LOCUS       NM_024228               1081 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus glycerophosphodiester phosphodiesterase domain
            containing 3 (Gdpd3), mRNA.
ACCESSION   NM_024228
VERSION     NM_024228.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1081)
  AUTHORS   Li,W., Fan,Y., Lan,H., Li,X., Wu,Q. and Dong,R.
  TITLE     GDPD3 Deficiency Alleviates Neuropathic Pain and Reprograms
            Macrophagic Polarization Through PGE2 and PPARgamma Pathway
  JOURNAL   Neurochem Res 49 (8), 1980-1992 (2024)
   PUBMED   38769197
  REMARK    GeneRIF: GDPD3 Deficiency Alleviates Neuropathic Pain and
            Reprograms Macrophagic Polarization Through PGE2 and PPARgamma
            Pathway.
REFERENCE   2  (bases 1 to 1081)
  AUTHORS   Tserendavga,B., Ohshima,N., Fujita,C., Yuzawa,K., Ohshima,M.,
            Yanaka,N., Minamishima,Y.A. and Izumi,T.
  TITLE     Characterization of recombinant murine GDE4 and GDE7, enzymes
            producing lysophosphatidic acid and/or cyclic phosphatidic acid
  JOURNAL   J Biochem 170 (6), 713-727 (2022)
   PUBMED   34523685
  REMARK    GeneRIF: Characterization of recombinant murine GDE4 and GDE7,
            enzymes producing lysophosphatidic acid and/or cyclic phosphatidic
            acid.
            Erratum:[J Biochem. 2022 Mar 31;171(4):467. doi:
            10.1093/jb/mvab152.. PMID: 35137094]
REFERENCE   3  (bases 1 to 1081)
  AUTHORS   Naka,K., Ochiai,R., Matsubara,E., Kondo,C., Yang,K.M., Hoshii,T.,
            Araki,M., Araki,K., Sotomaru,Y., Sasaki,K., Mitani,K., Kim,D.W.,
            Ooshima,A. and Kim,S.J.
  TITLE     The lysophospholipase D enzyme Gdpd3 is required to maintain
            chronic myelogenous leukaemia stem cells
  JOURNAL   Nat Commun 11 (1), 4681 (2020)
   PUBMED   32943626
  REMARK    GeneRIF: The lysophospholipase D enzyme Gdpd3 is required to
            maintain chronic myelogenous leukaemia stem cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1081)
  AUTHORS   Wijayatunge,R., Holmstrom,S.R., Foley,S.B., Mgbemena,V.E.,
            Bhargava,V., Perez,G.L., McCrum,K. and Ross,T.S.
  TITLE     Deficiency of the Endocytic Protein Hip1 Leads to Decreased Gdpd3
            Expression, Low Phosphocholine, and Kypholordosis
  JOURNAL   Mol Cell Biol 38 (23), e00385-18 (2018)
   PUBMED   30224518
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1081)
  AUTHORS   Rahman,I.A., Tsuboi,K., Hussain,Z., Yamashita,R., Okamoto,Y.,
            Uyama,T., Yamazaki,N., Tanaka,T., Tokumura,A. and Ueda,N.
  TITLE     Calcium-dependent generation of N-acylethanolamines and
            lysophosphatidic acids by glycerophosphodiesterase GDE7
  JOURNAL   Biochim Biophys Acta 1861 (12 Pt A), 1881-1892 (2016)
   PUBMED   27637550
REFERENCE   6  (bases 1 to 1081)
  AUTHORS   Kaji,T., Hijikata,A., Ishige,A., Kitami,T., Watanabe,T., Ohara,O.,
            Yanaka,N., Okada,M., Shimoda,M., Taniguchi,M. and Takemori,T.
  TITLE     CD4 memory T cells develop and acquire functional competence by
            sequential cognate interactions and stepwise gene regulation
  JOURNAL   Int Immunol 28 (6), 267-282 (2016)
   PUBMED   26714588
  REMARK    GeneRIF: this study identified Gdpd3 as a candidate genetic marker
            for memory T cells
REFERENCE   7  (bases 1 to 1081)
  AUTHORS   Ohshima,N., Kudo,T., Yamashita,Y., Mariggio,S., Araki,M., Honda,A.,
            Nagano,T., Isaji,C., Kato,N., Corda,D., Izumi,T. and Yanaka,N.
  TITLE     New members of the mammalian glycerophosphodiester
            phosphodiesterase family: GDE4 and GDE7 produce lysophosphatidic
            acid by lysophospholipase D activity
  JOURNAL   J Biol Chem 290 (7), 4260-4271 (2015)
   PUBMED   25528375
REFERENCE   8  (bases 1 to 1081)
  AUTHORS   Yu,Z., Lin,K.K., Bhandari,A., Spencer,J.A., Xu,X., Wang,N., Lu,Z.,
            Gill,G.N., Roop,D.R., Wertz,P. and Andersen,B.
  TITLE     The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates
            epidermal terminal differentiation and interacts functionally with
            LMO4
  JOURNAL   Dev Biol 299 (1), 122-136 (2006)
   PUBMED   16949565
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY101331.1, AK003726.1 and AW045753.1.
            
            On Jul 18, 2006 this sequence version replaced NM_024228.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003726.1, BY703985.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BY101331.1         82-89
            9-1066              AK003726.1         11-1068
            1067-1081           AW045753.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..1081
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.25 cM"
     gene            1..1081
                     /gene="Gdpd3"
                     /gene_synonym="1110015E22Rik"
                     /note="glycerophosphodiester phosphodiesterase domain
                     containing 3"
                     /db_xref="GeneID:68616"
                     /db_xref="MGI:MGI:1915866"
     exon            1..196
                     /gene="Gdpd3"
                     /gene_synonym="1110015E22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1050
                     /gene="Gdpd3"
                     /gene_synonym="1110015E22Rik"
                     /note="glycerophosphodiester phosphodiesterase
                     domain-containing protein 3; glycerophosphodiester
                     phosphodiesterase 7"
                     /codon_start=1
                     /product="lysophospholipase D GDPD3"
                     /protein_id="NP_077190.2"
                     /db_xref="CCDS:CCDS40130.1"
                     /db_xref="GeneID:68616"
                     /db_xref="MGI:MGI:1915866"
                     /translation="MIPLLYFVLPTLGSYVMLSIFFLRRPHLLHTPRAPVFPIRLAAH
                     RGGSGERLENTMEAVENSMAQRADLLEFDCQLTRDGVVVVSHDKNLSRQSGLNKDVNT
                     LDFEELPLYKEELEIYFSPGHFAHGSDRHMISLEDVFQKFPRTPMCLEVKERNEELIH
                     KVANLTRRFDRNEITIWAAEKSSVMKRCRAANPEMPMAFTIWRSFWILLLYYLGLLPF
                     VSIPEKFFFCFLPTIINRTYFPFRCGWMNQLSATITKWIIMRKSLIRHLQDRGVQVLF
                     WCLNEESDFEVAFSLGANGVMTDYPTALRHYLDKQEEETQPPQPEALSCLSLKK"
     exon            197..239
                     /gene="Gdpd3"
                     /gene_synonym="1110015E22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            240..375
                     /gene="Gdpd3"
                     /gene_synonym="1110015E22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            376..421
                     /gene="Gdpd3"
                     /gene_synonym="1110015E22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            422..540
                     /gene="Gdpd3"
                     /gene_synonym="1110015E22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            541..630
                     /gene="Gdpd3"
                     /gene_synonym="1110015E22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            631..764
                     /gene="Gdpd3"
                     /gene_synonym="1110015E22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            765..824
                     /gene="Gdpd3"
                     /gene_synonym="1110015E22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            825..876
                     /gene="Gdpd3"
                     /gene_synonym="1110015E22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1068
                     /gene="Gdpd3"
                     /gene_synonym="1110015E22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1046..1051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gdpd3"
                     /gene_synonym="1110015E22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1068
                     /gene="Gdpd3"
                     /gene_synonym="1110015E22Rik"
                     /note="major polyA site"
ORIGIN      
        1 gccctttggg acagggaagg ctgtgctttt gacagaagcc tgccgtggag cgaggctatg
       61 atccctctcc tgtactttgt tctgcccacc ctgggcagtt acgtcatgct ctccatcttc
      121 ttcctgcgcc gacctcatct gctgcacacg ccgcgggctc ccgtcttccc tatccgcctg
      181 gctgcccacc gtggagggtc tggggagcga ctggagaaca ccatggaagc agtagagaat
      241 tccatggccc agcgagcaga tctcttggaa tttgactgcc agctcacccg ggatggcgtg
      301 gtggtagtgt cacacgacaa gaacctgtcc cgccagtcag gcctaaataa ggatgtgaac
      361 accctggact ttgaggagct gcccctctac aaggaagagt tggaaattta cttctcacca
      421 ggccattttg cccacgggtc agaccggcac atgattagtt tggaggatgt attccagaaa
      481 tttccaagga ctcccatgtg cttggaggtc aaagaaagaa atgaagaact cattcacaag
      541 gtagccaacc tgactaggcg ctttgaccgg aatgagatta ctatttgggc tgcagagaaa
      601 agctcagtca tgaagagatg cagggctgct aaccccgaga tgcccatggc cttcacgata
      661 tggcgatcgt tctggatact gctgctctac tacctggggc tgctcccttt tgtctccatc
      721 cctgagaagt ttttcttctg tttcctgccc accatcatca acaggactta cttcccattt
      781 cgctgtggat ggatgaacca actgtcggct accattacaa aatggatcat catgagaaaa
      841 agtctgatcc gacacttgca ggaccgaggg gtgcaggtgc tattttggtg ccttaatgaa
      901 gaatcggatt ttgaagtggc cttcagcttg ggagccaatg gcgtcatgac cgattacccc
      961 acagccctga gacactacct ggacaagcag gaagaagaga cccagcctcc tcagcctgag
     1021 gccctgtcct gtctttctct taaaaaataa atattttctt gtcagtaaaa aaaaaaaaaa
     1081 a
//
