LOCUS       NM_010279               4560 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus glial cell line derived neurotrophic factor family
            receptor alpha 1 (Gfra1), transcript variant 1, mRNA.
ACCESSION   NM_010279
VERSION     NM_010279.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4560)
  AUTHORS   Zhou,B., Feng,C., Sun,S., Chen,X., Zhuansun,D., Wang,D., Yu,X.,
            Meng,X., Xiao,J., Wu,L., Wang,J., Wang,J., Chen,K., Li,Z., You,J.,
            Mao,H., Yang,S., Zhang,J., Jiao,C., Li,Z., Yu,D., Wu,X., Zhu,T.,
            Yang,J., Xiang,L., Liu,J., Chai,T., Shen,J., Mao,C.X., Hu,J.,
            Hao,X., Xiong,B., Zheng,S., Liu,Z. and Feng,J.
  TITLE     Identification of signaling pathways that specify a subset of
            migrating enteric neural crest cells at the wavefront in mouse
            embryos
  JOURNAL   Dev Cell 59 (13), 1689-1706 (2024)
   PUBMED   38636517
REFERENCE   2  (bases 1 to 4560)
  AUTHORS   Morikawa,M., Yoshizaki,H., Yasui,Y., Nishida,S., Saikawa,Y.,
            Kohno,M. and Okajima,H.
  TITLE     Mesenchymal cells regulate enteric neural crest cell migration via
            RET-GFRA1b trans-signaling
  JOURNAL   Biochem Biophys Res Commun 710, 149861 (2024)
   PUBMED   38581949
REFERENCE   3  (bases 1 to 4560)
  AUTHORS   Baur,K., Carrillo-Garcia,C., San,S., von Hahn,M., Strelau,J.,
            Holzl-Wenig,G., Mandl,C. and Ciccolini,F.
  TITLE     Growth/differentiation factor 15 controls ependymal and stem cell
            number in the V-SVZ
  JOURNAL   Stem Cell Reports 19 (3), 351-365 (2024)
   PUBMED   38366596
REFERENCE   4  (bases 1 to 4560)
  AUTHORS   Virtanen,H.T., Choopanian,P., Porokuokka,L.L., Forsgard,R.,
            Garton,D.R., Olfat,S., Korpela,R., Mirzaie,M. and Andressoo,J.O.
  TITLE     Interindividual Variation in Gut Nitrergic Neuron Density Is
            Regulated By GDNF Levels and ETV1
  JOURNAL   Cell Mol Gastroenterol Hepatol 18 (6), 101405 (2024)
   PUBMED   39299667
REFERENCE   5  (bases 1 to 4560)
  AUTHORS   Lee,Y., Yeo,I.S., Kim,N., Lee,D.K., Kim,K.T., Yoon,J., Yi,J.,
            Hong,Y.B., Choi,B.O., Kosodo,Y., Kim,D., Park,J. and Song,M.R.
  TITLE     Transcriptional control of motor pool formation and motor circuit
            connectivity by the LIM-HD protein Isl2
  JOURNAL   Elife 12, e84596 (2023)
   PUBMED   37869988
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4560)
  AUTHORS   Widenfalk,J., Nosrat,C., Tomac,A., Westphal,H., Hoffer,B. and
            Olson,L.
  TITLE     Neurturin and glial cell line-derived neurotrophic factor
            receptor-beta (GDNFR-beta), novel proteins related to GDNF and
            GDNFR-alpha with specific cellular patterns of expression
            suggesting roles in the developing and adult nervous system and in
            peripheral organs
  JOURNAL   J Neurosci 17 (21), 8506-8519 (1997)
   PUBMED   9334423
REFERENCE   7  (bases 1 to 4560)
  AUTHORS   Molliver,D.C., Wright,D.E., Leitner,M.L., Parsadanian,A.S.,
            Doster,K., Wen,D., Yan,Q. and Snider,W.D.
  TITLE     IB4-binding DRG neurons switch from NGF to GDNF dependence in early
            postnatal life
  JOURNAL   Neuron 19 (4), 849-861 (1997)
   PUBMED   9354331
REFERENCE   8  (bases 1 to 4560)
  AUTHORS   Suvanto,P., Wartiovaara,K., Lindahl,M., Arumae,U., Moshnyakov,M.,
            Horelli-Kuitunen,N., Airaksinen,M.S., Palotie,A., Sariola,H. and
            Saarma,M.
  TITLE     Cloning, mRNA distribution and chromosomal localisation of the gene
            for glial cell line-derived neurotrophic factor receptor beta, a
            homologue to GDNFR-alpha
  JOURNAL   Hum Mol Genet 6 (8), 1267-1273 (1997)
   PUBMED   9259272
REFERENCE   9  (bases 1 to 4560)
  AUTHORS   Nosrat,C.A., Tomac,A., Hoffer,B.J. and Olson,L.
  TITLE     Cellular and developmental patterns of expression of Ret and glial
            cell line-derived neurotrophic factor receptor alpha mRNAs
  JOURNAL   Exp Brain Res 115 (3), 410-422 (1997)
   PUBMED   9262196
REFERENCE   10 (bases 1 to 4560)
  AUTHORS   Baloh,R.H., Tansey,M.G., Golden,J.P., Creedon,D.J.,
            Heuckeroth,R.O., Keck,C.L., Zimonjic,D.B., Popescu,N.C.,
            Johnson,E.M. Jr. and Milbrandt,J.
  TITLE     TrnR2, a novel receptor that mediates neurturin and GDNF signaling
            through Ret
  JOURNAL   Neuron 18 (5), 793-802 (1997)
   PUBMED   9182803
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC102610.18 and AC102457.11.
            
            On Aug 4, 2022 this sequence version replaced NM_010279.3.
            
            Summary: This gene encodes a transmembrane protein that functions
            as the receptor for glial cell line derived neurotrophic factor
            (GDNF). The encoded protein undergoes proteolytic processing to
            generate a glycosylphosphatidylinositol-anchored cell surface
            coreceptor that forms a complex with the Ret tyrosine kinase in
            GDNF signaling pathway. Mice lacking the encoded protein exhibit
            deficits in the kidneys, the enteric nervous system, and spinal
            motor and sensory neurons similar mice deficient in GDNF or Ret.
            [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076171.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC102610.18        87215-87334
            121-406             AC102610.18        87938-88223
            407-700             AC102610.18        89075-89368
            701-784             AC102610.18        90480-90563
            785-799             AC102610.18        149945-149959
            800-1136            AC102457.11        122748-123084       c
            1137-1246           AC102457.11        92560-92669         c
            1247-1381           AC102457.11        89505-89639         c
            1382-1563           AC102457.11        86418-86599         c
            1564-1617           AC102457.11        61760-61813         c
            1618-4560           AC102457.11        58110-61052         c
FEATURES             Location/Qualifiers
     source          1..4560
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 54.18 cM"
     gene            1..4560
                     /gene="Gfra1"
                     /gene_synonym="GFRalpha-1"
                     /note="glial cell line derived neurotrophic factor family
                     receptor alpha 1"
                     /db_xref="GeneID:14585"
                     /db_xref="MGI:MGI:1100842"
     exon            1..120
                     /gene="Gfra1"
                     /gene_synonym="GFRalpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            121..406
                     /gene="Gfra1"
                     /gene_synonym="GFRalpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..700
                     /gene="Gfra1"
                     /gene_synonym="GFRalpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..784
                     /gene="Gfra1"
                     /gene_synonym="GFRalpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..799
                     /gene="Gfra1"
                     /gene_synonym="GFRalpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            800..1136
                     /gene="Gfra1"
                     /gene_synonym="GFRalpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1246
                     /gene="Gfra1"
                     /gene_synonym="GFRalpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1381
                     /gene="Gfra1"
                     /gene_synonym="GFRalpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1563
                     /gene="Gfra1"
                     /gene_synonym="GFRalpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1617
                     /gene="Gfra1"
                     /gene_synonym="GFRalpha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..4560
                     /gene="Gfra1"
                     /gene_synonym="GFRalpha-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3643..3648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gfra1"
                     /gene_synonym="GFRalpha-1"
                     /note="hexamer: AATAAA"
     polyA_site      3667
                     /gene="Gfra1"
                     /gene_synonym="GFRalpha-1"
                     /note="major polyA site"
ORIGIN      
        1 gcagatgctg tggactagct cgctctcacg gggcagtggt gtggatgcac aggagttcgg
       61 gcgctaggca agtgcgtgtg aagcactgaa gtctaggaag gagcccagga tgagcggcag
      121 gttgggtcgg aactgaaccc ctaaaagcgg gtccgcctcc cgccctcgcg cccgctcgga
      181 gctgagtccc tggcggcggt gggcggcaga gcaacgggga gtctgctctc accctggatg
      241 gagcttaact ttgagtggcc agaggagcgc agtcgcccgg ggatctctgc acgctgagct
      301 ctctccgcga gatccggtgg cggctttgga ttttgggggg gcggggacca gctgcgcggc
      361 ggcaccatgt tcctagccac tctgtacttc gtgctgccac tcctggattt gctgatgtcg
      421 gccgaggtga gtggtgggga ccgcctggac tgtgtgaaag ccagtgatca gtgcctgaag
      481 gaacagagct gcagcaccaa gtaccgcaca ctgaggcagt gcgtggcggg caaggaaacc
      541 aacttcagcc tgacatccgg cctcgaggcc aaggatgagt gccgcagcgc tatggaggcc
      601 ttgaagcaga agtctctcta caactgccgc tgcaagcggg gcatgaagaa agagaagaat
      661 tgtctgcgta tctactggag catgtaccag agcctgcagg gaaatgacct actggaagat
      721 tccccatatg agccggttaa cagcaggctg tcagatatat tccgggcagt cccgttcata
      781 tcagatgttt tccagcaagt ggaacacatt tccaaaggga acaactgcct cgatgcagcc
      841 aaggcctgca acctggatga cacctgcaag aagtacaggt ccgcctacat caccccctgt
      901 accaccagca tgtccaatga agtctgcaac cgccgcaagt gccacaaagc cctcaggcag
      961 ttcttcgaca aagttccagc caagcacagc tacgggatgc tcttctgctc ctgccgggac
     1021 gtcgcctgca ccgagaggcg gcgacagact atcgtccctg tgtgctccta tgaagaacga
     1081 gagaggccca actgcctgaa tctgcaagac tcctgcaaga caaattacat ctgcagatct
     1141 cgccttgcag atttttttac caactgccag ccagagtcaa ggtctgtcag caactgtctt
     1201 aaggagaact acgcagactg cctcctggcc tactcgggac tgattggcac agtcatgact
     1261 cctaactaca tagactccag cagcctcagt gtggcgccgt ggtgcgattg cagcaacagt
     1321 ggcaatgacc tggaagattg cctgaagttt ctgaattttt ttaaggacaa tacgtgtctc
     1381 aaaaatgcaa ttcaagcctt tggcaatggc tcggatgtga ccatgtggca gccagccccc
     1441 ccagtccaga ccaccactgc cacgactacc actgccttcc ggatcaagaa caagcctcta
     1501 gggccagcag gctctgagaa tgagattccc acacacgttt taccaccgtg tgctaatttg
     1561 caggcacaga agctgaaatc caatgtatcg ggcagtacac atctctgtct ttctgataat
     1621 gattacggaa aggatggtct cgctggtgcc tccagccaca taaccacaaa atcaatggct
     1681 gctcctccca gctgcggtct gagctcactg ccggtgatgg tgttcaccgc tctggctgcc
     1741 ctgttgtctg tatcattggc agaaacatcg tagctgcatc cagtatgaaa agacaaaaga
     1801 aaaccaagta ttctgtcccc tgtcctcttg tatatctgaa aatccagttt taaaagctcg
     1861 gttgagaagc agtttcaccc agcgggaact cctttgttgt ttttaagaaa gctttttgcc
     1921 gccctcacag gcttctgttg aagaactgct acagggctaa ttccaaactc agaaaactct
     1981 ggggcatggt gtggcttcag gggactgttt gtaacctgga ctgtaaagca agctgagctt
     2041 atgtttttga tggtgatggt ggtggtgatg atgaagatga tagttttaac agcttgaacc
     2101 ctgttctctc tactggctag gaggaggaga tgctattgat agagattctt ccggatctta
     2161 tttaatagcg ttggattcta aagacatgac tgcagcctag tgtggatgga tgacaattgg
     2221 gggttggcct caagagtgga ctttgcagac tctatcttgt actaacgttc accgttctat
     2281 gtatgctctc cacagagtgt ttatgtgatc cccaacaaaa caaaaaagtc cctggtcaca
     2341 tccagatgta gaagctacca tttagcccag tagaggagag tgggtgtggt ccttgcacag
     2401 cacccgggat tgttcactgg tgcgctctcc tgagctttgc ttgagtgaga agctgaatgt
     2461 agctgaagat caactcttac cacttcttac acttacgagg tcacatgtag aacaagcatt
     2521 accaactgtc agctctccaa ctgttagctt tctacatttt gaaggcagcg ataccggtcc
     2581 catgttttaa tgatggttta atacacacag cccttgcccc tcatcagtaa tactagctcc
     2641 agcatcaact tcatgcatat ggctctcatt aaaagcaggc ccccaagaag cccagtgctt
     2701 tagcagaaag ccacatcaca tttctgtgga caggcaggat gaaatagagc agccagccca
     2761 tgtctcatct gtcttgagat caaggctgcc tatatgtaag gaatggttag atacttgtaa
     2821 agggtgccac agtagacagc gcttctggca gttgatatag ccccagtaca tgggttttca
     2881 tgttgtctgg cagagacagc ttggattagg actggctggg atggagatat gctgccctct
     2941 ctttcacagt tgagtcctgc cagggcacat ggaagtttct ttgcttttga ccacaactta
     3001 gaacagtttg gattcaaggt caccaagtat ctcctgtatt ttgctctgtg tccttcatga
     3061 cagactgtca cacacaaaag gaatggtagg ttatggatct agagggccag cacagggtct
     3121 gggaaggtga actgaatggc acaagtacac agagcaggag gggacgctcg agaaaagaca
     3181 cacacaccat ctcctggagc cctcctcctt gcctgggcag acccttaggc atatatctaa
     3241 agactgcttt acatggtcag gctcagaatt tgttaatggt tgcgtactgg caaccatgtt
     3301 tcctgcaaag tgaataaggg ggggggggga gaatcttcct tcccttgagc cctagaagta
     3361 tgatctggcc cctcaccctc ccacagagca gggagccctg gtgcacggtc tcctgatacc
     3421 cgctctgctc tctgaggttt gcctttggga taataaataa cgattcacct gggagggact
     3481 cctctggtgt ctgaagtgca tttatattga aatgtttttg aataacaatg taaaatactc
     3541 agtagcaacc tctttttccc cttcacaatg tttttgaggg gaatgcatcc aacatccaag
     3601 tgtacctgat cagtgggacg ttccatgaag actcatacat tgaataaaca tattcgatgt
     3661 gtcggaacag aatggcggtc atgaatggga acataatctc ttactgatca tattttcgtt
     3721 ttaattaaga tatatacata tatctccact gcactaattt cataagggtc tgattggatg
     3781 tgatccgcca taggaggcta ttgattacct ctgcagtata atgcagctgt cattagcttc
     3841 agagggtcag agaggaaaca ggagccctgt gctaacaagg ggacttcagc aagaactcgt
     3901 agataggcaa catacaaatt aaactttgaa gagcactgtc accagtaaaa attgcatttt
     3961 cctttagaga taaaagcgac tgagagttac caaatcctcg atttgaaaac aagttgctga
     4021 tgaaataaaa tagtgagaag gaccccattt agggacatgt cagagatggc tacaaaacca
     4081 aggcaagcat ataggtcttc catttgctgt ggcctcctcg acaaagcgct tgcttcatct
     4141 caagactaga acagggaaac ttggccatct gttatgcact cgacttcctc ttggagcgcc
     4201 gcccatgagc ggaagtgatt ccctgctttc cctggtcaga gacagttttc gtctgctgag
     4261 gttgggttcc ttacagaaag tcctttgcga agttgatttt actgacagtt gcgtccacac
     4321 agtgactcgg aatccagcct acgtcgggga gagacaaagg tgatggagcc actttgagca
     4381 gaagcacatt cattctgttt gaccttgaat gtccttgaga agatggagtt tgagagtctt
     4441 tttaagagag cacacgagag gacaagtgca caacacagag ggaatttgga atgctggctg
     4501 tttatatttc cacatctgat ttttttccaa acctcaaata aaaaaaatat agacattaaa
//
