   Genomics and Computational Biology Core
  TITLE     Generation of a Single-Cell RNAseq Atlas of Murine Salivary Gland
            Development
  JOURNAL   iScience 23 (12), 101838 (2020)
   PUBMED   33305192
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1997)
  AUTHORS   Peng,Y.R., James,R.E., Yan,W., Kay,J.N., Kolodkin,A.L. and
            Sanes,J.R.
  TITLE     Binary Fate Choice between Closely Related Interneuronal Types Is
            Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch
  JOURNAL   Neuron 105 (3), 464-474 (2020)
   PUBMED   31812516
REFERENCE   6  (bases 1 to 1997)
  AUTHORS   Baloh,R.H., Gorodinsky,A., Golden,J.P., Tansey,M.G., Keck,C.L.,
            Popescu,N.C., Johnson,E.M. Jr. and Milbrandt,J.
  TITLE     GFRalpha3 is an orphan member of the GDNF/neurturin/persephin
            receptor family
  JOURNAL   Proc Natl Acad Sci U S A 95 (10), 5801-5806 (1998)
   PUBMED   9576965
REFERENCE   7  (bases 1 to 1997)
  AUTHORS   Trupp,M., Raynoschek,C., Belluardo,N. and Ibanez,C.F.
  TITLE     Multiple GPI-anchored receptors control GDNF-dependent and
            independent activation of the c-Ret receptor tyrosine kinase
  JOURNAL   Mol Cell Neurosci 11 (1-2), 47-63 (1998)
   PUBMED   9608533
REFERENCE   8  (bases 1 to 1997)
  AUTHORS   Nomoto,S., Ito,S., Yang,L.X. and Kiuchi,K.
  TITLE     Molecular cloning and expression analysis of GFR alpha-3, a novel
            cDNA related to GDNFR alpha and NTNR alpha
  JOURNAL   Biochem Biophys Res Commun 244 (3), 849-853 (1998)
   PUBMED   9535755
REFERENCE   9  (bases 1 to 1997)
  AUTHORS   Worby,C.A., Vega,Q.C., Chao,H.H., Seasholtz,A.F., Thompson,R.C. and
            Dixon,J.E.
  TITLE     Identification and characterization of GFRalpha-3, a novel
            Co-receptor belonging to the glial cell line-derived neurotrophic
            receptor family
  JOURNAL   J Biol Chem 273 (6), 3502-3508 (1998)
   PUBMED   9452475
REFERENCE   10 (bases 1 to 1997)
  AUTHORS   Naveilhan,P., Baudet,C., Mikaels,A., Shen,L., Westphal,H. and
            Ernfors,P.
  TITLE     Expression and regulation of GFRalpha3, a glial cell line-derived
            neurotrophic factor family receptor
  JOURNAL   Proc Natl Acad Sci U S A 95 (3), 1295-1300 (1998)
   PUBMED   9448325
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC145591.5 and AK046542.1.
            
            On Aug 15, 2015 this sequence version replaced NM_010280.3.
            
            Summary: This gene encodes a cell surface glycoprotein and member
            of the glial cell line-derived neurotrophic receptor (GDNFR) family
            of proteins. The encoded preproprotein is proteolytically processed
            to generate the mature protein. This protein mediates binding of
            the ligand artemin to the ret receptor tyrosine kinase, and this
            interaction may regulate thermal pain and axon regeneration.
            Homozygous knockout mice for this gene exhibit impaired
            proliferation of cultured neuroblasts and impaired development of
            the superior cervical ganglion. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066202.1, Y15110.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC145591.5         56859-56931
            74-363              AK046542.1         1-290
            364-364             AC145591.5         65957-65957
            365-1831            AK046542.1         292-1758
            1832-1832           AC145591.5         87183-87183
            1833-1992           AK046542.1         1760-1919
            1993-1997           AC145591.5         87344-87348
FEATURES             Location/Qualifiers
     source          1..1997
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.69 cM"
     gene            1..1997
                     /gene="Gfra3"
                     /gene_synonym="GFRalpha3"
                     /note="glial cell line derived neurotrophic factor family
                     receptor alpha 3"
                     /db_xref="GeneID:14587"
                     /db_xref="MGI:MGI:1201403"
     exon            1..249
                     /gene="Gfra3"
                     /gene_synonym="GFRalpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            250..537
                     /gene="Gfra3"
                     /gene_synonym="GFRalpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            538..630
                     /gene="Gfra3"
                     /gene_synonym="GFRalpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            631..943
                     /gene="Gfra3"
                     /gene_synonym="GFRalpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1047
                     /gene="Gfra3"
                     /gene_synonym="GFRalpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1182
                     /gene="Gfra3"
                     /gene_synonym="GFRalpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1271
                     /gene="Gfra3"
                     /gene_synonym="GFRalpha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1997
                     /gene="Gfra3"
                     /gene_synonym="GFRalpha3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1973..1978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gfra3"
                     /gene_synonym="GFRalpha3"
                     /note="hexamer: ATTAAA"
     polyA_site      1993
                     /gene="Gfra3"
                     /gene_synonym="GFRalpha3"
                     /note="major polyA site"
ORIGIN      
        1 gcccacgacc ctagtgggag agtggcggcg ccgcgaggag gggcgggagg cggcggtggg
       61 aggtgtcggc cgagggagcc cagctctccg agtcctgtgc accaaggcag gggaacgcgg
      121 cgcccagcgc aggcagagcg ctgtcgcatc ccgggcgtcc acccgccatg gggctctcct
      181 ggagcccgcg acctccactg ctgatgatcc tgctactggt gctgtcgttg tggctgccac
      241 ttggagcagg aaactccctt gccacagaga acaggtttgt gaacagctgt acccaggcca
      301 gaaagaaatg cgaggctaat cccgcttgca aggctgccta ccagcacctg ggctcctgca
      361 cctccagttt aagcaggccg ctgcccttag aggagtctgc catgtctgca gactgcctag
      421 aggcagcaga acaactcagg aacagctctc tgatagactg caggtgccat cggcgcatga
      481 agcaccaagc tacctgtctg gacatttatt ggaccgttca ccctgcccga agccttggtg
      541 actacgagtt ggatgtctca ccctatgaag acacagtgac cagcaaaccc tggaaaatga
      601 atcttagcaa gttgaacatg ctcaaaccag actcggacct ctgcctcaaa tttgctatgc
      661 tgtgtactct tcacgacaag tgtgaccgcc tgcgcaaggc ctacggggag gcatgctcag
      721 ggatccgctg ccagcgccac ctctgcctag cccagctgcg ctccttcttt gagaaggcag
      781 cagagtccca cgctcagggt ctgctgctgt gtccctgtgc accagaagat gcgggctgtg
      841 gggagcggcg gcgtaacacc atcgccccca gttgcgccct gccttctgta acccccaatt
      901 gcctggatct gcggagcttc tgccgtgcgg accctttgtg cagatcacgc ctgatggact
      961 tccagaccca ctgtcatcct atggacatcc ttgggacttg tgcaactgag cagtccagat
     1021 gtctgcgggc atacctgggg ctgattggga ctgccatgac cccaaacttc atcagcaagg
     1081 tcaacactac tgttgcctta agctgcacct gccgaggcag cggcaaccta caggacgagt
     1141 gtgaacagct ggaaaggtcc ttctcccaga acccctgcct cgtggaggcc attgcagcta
     1201 agatgcgttt ccacagacag ctcttctccc aggactgggc agactctact ttttcagtgg
     1261 tgcagcagca gaacagcaac cctgctctga gactgcagcc caggctaccc attctttctt
     1321 tctccatcct tcccttgatt ctgctgcaga ccctctggta gctgggcttc ctcagggtcc
     1381 tttgtcctct ccaccacacc cagactgatt tgcagcctgt ggtgggagag aactcgccag
     1441 cctgtggaag aagacgcagc gtgctacaca gcaacccgga accaaccagg cattccgcag
     1501 cacatcccgt ctgctccaga agaggtctta gaagtgaggg ctgtgaccct tccgatcctg
     1561 agcggctagt tttcaaacct cccttgcccc tgcttccttc tggctcaggc tgctcctcct
     1621 taggactttg tgggtccagt tttgccttct gttctgatgg tgattagcgg ctcacctcca
     1681 gcgcttcttc ctgtttccca ggaccaccca gaggctaagg aatcagtcat tccctgttgc
     1741 cttctccagg aaggcaggct aagggttctg aggtgactga gaaaaatgtt tcctttgtgt
     1801 ggaaggctgg tgctccagcc tccacgtccc tctgaatgga agataaaaac ctgctggtgt
     1861 cttgactgct ctgccaggca atcctgaaca tttgggcatg aagagctaaa gtctttgggt
     1921 cttgtttaac tcctattact gtccccaaat tcccctagtc ccttgggtca tgattaaaca
     1981 ttttgactta ggacttt
//
