LOCUS       NM_023608               2614 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus glycerophosphodiester phosphodiesterase domain
            containing 2 (Gdpd2), transcript variant 1, mRNA.
ACCESSION   NM_023608
VERSION     NM_023608.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2614)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2614)
  AUTHORS   Levy-Myers,R., Daudelin,D., Na,C.H. and Sockanathan,S.
  TITLE     An independent regulator of global release pathways in astrocytes
            generates a subtype of extracellular vesicles required for
            postsynaptic function
  JOURNAL   Sci Adv 9 (25), eadg2067 (2023)
   PUBMED   37352348
REFERENCE   3  (bases 1 to 2614)
  AUTHORS   Yue,Q., Li,K., Song,Z., Wang,Q., Wang,J., Li,X., Li,Y., Zhang,Q.,
            Zhu,Y. and Chen,H.
  TITLE     Nitric oxide hinders club cell proliferation through Gdpd2 during
            allergic airway inflammation
  JOURNAL   FEBS Open Bio 13 (6), 1041-1055 (2023)
   PUBMED   37078963
  REMARK    GeneRIF: Nitric oxide hinders club cell proliferation through Gdpd2
            during allergic airway inflammation.
REFERENCE   4  (bases 1 to 2614)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2614)
  AUTHORS   van Veen,M., Matas-Rico,E., van de Wetering,K., Leyton-Puig,D.,
            Kedziora,K.M., De Lorenzi,V., Stijf-Bultsma,Y., van den Broek,B.,
            Jalink,K., Sidenius,N., Perrakis,A. and Moolenaar,W.H.
  TITLE     Negative regulation of urokinase receptor activity by a
            GPI-specific phospholipase C in breast cancer cells
  JOURNAL   Elife 6, e23649 (2017)
   PUBMED   28849762
  REMARK    GeneRIF: The results establish GDE3 as a negative regulator of the
            uPAR signaling network and, furthermore, highlight GPI-anchor
            hydrolysis as a cell-intrinsic mechanism to alter cell behavior.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2614)
  AUTHORS   Corda,D., Mosca,M.G., Ohshima,N., Grauso,L., Yanaka,N. and
            Mariggio,S.
  TITLE     The emerging physiological roles of the glycerophosphodiesterase
            family
  JOURNAL   FEBS J 281 (4), 998-1016 (2014)
   PUBMED   24373430
  REMARK    Review article
REFERENCE   7  (bases 1 to 2614)
  AUTHORS   Corda,D., Kudo,T., Zizza,P., Iurisci,C., Kawai,E., Kato,N.,
            Yanaka,N. and Mariggio,S.
  TITLE     The developmentally regulated osteoblast phosphodiesterase GDE3 is
            glycerophosphoinositol-specific and modulates cell growth
  JOURNAL   J Biol Chem 284 (37), 24848-24856 (2009)
   PUBMED   19596859
  REMARK    GeneRIF: GDE3 substrate GroPIns is a candidate mediator for
            osteoblast proliferation
REFERENCE   8  (bases 1 to 2614)
  AUTHORS   Yanaka,N.
  TITLE     Mammalian glycerophosphodiester phosphodiesterases
  JOURNAL   Biosci Biotechnol Biochem 71 (8), 1811-1818 (2007)
   PUBMED   17690467
  REMARK    Review article
REFERENCE   9  (bases 1 to 2614)
  AUTHORS   Nogusa,Y., Fujioka,Y., Komatsu,R., Kato,N. and Yanaka,N.
  TITLE     Isolation and characterization of two serpentine membrane proteins
            containing glycerophosphodiester phosphodiesterase, GDE2 and GDE6
  JOURNAL   Gene 337, 173-179 (2004)
   PUBMED   15276213
REFERENCE   10 (bases 1 to 2614)
  AUTHORS   Yanaka,N., Imai,Y., Kawai,E., Akatsuka,H., Wakimoto,K., Nogusa,Y.,
            Kato,N., Chiba,H., Kotani,E., Omori,K. and Sakurai,N.
  TITLE     Novel membrane protein containing glycerophosphodiester
            phosphodiesterase motif is transiently expressed during osteoblast
            differentiation
  JOURNAL   J Biol Chem 278 (44), 43595-43602 (2003)
   PUBMED   12933806
  REMARK    GeneRIF: GDE3 is a novel seven-transmembrane protein with a
            GP-PDE-like extracellular motif expressed during osteoblast
            differentiation that accelerates the program of osteoblast
            differentiation and is involved in morphological change of cells
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX005480.12, BB844010.1,
            AK018634.1 and BE948924.1.
            
            On Apr 8, 2015 this sequence version replaced NM_023608.3.
            
            Summary: This gene encodes a member of the glycerophosphodiester
            phosphodiesterase enzyme family. The encoded protein hydrolyzes
            glycerophosphoinositol to produce inositol 1-phosphate and
            glycerol. Overexpression of this gene is associated with
            activity-dependent actin cytoskeleton disorganization. The encoded
            protein may negatively regulate growth rate and induce
            differentiation of osteoblasts. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038274.1, AB048364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                BX005480.12        46648-46724
            78-329              BB844010.1         2-253
            330-2588            AK018634.1         3-2261
            2589-2614           BE948924.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..2614
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 43.72 cM"
     gene            1..2614
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /note="glycerophosphodiester phosphodiesterase domain
                     containing 2"
                     /db_xref="GeneID:71584"
                     /db_xref="MGI:MGI:1918834"
     exon            1..349
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /inference="alignment:Splign:2.1.0"
     exon            350..463
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..1978
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /EC_number="3.1.4.43"
                     /note="osteoblast differentiation promoting factor;
                     glycerophosphodiester phosphodiesterase 3"
                     /codon_start=1
                     /product="glycerophosphoinositol inositolphosphodiesterase
                     GDPD2"
                     /protein_id="NP_076097.1"
                     /db_xref="CCDS:CCDS30306.1"
                     /db_xref="GeneID:71584"
                     /db_xref="MGI:MGI:1918834"
                     /translation="MADSPGCCSIWARCLHCLYSCHWRKYPKQKMQTSKCDCIWFGLL
                     FLTFLLSLGWLYIGLILLNDLHNFNEFLFRHWGHWMDWSLIVLLVVSLLVTYASLLLL
                     LGLLLQLCGQPLHLHSLHKVLLLLIVLLVAAGLVGLDIQWRQEWHSLRLSLQATAPFL
                     HIGAVAGITLLAWPVADTFYRIHPRGPKVLLLLLFFGVTLVIYLMPLLFISSPCIMKL
                     RDLPPKPGLVGHRGAPMLAPENTLMSLRKTAECGAAVFETDVMVSSDGVPFLMHDERL
                     SRTTNVASVFPERISAHSSDFSWAELQRLNAGTWFLERQPFWGAKKLSGSDRKEAENQ
                     TIPALEELLKEAAALNLSIMFDLRRPPRNHTYYDTFVNQTLEAVLSANVSQAMVLWLP
                     DEDRANVQQRAPRMRQIYGHQGGNWTERPQFLNLPYQDLPALDIKALHQDNISVNLFV
                     VNKPWLFSLLWCAGVDSVTTNACQLLQQMQNPLWLLPPQKYLMIWVITDCASILLLLS
                     IFLLRGGCAKRNRTGLETAVLLTKINNFASE"
     exon            464..567
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /inference="alignment:Splign:2.1.0"
     exon            568..661
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /inference="alignment:Splign:2.1.0"
     exon            662..721
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /inference="alignment:Splign:2.1.0"
     exon            722..820
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /inference="alignment:Splign:2.1.0"
     exon            821..914
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1063
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1146
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1297
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1519
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1668
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1816
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1899
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..1925
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2597
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2572..2577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /note="hexamer: AATGAA"
     polyA_site      2591
                     /gene="Gdpd2"
                     /gene_synonym="9130017L10Rik; Gde3; Obdpf"
                     /note="major polyA site"
ORIGIN      
        1 aagccctcag gcagtgactg ggaggggaac aggaggaggg acagagggat ggggaaggct
       61 gcacaaagga attcctcaca ccaagccccc tgactgccag ctccagagag taaagaagcc
      121 gacctcctct ccagctagct cactcgctca tcttcccacc atgactgtgc tcgagccata
      181 gcgcctctcc cggccttcca agaggaccca cacttcttcc tgtaggtggc aacagtgaca
      241 cctgtttgac cagtgaggct gagccaggga ctgcaagagg gaggaggcag acaactcgga
      301 gaggagctgg gaggcagagc tgcgggcttg cttgctcact gtgtaaaagg ccttaaccat
      361 ggcagattcc cccggctgct gctccatctg ggcccgctgc ctccactgcc tgtacagctg
      421 ccactggagg aaatatccta aacagaagat gcaaaccagc aagtgcgact gtatctggtt
      481 tggcctgctc ttcctcacct tcctcctgtc cctgggatgg ctgtacatcg ggctcatcct
      541 tctcaatgat ctgcacaact tcaatgaatt cctgttccgc cattggggac actggatgga
      601 ctggtccctg atagtcctgc tggtcgtctc tctcctggtc acatatgcat ccttgctatt
      661 gctcctgggc ctgctcctgc aactctgtgg acagcctctg catcttcaca gtctccacaa
      721 ggtgctgctg ctcctcattg tacttctagt ggccgcggga ctggtgggcc tggatatcca
      781 atggcggcag gagtggcata gtttacgact gtcactgcag gccacagccc cattccttca
      841 cattggagca gttgctggaa tcaccttgtt ggcctggcct gtggctgata ccttctaccg
      901 catccaccca agaggcccca aggttctgct actgttgcta ttttttggag tcactctggt
      961 catctacctg atgccgctgc tgttcatctc ttccccctgc atcatgaaac tcagagattt
     1021 accccccaag cctgggctgg tgggacaccg aggggccccc atgctggccc ctgagaatac
     1081 cctgatgtcc ctgaggaaga cagctgaatg tggagcggct gtgtttgaga cagatgtgat
     1141 ggtcagctct gacggagtcc cctttctcat gcatgatgag cgactgagca ggactaccaa
     1201 tgtagcctct gtgtttccag agcgaatctc agcccacagc agtgacttct cctgggctga
     1261 actgcagaga ctcaatgctg gaacctggtt cctagagagg caacctttct ggggggccaa
     1321 aaagctgtca ggctctgatc ggaaggaggc tgagaatcag accataccag cattagaaga
     1381 actactgaag gaagcagcag ctctcaacct ttccatcatg tttgacttgc gccgaccccc
     1441 aagaaaccac acatactatg atacttttgt gaatcagaca ctggaggctg tgttgagtgc
     1501 aaacgtgtcc caagctatgg ttctttggct cccagatgaa gaccgtgcta acgtgcagca
     1561 acgcgccccc agaatgcgcc agatatatgg acatcaggga ggcaattgga ctgagaggcc
     1621 ccagtttctc aacctcccct atcaagacct gccagcattg gatatcaagg ccctgcacca
     1681 ggataatatc tcagtgaacc tgtttgtagt gaacaagccc tggctcttct ccctgctctg
     1741 gtgtgcaggg gtggattctg tcaccaccaa tgcctgccag ctgctgcaac agatgcagaa
     1801 ccccctctgg cttcttcccc ctcaaaaata cttaatgatt tgggtgatca ccgactgtgc
     1861 ctccattctg ctgcttttga gtatcttcct cctccgaggg ggatgtgcta agagaaacag
     1921 aacaggctta gaaacagcag tgctactgac caagatcaac aatttcgcct ctgagtgaat
     1981 gccgggccca ggccgccacc agctgctgtc taaggcctgt gtgcactgtt caaagggaag
     2041 gacaggagct gaagtggaat gtcctagaat caaatgtttg gaggagggag cattgctaac
     2101 agaagatttt gaactcagag ggccctctgt ccagatggtg ggcatgtctc aagctgccat
     2161 ggaatttgct gcctttggtg tttgacatga attagtcgga aagacagtga ctgacaagaa
     2221 gttactccca aaatgaaatt aaagcaagga agtgagagag attgccaaga taatgcatta
     2281 ggcttgtgtg cacatgtact tggatagaag aagcagggtg tgtcagggtg ggatagctca
     2341 gaatgatgac tgaaggaaat ttggccacaa tggcctttcc ggaagaactc ttaagatgct
     2401 gaagacagtc cacactccat gccttctctt ctcaccctca cacttcatct tcttttctgc
     2461 ctacaggctg ggagtgaaaa agctcattta gcaatataat attgtgtcta tggtaggttt
     2521 ttgttgtgag caatgaatgg ttcctgtatc ttgcctgtta atctgttatt caatgaattt
     2581 ttaatttgtc atttggtaaa aaaaaaaaaa aaaa
//
