LOCUS       NM_008114               1724 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus growth factor independent 1B (Gfi1b), transcript
            variant 1, mRNA.
ACCESSION   NM_008114
VERSION     NM_008114.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1724)
  AUTHORS   Huang,Q., H J Cao,W., Curio,S., Yu,H., Denman,R., Chen,E.,
            Schreuder,J., Dight,J., Chaudhry,M., Jacquelot,N., Wimmer,V.C.,
            Seillet,C., Moroy,T. and Belz,G.T.
  TITLE     GFI1B specifies developmental potential of innate lymphoid cell
            progenitors in the lungs
  JOURNAL   Sci Immunol 9 (95), eadj2654 (2024)
   PUBMED   38820141
  REMARK    GeneRIF: GFI1B specifies developmental potential of innate lymphoid
            cell progenitors in the lungs.
REFERENCE   2  (bases 1 to 1724)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1724)
  AUTHORS   Guo,P., Lim,R.C., Rajawasam,K., Trinh,T., Sun,H. and Zhang,H.
  TITLE     A methylation-phosphorylation switch controls EZH2 stability and
            hematopoiesis
  JOURNAL   Elife 13, e86168 (2024)
   PUBMED   38346162
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1724)
  AUTHORS   Koyunlar,C., Gioacchino,E., Vadgama,D., de Looper,H., Zink,J., Ter
            Borg,M.N.D., Hoogenboezem,R., Havermans,M., Sanders,M.A.,
            Bindels,E., Dzierzak,E., Touw,I.P. and de Pater,E.
  TITLE     Gata2-regulated Gfi1b expression controls endothelial programming
            during endothelial-to-hematopoietic transition
  JOURNAL   Blood Adv 7 (10), 2082-2093 (2023)
   PUBMED   36649572
  REMARK    GeneRIF: Gata2-regulated Gfi1b expression controls endothelial
            programming during endothelial-to-hematopoietic transition.
REFERENCE   5  (bases 1 to 1724)
  AUTHORS   Liu,L., Patnana,P.K., Xie,X., Frank,D., Nimmagadda,S.C., Su,M.,
            Zhang,D., Koenig,T., Rosenbauer,F., Liebmann,M., Klotz,L., Xu,W.,
            Vorwerk,J., Neumann,F., Huve,J., Unger,A., Okun,J.G., Opalka,B. and
            Khandanpour,C.
  TITLE     GFI1B acts as a metabolic regulator in hematopoiesis and acute
            myeloid leukemia
  JOURNAL   Leukemia 36 (9), 2196-2207 (2022)
   PUBMED   35804097
REFERENCE   6  (bases 1 to 1724)
  AUTHORS   Saleque,S., Cameron,S. and Orkin,S.H.
  TITLE     The zinc-finger proto-oncogene Gfi-1b is essential for development
            of the erythroid and megakaryocytic lineages
  JOURNAL   Genes Dev 16 (3), 301-306 (2002)
   PUBMED   11825872
REFERENCE   7  (bases 1 to 1724)
  AUTHORS   Tateno,M., Fukunishi,Y., Komatsu,S., Okazaki,Y., Kawai,J.,
            Shibata,K., Itoh,M., Muramatsu,M., Held,W.A. and Hayashizaki,Y.
  TITLE     Identification of a novel member of the snail/Gfi-1 repressor
            family, mlt 1, which is methylated and silenced in liver tumors of
            SV40 T antigen transgenic mice
  JOURNAL   Cancer Res 61 (3), 1144-1153 (2001)
   PUBMED   11221845
REFERENCE   8  (bases 1 to 1724)
  AUTHORS   Neidhardt,L., Gasca,S., Wertz,K., Obermayr,F., Worpenberg,S.,
            Lehrach,H. and Herrmann,B.G.
  TITLE     Large-scale screen for genes controlling mammalian embryogenesis,
            using high-throughput gene expression analysis in mouse embryos
  JOURNAL   Mech Dev 98 (1-2), 77-94 (2000)
   PUBMED   11044609
REFERENCE   9  (bases 1 to 1724)
  AUTHORS   Rodel,B., Wagner,T., Zornig,M., Niessing,J. and Moroy,T.
  TITLE     The human homologue (GFI1B) of the chicken GFI gene maps to
            chromosome 9q34.13-A locus frequently altered in hematopoietic
            diseases
  JOURNAL   Genomics 54 (3), 580-582 (1998)
   PUBMED   9878267
REFERENCE   10 (bases 1 to 1724)
  AUTHORS   Tong,B., Grimes,H.L., Yang,T.Y., Bear,S.E., Qin,Z., Du,K.,
            El-Deiry,W.S. and Tsichlis,P.N.
  TITLE     The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid
            cell differentiation
  JOURNAL   Mol Cell Biol 18 (5), 2462-2473 (1998)
   PUBMED   9566867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            W65842.1, BC132367.1 and BB734623.1.
            
            [WARNING] On Oct 24, 2024 this sequence was replaced by
            NM_008114.4.
            
            On May 22, 2009 this sequence version replaced NM_008114.2.
            
            Transcript Variant: This variant (1) encodes a dominant isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157262.1, BC052654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                W65842.1           1-64
            65-1605             BC132367.1         1-1541
            1606-1724           BB734623.1         43-161
FEATURES             Location/Qualifiers
     source          1..1724
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.38 cM"
     gene            1..1724
                     /gene="Gfi1b"
                     /gene_synonym="Gfi-1B"
                     /note="growth factor independent 1B"
                     /db_xref="GeneID:14582"
                     /db_xref="MGI:MGI:1276578"
     exon            1..134
                     /gene="Gfi1b"
                     /gene_synonym="Gfi-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            135..255
                     /gene="Gfi1b"
                     /gene_synonym="Gfi-1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1148
                     /gene="Gfi1b"
                     /gene_synonym="Gfi-1B"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein Gfi-1b; growth factor independent protein
                     1B"
                     /codon_start=1
                     /product="zinc finger protein Gfi-1b isoform 1"
                     /protein_id="NP_032140.1"
                     /db_xref="CCDS:CCDS15843.1"
                     /db_xref="GeneID:14582"
                     /db_xref="MGI:MGI:1276578"
                     /translation="MPRSFLVKSKKAHTYHQPRAQGDELVWPPAVIPVAKEHSQSASP
                     LLSTPLPSQTLDWNTIKQEREMLLNQSLPKMASAPEGPLVTPQPQDGESPLSESPPFY
                     KPSFSWDTLASSYSHSYTQTPSTMQSAFLERSVRLYGSPLVPSTESPLDFRLRYSPGM
                     DTYHCVKCNKVFSTPHGLEVHVRRSHSGTRPFACDVCGKTFGHAVSLEQHTHVHSQER
                     SFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKKHTYIHTGEKPH
                     KCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCTKGFQRKVDLRRHRESQHNLK"
     exon            256..393
                     /gene="Gfi1b"
                     /gene_synonym="Gfi-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            394..665
                     /gene="Gfi1b"
                     /gene_synonym="Gfi-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            666..803
                     /gene="Gfi1b"
                     /gene_synonym="Gfi-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            804..969
                     /gene="Gfi1b"
                     /gene_synonym="Gfi-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1723
                     /gene="Gfi1b"
                     /gene_synonym="Gfi-1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1697..1702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gfi1b"
                     /gene_synonym="Gfi-1B"
                     /note="hexamer: AATAAA"
     polyA_site      1716
                     /gene="Gfi1b"
                     /gene_synonym="Gfi-1B"
                     /note="major polyA site"
ORIGIN      
        1 cacagaaacg aaaaggagaa gtgtctgtct gtgcagagac tcataacgtt gaccgagccg
       61 agagcagtcc ccagggacag tgtggaggtt cgtggctctc gggcagaact cagaagaggg
      121 acagctccct gacggtgtgg cgtgcacgca gaaaaatgcc acggtccttt ctagtgaaga
      181 gtaagaaggc acacacttac caccagcccc gggcacaggg tgatgagctg gtctggcctc
      241 ctgctgtaat tcctgtggca aaagagcata gccagagtgc cagccctctt ctcagcacac
      301 cgcttccaag ccagaccttg gactggaaca caatcaaaca ggagcgggag atgttgctga
      361 accagagcct tcccaagatg gcctcagccc cagaggggcc tctcgtgaca ccccaacccc
      421 aggatgggga atcaccactc tctgagtcac cccctttcta caagcccagc ttctcctggg
      481 ataccttggc ctcctcctac agccacagct acacacagac cccctccacc atgcagtccg
      541 ccttcctgga gcgctccgtg aggctgtacg gcagccccct cgtgcccagc acagagtctc
      601 ccttggactt ccgcctccgc tactctccag gcatggacac ttaccactgt gtcaagtgca
      661 acaaggtgtt ctccacccct catgggctag aagtgcatgt ccgccgctct cacagcggaa
      721 cccggccctt tgcctgtgat gtctgtggca aaacctttgg ccacgctgtg agcttggagc
      781 agcatactca cgtccactca caggagcgaa gcttcgagtg ccggatgtgt ggcaaagcct
      841 tcaagcgttc atccaccctg tccacccacc tgctcatcca ctcggacact cggccctacc
      901 cctgccagtt ctgtgggaag cgcttccacc agaagtcgga catgaagaaa cacacctaca
      961 tccacacagg tgagaagccc cacaagtgcc aggtgtgtgg gaaagccttc agccagagct
     1021 ccaacctcat cacccacagc cgcaagcaca caggcttcaa gccgttcagc tgtgagctgt
     1081 gcaccaaggg cttccagcgc aaggtggacc tgcgacgtca ccgtgagagt caacacaatc
     1141 tcaagtgaga cggttggccg cctgctttag tgtgtctcgc ctgaaggcca gcctctcctt
     1201 tccaatcctg atcccagtcc tcctggaagc agcattgccc atgagcctct ctgcttcttt
     1261 tgagactgga tgacctcaac caagccacac tcctcctctg accacagctg atgtgggagt
     1321 cagttcgggc ctttctgaac tgaggcagtc acagacatgc tctggtctca ttcaatgcca
     1381 gagcacagac agctacaaag ccctcgtgga catggcaaaa ccaggcaaga gccaggatcc
     1441 acagagaaac cctcttgctt gcttctctgg gtctagtgac tgaattttta gggattctct
     1501 ttttggctgc cacagtcaga gttgtcccct ggcctagagg tctggcgccc ctctgcttcg
     1561 gccagatgtg ctctctgtcc cccacctctc accacatcca tccgcccact gggagtcagg
     1621 ctcctgaggt gagccacgag gctatgaaat cagccatgat agtagaagcc tgctcctatc
     1681 agttgatgta aatgtaaata aaggtgggtt tatttacatg tgaa
//
