LOCUS       NM_010278               2862 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus growth factor independent 1 transcription repressor
            (Gfi1), transcript variant 1, mRNA.
ACCESSION   NM_010278
VERSION     NM_010278.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2862)
  AUTHORS   Hartig,E.I., Day,M., Jarysta,A. and Tarchini,B.
  TITLE     Proteins required for stereocilia elongation during mammalian hair
            cell development ensure precise and steady heights during adult
            life
  JOURNAL   Proc Natl Acad Sci U S A 121 (40), e2405455121 (2024)
   PUBMED   39320919
REFERENCE   2  (bases 1 to 2862)
  AUTHORS   Wang,G., Gu,Y. and Liu,Z.
  TITLE     Deciphering the genetic interactions between Pou4f3, Gfi1, and
            Rbm24 in maintaining mouse cochlear hair cell survival
  JOURNAL   Elife 12, 90025 (2024)
   PUBMED   38483314
  REMARK    GeneRIF: Deciphering the genetic interactions between Pou4f3, Gfi1,
            and Rbm24 in maintaining mouse cochlear hair cell survival.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2862)
  AUTHORS   Thambyrajah,R., Maqueda,M., Neo,W.H., Imbach,K., Guillen,Y.,
            Grases,D., Fadlullah,Z., Gambera,S., Matteini,F., Wang,X.,
            Calero-Nieto,F.J., Esteller,M., Florian,M.C., Porta,E.,
            Benedito,R., Gottgens,B., Lacaud,G., Espinosa,L. and Bigas,A.
  TITLE     Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic
            hematopoietic stem cell fate
  JOURNAL   Nat Commun 15 (1), 1604 (2024)
   PUBMED   38383534
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2862)
  AUTHORS   Guo,P., Lim,R.C., Rajawasam,K., Trinh,T., Sun,H. and Zhang,H.
  TITLE     A methylation-phosphorylation switch controls EZH2 stability and
            hematopoiesis
  JOURNAL   Elife 13, e86168 (2024)
   PUBMED   38346162
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2862)
  AUTHORS   Xie,X., Patnana,P.K., Frank,D., Schutte,J., Al-Matary,Y.,
            Kunstner,A., Busch,H., Ahmed,H., Liu,L., Engel,D.R., Duhrsen,U.,
            Rosenbauer,F., Von Bubnoff,N., Lenz,G. and Khandanpour,C.
  TITLE     Dose-dependent effect of GFI1 expression in the reconstitution and
            the differentiation capacity of HSCs
  JOURNAL   Front Cell Dev Biol 11, 866847 (2023)
   PUBMED   37091981
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2862)
  AUTHORS   Zornig,M., Schmidt,T., Karsunky,H., Grzeschiczek,A. and Moroy,T.
  TITLE     Zinc finger protein GFI-1 cooperates with myc and pim-1 in T-cell
            lymphomagenesis by reducing the requirements for IL-2
  JOURNAL   Oncogene 12 (8), 1789-1801 (1996)
   PUBMED   8622900
REFERENCE   7  (bases 1 to 2862)
  AUTHORS   Liao,X., Buchberg,A.M., Jenkins,N.A. and Copeland,N.G.
  TITLE     Evi-5, a common site of retroviral integration in AKXD T-cell
            lymphomas, maps near Gfi-1 on mouse chromosome 5
  JOURNAL   J Virol 69 (11), 7132-7137 (1995)
   PUBMED   7474133
REFERENCE   8  (bases 1 to 2862)
  AUTHORS   Bell,D.W., Taguchi,T., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.,
            Gilks,C.B., Zweidler-McKay,P., Grimes,H.L., Tsichlis,P.N. and
            Testa,J.R.
  TITLE     Chromosomal localization of a gene, GF1, encoding a novel zinc
            finger protein reveals a new syntenic region between man and
            rodents
  JOURNAL   Cytogenet Cell Genet 70 (3-4), 263-267 (1995)
   PUBMED   7789186
REFERENCE   9  (bases 1 to 2862)
  AUTHORS   Gilks,C.B., Bear,S.E., Grimes,H.L. and Tsichlis,P.N.
  TITLE     Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma
            lines to IL-2-independent growth following activation of a gene
            (Gfi-1) encoding a novel zinc finger protein
  JOURNAL   Mol Cell Biol 13 (3), 1759-1768 (1993)
   PUBMED   8441411
REFERENCE   10 (bases 1 to 2862)
  AUTHORS   van Lohuizen,M., Verbeek,S., Scheijen,B., Wientjens,E., van der
            Gulden,H. and Berns,A.
  TITLE     Identification of cooperating oncogenes in E mu-myc transgenic mice
            by provirus tagging
  JOURNAL   Cell 65 (5), 737-752 (1991)
   PUBMED   1904008
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138666.6 and AV261275.1.
            
            On Mar 20, 2007 this sequence version replaced NM_010278.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the shorter isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KY467439.1, U78312.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-620               AC138666.6         32602-33221         c
            621-806             AC138666.6         32101-32286         c
            807-1294            AC138666.6         30254-30741         c
            1295-1432           AC138666.6         29998-30135         c
            1433-1598           AC138666.6         28988-29153         c
            1599-2838           AC138666.6         25557-26796         c
            2839-2862           AV261275.1         240-263
FEATURES             Location/Qualifiers
     source          1..2862
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 52.23 cM"
     gene            1..2862
                     /gene="Gfi1"
                     /gene_synonym="Gfi-1; Pal-1; Pal1"
                     /note="growth factor independent 1 transcription
                     repressor"
                     /db_xref="GeneID:14581"
                     /db_xref="MGI:MGI:103170"
     exon            1..620
                     /gene="Gfi1"
                     /gene_synonym="Gfi-1; Pal-1; Pal1"
                     /inference="alignment:Splign:2.1.0"
     CDS             506..1777
                     /gene="Gfi1"
                     /gene_synonym="Gfi-1; Pal-1; Pal1"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein Gfi-1; growth factor independent protein 1"
                     /codon_start=1
                     /product="zinc finger protein Gfi-1 isoform 1"
                     /protein_id="NP_034408.1"
                     /db_xref="CCDS:CCDS57371.1"
                     /db_xref="GeneID:14581"
                     /db_xref="MGI:MGI:103170"
                     /translation="MPRSFLVKSKKAHSYHQPRSPGPDYSLRLETVPAPGRAEGGAVS
                     AGESKMEPRERLSPDSQLTEAPDRASASPNSCEGSVCDPCSEFEDFWRPPSPSVSPAS
                     EKSLCRSLDEAQPYTLPFKPYAWSGLAGSDLRHLVQSYRQCSALERSAGLSLFCERGS
                     EPGRPAARYGPEQAAGGAGAGQPGSCGVAGGATSAAGLGLYGDFAPAAAGLYERPSTA
                     AGRLYQDHGHELHADKSVGVKVESELLCTRLLLGGGSYKCIKCSKVFSTPHGLEVHVR
                     RSHSGTRPFACEMCGKTFGHAVSLEQHKAVHSQERSFDCKICGKSFKRSSTLSTHLLI
                     HSDTRPYPCQYCGKRFHQKSDMKKHTFIHTGEKPHKCQVCGKAFSQSSNLITHSRKHT
                     GFKPFGCDLCGKGFQRKVDLRRHRETQHGLK"
     exon            621..806
                     /gene="Gfi1"
                     /gene_synonym="Gfi-1; Pal-1; Pal1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1294
                     /gene="Gfi1"
                     /gene_synonym="Gfi-1; Pal-1; Pal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1432
                     /gene="Gfi1"
                     /gene_synonym="Gfi-1; Pal-1; Pal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1598
                     /gene="Gfi1"
                     /gene_synonym="Gfi-1; Pal-1; Pal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..2862
                     /gene="Gfi1"
                     /gene_synonym="Gfi-1; Pal-1; Pal1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2841..2846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gfi1"
                     /gene_synonym="Gfi-1; Pal-1; Pal1"
                     /note="hexamer: AATAAA"
     polyA_site      2858
                     /gene="Gfi1"
                     /gene_synonym="Gfi-1; Pal-1; Pal1"
                     /note="major polyA site"
ORIGIN      
        1 ctccaagccc cttccgggtc ccaaacactg atgccccctg actggctaaa ctaagccacg
       61 catccctggc gtgagccaca acccagaagg gagcaggtgg gcttgcaggg ttgacttggg
      121 ataacggacc agttgtggac tactgctctc aggagagtga tgatctagct ttggtaggga
      181 aggggagggg ctgaggcgtg ggcagggcag agcaaaggga ccagagccag agcctgggga
      241 caggttttac cactgagctg ttgcagtggc ggcggaggcc gggattcgtg ccacctgtcc
      301 gagtgccacc tggtgagcgt ggcgcctggg tccaggcccc tcctcccgcg gcttccctct
      361 ctcctccctg gcccacactc ttccttggcc tgggaaccta ccacaaccgc catcggtgct
      421 gaccctcgtt tccacccaat tttccccctt ctctcagaac tcagagtatc cgagggtcca
      481 aacattcgtc cagcggctga ccaccatgcc gcgctcattc ctggtcaaga gcaagaaggc
      541 gcacagctat caccagccgc gttctccggg gccggactac tccctgcgcc tggagaccgt
      601 gcctgcgccg ggcagagcag agggcggcgc tgtgagtgca ggcgagtcga aaatggagcc
      661 ccgagagcgt ttgtcccccg actctcagct taccgaggct cccgacaggg cctccgcgtc
      721 ccccaacagc tgcgaaggca gcgtttgtga cccctgctcc gagttcgagg acttttggag
      781 gcccccttct ccctccgtgt ctccagcgtc ggagaagtca ctgtgccgct ctctggacga
      841 agcccagccc tacacgctgc ctttcaagcc ctatgcatgg agcggtcttg ctgggtctga
      901 cctgcggcac ctggtgcaga gctatcggca gtgcagcgcg ctggagcgca gcgcgggcct
      961 gagcctcttc tgcgagcgcg gctcggagcc gggccgcccg gcagcgcgct acggccccga
     1021 gcaggctgcg ggcggagccg gtgcgggaca gccagggagc tgcggggtcg ccgggggcgc
     1081 caccagcgct gcgggcctgg ggctctacgg cgacttcgcg cctgcggcgg ccgggctgta
     1141 cgagcggccg agcacagcag caggccggct gtaccaagat catggccacg agctgcacgc
     1201 ggacaagagc gtgggcgtca aggtggagtc ggagctgctt tgcacccgtc tgctgctggg
     1261 cggcggctcc tacaaatgca tcaaatgcag caaggtgttc tccacaccgc acgggctgga
     1321 ggtgcacgtg cgccggtccc acagcggcac aagacccttt gcgtgcgaga tgtgcggcaa
     1381 gaccttcggg cacgcggtga gcctggagca acacaaggca gtgcactccc aggaacgcag
     1441 ctttgactgt aagatctgtg gcaagagctt caagaggtca tccacgctgt ccacacatct
     1501 gctcattcac tcggacaccc ggccctatcc ctgtcagtac tgtggcaaaa gattccacca
     1561 gaagtcagat atgaagaaac acaccttcat ccacacaggt gagaagcccc acaaatgcca
     1621 ggtgtgcggc aaagccttca gtcagagctc caacctcatc actcatagca gaaagcacac
     1681 aggcttcaag ccctttggct gtgacctgtg tgggaagggc ttccagagga aggtggatct
     1741 caggaggcac cgagagactc agcatggact caaatgagta ccctggcagc ccgcaacacc
     1801 agctgtgtaa cactaccgtg agggatgtct tccctgcctc cctccagccc cttctcaggc
     1861 cctgagtcca gtgtgcaaag ctcatcatgg ttagtcccct tcaccttcct tcccggagct
     1921 gctggaggag atgaactccc gtttctaagg tcaacccaga gtgggaaccg cagcagcagc
     1981 agcagtcgtc tgtgctttgg gcttccctac agctgaagat ggggatcaaa tgagatcttg
     2041 cacctcccag ttcttccctt ttttgctgtc tcacaggcca gaatgaactc tgggcagctg
     2101 ctacaagagg aggcatcacc tcttaagctt tgagcgccac tgatgcattt attgagaacg
     2161 aatgaacatt aattttctct tctggggaga ctgctgactc ctttatcctc caccagactc
     2221 tggtttaggg aaggaacctc gttcctttga aatcatcaga tgcaccatca agcctgccac
     2281 gagaagaagg ggacttggtg atgagaggga gtcagaggtc ctgtggtgcc atcagaggag
     2341 gtgaagctgt ggagcagctc cggggaacag ggtcttcact tactcagcga gtgattattg
     2401 gccgcaggtt atcagagtaa ggaactgtgc taggtatggg agagccagag attaaagtca
     2461 taggccctaa cccccaaaag ctatcagttg gacttcaaca tagctagagc ctgtgttctg
     2521 tgcttccaag ggagttctga agaaggccac acaaacattg ggacttcttt ttgacactta
     2581 cggagttttt caagtgtaaa caaataggaa ctggaggatt atttctaaag ttcatgagta
     2641 aatccagctt ttattgttag gtgggacttt attagatgcc tgcgctggga gatgtggggt
     2701 gaaggctatg gcctcagctc ctgcccctta tcatcttagg aacaacttat ttttcctgtg
     2761 agggttgtag acgttcctaa atcttcttga gtgcattatg tattagcata atcatattta
     2821 ttagaatgtt gttttaactt aataaagtat taagattatt ac
//
