LOCUS       NM_001301357            3449 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus glial cell line derived neurotrophic factor (Gdnf),
            transcript variant 4, mRNA.
ACCESSION   NM_001301357
VERSION     NM_001301357.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3449)
  AUTHORS   Franks,N.E. and Allen,B.L.
  TITLE     Hedgehog-dependent and hedgehog-independent roles for growth arrest
            specific 1 in mammalian kidney morphogenesis
  JOURNAL   Development 151 (24) (2024)
   PUBMED   39629522
REFERENCE   2  (bases 1 to 3449)
  AUTHORS   Lemmetyinen,T.T., Viitala,E.W., Wartiovaara,L., Paivinen,P.,
            Virtanen,H.T., Pentinmikko,N., Katajisto,P., Makela,T.P.,
            Wang,T.C., Andressoo,J.O. and Ollila,S.
  TITLE     Mesenchymal GDNF promotes intestinal enterochromaffin cell
            differentiation
  JOURNAL   iScience 27 (12), 111246 (2024)
   PUBMED   39634560
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3449)
  AUTHORS   Yoo,K., Jo,Y.W., Yoo,T., Hann,S.H., Park,I., Kim,Y.E., Kim,Y.L.,
            Rhee,J., Song,I.W., Kim,J.H., Baek,D. and Kong,Y.Y.
  TITLE     Muscle-resident mesenchymal progenitors sense and repair peripheral
            nerve injury via the GDNF-BDNF axis
  JOURNAL   Elife 13, 97662 (2024)
   PUBMED   39324575
  REMARK    GeneRIF: Muscle-resident mesenchymal progenitors sense and repair
            peripheral nerve injury via the GDNF-BDNF axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3449)
  AUTHORS   Virtanen,H.T., Choopanian,P., Porokuokka,L.L., Forsgard,R.,
            Garton,D.R., Olfat,S., Korpela,R., Mirzaie,M. and Andressoo,J.O.
  TITLE     Interindividual Variation in Gut Nitrergic Neuron Density Is
            Regulated By GDNF Levels and ETV1
  JOURNAL   Cell Mol Gastroenterol Hepatol 18 (6), 101405 (2024)
   PUBMED   39299667
REFERENCE   5  (bases 1 to 3449)
  AUTHORS   Tanaka,M., Ito,S. and Kiuchi,K.
  TITLE     The 5'-untranslated region of the mouse glial cell line-derived
            neurotrophic factor gene regulates expression at both the
            transcriptional and translational levels
  JOURNAL   Brain Res Mol Brain Res 91 (1-2), 81-95 (2001)
   PUBMED   11457495
REFERENCE   6  (bases 1 to 3449)
  AUTHORS   Tanaka,M., Ito,S. and Kiuchi,K.
  TITLE     Novel alternative promoters of mouse glial cell line-derived
            neurotrophic factor gene
  JOURNAL   Biochim Biophys Acta 1494 (1-2), 63-74 (2000)
   PUBMED   11072069
REFERENCE   7  (bases 1 to 3449)
  AUTHORS   Matsushita,N., Fujita,Y., Tanaka,M., Nagatsu,T. and Kiuchi,K.
  TITLE     Cloning and structural organization of the gene encoding the mouse
            glial cell line-derived neurotrophic factor, GDNF
  JOURNAL   Gene 203 (2), 149-157 (1997)
   PUBMED   9426245
REFERENCE   8  (bases 1 to 3449)
  AUTHORS   Sanchez,M.P., Silos-Santiago,I., Frisen,J., He,B., Lira,S.A. and
            Barbacid,M.
  TITLE     Renal agenesis and the absence of enteric neurons in mice lacking
            GDNF
  JOURNAL   Nature 382 (6586), 70-73 (1996)
   PUBMED   8657306
REFERENCE   9  (bases 1 to 3449)
  AUTHORS   Watabe,K., Fukuda,T., Tanaka,J., Honda,H., Toyohara,K. and Sakai,O.
  TITLE     Spontaneously immortalized adult mouse Schwann cells secrete
            autocrine and paracrine growth-promoting activities
  JOURNAL   J Neurosci Res 41 (2), 279-290 (1995)
   PUBMED   7650763
REFERENCE   10 (bases 1 to 3449)
  AUTHORS   Lin,L.F., Doherty,D.H., Lile,J.D., Bektesh,S. and Collins,F.
  TITLE     GDNF: a glial cell line-derived neurotrophic factor for midbrain
            dopaminergic neurons
  JOURNAL   Science 260 (5111), 1130-1132 (1993)
   PUBMED   8493557
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC130656.11.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. The recombinant form of this protein, a
            highly conserved neurotrophic factor, was shown to promote the
            survival and differentiation of dopaminergic neurons in culture,
            and was able to prevent apoptosis of motor neurons induced by
            axotomy. This protein is a ligand for the product of the RET
            (rearranged during transfection) protooncogene. Homozygous knockout
            mice for this gene exhibit defects in kidney development and
            neonatal death. This gene encodes multiple protein isoforms that
            may undergo similar proteolytic processing. [provided by RefSeq,
            Aug 2016].
            
            Transcript Variant: This variant (4) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The resulting
            isoform (4) has a shorter N-terminus, compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D49921.1, SRR12282455.34652520.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               AC130656.11        78511-78726
            217-3449            AC130656.11        97309-100541
FEATURES             Location/Qualifiers
     source          1..3449
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 3.8 cM"
     gene            1..3449
                     /gene="Gdnf"
                     /gene_synonym="ATF"
                     /note="glial cell line derived neurotrophic factor"
                     /db_xref="GeneID:14573"
                     /db_xref="MGI:MGI:107430"
     exon            1..216
                     /gene="Gdnf"
                     /gene_synonym="ATF"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..701
                     /gene="Gdnf"
                     /gene_synonym="ATF"
                     /note="isoform 4 preproprotein is encoded by transcript
                     variant 4; neurotrophic factor; astrocyte-derived trophic
                     factor"
                     /codon_start=1
                     /product="glial cell line-derived neurotrophic factor
                     isoform 4 preproprotein"
                     /protein_id="NP_001288286.1"
                     /db_xref="GeneID:14573"
                     /db_xref="MGI:MGI:107430"
                     /translation="MKLWDVVAVCLVLLHTASAFPLPAGKRLLEAPAEDHSLGHRRVP
                     FALTSDSNMPEDYPDQFDDVMDFIQATIKRLKRSPDKQAAALPRRERNRQAAAASPEN
                     SRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCESAETMYDKIL
                     KNLSRSRRLTSDKVGQACCRPVAFDDDLSFLDDNLVYHILRKHSAKRCGCI"
     exon            217..3449
                     /gene="Gdnf"
                     /gene_synonym="ATF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3427..3432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gdnf"
                     /gene_synonym="ATF"
                     /note="hexamer: AATAAA"
     polyA_site      3448
                     /gene="Gdnf"
                     /gene_synonym="ATF"
                     /note="major polyA site"
ORIGIN      
        1 gcctggtgcg gttctcttcc ccgctgcccg cccgcgcagg tgccgccgcc ggacgggact
       61 ctaagatgaa gttatgggat gtcgtggctg tctgcctggt gttgctccac accgcgtctg
      121 ccttcccgct gcccgccggt aagaggcttc tcgaagcgcc cgctgaagac cactccctcg
      181 gccaccgccg cgtgcccttc gcgctgacca gtgactccaa tatgcctgaa gattatcctg
      241 accagtttga tgacgtcatg gattttattc aagccaccat taaaagactg aaaaggtcac
      301 cagataaaca agcggcagcg cttcctcgaa gagagaggaa tcggcaggct gcagctgcca
      361 gcccagagaa ttccagaggg aaaggtcgca gaggccagag gggcaaaaat cgggggtgcg
      421 ttttaactgc catacactta aatgtcactg acttgggttt gggctatgaa accaaggagg
      481 aactgatctt tcgatattgc agcggttcct gtgaatcggc cgagacaatg tatgacaaaa
      541 tactaaaaaa cctgtctcgg agtagaaggc taacaagtga caaagtaggc caggcatgtt
      601 gcaggccggt cgccttcgac gacgacctgt cgtttttaga tgacaacctg gtttaccata
      661 ttctaagaaa gcattccgct aaacggtgtg gatgtatctg accccggctc cagagactgc
      721 tgtgtattgc attcctgcta cagtgcgaag aaagggacca aggttcccag gaaatgtttg
      781 cccagagtgg aagataagga ccaagatggc ggaggcagag gcagaagaag agaaaaagaa
      841 ggaggaaggt agccaccgtg ggagcctggt ggaagaaggc ccagctacag aaaactggat
      901 aggagtgaga acagccgtct gagcacttca gggtggcagc tgatgtcacc agaagctcag
      961 ggctggtgtc cttacttagc tgttgccagt gtttatctga tacagtccat ggtcaccgat
     1021 ggcggtccga gtcgtggatg catgcaaaga accaagccag tgtatctcct gtggtttgtt
     1081 ttcacgtgtt tgaagacgcc agggaaatgt gacgattccg gtgtcacctc ttgtcactac
     1141 attttactgc tgaaaataag aaagatgtat tttcctgtca ctcaatggat tcataccctg
     1201 gaaaggaaag ggggtgggga ggacaaaggc agagacgata aaaagatgac aacctttgaa
     1261 tttgaaaacc ggggcctgag gtctattaca tccagcattt tgggggacgc ttggtggttg
     1321 attctggaca cagagtgtgg gggtatggag aagttggcta ggaacccaaa aaaggctgtc
     1381 ctcatactta gaaacaaacc tggaggcatc tccttcgtgc cctcagaaac aggaagcaag
     1441 ttgtggtttt cggcagcatt ctcataggag agccaatggg gaaagccccc agctgccccg
     1501 gccagggaga ccccggggcc tgttggttta caaagacgga tgttacatac acagctccgt
     1561 tcatgcgtgg tcaccagtga ccacagaagc tcctcgatgc aatgcatctg tttcaaatac
     1621 agagatatag agaagatatt tattgagatt ttaagttatt attatttatt accattcact
     1681 aatgaatatc ttttttcttc ccttatttat taaagtctct tttcaaaggt gccaaagtat
     1741 atgtgctcac aaaatacaaa ggtgacagag gaaatattaa cattgagaac aagggtccat
     1801 tctcttcaga gtataagagg gtttttgcta ggcaaaaaat cacttacttt ataaggcagt
     1861 ccttcactaa ctgccacaga tttcagcatt tccctccccc tctttctgtg gacaggatct
     1921 cctgtagcct aggctgacct tgaacttact gcttggtcaa ggacgacctt ggccttctga
     1981 tcctctgact tcctgtggtc ttggcatggc agacatcaat cacaccgtat ccacaggact
     2041 aagtatagaa ttcagggctt catccatgcc aggcaactgt aggtaccaac tgggttacac
     2101 ccagcccctg ctttctatct gctaaaggaa agggtcagga gggccatctc agctccaccc
     2161 cctcactggg agtaccagtg ggactgccac ctgtttgcat ctcctcttct atccatctga
     2221 gcagcaaggc cccagctcca ctgcccattg agttcaactc tttttccccc ttcatcatgg
     2281 gcaatatcat aaccacgcat tcagaaggct gaactgccct tggaagccct gaacatattg
     2341 tcacctgaaa gtgcaatgaa ggcccctgac aggcagccag ggtttaacag ccccctcacc
     2401 cccccgggca ggtggtacct cttcctctat ccttgcccac ctgcttcgtc cctatggtta
     2461 cacagacagg agaacatagg ggaactgtgc agggagaggc catctgcctt gtcctttgcc
     2521 agggctcagt tgtcacctgg gctcaacttt tgctaccccc tcaaacccaa tggattccaa
     2581 ggagaaagat ggacaggaag agacatctga ctggccatag aacaaagaag aggccctccc
     2641 tcattgtttg gagggaagaa gcagagggtg ggaatggcaa ctctccctgc accccataat
     2701 gtccttgtct ggcagccaac aaacaggtca tgccttgagt cctatgttag agccttgagt
     2761 cctatgttac agatttcata aatggaattt ttatgtagaa gttaatgtat cactcccttt
     2821 gtggctgcta tcccccgccc ccagagtagg acagatagat ctaaaataat aaatgaccaa
     2881 ttaattggcc tctctcgaat agtcatgtca aattttcaaa gtaaccaaga ggtaaaagtt
     2941 actaggtatc ctttcccctt ccgtggccct aaagacccac gtttcgcatg gttccacacc
     3001 ctctgcagga ctgggaagtg gagctacgta tgcgctgctc tctccgctcc tcctgctcaa
     3061 aattgtgaca acctcagctg cccagcacat ttcagatgtc gttccagacc ctctgttcac
     3121 tccagagaat cctgaaagat gtggtagctg atgctcccag gtccagacac agcctctagc
     3181 tcttggggga atccctggag aactcagcat ctcgagcagg ttcgaatggg agcaggctgc
     3241 cccacccagt ccgcagcagg gtaaagtttg cgacggttct ttactgttgt gatcagcatc
     3301 tgccccagta aagagcacac ttctttggaa gttctgacct ctctgatgtc tcggtcgttt
     3361 gtgttataca accaaagttc tctacaaact ttatttttgt acaatatcat tttgtaactt
     3421 tttacaaata aaagctcatt tctattgct
//
