LOCUS       NM_010276               2257 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus GTP binding protein overexpressed in skeletal muscle
            (Gem), mRNA.
ACCESSION   NM_010276
VERSION     NM_010276.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2257)
  AUTHORS   Matsuo,M., Seo,K., Taruno,A., Mizoro,Y., Yamaguchi,Y., Doi,M.,
            Nakao,R., Kori,H., Abe,T., Ohmori,H., Tominaga,K. and Okamura,H.
  TITLE     A light-induced small G-protein gem limits the circadian clock
            phase-shift magnitude by inhibiting voltage-dependent calcium
            channels
  JOURNAL   Cell Rep 39 (8), 110844 (2022)
   PUBMED   35613591
REFERENCE   2  (bases 1 to 2257)
  AUTHORS   Johnson,J.L., Ramadass,M., Rahman,F., Meneses-Salas,E.,
            Zgajnar,N.R., Carvalho Gontijo,R., Zhang,J., Kiosses,W.B.,
            Zhu,Y.P., Hedrick,C.C., Perego,M., Gunton,J.E., Pestonjamasp,K.,
            Napolitano,G. and Catz,S.D.
  TITLE     The atypical small GTPase GEM/Kir is a negative regulator of the
            NADPH oxidase and NETs production through macroautophagy
  JOURNAL   J Leukoc Biol 110 (4), 629-649 (2021)
   PUBMED   34085299
  REMARK    GeneRIF: The atypical small GTPase GEM/Kir is a negative regulator
            of the NADPH oxidase and NETs production through macroautophagy.
REFERENCE   3  (bases 1 to 2257)
  AUTHORS   Takahashi,H., Asahina,R., Fujioka,M., Matsui,T.K., Kato,S.,
            Mori,E., Hioki,H., Yamamoto,T., Kobayashi,K. and Tsuboi,A.
  TITLE     Ras-like Gem GTPase induced by Npas4 promotes activity-dependent
            neuronal tolerance for ischemic stroke
  JOURNAL   Proc Natl Acad Sci U S A 118 (32) (2021)
   PUBMED   34349016
  REMARK    GeneRIF: Ras-like Gem GTPase induced by Npas4 promotes
            activity-dependent neuronal tolerance for ischemic stroke.
REFERENCE   4  (bases 1 to 2257)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2257)
  AUTHORS   Gurdziel,K., Vogt,K.R., Walton,K.D., Schneider,G.K. and
            Gumucio,D.L.
  TITLE     Transcriptome of the inner circular smooth muscle of the developing
            mouse intestine: Evidence for regulation of visceral smooth muscle
            genes by the hedgehog target gene, cJun
  JOURNAL   Dev Dyn 245 (5), 614-626 (2016)
   PUBMED   26930384
REFERENCE   6  (bases 1 to 2257)
  AUTHORS   Downes,G.B., Gilbert,D.J., Copeland,N.G., Gautam,N. and
            Jenkins,N.A.
  TITLE     Chromosomal mapping of five mouse G protein gamma subunits
  JOURNAL   Genomics 57 (1), 173-176 (1999)
   PUBMED   10191100
REFERENCE   7  (bases 1 to 2257)
  AUTHORS   Fischer,R., Wei,Y., Anagli,J. and Berchtold,M.W.
  TITLE     Calmodulin binds to and inhibits GTP binding of the ras-like GTPase
            Kir/Gem
  JOURNAL   J Biol Chem 271 (41), 25067-25070 (1996)
   PUBMED   8810259
REFERENCE   8  (bases 1 to 2257)
  AUTHORS   Santoro,T., Maguire,J., McBride,O.W., Avraham,K.B., Copeland,N.G.,
            Jenkins,N.A. and Kelly,K.
  TITLE     Chromosomal organization and transcriptional regulation of human
            GEM and localization of the human and mouse GEM loci encoding an
            inducible Ras-like protein
  JOURNAL   Genomics 30 (3), 558-564 (1995)
   PUBMED   8825643
REFERENCE   9  (bases 1 to 2257)
  AUTHORS   Cohen,L., Mohr,R., Chen,Y.Y., Huang,M., Kato,R., Dorin,D.,
            Tamanoi,F., Goga,A., Afar,D., Rosenberg,N. et al.
  TITLE     Transcriptional activation of a ras-like gene (kir) by oncogenic
            tyrosine kinases
  JOURNAL   Proc Natl Acad Sci U S A 91 (26), 12448-12452 (1994)
   PUBMED   7809057
REFERENCE   10 (bases 1 to 2257)
  AUTHORS   Maguire,J., Santoro,T., Jensen,P., Siebenlist,U., Yewdell,J. and
            Kelly,K.
  TITLE     Gem: an induced, immediate early protein belonging to the Ras
            family
  JOURNAL   Science 265 (5169), 241-244 (1994)
   PUBMED   7912851
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158393.1, AK168401.1 and BY574090.1.
            
            On Oct 6, 2009 this sequence version replaced NM_010276.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157655.1, AK168401.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-794               AK158393.1         3-796
            795-2013            AK168401.1         796-2014
            2014-2144           AK158393.1         2016-2146
            2145-2210           BY574090.1         285-350
            2211-2257           AK158393.1         2210-2256
FEATURES             Location/Qualifiers
     source          1..2257
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 5.34 cM"
     gene            1..2257
                     /gene="Gem"
                     /note="GTP binding protein overexpressed in skeletal
                     muscle"
                     /db_xref="GeneID:14579"
                     /db_xref="MGI:MGI:99844"
     exon            1..120
                     /gene="Gem"
                     /inference="alignment:Splign:2.1.0"
     exon            121..457
                     /gene="Gem"
                     /inference="alignment:Splign:2.1.0"
     exon            458..534
                     /gene="Gem"
                     /inference="alignment:Splign:2.1.0"
     exon            535..739
                     /gene="Gem"
                     /inference="alignment:Splign:2.1.0"
     exon            740..2257
                     /gene="Gem"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1995..2000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gem"
                     /note="hexamer: AATAAA"
     polyA_site      2016
                     /gene="Gem"
ORIGIN      
        1 ggaggcggca ctgccagcgg acatcacaca gcctcggact gcggagcccg catcgcagac
       61 gtcaggcgtt gcagcaggcg gatcgacggc agacgcccac ccagcgccca gtgcagccaa
      121 gatcccgcaa tgactctgaa taatgtcacc atgcgccaag gcactgtggg catgcagcca
      181 cagcagcgct ggagtatccc tgctgatgcc aggcatctga tggtccagaa ggatccccac
      241 ccctgcaacc tccgaaaccg ccactctact gctccggaag agcactgccg gcggagctgg
      301 tcgtccgact ccacagactc ggtcatctct tctgagtctg gaaacaccta ctaccgagta
      361 gtgcttatag gggagcaagg agtgggcaag tccaccctgg ccaacatctt tgcaggtgtg
      421 catgacagca tggacagcga ctgtgaggtc ttgggagaag atacatatga gcgtaccctg
      481 gtcgttgacg gagagagtgc aaccattatc ctcctggaca tgtgggaaaa taagggggag
      541 aacgaatggc tccatgacca ctgcatgcag gtcggggatg cctatctgat cgtctactct
      601 atcacagacc gtgcaagctt cgagaaggca tctgagctga ggattcagct ccgcagggcc
      661 cggcagacag aagacattcc tataattttg gttggcaaca aaagcgactt agtgcggtgt
      721 cgagaagtgt ctgtgtcaga agggagagct tgtgctgtgg tgttcgactg caaattcatc
      781 gagacctctg cggctgtgca gcacaacgtg aaggaactgt ttgagggcat tgtgcgacag
      841 gtgcgcctgc gcagggacag caaggagaag aatgagagga ggctggccta ccagaagagg
      901 cgggagagca ttcccaggaa agccaggcgc ttctggggca aaattgtggc caaaaacaac
      961 aagaacatgg ctttcaagct caagtcaaaa tcctgccatg acctgtctgt gctctaggca
     1021 cccagtgtca cccagatgtc cccttggtgg acatcgttga aggctattgg gaccagtgat
     1081 ctatattaga ttggatacat aagcattgtt agacgcaact tcccctatgg cagatggaaa
     1141 ccaacaggtt agccttgtgg gcaaccaagt gcacgggcaa tgaatgagct ctgtcaagag
     1201 tcagtattta ttcataggaa aagcttgacc tgctacgtgg atgtctcaga ctcatttaag
     1261 acacgcttcg ggttcacatg agtttctctc tcctttggac agcagaatat ttttttcctc
     1321 agtgttgttc catgtgattt cgaggtcctt gggtcatata gaaatgtagg gaaatggtgg
     1381 tagtttattg gaaggagaag ggctcactgc atacttatat ccctgaaacg acatctttag
     1441 agctggcctc atcacagttg tgactatttc tgctccagtg aagagaattg ttagaatttg
     1501 ctggaaactg aggcttacta acagtttttg tttaaagacc acagagattt gtagacttag
     1561 gagctgatat gtgtactact tataggttca aaaaattgtt tacttatgtg tcgtagaagt
     1621 gtttattttg aggaaactat tttttttttt gccaaattct acttagtcaa atcatcttct
     1681 atgtcttgct gttttttaaa tcattaagct atcataaaat attttttaaa aaaatctcaa
     1741 ctatattgat aacctgcagt gcaaaatttt aaatatagtc ctgtttttcc cccaaaacat
     1801 aaacatgccc catcctttgg gttgcttctt gtatgccaca gctgaattat atttattatt
     1861 ttgcaaataa ccattttaat atttgataaa gcatatttat gagcatattt cttactgaga
     1921 aaatgtctgt tttattacct ttttatattt ttcaaagtat tcaagttttt acctatatgt
     1981 cttataataa aataaataaa atctttgaaa aggaaagcat tctgctatcc tccatgcata
     2041 agacaagtat gagtcttttc ctctggtgtt tagaacaagc tgtgtttcca agggacagac
     2101 agtttcccct gccattagct aagtccttag ctattttttt tttttttaag aatccccaag
     2161 ttctctcctt tggaatcatg gttcatagaa aagaagagtt atttctggct gattgaattg
     2221 ggaaggattt ggggtcaaat aaagctgagc tagaatc
//
