LOCUS       NM_010277               2733 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus glial fibrillary acidic protein (Gfap), transcript
            variant 2, mRNA.
ACCESSION   NM_010277
VERSION     NM_010277.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2733)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2733)
  AUTHORS   Xu,X., Fang,M., Chen,L., Huang,H., Dai,Z.M., Yang,J. and Qiu,M.
  TITLE     Nzf2 promotes oligodendrocyte differentiation and regeneration via
            repressing HDAC1-mediated histone deacetylation
  JOURNAL   Sci Adv 10 (50), eadf8405 (2024)
   PUBMED   39671488
REFERENCE   3  (bases 1 to 2733)
  AUTHORS   Feng,X., Du,X., Yang,X., Chen,C., Liang,Z., Xu,X., Wang,Y.,
            Zheng,J.C., Xia,X. and Liu,J.
  TITLE     miR-185-5p regulates the proliferation and differentiation of
            neural stem/progenitor cells
  JOURNAL   Front Cell Dev Biol 12, 1510746 (2024)
   PUBMED   39703696
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2733)
  AUTHORS   Pelenyi,A., Atterton,C., Jones,J., Currey,L., Al-Khalily,M.,
            Wright,L., Kurniawan,N.D., Thor,S. and Piper,M.
  TITLE     Expression of the Hippo pathway effector, TEAD1, within the
            developing murine forebrain
  JOURNAL   Gene Expr Patterns 54, 119384 (2024)
   PUBMED   39557142
REFERENCE   5  (bases 1 to 2733)
  AUTHORS   Omura,S., Ogawa,R., Kawachi,T., Ogawa,A., Arai,Y., Takayama,N.,
            Masui,A., Kondo,K., Sugimoto,H., Shinohara,H.M., Takahashi,T.,
            Maeda,H. and Ohyama,K.
  TITLE     Olig2+/NG2+/BLBP+ astrocyte progenitors: a novel component of the
            neurovascular unit in the developing mouse hippocampus
  JOURNAL   Front Cell Neurosci 18, 1464402 (2024)
   PUBMED   39484182
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2733)
  AUTHORS   Miragall,F., Hwang,T.K., Traub,O., Hertzberg,E.L. and Dermietzel,R.
  TITLE     Expression of connexins in the developing olfactory system of the
            mouse
  JOURNAL   J Comp Neurol 325 (3), 359-378 (1992)
   PUBMED   1332989
REFERENCE   7  (bases 1 to 2733)
  AUTHORS   Nonaka,M., Matsuda,Y., Shiroishi,T., Moriwaki,K., Nonaka,M. and
            Natsuume-Sakai,S.
  TITLE     Molecular cloning of mouse beta 2-glycoprotein I and mapping of the
            gene to chromosome 11
  JOURNAL   Genomics 13 (4), 1082-1087 (1992)
   PUBMED   1339387
REFERENCE   8  (bases 1 to 2733)
  AUTHORS   Dietrich,W., Katz,H., Lincoln,S.E., Shin,H.S., Friedman,J.,
            Dracopoli,N.C. and Lander,E.S.
  TITLE     A genetic map of the mouse suitable for typing intraspecific
            crosses
  JOURNAL   Genetics 131 (2), 423-447 (1992)
   PUBMED   1353738
REFERENCE   9  (bases 1 to 2733)
  AUTHORS   Karolyi,I.J., Guenet,J.L., Rey-Campos,J. and Camper,S.A.
  TITLE     The gene coding for variant hepatic nuclear factor 1 (Tcf-2), maps
            between the Edp-1 and Erba genes on mouse chromosome 11
  JOURNAL   Mamm Genome 3 (3), 184-185 (1992)
   PUBMED   1352161
REFERENCE   10 (bases 1 to 2733)
  AUTHORS   Dyson,P.J., de Smet,C., Knight,A.M., Simon-Chazottes,D.,
            Guenet,J.L. and Boon,T.
  TITLE     Mapping of the genes encoding tum- transplantation antigens P91A,
            P35B, and P198
  JOURNAL   Immunogenetics 35 (5), 316-323 (1992)
   PUBMED   1348494
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC139357.1, AK079577.1, CX223233.1, BE651678.1 and AI835063.1.
            
            On Aug 14, 2008 this sequence version replaced NM_010277.2.
            
            Transcript Variant: This variant (2) differs in the 3' coding
            region and 3' UTR, compared to variant 1, which results in a
            protein (isoform 2) with a shorter and distinct C-terminus when
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC139357.1, AK079577.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1462              BC139357.1         1-1462
            1463-1731           AK079577.1         1398-1666
            1732-2049           CX223233.1         130-447
            2050-2423           BE651678.1         22-395
            2424-2733           AI835063.1         1-310               c
FEATURES             Location/Qualifiers
     source          1..2733
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.48 cM"
     gene            1..2733
                     /gene="Gfap"
                     /note="glial fibrillary acidic protein"
                     /db_xref="GeneID:14580"
                     /db_xref="MGI:MGI:95697"
     exon            1..535
                     /gene="Gfap"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1376
                     /gene="Gfap"
                     /note="isoform 2 is encoded by transcript variant 2;
                     intermediate filament protein"
                     /codon_start=1
                     /product="glial fibrillary acidic protein isoform 2"
                     /protein_id="NP_034407.2"
                     /db_xref="CCDS:CCDS25507.1"
                     /db_xref="GeneID:14580"
                     /db_xref="MGI:MGI:95697"
                     /translation="MERRRITSARRSYASETVVRGLGPSRQLGTMPRFSLSRMTPPLP
                     ARVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLR
                     AKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNFAQDLGTLRQKLQDETNLRL
                     EAENNLAAYRQEADEATLARVDLERKVESLEEEIQFLRKIYEEEVRELREQLAQQQVH
                     VEMDVAKPDLTAALREIRTQYEAVATSNMQETEEWYRSKFADLTDAASRNAELLRQAK
                     HEANDYRRQLQALTCDLESLRGTNESLERQMREQEERHARESASYQEALARLEEEGQS
                     LKEEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLD
                     TKSVSEGHLKRNIVVKTVEMRDGEVIKDSKQEHKDVVM"
     exon            536..596
                     /gene="Gfap"
                     /inference="alignment:Splign:2.1.0"
     exon            597..692
                     /gene="Gfap"
                     /inference="alignment:Splign:2.1.0"
     exon            693..854
                     /gene="Gfap"
                     /inference="alignment:Splign:2.1.0"
     exon            855..980
                     /gene="Gfap"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1201
                     /gene="Gfap"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1245
                     /gene="Gfap"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1331
                     /gene="Gfap"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..2717
                     /gene="Gfap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2691..2696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gfap"
                     /note="hexamer: AATAAA"
     polyA_site      2711
                     /gene="Gfap"
                     /note="major polyA site"
ORIGIN      
        1 ccaggaagtc aggggcagat ttagtccaac ccgttcctcc ataaaggccc tgacatccca
       61 ggagccagca gaggcagggc aggatggagc ggagacgcat cacctctgcg cgccgctcct
      121 atgcctccga gacggtggtc aggggcctcg gtcctagtcg acaactgggt accatgccac
      181 gcttctcctt gtctcgaatg actcctccac tccctgccag ggtggacttc tccctggccg
      241 gggcgctcaa tgctggcttc aaggagacac gggcgagcga gcgtgcagag atgatggagc
      301 tcaatgaccg ctttgctagc tacatcgaga aggtccgctt cctggaacag caaaacaagg
      361 cgctggcagc tgaactgaac cagcttcgag ccaaggagcc caccaaactg gctgatgtct
      421 accaggcgga gcttcgggag ctgcggctgc ggctggacca gcttacggcc aacagtgccc
      481 ggctggaggt ggagagggac aactttgcac aggacctcgg caccctgagg cagaagctcc
      541 aagatgaaac caacctgagg ctggaggcag agaacaacct ggctgcgtat agacaggagg
      601 cagatgaagc caccctggct cgtgtggatt tggagagaaa ggttgaatcg ctggaggagg
      661 agatccagtt cttaaggaag atctatgagg aggaagttcg agaactccgg gagcagctgg
      721 cccaacagca ggtccacgtg gagatggatg tggccaagcc agacctcaca gcggccctga
      781 gagagattcg cactcaatac gaggcagtgg ccaccagtaa catgcaagag acagaggagt
      841 ggtatcggtc taagtttgca gacctcacag acgctgcgtc ccgcaacgca gagctgctcc
      901 gccaagccaa gcacgaagct aacgactatc gccgccaact gcaggccttg acctgcgatc
      961 tggagtccct gcgcggcacg aacgagtccc tagagcggca aatgcgcgaa caggaagagc
     1021 gccatgcgcg ggagtcggcc agttaccagg aggcacttgc tcggctggag gaggagggcc
     1081 aaagcctcaa ggaggagatg gcccgccacc tgcaggagta ccaggatcta ctcaacgtta
     1141 agctagccct ggacatcgag atcgccacct acaggaaatt gctggagggc gaagaaaacc
     1201 gcatcaccat tcctgtacag actttctcca acctccagat ccgagaaacc agcctggaca
     1261 ccaaatccgt gtcagaaggc cacctcaaga ggaacatcgt ggtaaagact gtggagatgc
     1321 gggatggtga ggtcattaag gactcgaagc aggagcacaa ggacgtggtg atgtgaggtg
     1381 tgcccacctg gtggcccttg ccatgcagtg tgagggccca aagcttatcc tcaaatagtc
     1441 ctgtttgcca ggctcagttc ccacccacac cagcacttcc cttccttctg gttttctgcc
     1501 tgtgtgctgc ccaaggctca atcagtgcta agcttcatag atggcatata cccttcacct
     1561 tcaactaaca ggatactcac cccaaaggcg cagtcaggag gggagggaac cccagctggg
     1621 ttagaattgg aagggaagag gaaagatgag cagagtagag agatttaaca aatcacttcc
     1681 ttcatccttg ttgttatgga aaccgttgcc agagctggaa gtttccacag gctgctggag
     1741 ctagacaaca attcagacag aaagggaaag tccctgaggc aaagtctctc tagccagaga
     1801 cctatgcatc ccgaatggcc actaaggcag tcctgaaggg ccctccaggg tgatgactcc
     1861 agtgtgtcag ccccactgag cagctatgca ggttgactgc ccacaggcat gtggaaactt
     1921 ggttctcagc acttggcagg atctatggca taagtggaga gggaaggtgt actggacggc
     1981 ggagaggagg gctccctggc ccctaagtgt ggatgcagag aggtggagcc caggaagggt
     2041 ctctgcttag gctgcagggg tgccaatggc agaggcactg gtagagatca tttggacact
     2101 ggagttgaaa gttacaggca atctgttaca cttggctctg aatcctatga atcaaggaaa
     2161 taacccgttc tctggaagac actgaaacag gagagaggga cttccgtcca ctgggcaggg
     2221 tacagatgtg tctcagttgt gaaggtctat tcctggctgc acagtcccca tccgctcagt
     2281 catcttaccc tgtgactgct ctcagccctg aagaatccac aaccatcctt ccaaggttct
     2341 ccatccccac aatgactagc tgttgctctc caagctaagg gaccattccc tgtcttatgc
     2401 atatacgtaa tgtcacctat ttaggtatca tcctatttga gagtttgagg aactgaaacg
     2461 tgttgtgttc aagcagcctg gtggctagtg ccttcatatt agagcacctt ctctgaggct
     2521 gattggtggg caggtaggga agacattgag cagacagtgt ccgctcagtt gtccttccct
     2581 cccttccaag gtccctccct ctttccagga catcgccccc ccaccccacc cctcctttcc
     2641 acctccgcta acctccagag cagtactgtc acctttactc actgggcaga aataaagaca
     2701 tgtgccatag acttccaaaa aaaaaaaaaa aaa
//
