LOCUS       NM_207301               2502 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus guided entry of tail-anchored proteins factor 1
            (Get1), mRNA.
ACCESSION   NM_207301 XM_148742 XM_358893
VERSION     NM_207301.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2502)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2502)
  AUTHORS   Rivera-Monroy,J., Musiol,L., Unthan-Fechner,K., Farkas,A.,
            Clancy,A., Coy-Vergara,J., Weill,U., Gockel,S., Lin,S.Y.,
            Corey,D.P., Kohl,T., Strobel,P., Schuldiner,M., Schwappach,B. and
            Vilardi,F.
  TITLE     Mice lacking WRB reveal differential biogenesis requirements of
            tail-anchored proteins in vivo
  JOURNAL   Sci Rep 6, 39464 (2016)
   PUBMED   28000760
  REMARK    GeneRIF: Stx5 is an autophagy target that is inefficiently
            membrane-targeted by alternative pathways; mice without WRB have
            different biogenesis requirements for tail anchored proteins
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2502)
  AUTHORS   Vogl,C., Panou,I., Yamanbaeva,G., Wichmann,C., Mangosing,S.J.,
            Vilardi,F., Indzhykulian,A.A., Pangrsic,T., Santarelli,R.,
            Rodriguez-Ballesteros,M., Weber,T., Jung,S., Cardenas,E., Wu,X.,
            Wojcik,S.M., Kwan,K.Y., Del Castillo,I., Schwappach,B.,
            Strenzke,N., Corey,D.P., Lin,S.Y. and Moser,T.
  TITLE     Tryptophan-rich basic protein (WRB) mediates insertion of the
            tail-anchored protein otoferlin and is required for hair cell
            exocytosis and hearing
  JOURNAL   EMBO J 35 (23), 2536-2552 (2016)
   PUBMED   27458190
REFERENCE   4  (bases 1 to 2502)
  AUTHORS   Cai,Y., Yoneda,M., Tomita,T., Kurotani,R., Okamoto,M., Kido,T.,
            Abe,H., Mitzner,W., Guha,A. and Kimura,S.
  TITLE     Transgenically-expressed secretoglobin 3A2 accelerates resolution
            of bleomycin-induced pulmonary fibrosis in mice
  JOURNAL   BMC Pulm Med 15, 72 (2015)
   PUBMED   26178733
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164647.3.
            
            On Apr 20, 2018 this sequence version replaced NM_207301.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031769.1, SRR9219381.101875.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AC164647.3         71759-71937         c
            180-345             AC164647.3         65359-65524         c
            346-413             AC164647.3         64299-64366         c
            414-528             AC164647.3         63142-63256         c
            529-2502            AC164647.3         59485-61458         c
FEATURES             Location/Qualifiers
     source          1..2502
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 56.84 cM"
     gene            1..2502
                     /gene="Get1"
                     /gene_synonym="5530402J05Rik; C030018G21Rik; Chd5; Wrb"
                     /note="guided entry of tail-anchored proteins factor 1"
                     /db_xref="GeneID:71446"
                     /db_xref="MGI:MGI:2136882"
     exon            1..179
                     /gene="Get1"
                     /gene_synonym="5530402J05Rik; C030018G21Rik; Chd5; Wrb"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..602
                     /gene="Get1"
                     /gene_synonym="5530402J05Rik; C030018G21Rik; Chd5; Wrb"
                     /note="tail-anchored protein insertion receptor WRB;
                     tryptophan rich basic protein"
                     /codon_start=1
                     /product="guided entry of tail-anchored proteins factor 1"
                     /protein_id="NP_997184.1"
                     /db_xref="CCDS:CCDS28354.1"
                     /db_xref="GeneID:71446"
                     /db_xref="MGI:MGI:2136882"
                     /translation="MSASETDRWAWLLVLSFVFGCNLLRILLPSLSSFISRVLQKDAE
                     QESQMRAEIQGMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKW
                     FISVAFYILQAALMISLIWKYYSVPVAVVPSKWITPLDRLVAFPTRVAGGIGITCWIL
                     VCNKVVAIVLHPFS"
     exon            180..345
                     /gene="Get1"
                     /gene_synonym="5530402J05Rik; C030018G21Rik; Chd5; Wrb"
                     /inference="alignment:Splign:2.1.0"
     exon            346..413
                     /gene="Get1"
                     /gene_synonym="5530402J05Rik; C030018G21Rik; Chd5; Wrb"
                     /inference="alignment:Splign:2.1.0"
     exon            414..528
                     /gene="Get1"
                     /gene_synonym="5530402J05Rik; C030018G21Rik; Chd5; Wrb"
                     /inference="alignment:Splign:2.1.0"
     exon            529..2502
                     /gene="Get1"
                     /gene_synonym="5530402J05Rik; C030018G21Rik; Chd5; Wrb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2474..2479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Get1"
                     /gene_synonym="5530402J05Rik; C030018G21Rik; Chd5; Wrb"
                     /note="hexamer: AATAAA"
     polyA_site      2497
                     /gene="Get1"
                     /gene_synonym="5530402J05Rik; C030018G21Rik; Chd5; Wrb"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgcagg cgtaggcgag cgcggaggcg cggtcaccat ggcgctgtcg tagcggtgca
       61 ggtgcctggg atccagcatg agcgcgtccg agacggaccg ctgggcgtgg ctgctggtgt
      121 tgagcttcgt gttcgggtgt aacttgctgc gcatcctcct gccgtccctg tcctcgttta
      181 tttccagggt gctgcagaag gatgcagagc aggagtcaca gatgagggca gagatccagg
      241 gcatgaagca ggagctgtcc accgtcaaca tgatggacga gtttgccaga tacgccaggc
      301 tggaaaggaa gatcaacaag atgacggaca agctcaaaac gcacgtgaag gcacggacag
      361 ctcagttggc caagatcaag tggtttataa gtgttgcttt ctacatacta caagcagcgc
      421 tgatgatctc gctcatttgg aagtattact ccgtccctgt ggctgtggtg cccagcaagt
      481 ggatcacccc actagaccgc ctggtagcct ttcctactcg agtagcaggt ggaattggaa
      541 tcacctgttg gattttagtc tgtaacaaag ttgtggctat cgttctccac cctttcagct
      601 gaggggaagg ccagctacaa gtctttacaa aaggattctg atagggtaaa gagcggattg
      661 cacacaagtc cacagattct tgtgttttat gttttggaac atttgctttt gtgtgtcacc
      721 tgggattctt gttgaagtca ggattttcta cacccgccat tgagccagaa agaccagtta
      781 cggcactccc atatcgtctg atgtaggtct ggattcatac caactgggaa ccaccacgtg
      841 gcatctgctg atgcttgttt ctgggcatgg cttgggtctg ttgccagctg cagagtcaga
      901 cttgtaacaa ctccgttagt gctgttttaa ttttagaaaa acccacactt tcgtaccact
      961 actaaacctc ctttttatct cagttacaga aagtgacgca cactagtgat gtagctgtac
     1021 ttgtctcctg aaatgtcaca cataagtgtg tggaaagtat cgctgtatgt ctaagtttgt
     1081 tcatttttta tagtgcttcc tacatgtgtt catgagacga cgtgtatttt tatttaaagc
     1141 atttcaaatg aagtctgtct ttaaagcatt gggtgtttat gctgtgcgca gaatagggtt
     1201 aaacaaggtg cggtctgatc cagttcatct gagactcctt aggctcatga agttactagg
     1261 cagaaatctg ccaagtctgt ttttttttgt ttgttttgtt tttttgtttt tttttttttt
     1321 tttttgtttt gagacaaggt ctctcagtgt agctgcagct ctcctgaaat tatgtagacc
     1381 aggcttgtct caaacccaca gagatccacc tccctctatc tcccagatga taggattaaa
     1441 ggcgtatgcc gctactgttt ttgtatatgc cgtcaagact gtttttgaag cactttccct
     1501 agttacagta tttgccagtg ctagtgtgac tgtcccacca gccttacagc aggagctggg
     1561 ctcactgcct gcgctgcaag ctgcggtatt cgcccctggg gaaccatagc acagaaaagc
     1621 tccctgacag cactgcaggt ctctgcacag ctctggctgt cctggaatca ctatgtagac
     1681 caggctgacc tggaatttat aggaatcctc tcgtctctgc ctcatagctg ctgggattaa
     1741 aggcgtagca ctgggtttga aggatcatat ttatactcca gtgtttccta atgatctcct
     1801 aagtagctct ttgttttcct gactgtactg tgaacaggcc cagtgtgcgg cccttggatt
     1861 ggttgtagac cgagtgccac cagagcaggc ttgagagtcc attgatttaa actccgcaga
     1921 tgctgcagat agatccacgt ggcaccaaga ttacttggct gtatttgttg tgggcacaaa
     1981 cggaacatag tagtaggcat agccaacatt gccaggagga cctgcccact agctccagca
     2041 tgctcatcac gaaggaagca cgtggtctac acaagattat tttgggacct gaggaggttg
     2101 gctgcagaat ctgggttccc tctgggtatt cagccctcgg ggtgagggag ggtgtgcgct
     2161 ttcctctttt ttgcagtgag ccatagtctg caatggcgct ttttgcccac atcgtttagg
     2221 tagcctgggt cagcatccca aggccacttg gaagggcaat cagaagtgcc cagaacagat
     2281 gcctctcatg atttcagctg acctgaagga acaaatgact tagtgttccc atgtgtgtaa
     2341 tgtggatgtc agcgcttcca catgcataat gtatgtaaga ctgttagtgt tcccatgtgt
     2401 gtagtgtatg taacaccgca agtaggggac agctgtgttt ttatccccaa attgtatttg
     2461 tttattaatg ggtaataaac attgagttaa aaagggactg gg
//
