LOCUS       NM_023040               1711 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus growth factor, augmenter of liver regeneration (Gfer),
            transcript variant 1, mRNA.
ACCESSION   NM_023040
VERSION     NM_023040.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1711)
  AUTHORS   Feng,S., Zhao,J., Yang,T. and Li,L.
  TITLE     TMPRSS11D/ALR-mediated ER stress regulates the function of
            myeloid-derived suppressor cells in the cervical cancer
            microenvironment
  JOURNAL   Int Immunopharmacol 124 (Pt A), 110869 (2023)
   PUBMED   37666068
  REMARK    GeneRIF: TMPRSS11D/ALR-mediated ER stress regulates the function of
            myeloid-derived suppressor cells in the cervical cancer
            microenvironment.
REFERENCE   2  (bases 1 to 1711)
  AUTHORS   Zheng,M., Ai,Z., Guo,Y., Chen,Y., Xie,P. and An,W.
  TITLE     Imbalance in ALR ubiquitination accelerates the progression of
            nonalcoholic steatohepatitis to hepatocellular carcinoma
  JOURNAL   Oncogene 42 (4), 308-321 (2023)
   PUBMED   36434180
  REMARK    GeneRIF: Imbalance in ALR ubiquitination accelerates the
            progression of nonalcoholic steatohepatitis to hepatocellular
            carcinoma.
REFERENCE   3  (bases 1 to 1711)
  AUTHORS   Chang,H.C., Shapiro,J.S., Jiang,X., Senyei,G., Sato,T., Geier,J.,
            Sawicki,K.T. and Ardehali,H.
  TITLE     Augmenter of liver regeneration regulates cellular iron homeostasis
            by modulating mitochondrial transport of ATP-binding cassette B8
  JOURNAL   Elife 10, e65158 (2021)
   PUBMED   33835027
  REMARK    GeneRIF: Augmenter of liver regeneration regulates cellular iron
            homeostasis by modulating mitochondrial transport of ATP-binding
            cassette B8.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1711)
  AUTHORS   Kumar,S., Verma,A.K., Rani,R., Sharma,A., Wang,J., Shah,S.A.,
            Behari,J., Salazar Gonzalez,R., Kohli,R. and Gandhi,C.R.
  TITLE     Hepatic Deficiency of Augmenter of Liver Regeneration Predisposes
            to Nonalcoholic Steatohepatitis and Fibrosis
  JOURNAL   Hepatology 72 (5), 1586-1604 (2020)
   PUBMED   32031683
  REMARK    GeneRIF: Hepatic Deficiency of Augmenter of Liver Regeneration
            Predisposes to Nonalcoholic Steatohepatitis and Fibrosis.
REFERENCE   5  (bases 1 to 1711)
  AUTHORS   Kumar,S., Rani,R., Karns,R. and Gandhi,C.R.
  TITLE     Augmenter of liver regeneration protein deficiency promotes hepatic
            steatosis by inducing oxidative stress and microRNA-540 expression
  JOURNAL   FASEB J 33 (3), 3825-3840 (2019)
   PUBMED   30540918
REFERENCE   6  (bases 1 to 1711)
  AUTHORS   Todd,L.R., Damin,M.N., Gomathinayagam,R., Horn,S.R., Means,A.R. and
            Sankar,U.
  TITLE     Growth factor erv1-like modulates Drp1 to preserve mitochondrial
            dynamics and function in mouse embryonic stem cells
  JOURNAL   Mol Biol Cell 21 (7), 1225-1236 (2010)
   PUBMED   20147447
  REMARK    GeneRIF: Growth factor erv1-like modulates Drp1 to preserve
            mitochondrial dynamics and function in mouse embryonic stem cells
REFERENCE   7  (bases 1 to 1711)
  AUTHORS   Gatzidou,E., Kouraklis,G. and Theocharis,S.
  TITLE     Insights on augmenter of liver regeneration cloning and function
  JOURNAL   World J Gastroenterol 12 (31), 4951-4958 (2006)
   PUBMED   16937489
  REMARK    GeneRIF: review of the molecular biology of ALR [review]
            Review article
REFERENCE   8  (bases 1 to 1711)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 1711)
  AUTHORS   Klissenbauer,M., Winters,S., Heinlein,U.A. and Lisowsky,T.
  TITLE     Accumulation of the mitochondrial form of the sulphydryl oxidase
            Erv1p/Alrp during the early stages of spermatogenesis
  JOURNAL   J Exp Biol 205 (Pt 14), 1979-1986 (2002)
   PUBMED   12089204
  REMARK    GeneRIF: studies demonstrated a specific accumulation of
            full-length mouse Alrp during the early stages of spermatogenesis;
            the highest levels of Alrp were found in spermatogonia and primary
            spermatocytes
REFERENCE   10 (bases 1 to 1711)
  AUTHORS   Giorda,R., Hagiya,M., Seki,T., Shimonishi,M., Sakai,H.,
            Michaelson,J., Francavilla,A., Starzl,T.E. and Trucco,M.
  TITLE     Analysis of the structure and expression of the augmenter of liver
            regeneration (ALR) gene
  JOURNAL   Mol Med 2 (1), 97-108 (1996)
   PUBMED   8900538
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154566.2.
            
            On Jul 25, 2022 this sequence version replaced NM_023040.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB041561.1, SRR13862062.154671.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               AC154566.2         67030-67290
            262-458             AC154566.2         67671-67867
            459-1711            AC154566.2         68679-69931
FEATURES             Location/Qualifiers
     source          1..1711
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.48 cM"
     gene            1..1711
                     /gene="Gfer"
                     /gene_synonym="Alr; ERV1"
                     /note="growth factor, augmenter of liver regeneration"
                     /db_xref="GeneID:11692"
                     /db_xref="MGI:MGI:107757"
     exon            1..261
                     /gene="Gfer"
                     /gene_synonym="Alr; ERV1"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..621
                     /gene="Gfer"
                     /gene_synonym="Alr; ERV1"
                     /EC_number="1.8.3.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     FAD-linked sulfhydryl oxidase ALR; augmenter of liver
                     regeneration; growth factor, erv1-like (augmenter of liver
                     regeneration)"
                     /codon_start=1
                     /product="FAD-linked sulfhydryl oxidase ALR isoform 1"
                     /protein_id="NP_075527.2"
                     /db_xref="CCDS:CCDS28492.1"
                     /db_xref="GeneID:11692"
                     /db_xref="MGI:MGI:107757"
                     /translation="MAAPSEPAGFPRGSRFSFLPGGARSEMTDDLVTDARGRGARHRD
                     DTTPAAAPAPQGLEHGKRPCRACVDFKSWMRTQQKRDIKFREDCPQDREELGRHTWAF
                     LHTLAAYYPDRPTPEQQQDMAQFIHIFSKFYPCEECAEDIRKRIGRNQPDTSTRVSFS
                     QWLCRLHNEVNRKLGKPDFDCSRVDERWRDGWKDGSCD"
     exon            262..458
                     /gene="Gfer"
                     /gene_synonym="Alr; ERV1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..1711
                     /gene="Gfer"
                     /gene_synonym="Alr; ERV1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      685..690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gfer"
                     /gene_synonym="Alr; ERV1"
                     /note="hexamer: ATTAAA"
     polyA_site      705
                     /gene="Gfer"
                     /gene_synonym="Alr; ERV1"
                     /note="major polyA site"
     regulatory      1693..1698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gfer"
                     /gene_synonym="Alr; ERV1"
                     /note="hexamer: AATAAA"
     polyA_site      1711
                     /gene="Gfer"
                     /gene_synonym="Alr; ERV1"
                     /note="major polyA site"
ORIGIN      
        1 ccccgctgcc cgcacgccag caagatggcg gcgcccagcg agccggcggg cttccctcgc
       61 ggcagtcgct tctccttcct gccgggcggc gcgcgctccg agatgaccga cgacctggtg
      121 actgacgcgc ggggccgcgg cgcaaggcat agagacgaca ccacccctgc cgcggccccg
      181 gcgccgcaag gtttggagca cgggaagcga ccgtgccggg cctgcgtgga cttcaagtcg
      241 tggatgcgga cccagcagaa gcgggacatc aagtttaggg aggactgtcc acaggatcgg
      301 gaagaattgg gtcgccacac ctgggctttc ctccatacgc tggccgccta ttacccggac
      361 aggcccacgc cagaacaaca acaggatatg gcccagttca tacatatatt ttccaagttt
      421 tacccctgcg aggaatgtgc ggaagacata aggaagagga taggcaggaa ccagccagac
      481 acaagcactc gagtatcctt cagccagtgg ctgtgccgcc tgcacaatga ggtgaatcgg
      541 aagctgggca agcctgattt tgactgctcg agagtagatg agcgttggcg tgacggctgg
      601 aaggacggct cctgtgacta gaagattacc agcagttcgt gaggggcatc tagcctggtt
      661 ctatgggcaa cagcctgatt gacgattaaa gtgcatctga gccaacactt gtttctgtag
      721 ttgatttctg gatgtattca agagtttagc gtactgactc tctaatctgt gcaacttatc
      781 tgtgtaagag agtttcagag gcgctgtcat ctgaatctca ctaattttag cttccttaag
      841 gctggattca aattcttcaa tggctcggtg aacattttta tggttttcta aatggctttc
      901 aacacttggc aaatctgagc cccattcagt gcggtccagc tgcacctgca tctcatcaac
      961 ccagttcaag agatcttgaa caaatttcat attgacttcc tcttctgtca agttctgatc
     1021 cagcaaagac gacttgagaa ggggctttcg gatctgcatt agcttcagag tctgtaatga
     1081 atttggctct acccctaaac tgaagtttgg agctacaact gaagggaacc caggtgcata
     1141 caccggagta actgatggcg tcaggcggga agtcatcccg gacgacaagc cagaagtcac
     1201 gctagaagac gtcaaggaag gggttaaact ctgggttagc cctgagttca ggctggggtg
     1261 taaggtttgt gcaaatcctg agtttaagct ttgaacactg cctctgggaa ccctgccaca
     1321 ggattaagaa atggaggtgc ctactacaga cacttgggtg gcctcctcag cgaaagcccc
     1381 atgagactga aggtgagagg caggagtggt ccaggtgcct cgtacccttc atttgggaca
     1441 tagttgcccc aaaggaagat gggctagatg attgccttac tactacacag ccctggctgc
     1501 ctacaagaac tgtgatcctg gcaactctgc catttcagaa ttgaagcagg gttccccagc
     1561 tccagcaggg tttttctctt agggtgtacc aaccatggtg cccactgtca gcctggcaca
     1621 tggtcttctg cagctatgac aagcatgtca gcagagggtc ctgggaacag cttccttagc
     1681 gtttgaggcc aaaataaact gaagtgactt a
//
