LOCUS       NM_177367               3448 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus gem nuclear organelle associated protein 4 (Gemin4),
            mRNA.
ACCESSION   NM_177367
VERSION     NM_177367.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3448)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3448)
  AUTHORS   Bizen,N., Bepari,A.K., Zhou,L., Abe,M., Sakimura,K., Ono,K. and
            Takebayashi,H.
  TITLE     Ddx20, an Olig2 binding factor, governs the survival of neural and
            oligodendrocyte progenitor cells via proper Mdm2 splicing and p53
            suppression
  JOURNAL   Cell Death Differ 29 (5), 1028-1041 (2022)
   PUBMED   34974536
REFERENCE   3  (bases 1 to 3448)
  AUTHORS   Meier,I.D., Walker,M.P. and Matera,A.G.
  TITLE     Gemin4 is an essential gene in mice, and its overexpression in
            human cells causes relocalization of the SMN complex to the
            nucleoplasm
  JOURNAL   Biol Open 7 (2) (2018)
   PUBMED   29371219
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3448)
  AUTHORS   Gabanella,F., Carissimi,C., Usiello,A. and Pellizzoni,L.
  TITLE     The activity of the spinal muscular atrophy protein is regulated
            during development and cellular differentiation
  JOURNAL   Hum Mol Genet 14 (23), 3629-3642 (2005)
   PUBMED   16236758
REFERENCE   5  (bases 1 to 3448)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591129.24.
            
            On Nov 3, 2009 this sequence version replaced NM_177367.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031425.1, AK154061.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AL591129.24        178765-178859       c
            96-3448             AL591129.24        171858-175210       c
FEATURES             Location/Qualifiers
     source          1..3448
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.92 cM"
     gene            1..3448
                     /gene="Gemin4"
                     /gene_synonym="4932415L08Rik"
                     /note="gem nuclear organelle associated protein 4"
                     /db_xref="GeneID:276919"
                     /db_xref="MGI:MGI:2449313"
     exon            1..95
                     /gene="Gemin4"
                     /gene_synonym="4932415L08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..3262
                     /gene="Gemin4"
                     /gene_synonym="4932415L08Rik"
                     /codon_start=1
                     /product="gem-associated protein 4"
                     /protein_id="NP_796341.2"
                     /db_xref="CCDS:CCDS25061.1"
                     /db_xref="GeneID:276919"
                     /db_xref="MGI:MGI:2449313"
                     /translation="MDLGPLNICEEMTILHGGFLMAEQLFHPKALVQLTKSDWEHVGQ
                     PIVEALKEISSATAHSQPFAWKKKALIIIWTKVLQPSPVSPSDTDTRWQEDVFFSVGN
                     MIPTINHTVLFELLKSLEASGLFIQLLMALPTTIGRSELQSFLEHMTVDTSSKDVAFF
                     LDVWWEMMKHKGDQQDPLLSQFRTMAHKYLPSSDEFSHPPKRFKSDPDVGPTMPLLAM
                     LLNGLKQIQKRILSLGMKCCALANLADMLSVFALLEDDTQEVSATVYLDKLATVISVW
                     NSDTQNPYHRQALADKVKEAERDVSLTSLAKLPSETVFMGFELMYNLLQEWGAELQDM
                     LNSSQGTNYDTYRLCDSLTSFSQNLELYLDTTNMPKEEREVVSELAECVRDFLRKTSR
                     MLNDKGLEDITASIAMAIIEQKMDRHMEMCYIFASEKKWAFSDEWVACLVNNRSLFRE
                     PDLVLSLLETVMEVISSDRVIPQPQIKQVICLTLECYEDLSLPDKNKVLSGVLHYLGP
                     KGLSDRLSDYLEGFQEDLNTTFNQLAQSTSEQGLAKAVASVAHLVILNPEVVVKKMCS
                     LAVTNLGTHRFLAQILTAFPALKFTEEQGANPCTSFMVSCLKETVWTKFSTPKEEKQF
                     LELVSCLTNPVKPQGIPVAALLEPDEVLKEFVLPFLMLDMEEVGLSLKLFIQTLEANA
                     GLEEYWLQTCSPFPLLFSLCQLLDSFSKFWQLPREKRYLTLDSKDLVTHILELLCEIV
                     LANTETFSPDTWAKSLSWLHRKLDQLDWTVGLRLKNFFEGHFKCEVPATLFDICKLSE
                     AQWTSQVHEGYGPGTGLLAWMECCSVSSSISDQMLSLLVMDVGNPEEVRLFSKGFLVA
                     LVQVMPWCSPQEWQYLQQLTRKLLEKQLLHVPYSLEYIQFVPLLNLKPFAQELQLSVL
                     SLRVFQFLCSQSCCNWLPLDGWSHVVKLLCNSLTSVLDAVRLMQSVGPWAQGQEGDLT
                     QETLFVYTQMFCHVLHIMAMLPQEVCEPLYVLALEILTCYETLSKSNPSVSSLLQKVD
                     EQRFLKSIAKNISPEERRQTLLQKINNF"
     exon            96..3448
                     /gene="Gemin4"
                     /gene_synonym="4932415L08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3422..3427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gemin4"
                     /gene_synonym="4932415L08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3448
                     /gene="Gemin4"
                     /gene_synonym="4932415L08Rik"
                     /note="major polyA site"
ORIGIN      
        1 gccgcccttt gtgccgtggc gcgggcaacg cgttcgcggc cttggactag gaggggcggt
       61 ctagcccgcc gccagcgtcg ccgccatgga cctaggaccc ttgaatatct gtgaggagat
      121 gactattctg catgggggct tcttgatggc tgagcagctg ttccacccca aagccctggt
      181 acagttgacc aagtctgatt gggaacacgt gggacagccc attgtggagg ccttgaagga
      241 gatctcctca gccacagcac attcccagcc ctttgcctgg aagaagaaag cactgatcat
      301 catctggacc aaggttcttc agccctcccc tgtcagccct tctgacactg atactcggtg
      361 gcaggaagat gtattcttct ccgtgggcaa catgatccct accatcaacc acacagtcct
      421 ttttgagctg ctcaagtctc tggaagcttc tggactcttc attcagctgc taatggcctt
      481 gcctaccacc attggccgct cagaactaca gagcttcctg gagcacatga ctgttgacac
      541 atcttccaag gatgtggcct tcttcttaga tgtctggtgg gaaatgatga agcacaaggg
      601 cgaccagcag gaccccttgc tttcccagtt caggacgatg gcccataaat acttgccatc
      661 ctcagatgag ttttcccatc ctccaaagag gtttaagtct gacccagatg tgggtcccac
      721 catgcctctt ttggccatgt tgcttaacgg gctgaagcag atccaaaaga gaatcctgtc
      781 ccttggaatg aagtgctgtg ccttagctaa cttggctgac atgctgagtg tgtttgcact
      841 tctggaggat gacacccagg aggtgtcggc caccgtgtac ctagacaaac tagctacagt
      901 gatctctgtg tggaactcgg acacccagaa cccataccat cgacaggccc tggcagacaa
      961 ggtaaaggag gcagagcgag atgtgagtct cacctcactg gccaaactcc ccagcgagac
     1021 tgttttcatg gggtttgagc ttatgtacaa cctgctgcaa gagtggggtg cagaactgca
     1081 ggacatgctc aacagcagtc agggaacaaa ttatgacact taccggctgt gtgacagcct
     1141 gacttccttc agccagaact tggagctcta cctggatact accaacatgc ccaaggagga
     1201 gagggaggtg gtctcagaat tggctgagtg tgtcagggac ttcctgagga aaaccagcag
     1261 aatgctgaat gacaagggcc ttgaggacat cactgcctcc attgccatgg ccatcattga
     1321 gcagaagatg gaccggcaca tggaaatgtg ctacattttt gcttctgaga agaagtgggc
     1381 cttttcagac gagtgggttg cctgcctggt taacaacagg tctctcttca gagaaccaga
     1441 cttggtcttg agtctgctag aaacagtgat ggaagtcatc agctctgatc gggttatccc
     1501 ccagcctcag atcaagcagg taatctgctt gaccctggaa tgctatgaag acctctctct
     1561 tccagacaaa aataaagttc tttctggtgt cctgcattat ttggggccaa agggtctctc
     1621 agacaggttg tctgattact tggagggttt tcaggaagac ctcaacacga cgtttaacca
     1681 gctcgcacag agtacctctg aacagggcct ggctaaagct gtggcctccg tggcccacct
     1741 ggtgatcctg aacccagaag ttgtggtgaa gaagatgtgt agcctagctg tgaccaatct
     1801 tggcacacat aggttcttgg ctcagattct cactgccttc cctgctctga agttcacgga
     1861 agaacaaggg gcaaatccat gtaccagttt catggtgtct tgcctcaaag aaactgtctg
     1921 gaccaagttc tccacaccca aagaagagaa gcagtttctg gagctggtaa gctgcctgac
     1981 gaatcctgtg aagccacagg ggattccagt ggctgctctt ctggagccag atgaggtgct
     2041 caaggagttt gtcctgcctt tcttgatgtt ggacatggag gaggtgggcc tgagtctgaa
     2101 gctcttcatc cagaccctcg aagccaatgc aggcctggaa gagtattggc tgcagacctg
     2161 ctccccattc cctctgctct tcagcctgtg ccagctcctg gacagcttca gcaagttctg
     2221 gcagctcccc cgggagaagc gctacctcac gctggacagc aaggatcttg tgacccacat
     2281 tctggaactc ctctgtgaga tcgtgctagc caacacagaa accttctccc cagacacctg
     2341 ggccaagtcc ctgtcctggc tccaccgcaa attagaccag ctagattgga ctgtgggcct
     2401 gagactaaag aacttctttg aaggccactt caagtgtgag gtgccagcta ccctttttga
     2461 tatctgtaag ctctctgagg cccagtggac ctcacaggtc cacgaagggt atgggcctgg
     2521 cacgggcctt ctcgcctgga tggagtgctg ttcagtctcc agcagtatct ctgaccagat
     2581 gctttccctt ctggtgatgg atgtgggcaa tcctgaggag gtcagactgt ttagcaaggg
     2641 ctttctggtg gccctggtac aagtcatgcc ttggtgtagc ccccaggaat ggcagtacct
     2701 tcagcagctg accaggaagc tattggagaa acagcttctt catgtccctt acagtctaga
     2761 gtatattcag tttgttcccc tgctcaacct gaagcctttt gcccaggaac ttcagctctc
     2821 tgttctttct ttgagagtgt tccagtttct ctgcagccag agctgttgta actggcttcc
     2881 tttggacggt tggagccatg tggtcaaact cctctgtaac agtctgacca gtgtcctgga
     2941 tgcagtcagg ttgatgcagt cggtgggtcc ctgggcccaa ggacaagaag gggatcttac
     3001 tcaggaaacc ctgtttgtct atacccagat gttctgtcat gttctgcata tcatggccat
     3061 gctccctcag gaggtctgtg aacccctcta cgtgctggcc ttggaaatcc ttacctgcta
     3121 cgagactcta agcaaaagca acccttctgt cagctccttg ctccagaagg tagacgagca
     3181 gcgcttctta aagtctatcg ccaagaacat tagccctgag gagcggcgcc aaaccctgct
     3241 acaaaagatc aacaacttct gacctgttga gggcagaaca aaactatgcc tccgtccacc
     3301 gtggtgtttc tgcagggccc agagctaaga acaaacaaag ttataagaac gtacacagtg
     3361 aaaggagtac aagagcagtg taaagaaata gttttcttag atatttgtca catactactt
     3421 aaataaaatt ctcttgggtt taatctta
//
