LOCUS       NP_034407                430 aa            linear   ROD 12-JUN-2025
DEFINITION  glial fibrillary acidic protein isoform 2 [Mus musculus].
ACCESSION   NP_034407
VERSION     NP_034407.2
DBSOURCE    REFSEQ: accession NM_010277.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 430)
  AUTHORS   Liu,G., Wu,C., Yin,L., Hou,L., Yin,B., Qiang,B., Shu,P. and Peng,X.
  TITLE     MiR-125/let-7 cluster orchestrates neuronal cell fate determination
            and cortical layer formation during neurogenesis
  JOURNAL   Biochem Biophys Res Commun 766, 151815 (2025)
   PUBMED   40300336
REFERENCE   2  (residues 1 to 430)
  AUTHORS   Lv,Y., Zou,W., Li,L., Zhang,S., Liang,J., Pu,J. and Jiao,J.
  TITLE     IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in
            Developing Neocortex
  JOURNAL   Adv Sci (Weinh) 12 (17), e2501593 (2025)
   PUBMED   40052215
REFERENCE   3  (residues 1 to 430)
  AUTHORS   Martin-Lopez,E., Brennan,B., Lefevre,M., Spence,N.J., Han,K. and
            Greer,C.A.
  TITLE     Laminar organization of the anterior olfactory nucleus-the
            interplay between neurogenesis timing and neuroblast migration
  JOURNAL   Front Neurosci 19, 1546397 (2025)
   PUBMED   40370659
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 430)
  AUTHORS   McKinsey,G.L., Santander,N., Zhang,X., Kleemann,K.L., Tran,L.,
            Katewa,A., Conant,K., Barraza,M., Waddell,K., Lizama,C.O., La
            Russa,M., Koo,J.H., Lee,H., Mukherjee,D., Paidassi,H., Anton,E.S.,
            Atabai,K., Sheppard,D., Butovsky,O. and Arnold,T.D.
  TITLE     Radial glia integrin avb8 regulates cell autonomous microglial
            TGFbeta1 signaling that is necessary for microglial identity
  JOURNAL   Nat Commun 16 (1), 2840 (2025)
   PUBMED   40121230
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 430)
  AUTHORS   Ahmad,K., Khan,B., Khan,K., Khalid Iqbal,M., Wang,X., Shaikh,S.,
            Sui,A.R., Huang,Y.L., Ntim,M., Kong,Y., Shu,J., Wu,Q., Li,Q.F.,
            Li,S. and Yang,G.
  TITLE     Cell-type-specific expression of Nav1.6 in the developing brain of
            mice and its involvement in glial activation in Alzheimer's disease
  JOURNAL   Cereb Cortex 35 (2) (2025)
   PUBMED   40037549
REFERENCE   6  (residues 1 to 430)
  AUTHORS   Miragall,F., Hwang,T.K., Traub,O., Hertzberg,E.L. and Dermietzel,R.
  TITLE     Expression of connexins in the developing olfactory system of the
            mouse
  JOURNAL   J Comp Neurol 325 (3), 359-378 (1992)
   PUBMED   1332989
REFERENCE   7  (residues 1 to 430)
  AUTHORS   Nonaka,M., Matsuda,Y., Shiroishi,T., Moriwaki,K., Nonaka,M. and
            Natsuume-Sakai,S.
  TITLE     Molecular cloning of mouse beta 2-glycoprotein I and mapping of the
            gene to chromosome 11
  JOURNAL   Genomics 13 (4), 1082-1087 (1992)
   PUBMED   1339387
REFERENCE   8  (residues 1 to 430)
  AUTHORS   Dietrich,W., Katz,H., Lincoln,S.E., Shin,H.S., Friedman,J.,
            Dracopoli,N.C. and Lander,E.S.
  TITLE     A genetic map of the mouse suitable for typing intraspecific
            crosses
  JOURNAL   Genetics 131 (2), 423-447 (1992)
   PUBMED   1353738
REFERENCE   9  (residues 1 to 430)
  AUTHORS   Karolyi,I.J., Guenet,J.L., Rey-Campos,J. and Camper,S.A.
  TITLE     The gene coding for variant hepatic nuclear factor 1 (Tcf-2), maps
            between the Edp-1 and Erba genes on mouse chromosome 11
  JOURNAL   Mamm Genome 3 (3), 184-185 (1992)
   PUBMED   1352161
REFERENCE   10 (residues 1 to 430)
  AUTHORS   Dyson,P.J., de Smet,C., Knight,A.M., Simon-Chazottes,D.,
            Guenet,J.L. and Boon,T.
  TITLE     Mapping of the genes encoding tum- transplantation antigens P91A,
            P35B, and P198
  JOURNAL   Immunogenetics 35 (5), 316-323 (1992)
   PUBMED   1348494
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC139357.1, AK079577.1, CX223233.1, BE651678.1 and AI835063.1.
            
            On Dec 24, 2005 this sequence version replaced NP_034407.1.
            
            Transcript Variant: This variant (2) differs in the 3' coding
            region and 3' UTR, compared to variant 1, which results in a
            protein (isoform 2) with a shorter and distinct C-terminus when
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC139357.1, AK079577.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.48 cM"
     Protein         1..430
                     /product="glial fibrillary acidic protein isoform 2"
                     /note="intermediate filament protein"
                     /calculated_mol_wt=49769
     Region          1..69
                     /region_name="Head"
                     /note="propagated from UniProtKB/Swiss-Prot (P03995.4)"
     Region          4..63
                     /region_name="Filament_head"
                     /note="Intermediate filament head (DNA binding) region;
                     pfam04732"
                     /db_xref="CDD:461414"
     Site            7
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by AURKB and ROCK1.
                     /evidence=ECO:0000250|UniProtKB:P14136; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Site            11
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Site            12
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by AURKB and ROCK1.
                     /evidence=ECO:0000250|UniProtKB:P14136; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Site            20
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Site            35
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by AURKB and ROCK1.
                     /evidence=ECO:0000250|UniProtKB:P14136; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Site            40
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:16452087; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Region          65..373
                     /region_name="Filament"
                     /note="Intermediate filament protein; pfam00038"
                     /db_xref="CDD:459643"
     Region          70..101
                     /region_name="Coil 1A"
                     /note="propagated from UniProtKB/Swiss-Prot (P03995.4)"
     Site            79
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47819; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Region          102..112
                     /region_name="Linker 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P03995.4)"
     Site            107
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P47819; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Region          113..211
                     /region_name="Coil 1B"
                     /note="propagated from UniProtKB/Swiss-Prot (P03995.4)"
     Site            147
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P47819; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Region          212..227
                     /region_name="Linker 12"
                     /note="propagated from UniProtKB/Swiss-Prot (P03995.4)"
     Region          228..249
                     /region_name="Coil 2A"
                     /note="propagated from UniProtKB/Swiss-Prot (P03995.4)"
     Region          250..253
                     /region_name="Linker 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P03995.4)"
     Region          254..374
                     /region_name="Coil 2B"
                     /note="propagated from UniProtKB/Swiss-Prot (P03995.4)"
     Site            266
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47819; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Site            320
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47819; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Region          375..430
                     /region_name="Tail"
                     /note="propagated from UniProtKB/Swiss-Prot (P03995.4)"
     Site            380
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P47819; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Site            382
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47819; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     CDS             1..430
                     /gene="Gfap"
                     /coded_by="NM_010277.3:84..1376"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS25507.1"
                     /db_xref="GeneID:14580"
                     /db_xref="MGI:MGI:95697"
ORIGIN      
        1 merrritsar rsyasetvvr glgpsrqlgt mprfslsrmt pplparvdfs lagalnagfk
       61 etraseraem melndrfasy iekvrfleqq nkalaaelnq lrakeptkla dvyqaelrel
      121 rlrldqltan sarleverdn faqdlgtlrq klqdetnlrl eaennlaayr qeadeatlar
      181 vdlerkvesl eeeiqflrki yeeevrelre qlaqqqvhve mdvakpdlta alreirtqye
      241 avatsnmqet eewyrskfad ltdaasrnae llrqakhean dyrrqlqalt cdleslrgtn
      301 eslerqmreq eerharesas yqealarlee egqslkeema rhlqeyqdll nvklaldiei
      361 atyrkllege enritipvqt fsnlqirets ldtksvsegh lkrnivvktv emrdgevikd
      421 skqehkdvvm
//
