LOCUS       NM_026053               1124 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus gem nuclear organelle associated protein 6 (Gemin6),
            transcript variant 1, mRNA.
ACCESSION   NM_026053
VERSION     NM_026053.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1124)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1124)
  AUTHORS   Bizen,N., Bepari,A.K., Zhou,L., Abe,M., Sakimura,K., Ono,K. and
            Takebayashi,H.
  TITLE     Ddx20, an Olig2 binding factor, governs the survival of neural and
            oligodendrocyte progenitor cells via proper Mdm2 splicing and p53
            suppression
  JOURNAL   Cell Death Differ 29 (5), 1028-1041 (2022)
   PUBMED   34974536
REFERENCE   3  (bases 1 to 1124)
  AUTHORS   Carissimi,C., Saieva,L., Gabanella,F. and Pellizzoni,L.
  TITLE     Gemin8 is required for the architecture and function of the
            survival motor neuron complex
  JOURNAL   J Biol Chem 281 (48), 37009-37016 (2006)
   PUBMED   17023415
  REMARK    GeneRIF: Gemin8 has an essential role in the proper structural
            organization of the SMN complex and the involvement of the
            heteromeric subunit containing Gemin6, Gemin7, Gemin8, and Unrip in
            the recruitment of Sm proteins to the snRNP assembly pathway
REFERENCE   4  (bases 1 to 1124)
  AUTHORS   Gabanella,F., Carissimi,C., Usiello,A. and Pellizzoni,L.
  TITLE     The activity of the spinal muscular atrophy protein is regulated
            during development and cellular differentiation
  JOURNAL   Hum Mol Genet 14 (23), 3629-3642 (2005)
   PUBMED   16236758
REFERENCE   5  (bases 1 to 1124)
  AUTHORS   Pellizzoni,L., Baccon,J., Rappsilber,J., Mann,M. and Dreyfuss,G.
  TITLE     Purification of native survival of motor neurons complexes and
            identification of Gemin6 as a novel component
  JOURNAL   J Biol Chem 277 (9), 7540-7545 (2002)
   PUBMED   11748230
REFERENCE   6  (bases 1 to 1124)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132910.8.
            
            On Sep 16, 2017 this sequence version replaced NM_026053.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167920.1, AK013396.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               AC132910.8         114116-114335       c
            221-364             AC132910.8         113022-113165       c
            365-1124            AC132910.8         110289-111048       c
FEATURES             Location/Qualifiers
     source          1..1124
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 50.63 cM"
     gene            1..1124
                     /gene="Gemin6"
                     /gene_synonym="2610019B15Rik; 2810470M17Rik"
                     /note="gem nuclear organelle associated protein 6"
                     /db_xref="GeneID:67242"
                     /db_xref="MGI:MGI:1914492"
     exon            1..220
                     /gene="Gemin6"
                     /gene_synonym="2610019B15Rik; 2810470M17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            221..364
                     /gene="Gemin6"
                     /gene_synonym="2610019B15Rik; 2810470M17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..740
                     /gene="Gemin6"
                     /gene_synonym="2610019B15Rik; 2810470M17Rik"
                     /note="gemin-6"
                     /codon_start=1
                     /product="gem-associated protein 6"
                     /protein_id="NP_080329.1"
                     /db_xref="CCDS:CCDS28989.1"
                     /db_xref="GeneID:67242"
                     /db_xref="MGI:MGI:1914492"
                     /translation="MSEWMKKSPLEWEDYVYKEVRVIACEKEYKGWLLTTDPVSANIV
                     LVNFLEDGRLSVTGIMGHSVQTVETISEGDHRVREKLMHVFASGDCKGYSPEDLEEKR
                     TSLKKWLEKNHIPVTEQGDAQRTLCVAGVLTIDPPYAPENCSSSNEIILSRIQDLIQG
                     HLSASQ"
     exon            365..1124
                     /gene="Gemin6"
                     /gene_synonym="2610019B15Rik; 2810470M17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1090..1095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gemin6"
                     /gene_synonym="2610019B15Rik; 2810470M17Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1102
                     /gene="Gemin6"
                     /gene_synonym="2610019B15Rik; 2810470M17Rik"
                     /note="major polyA site"
ORIGIN      
        1 atgctgggct caggcgggcc gactcaagcc cgctcggcgg cgtgtgagct aagtagaaat
       61 atagccaggg tctctgcggc gtttccctga gtcgtgcaga gttctgggta tggcggcctc
      121 tggacaggac ctggtgttgg agctctagag cttcgctaac gggtcctcag cgctttacga
      181 gaaaattggc gcaaagcccg tggagagtca tctagaaaga atctgggcaa ctggtaacca
      241 tgagcgaatg gatgaagaaa agccccttag aatgggaaga ttacgtttat aaagaagtga
      301 gagtgatagc ctgtgagaag gagtataaag gatggcttct aaccacagat ccagtctctg
      361 ccaacattgt cctcgtaaac ttccttgaag atggcagatt gtctgtgact ggaatcatgg
      421 gccactctgt gcagactgtg gaaaccataa gtgaagggga ccacagagta cgcgagaagc
      481 tgatgcatgt gtttgcatct ggagactgta aaggatacag ccccgaggat ctggaagaga
      541 agaggaccag cctcaagaaa tggctggaga agaaccacat tcctgtcacc gagcaggggg
      601 atgcacaaag gactctctgt gtggctgggg ttctgactat agacccacca tacgctccag
      661 aaaactgcag cagctccaat gagatcattc tgtcccgaat tcaggatctt attcaaggac
      721 atctttcagc ttcccagtga gaggccaagc actgtgaaca tgctggcttc accgtttggt
      781 tttgtattca attcttccaa tgtaagttga ttatattaca agacatcaga agcacatgag
      841 ggttataggt gtgtgtgcgt attttaaggt tttgttcaga tcagatcaga tgagtagatc
      901 atgagtgctg ggttccttag gaattgaagg tacaagagca gtgcctctgt gaaaataaca
      961 cagggaagtc agatttgaaa ggagcttttc ttgtgtgtga tttaagataa attgcccttt
     1021 tttgtgagac aagaatacat tttgaatagg tataacaatg aaataaattt ataaatttca
     1081 atataagata ttaaagtaaa aatccgtttc gggttctttt gact
//
