LOCUS       NM_013529               2986 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus glutamine fructose-6-phosphate transaminase 2 (Gfpt2),
            mRNA.
ACCESSION   NM_013529
VERSION     NM_013529.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2986)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2986)
  AUTHORS   Al-Mukh,H., Baudoin,L., Bouaboud,A., Sanchez-Salgado,J.L.,
            Maraqa,N., Khair,M., Pagesy,P., Bismuth,G., Niedergang,F. and
            Issad,T.
  TITLE     Lipopolysaccharide Induces GFAT2 Expression to Promote O-Linked
            beta-N-Acetylglucosaminylation and Attenuate Inflammation in
            Macrophages
  JOURNAL   J Immunol 205 (9), 2499-2510 (2020)
   PUBMED   32978282
  REMARK    GeneRIF: Lipopolysaccharide Induces GFAT2 Expression to Promote
            O-Linked beta-N-Acetylglucosaminylation and Attenuate Inflammation
            in Macrophages.
REFERENCE   3  (bases 1 to 2986)
  AUTHORS   Dai,W., Dierschke,S.K., Toro,A.L. and Dennis,M.D.
  TITLE     Consumption of a high fat diet promotes protein O-GlcNAcylation in
            mouse retina via NR4A1-dependent GFAT2 expression
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1864 (12), 3568-3576 (2018)
   PUBMED   30254013
  REMARK    GeneRIF: These results support a model wherein high fat diet
            increases retinal protein O-GlcNAcylation by promoting
            NR4A1-dependent GFAT2 expression.
REFERENCE   4  (bases 1 to 2986)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2986)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   6  (bases 1 to 2986)
  AUTHORS   Hu,Y., Riesland,L., Paterson,A.J. and Kudlow,J.E.
  TITLE     Phosphorylation of mouse glutamine-fructose-6-phosphate
            amidotransferase 2 (GFAT2) by cAMP-dependent protein kinase
            increases the enzyme activity
  JOURNAL   J Biol Chem 279 (29), 29988-29993 (2004)
   PUBMED   15133036
  REMARK    GeneRIF: mouse glutamine-fructose-6-phosphate amidotransferase 2
            (GFAT2) is phosphorylated by cAMP-dependent protein kinase, which
            increases the enzyme activity
REFERENCE   7  (bases 1 to 2986)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 2986)
  AUTHORS   Yamazaki,K., Mizui,Y., Oki,T., Okada,M. and Tanaka,I.
  TITLE     Cloning and characterization of mouse
            glutamine:fructose-6-phosphate amidotransferase 2 gene promoter
  JOURNAL   Gene 261 (2), 329-336 (2000)
   PUBMED   11167021
REFERENCE   9  (bases 1 to 2986)
  AUTHORS   Oki,T., Yamazaki,K., Kuromitsu,J., Okada,M. and Tanaka,I.
  TITLE     cDNA cloning and mapping of a novel subtype of
            glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human
            and mouse
  JOURNAL   Genomics 57 (2), 227-234 (1999)
   PUBMED   10198162
REFERENCE   10 (bases 1 to 2986)
  AUTHORS   Sayeski,P.P., Wang,D., Su,K., Han,I.O. and Kudlow,J.E.
  TITLE     Cloning and partial characterization of the mouse
            glutamine:fructose-6-phosphate amidotransferase (GFAT) gene
            promoter
  JOURNAL   Nucleic Acids Res 25 (7), 1458-1466 (1997)
   PUBMED   9060444
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ163487.1, AK132821.1, DY247913.1, BE198515.1 and BM204562.2.
            
            On Apr 16, 2009 this sequence version replaced NM_013529.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031928.1, SRR1660815.213604.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               CJ163487.1         3-156
            155-2470            AK132821.1         1-2316
            2471-2524           DY247913.1         115-168
            2525-2977           BE198515.1         54-506
            2978-2986           BM204562.2         1-9                 c
FEATURES             Location/Qualifiers
     source          1..2986
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 29.9 cM"
     gene            1..2986
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /note="glutamine fructose-6-phosphate transaminase 2"
                     /db_xref="GeneID:14584"
                     /db_xref="MGI:MGI:1338883"
     exon            1..89
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            90..197
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            198..296
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            297..422
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            423..481
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..616
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            617..678
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            679..758
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            759..876
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1040
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1136
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1234
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1355
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1513
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1628
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1756
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1924
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2086
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2986
                     /gene="Gfpt2"
                     /gene_synonym="GFAT2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggagaccga gcggcgggag cctgagccag ggagcgcgag gcgcagcgag tcgtctgagc
       61 gtctggagcg atcggagcca ccatgtgcgg aatctttgcc tacatgaatt acagagttcc
      121 caagacaagg aaagagattt tcgaaaccct tatcaggggt ctgcagcggc tggagtaccg
      181 gggctatgac tctgcggggg ttgccattga tgggaataac cacgaagtca aagaaagaca
      241 catccatctt gtgaagaaaa gggggaaagt aaaggctctg gatgaagaac tttacaagca
      301 agatagcatg gacttgaagg tggagtttga gacacacttc ggcattgccc acacacgttg
      361 ggccacccac ggggttccca atgctgtcaa cagtcacccg cagcgttcgg acaaagacaa
      421 tgaatttgtt gtcatccaca acgggatcat cactaattac aaggatctaa ggaagtttct
      481 ggaaagcaaa ggctacgagt ttgagtcaga aacagacacg gagaccatcg ccaagctgat
      541 taaatatgta tttgacaaca gagagactga ggacataacg ttttccacat tggtcgaaag
      601 agtcattcag cagttggaag gcgcctttgc actggttttc aagagtattc actacccggg
      661 agaagctgtc gccacgagga gaggcagccc cttgctcatc ggggtacgaa gcaaatacaa
      721 actctccaca gagcagatcc ccgtcttata tccgacatgc aatatcgaga atgtgaagaa
      781 tatctgcaag actaggatga agagactgga cagctccacc tgcctgcacg ctgtgggcga
      841 taaagctgtg gaattcttct ttgcttctga tgcaagtgcc atcatagaac acaccaaccg
      901 ggtcatcttc ttagaagatg atgatatcgc tgcagtggct gatgggaaac tctccattca
      961 ccgagtcaag cgctcagcta ctgatgaccc ctcccgagcc atccagacct tgcagatgga
     1021 actgcagcaa ataatgaaag gtaacttcag cgcatttatg cagaaggaga tcttcgagca
     1081 gccagaatca gtttttaata ccatgagagg tcgggtgaat tttgagacca acacagtgct
     1141 cctgggtggc ttgaaggacc atttgaaaga gatccgacga tgccgaaggc tcattgtgat
     1201 tggctgtgga accagctacc atgccgctgt ggctacacgg caagtcttag aggaactgac
     1261 cgagctgcct gtgatggttg aacttgccag tgactttctg gacaggaaca cacctgtgtt
     1321 cagggatgac gtttgctttt tcataagcca atcaggtgag actgcagaca cgctcctggc
     1381 gctgcgatac tgtaaggatc gaggtgcgct gaccgtgggc atcaccaaca ccgtgggtag
     1441 ctccatctcc cgggagactg actgtggcgt ccacatcaac gcagggcccg agattggggt
     1501 ggccagcacc aaggcgtaca ccagccagtt catctctctg gtgatgtttg gtttgatgat
     1561 gtctgaagat cgaatttctc tacagaacag gagacaagag atcatccgtg gcctcagatc
     1621 tttaccggag ctgatcaaag aagtgctgtc cctggatgag aagatccatg acttggccct
     1681 ggagctctac acacaaaggt ctctcctcgt gatgggacgg ggatataact atgccacatg
     1741 tctggaaggt gccttgaaaa ttaaggagat aacctacatg cattcagaag gtatcctagc
     1801 cggagagctg aagcacgggc cccttgctct cgtcgacaag cagatgccag tcatcatggt
     1861 catcatgaag gatccttgct ttgccaagtg ccagaatgcc ctgcagcagg tcactgcccg
     1921 ccagggtcgc ccaatcatac tgtgttccaa ggatgacacc gagagctcca agtttgcata
     1981 taaaaccatt gaacttcccc acacagtgga ctgtctccag ggtatcctga gcgtgattcc
     2041 actccagctt ctgtccttcc acctggctgt cctccgaggt tatgatgttg acttccccag
     2101 aaacctagcc aagtctgtca ctgtggaatg agaacaggac ttctatcaca agactgtcgt
     2161 cacctgcagt ctgattcaag acctgaacca actgccaaga tgccacacgg gaaaggaagt
     2221 gggcctccgt gggcccctca tgcttccagt agagcttgac agctttgacg tgccttgtac
     2281 ccaaagtgct ttgcttacag caaatgctgt ttctctgtgt cctgacgtca ctgagaaggg
     2341 attgtttaca catggggatc agagcagact ttccactact gtgcaataga gataccgctc
     2401 tcttcagagt aactgtgaac ctttttttaa ccaacactag ctagttttaa aagtcgaaat
     2461 atttataatg acgattgtat agcttttaag ttatttttct aatgtgtggc tttctgtagc
     2521 catggtaacg ccctagccca tgcctctgga ctacccagag tgctgtctct ggacacactc
     2581 gtgcaggtgt cattcatctc ggtttggggc actggcatga gccctttgtc tcctttctct
     2641 ttgttctccc tccacaagct gctcctgatt cctgtcccct gaaatcaacg cgtcccctct
     2701 cccctctccc tatgtttcct ttgagcccag ttaaagtctc tcctcctttc aatattctca
     2761 gatggactca aattccttag ctctctgact tctgcttaat cagattatgg tttttttctt
     2821 aagcccaggc agcactttgg tcccggctcc ctgttcatag taaaccagcc tgagatgccc
     2881 cacacaagag ggcggtttcg tggggctgcc ctgctctatt taaaagcgtg cacaatcaat
     2941 gtactatgca attttacaat aaagacagtg caactttttt tttccg
//
