LOCUS       NM_008112               2681 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus GDP dissociation inhibitor 2 (Gdi2), mRNA.
ACCESSION   NM_008112 XM_885801 XM_896411 XM_904479 XM_918847
VERSION     NM_008112.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2681)
  AUTHORS   Wang,M., He,X., Li,J., Han,D., You,P., Yu,H., Wang,L. and Su,B.
  TITLE     GDI2 deletion alleviates neurodegeneration and memory loss in the
            5xFAD mice model of Alzheimer's disease
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (4), 167093 (2024)
   PUBMED   38382624
  REMARK    GeneRIF: GDI2 deletion alleviates neurodegeneration and memory loss
            in the 5xFAD mice model of Alzheimer's disease.
REFERENCE   2  (bases 1 to 2681)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2681)
  AUTHORS   Wu,Y., Yang,D. and Chen,G.Y.
  TITLE     Targeted disruption of Gdi2 causes early embryonic lethality
  JOURNAL   Placenta 126, 17-25 (2022)
   PUBMED   35689892
  REMARK    GeneRIF: Targeted disruption of Gdi2 causes early embryonic
            lethality.
REFERENCE   4  (bases 1 to 2681)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 2681)
  AUTHORS   Ohshima,J., Sasai,M., Liu,J., Yamashita,K., Ma,J.S., Lee,Y.,
            Bando,H., Howard,J.C., Ebisu,S., Hayashi,M., Takeda,K.,
            Standley,D.M., Frickel,E.M. and Yamamoto,M.
  TITLE     RabGDIalpha is a negative regulator of interferon-gamma-inducible
            GTPase-dependent cell-autonomous immunity to Toxoplasma gondii
  JOURNAL   Proc Natl Acad Sci U S A 112 (33), E4581-E4590 (2015)
   PUBMED   26240314
REFERENCE   6  (bases 1 to 2681)
  AUTHORS   Nakanishi,H. and Takai,Y.
  TITLE     [Regulatory mechanism of neurotransmitter release by
            low-molecular-weight G protein, Rab3A and the regulatory proteins]
  JOURNAL   Masui 50 Suppl, S51-S55 (2001)
   PUBMED   11871104
  REMARK    GeneRIF: role in regulatory mechanism of neurotransmitter release
            Review article
REFERENCE   7  (bases 1 to 2681)
  AUTHORS   Bassett,D.E. Jr., Boguski,M.S., Spencer,F., Reeves,R., Kim,S.,
            Weaver,T. and Hieter,P.
  TITLE     Genome cross-referencing and XREFdb: implications for the
            identification and analysis of genes mutated in human disease
  JOURNAL   Nat Genet 15 (4), 339-344 (1997)
   PUBMED   9090377
REFERENCE   8  (bases 1 to 2681)
  AUTHORS   Janoueix-Lerosey,I., Jollivet,F., Camonis,J., Marche,P.N. and
            Goud,B.
  TITLE     Two-hybrid system screen with the small GTP-binding protein Rab6.
            Identification of a novel mouse GDP dissociation inhibitor isoform
            and two other potential partners of Rab6
  JOURNAL   J Biol Chem 270 (24), 14801-14808 (1995)
   PUBMED   7782346
REFERENCE   9  (bases 1 to 2681)
  AUTHORS   Bachner,D., Sedlacek,Z., Korn,B., Hameister,H. and Poustka,A.
  TITLE     Expression patterns of two human genes coding for different rab
            GDP-dissociation inhibitors (GDIs), extremely conserved proteins
            involved in cellular transport
  JOURNAL   Hum Mol Genet 4 (4), 701-708 (1995)
   PUBMED   7543319
REFERENCE   10 (bases 1 to 2681)
  AUTHORS   Shisheva,A., Sudhof,T.C. and Czech,M.P.
  TITLE     Cloning, characterization, and expression of a novel GDP
            dissociation inhibitor isoform from skeletal muscle
  JOURNAL   Mol Cell Biol 14 (5), 3459-3468 (1994)
   PUBMED   7513052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY072982.1, AK143681.1, AK083063.1 and AK163431.1.
            
            On Oct 13, 2006 this sequence version replaced NM_008112.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078144.1, AK143633.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BY072982.1         14-35
            23-2240             AK143681.1         2-2219
            2241-2628           AK083063.1         2183-2570
            2629-2681           AK163431.1         322-374
FEATURES             Location/Qualifiers
     source          1..2681
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 1.98 cM"
     gene            1..2681
                     /gene="Gdi2"
                     /gene_synonym="GDI-B; Gdi3; GDIB"
                     /note="GDP dissociation inhibitor 2"
                     /db_xref="GeneID:14569"
                     /db_xref="MGI:MGI:99845"
     exon            1..269
                     /gene="Gdi2"
                     /gene_synonym="GDI-B; Gdi3; GDIB"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1562
                     /gene="Gdi2"
                     /gene_synonym="GDI-B; Gdi3; GDIB"
                     /note="guanosine diphosphate (GDP) dissociation inhibitor
                     3; RAB GDP dissociation inhibitor beta-2; GDI-2; GDI-3;
                     rab GDI beta; guanosine diphosphate dissociation inhibitor
                     2; guanosine diphosphate (GDP) dissociation inhibitor 2"
                     /codon_start=1
                     /product="rab GDP dissociation inhibitor beta"
                     /protein_id="NP_032138.3"
                     /db_xref="CCDS:CCDS36581.1"
                     /db_xref="GeneID:14569"
                     /db_xref="MGI:MGI:99845"
                     /translation="MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDQNPYYGGESA
                     SITPLEDLYKRFKLPGQPPASMGRGRDWNVDLIPKFLMANGQLVKMLLFTEVTRYMDF
                     KVIEGSFVYKGGKIYKVPSTEAEALASSLMGLFEKRRFRKFLVYVANFDEKDPRTFEG
                     VDPKKTSMRDVYKKFDLGQDVIDFTGHSLALYRTDDYLDQPCCETINRIKLYSESLAR
                     YGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPIEEIIVQNGKVVGVKSEGEIAR
                     CKQLICDPSYVKDRVEKVGQVIRVICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYV
                     CMISFAHNVAAQGKYIAIVSTTVETKEPEKEIRPALELLEPIEQKFVSISDLFVPKDL
                     GTDSQIFISRAYDATTHFETTCDDIKDIYKRMTGSEFDFEEMKRKKNDIYGED"
     exon            270..377
                     /gene="Gdi2"
                     /gene_synonym="GDI-B; Gdi3; GDIB"
                     /inference="alignment:Splign:2.1.0"
     exon            378..477
                     /gene="Gdi2"
                     /gene_synonym="GDI-B; Gdi3; GDIB"
                     /inference="alignment:Splign:2.1.0"
     exon            478..612
                     /gene="Gdi2"
                     /gene_synonym="GDI-B; Gdi3; GDIB"
                     /inference="alignment:Splign:2.1.0"
     exon            613..811
                     /gene="Gdi2"
                     /gene_synonym="GDI-B; Gdi3; GDIB"
                     /inference="alignment:Splign:2.1.0"
     exon            812..943
                     /gene="Gdi2"
                     /gene_synonym="GDI-B; Gdi3; GDIB"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1043
                     /gene="Gdi2"
                     /gene_synonym="GDI-B; Gdi3; GDIB"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1215
                     /gene="Gdi2"
                     /gene_synonym="GDI-B; Gdi3; GDIB"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1360
                     /gene="Gdi2"
                     /gene_synonym="GDI-B; Gdi3; GDIB"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1415
                     /gene="Gdi2"
                     /gene_synonym="GDI-B; Gdi3; GDIB"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..2681
                     /gene="Gdi2"
                     /gene_synonym="GDI-B; Gdi3; GDIB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2218..2223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gdi2"
                     /gene_synonym="GDI-B; Gdi3; GDIB"
                     /note="hexamer: AATAAA"
     polyA_site      2241
                     /gene="Gdi2"
                     /gene_synonym="GDI-B; Gdi3; GDIB"
                     /note="major polyA site"
     regulatory      2607..2612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gdi2"
                     /gene_synonym="GDI-B; Gdi3; GDIB"
                     /note="hexamer: AATAAA"
     polyA_site      2627
                     /gene="Gdi2"
                     /gene_synonym="GDI-B; Gdi3; GDIB"
     regulatory      2647..2652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gdi2"
                     /gene_synonym="GDI-B; Gdi3; GDIB"
                     /note="hexamer: ATTAAA"
     polyA_site      2669
                     /gene="Gdi2"
                     /gene_synonym="GDI-B; Gdi3; GDIB"
ORIGIN      
        1 gagctcgctc tcctcacccc gcgctctccc cgcctcccct ccctcccctc cctgctcttc
       61 tcttcccgtt gaggtggcgg ccggcctctc ctcctcctca gctccgtttt tcctctcctc
      121 gctttttccc tttccccccg acccccgggg cccagagcgg ccggacttct cgctcccttc
      181 tctacggcgg cctccgagcc cccgcgtgcg ctcctttccc cgccatgaat gaggaatacg
      241 acgtgatcgt gctgggcacc ggcctgacgg aatgtatcct gtcggggata atgtcagtga
      301 atgggaagaa ggttcttcat atggatcaga acccatacta tggaggagaa agtgcgtcta
      361 taacaccgct ggaagattta tacaaaaggt ttaaattacc aggacaaccg ccagcatcaa
      421 tgggaagagg aagagactgg aatgttgact taattcccaa gttccttatg gccaatggtc
      481 agttggtgaa gatgctgctt ttcacagagg tcactcgtta catggacttc aaagtgattg
      541 agggaagctt tgtctacaag ggagggaaaa tctacaaggt tccttccact gaagcagaag
      601 ccctggcatc tagcttaatg ggactgtttg agaaacgccg tttcaggaag ttcctggttt
      661 atgttgccaa ctttgatgaa aaagatccta gaactttcga gggtgttgat cctaagaaga
      721 cctccatgag agatgtgtat aagaagtttg atttgggcca agatgttata gactttactg
      781 gccattctct tgcactgtac agaacagatg actacttaga tcagccgtgt tgtgaaacca
      841 ttaatagaat taaactttac agcgagtctt tggcaagata cggtaaaagc ccgtacctgt
      901 atccgcttta tggtcttgga gaattgccgc aaggatttgc aaggttaagt gccatatatg
      961 gaggtaccta catgttgaat aaaccaattg aagaaatcat tgtgcaaaat ggaaaagtgg
     1021 ttggtgtaaa atccgaagga gagattgctc gctgtaaaca gctcatctgt gatcccagct
     1081 atgtaaaaga tcgggttgaa aaagtgggcc aggtaatcag agtgatctgt atccttagcc
     1141 accctatcaa gaacaccaac gatgccaact cctgccagat catcattcca cagaaccaag
     1201 tcaaccgcaa gtcagatatc tatgtttgca tgatctcctt tgcacataat gtggcagcac
     1261 agggcaagta tattgccatt gtaagtacaa ccgtggagac caaggaacca gagaaagaaa
     1321 tcagaccggc tttggagctc ttggaaccaa ttgaacagaa atttgtcagc atcagtgacc
     1381 tctttgtacc taaagatttg ggaacagata gtcagatctt catttcccgt gcctatgatg
     1441 ctaccacgca ctttgagaca acctgtgatg acattaaaga tatctacaag aggatgacag
     1501 gatctgagtt tgactttgag gaaatgaagc gcaagaagaa tgacatttat ggagaagact
     1561 aacagcagta catattatgt aataattagg acaaacttaa aatttggcaa ataatgtata
     1621 ttgtatgaaa tcaatactgt aagccctgct tttatgatca aaatggagat tgaagagtgc
     1681 tataccagtg aatgctcctt cactttctaa tatcatgtat taacttgttt tcatggaatg
     1741 gctagtcaga attggttggt tctgttcagt ttaaccagac tgcattttgt tctaaaacaa
     1801 atattgatat cgatagagaa cttgtatcat ttaatcagtg tagcctttgc gattgtgtga
     1861 tccaagagct ggatccatac aatttgtgcc accctgaaat tgggactcta aattgagtat
     1921 cctttggttt ctgaagacgt tcaacgtttt ctctattttg ttatgtcaag tatcacagca
     1981 gggccaatag aagagagcca catgttttgt ttatgagggt agccaaactt cagacctaca
     2041 acagttgctg agaaaaggaa aggagcctta aggtaaagca ggtaaaatac aggagcccct
     2101 tttatcccag acacggctcc tcccccggac caagctgcaa tgcagtatta atctgacaga
     2161 gcctcaatgt caacgatgcc tgttccaaaa tggctccaga tgatttctgt actgcaaaat
     2221 aaagccaaac tctggaaacc actcttggta ttgagtgtct gtgtcctgga ctaaaagaac
     2281 tgctgtgcgc taagattttg gatgggtgtc atttcctggc ttcagtttag tagtcagtga
     2341 tcttcaaata ccagacaaga agcaacctgt gtttgtttca tggtttgagt gtacaattct
     2401 ttcttaaagg tatcctggtg atggcctaaa tgttgcacac agactacaaa tgactgcatt
     2461 ttcaattctt tatttaaaaa aaaaaaaaaa agacaacaca aaacaacaaa aaaaaccaaa
     2521 ctagaaacta ggtataaaag cctaagtata caaatggttt ttttcttgtt tgtattttaa
     2581 agatttaaga agtttctaat atcataaata aaggatttct tcctcaattg acttttgtag
     2641 tgcagcatta aaaaacccaa gtgtaaaaat ttgtcattta c
//
