LOCUS       NM_027469               4105 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus glucose-fructose oxidoreductase domain containing 2
            (Gfod2), transcript variant 2, mRNA.
ACCESSION   NM_027469
VERSION     NM_027469.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4105)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4105)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 4105)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 4105)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   5  (bases 1 to 4105)
  AUTHORS   Keegan,C.E., Hutz,J.E., Else,T., Adamska,M., Shah,S.P., Kent,A.E.,
            Howes,J.M., Beamer,W.G. and Hammer,G.D.
  TITLE     Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd)
            mice is caused by a splicing mutation in a novel telomeric
            regulator
  JOURNAL   Hum Mol Genet 14 (1), 113-123 (2005)
   PUBMED   15537664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152826.2.
            
            On Feb 9, 2019 this sequence version replaced NM_027469.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141521.1, AK017684.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AC152826.2         75487-75640
            155-498             AC152826.2         105763-106106
            499-4105            AC152826.2         116444-120050
FEATURES             Location/Qualifiers
     source          1..4105
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..4105
                     /gene="Gfod2"
                     /gene_synonym="5730466C23Rik"
                     /note="glucose-fructose oxidoreductase domain containing
                     2"
                     /db_xref="GeneID:70575"
                     /db_xref="MGI:MGI:1917825"
     exon            1..154
                     /gene="Gfod2"
                     /gene_synonym="5730466C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            155..498
                     /gene="Gfod2"
                     /gene_synonym="5730466C23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1397
                     /gene="Gfod2"
                     /gene_synonym="5730466C23Rik"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; glucose-fructose oxidoreductase
                     domain-containing protein 2"
                     /codon_start=1
                     /product="glucose-fructose oxidoreductase
                     domain-containing protein 2 isoform 2 precursor"
                     /protein_id="NP_081745.1"
                     /db_xref="CCDS:CCDS22612.1"
                     /db_xref="GeneID:70575"
                     /db_xref="MGI:MGI:1917825"
                     /translation="MKLLPGVGVFGTGSSARVLVPLLRAEGFTVEALWGKTEEEAKQL
                     AEEMNITFYTSRTDDVLLHQDVDLVCINIPPPLTRQISVKALGIGKNVVCEKAATSMD
                     AFRMVTASRYYPQLMSLVGNVLRFLPAFVRMKQLIAEHYVGAVMICDARIYSGSLLSP
                     SYGWICDELMGGGGLHTMGTYIVDLLTHLTGQKAEKVHGLLKTFVRQNATIRGIRHVT
                     SDDFCFFQMLMGGGVCSTVTLNFNMPGAFVHEVMVVGSAGRLVARGADLYGQKNSAAQ
                     EELLVRDSLAVGAGLPEQGPQDVPLLYLKGMVYMVQALRQSFQGQGDRRTWDRTPVSM
                     AASFEDGLYMQSVVDAIKRSSRSGEWETVEMLAEEPDANQNLSETLQRNNL"
     exon            499..4105
                     /gene="Gfod2"
                     /gene_synonym="5730466C23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2019..2024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gfod2"
                     /gene_synonym="5730466C23Rik"
                     /note="hexamer: AATAAG"
     polyA_site      2039
                     /gene="Gfod2"
                     /gene_synonym="5730466C23Rik"
                     /note="major polyA site"
     polyA_site      4070
                     /gene="Gfod2"
                     /gene_synonym="5730466C23Rik"
     regulatory      4089..4094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gfod2"
                     /gene_synonym="5730466C23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4103
                     /gene="Gfod2"
                     /gene_synonym="5730466C23Rik"
                     /note="major polyA site"
ORIGIN      
        1 agaaaccagg cggcgtgttc ccggtatcgg tgctttggat tccggcgcgc gcgcatccgc
       61 actagcctcc ctcagggcag gcggacggcc tcggaaaccc ctccggatcc atggtctctc
      121 gtgcagctct gggcgggcaa tgccagcatg ccaggagcca tgtttgatca ggatgacggg
      181 acggtcagct gcatcccggg gacccttgta aggacatgag tgcttgagca gaggccagga
      241 tgaagctgct cccaggagtc ggtgtgttcg ggactggcag ctcagcccgg gtcctggtcc
      301 cgctgctgag ggcagagggc ttcaccgtgg aggccctgtg ggggaagact gaggaagagg
      361 caaagcagct ggccgaggag atgaacatca ccttctacac cagccgcaca gacgacgtct
      421 tgctgcatca agacgtagac ctggtctgca tcaacatccc acctccgctc acccggcaga
      481 tatccgtgaa ggctctagga attgggaaga acgtggtgtg tgagaaggca gcgacatcca
      541 tggacgcctt ccggatggtg accgcatctc gctactaccc acagctgatg agcttggtgg
      601 ggaacgttct gcgcttcctg cctgccttcg tgcgcatgaa acagctcatt gcagagcact
      661 acgtgggtgc cgtgatgatc tgcgacgctc gcatctactc cgggagcctg ctcagcccca
      721 gctacggctg gatctgtgac gagcttatgg ggggcggggg cctgcacacc atgggtacct
      781 atatcgtgga cctgttgacc cacttgactg gccagaaagc cgagaaggtg cacgggctcc
      841 tcaagacctt tgtgaggcag aatgccacca tccgtggcat ccgccatgtc accagtgatg
      901 acttctgttt tttccagatg ctcatgggtg ggggggtatg cagcacagtg accctcaact
      961 tcaacatgcc aggtgccttt gtgcatgagg tcatggtagt gggctccgca gggcgccttg
     1021 ttgcccgggg agctgacctc tatgggcaga agaactctgc tgcacaggag gagctgctgg
     1081 tgagagactc tctggctgtg ggcgcagggc tccctgagca aggtccccag gatgtcccac
     1141 tgctttactt gaaaggtatg gtctatatgg ttcaggcctt gcgtcagtcc ttccaggggc
     1201 agggggatcg ccgtacctgg gaccgcaccc ctgtctctat ggctgcctca ttcgaggacg
     1261 gactgtatat gcagagcgtg gtagatgcta ttaaaaggtc cagccggtct ggggagtggg
     1321 agactgtgga gatgctggca gaggagccag atgccaacca gaatctaagt gaaacacttc
     1381 agcggaacaa cctgtgaacc tgcgcatgcg cgcttcctcc caagggccag aggctccagg
     1441 gagggcactg ggacctggga ttggctgtag cagagacacg gtgtcgtttt ttaaataaat
     1501 cagcttgggc cagggttagg agccaactga aggtggccaa ggaaaacacc catccatcca
     1561 tcattgattc ctcagacttg cctggggacc cctagctatg acgcacctgc tgtcatagct
     1621 taggctagca gtgtgtgcag gatagagctg tagcctgacc ccttgtggtt ctgccagtga
     1681 gcagggccaa tgaagatcaa tatgggctct tcaggctgag ttgtggtctc acaggatgag
     1741 aaaacccaac aggaactagc ttggttgagt ccttagggta gatggcaaga aaccttgcct
     1801 gttgtggacc agggcatctc aggactggag aaggcggtga caggtcatcc cttagggatc
     1861 ttcccccacc ctcccattcg atctgatctt ttcagccccc ttgcaagccc ttccaagaga
     1921 aaaggaggtt tctgtgttat acataactct gggggggggg ggcaacttgg cagagagaag
     1981 acaaagggga actgtagaac atctgagaaa tgtcagtaaa taagtcagaa aagaactgac
     2041 atcatggtgt gtggtcgttt gtttggggtt ggatttcttt aataatggaa ggcttgttta
     2101 tggctgtaga tctgttgttg ttctcccttc ttcacgagct cgagctccag agcagctatg
     2161 agaatatggc tcccaaacgc tctccaaata tctgcagcag agaggatatg aggctccctg
     2221 ttaggctgct gccaaacctg ccattccgag aagacaggat gagagcctgg ggacccctag
     2281 cctggatgtc atgagaggtt ctttttattt tatctgtctg tctgtctctc tgtctgtctg
     2341 tctgtctgtt tgtttgtttg ggacagggtt tctctgtgta gccctggctg tcctggaact
     2401 cactctgtag accaggctgg cctcgaactc agaaatccac ctgcctctgt ctcccaagtg
     2461 ctgggattaa aggcatgtgc caccacacct tgctcttttt attttttaaa gatttattat
     2521 atatttatgt gtctgtatgt gtatctatgt ttgtgtgagc tcatgagtgc aggtgcccac
     2581 agaggccaga agatggcatc agatttccca gtgcaagaag tgggtgctgg gaactgaacc
     2641 tttaactgct gagccatctc cagccccgcg gttctgttat ggaagctgtg gtgtggctgg
     2701 ctccaggaga gccctcggga ggagcttaag gaggaagggg cctgtgccac cctttggaac
     2761 aggtttaact ggcactactt gagtcagcca gcaagccacc agctgtgctt attaactggg
     2821 acaggtcgga gctgggtggg gacttgaagg tggaggattc ggcccctttt gttccccttg
     2881 tcatctgctg gattatgatg tctcaatgaa gcctgttctt tcttcagatt tcccccttgt
     2941 ctgggctcct tgccaaaaag gcctagggag gccttcctct tcctcttcct cttggcccaa
     3001 cttatagaaa ccatcggacc tatgtccccg tgctgccctg atttcaaaca tcgtctctgt
     3061 gaggcaaagt aaggttggaa tgttgttgct gggctggctc tccagagtaa accatgttta
     3121 aggccagcct ggtctacgta gcaagaacat gtctcaaagg aaaacaaaat ctatgcctat
     3181 tgtctctgac caggggaagc agaggcaaag ttactaggtc gggactttag ctcctaacct
     3241 taaggtgccc ttattccaac cctggggaat cttctctcag aaacctaggc attcattgac
     3301 tttctgcagc aagattcagc ctggcttgaa cgacgaaggc gctgcacagt gcccaccctc
     3361 aggaagctaa caagactggc catttctagc ccactcagct cagctccagc tgcccttgta
     3421 tatttaatta atatgccaag atcccgccta agttgaggat gtccaggaag accaaagctg
     3481 tacctgtgaa aagtgttttt tgctgacttg gaaatgttgg gtaggtttta gagatgttcg
     3541 tgctcagaga tcgcctccca gtgctggaag agggggtaag tagacatggg gcgggactac
     3601 tattatgaag acacagggac tttgagggca cctctcagag tctagatcta gacccctgac
     3661 aacttcccac ctccctggaa caagaacttg cagtcactaa gaatgaggtg agctgagcct
     3721 ttatggccca gatggtgaga gtccctgagc gagtgagcca aactagttct agacttgtcc
     3781 tgcagcgccc cctactggaa gaaggcagca gcttttaggt agaagtttct tctgagttag
     3841 ccctttgata gatcccagcc agatgagaat ttccaaaatg cctgttaagt cttcaacctc
     3901 cggaaggggg ttggggtggc tgagagatgg ttcagtggtt aagagcacca gctgttcttc
     3961 cagaggtcct gggttcaatt cccagcacct acatggcagc tcacaactga ctataactcc
     4021 agttctgggg atcctacacc atcacacaga cctatgtgtt ggcaaaaaaa caatacacat
     4081 gaaatgaaaa taaataaaat ttttt
//
