LOCUS       NM_010273               2657 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus GDP dissociation inhibitor 1 (Gdi1), mRNA.
ACCESSION   NM_010273
VERSION     NM_010273.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2657)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2657)
  AUTHORS   D'Adamo,P., Horvat,A., Gurgone,A., Mignogna,M.L., Bianchi,V.,
            Masetti,M., Ripamonti,M., Taverna,S., Velebit,J., Malnar,M.,
            Muhic,M., Fink,K., Bachi,A., Restuccia,U., Belloli,S.,
            Moresco,R.M., Mercalli,A., Piemonti,L., Potokar,M., Bobnar,S.T.,
            Kreft,M., Chowdhury,H.H., Stenovec,M., Vardjan,N. and Zorec,R.
  TITLE     Inhibiting glycolysis rescues memory impairment in an intellectual
            disability Gdi1-null mouse
  JOURNAL   Metabolism 116, 154463 (2021)
   PUBMED   33309713
  REMARK    GeneRIF: Inhibiting glycolysis rescues memory impairment in an
            intellectual disability Gdi1-null mouse.
REFERENCE   3  (bases 1 to 2657)
  AUTHORS   Gan,P., Patterson,M., Watanabe,H., Wang,K., Edmonds,R.A.,
            Reinholdt,L.G. and Sucov,H.M.
  TITLE     Allelic variants between mouse substrains BALB/cJ and BALB/cByJ
            influence mononuclear cardiomyocyte composition and cardiomyocyte
            nuclear ploidy
  JOURNAL   Sci Rep 10 (1), 7605 (2020)
   PUBMED   32371981
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2657)
  AUTHORS   More,L., Kunnecke,B., Yekhlef,L., Bruns,A., Marte,A., Fedele,E.,
            Bianchi,V., Taverna,S., Gatti,S. and D'Adamo,P.
  TITLE     Altered fronto-striatal functions in the Gdi1-null mouse model of
            X-linked Intellectual Disability
  JOURNAL   Neuroscience 344, 346-359 (2017)
   PUBMED   28057534
  REMARK    GeneRIF: Study used cognitive protocols with high translational
            validity to human condition that target the functionality of
            cortico-striatal circuitry such as attention and stimulus selection
            ability with progressive degree of complexity; showed that that
            Gdi1-null mice are impaired in attention and associative learning
            processes.
REFERENCE   5  (bases 1 to 2657)
  AUTHORS   Ohshima,J., Sasai,M., Liu,J., Yamashita,K., Ma,J.S., Lee,Y.,
            Bando,H., Howard,J.C., Ebisu,S., Hayashi,M., Takeda,K.,
            Standley,D.M., Frickel,E.M. and Yamamoto,M.
  TITLE     RabGDIalpha is a negative regulator of interferon-gamma-inducible
            GTPase-dependent cell-autonomous immunity to Toxoplasma gondii
  JOURNAL   Proc Natl Acad Sci U S A 112 (33), E4581-E4590 (2015)
   PUBMED   26240314
REFERENCE   6  (bases 1 to 2657)
  AUTHORS   Tanaka,M., Miyoshi,J., Ishizaki,H., Togawa,A., Ohnishi,K., Endo,K.,
            Matsubara,K., Mizoguchi,A., Nagano,T., Sato,M., Sasaki,T. and
            Takai,Y.
  TITLE     Role of Rab3 GDP/GTP exchange protein in synaptic vesicle
            trafficking at the mouse neuromuscular junction
  JOURNAL   Mol Biol Cell 12 (5), 1421-1430 (2001)
   PUBMED   11359932
REFERENCE   7  (bases 1 to 2657)
  AUTHORS   Ishizaki,H., Miyoshi,J., Kamiya,H., Togawa,A., Tanaka,M.,
            Sasaki,T., Endo,K., Mizoguchi,A., Ozawa,S. and Takai,Y.
  TITLE     Role of rab GDP dissociation inhibitor alpha in regulating
            plasticity of hippocampal neurotransmission
  JOURNAL   Proc Natl Acad Sci U S A 97 (21), 11587-11592 (2000)
   PUBMED   11027356
REFERENCE   8  (bases 1 to 2657)
  AUTHORS   Kuroiwa,A., Watanabe,T., Hishigaki,H., Takahashi,E., Namikawa,T.
            and Matsuda,Y.
  TITLE     Comparative FISH mapping of mouse and rat homologues of twenty-five
            human X-linked genes
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 208-212 (1998)
   PUBMED   9730605
REFERENCE   9  (bases 1 to 2657)
  AUTHORS   Bachner,D., Sedlacek,Z., Korn,B., Hameister,H. and Poustka,A.
  TITLE     Expression patterns of two human genes coding for different rab
            GDP-dissociation inhibitors (GDIs), extremely conserved proteins
            involved in cellular transport
  JOURNAL   Hum Mol Genet 4 (4), 701-708 (1995)
   PUBMED   7543319
REFERENCE   10 (bases 1 to 2657)
  AUTHORS   Shisheva,A., Sudhof,T.C. and Czech,M.P.
  TITLE     Cloning, characterization, and expression of a novel GDP
            dissociation inhibitor isoform from skeletal muscle
  JOURNAL   Mol Cell Biol 14 (5), 3459-3468 (1994)
   PUBMED   7513052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB613634.1, BC013758.1, AK028880.1 and CJ293471.1.
            
            On Oct 27, 2009 this sequence version replaced NM_010273.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.142408.1,
                                           SRR1660815.165110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-319               BB613634.1         1-319
            320-1858            BC013758.1         1-1539
            1859-2649           AK028880.1         1616-2406
            2650-2657           CJ293471.1         415-422
FEATURES             Location/Qualifiers
     source          1..2657
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.97 cM"
     gene            1..2657
                     /gene="Gdi1"
                     /gene_synonym="GDIA; GDIalpha"
                     /note="GDP dissociation inhibitor 1"
                     /db_xref="GeneID:14567"
                     /db_xref="MGI:MGI:99846"
     exon            1..430
                     /gene="Gdi1"
                     /gene_synonym="GDIA; GDIalpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..1729
                     /gene="Gdi1"
                     /gene_synonym="GDIA; GDIalpha"
                     /note="GDI-1; guanosine diphosphate (GDP) dissociation
                     inhibitor 1; rab GDI alpha; guanosine diphosphate
                     dissociation inhibitor 1; Rab GDIalpha"
                     /codon_start=1
                     /product="rab GDP dissociation inhibitor alpha"
                     /protein_id="NP_034403.1"
                     /db_xref="CCDS:CCDS30227.1"
                     /db_xref="GeneID:14567"
                     /db_xref="MGI:MGI:99846"
                     /translation="MDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESS
                     SITPLEELYKRFQILEGPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDF
                     KVVEGSFVYKGGKIYKVPSTETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEG
                     VDPQNTSMRDVYRKFDLGQDVIDFTGHALALYRTDDYLDQPCLETINRIKLYSESLAR
                     YGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPVDDIIMENGKVVGVKSEGEVAR
                     CKQLICDPSYIPDRVQKAGQVIRIICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYV
                     CMISYAHNVAAQGKYIAIASTTVETAEPEKEVEPALELLEPIDQKFVAISDLYEPIDD
                     GSESQVFCSCSYDATTHFETTCNDIKDIYKRMAGSAFDFENMKRKQNDVFGEADQ"
     exon            431..538
                     /gene="Gdi1"
                     /gene_synonym="GDIA; GDIalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            539..638
                     /gene="Gdi1"
                     /gene_synonym="GDIA; GDIalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            639..773
                     /gene="Gdi1"
                     /gene_synonym="GDIA; GDIalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            774..972
                     /gene="Gdi1"
                     /gene_synonym="GDIA; GDIalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1104
                     /gene="Gdi1"
                     /gene_synonym="GDIA; GDIalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1204
                     /gene="Gdi1"
                     /gene_synonym="GDIA; GDIalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1376
                     /gene="Gdi1"
                     /gene_synonym="GDIA; GDIalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1521
                     /gene="Gdi1"
                     /gene_synonym="GDIA; GDIalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1576
                     /gene="Gdi1"
                     /gene_synonym="GDIA; GDIalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..2657
                     /gene="Gdi1"
                     /gene_synonym="GDIA; GDIalpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2632..2637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gdi1"
                     /gene_synonym="GDIA; GDIalpha"
                     /note="hexamer: AATAAA"
     polyA_site      2652
                     /gene="Gdi1"
                     /gene_synonym="GDIA; GDIalpha"
                     /note="major polyA site"
ORIGIN      
        1 gatctttcgg aggactcagc acctgctgcc ggcctgcccc gccccgtatt tttctgggct
       61 cacgaagagc cccgataacc cctgcagtca ttctggtgct gggacccagg tgacagaagc
      121 cctcccagaa aacaagcaag gaaatgatga ctggttgggc ggggcggggc cagcggagag
      181 agagagggac tcattaacgc tgcgtaggga tcaggagaca accgacagac gccatctttg
      241 gttcagtgcg gcggcagtga cagaagcagc ggcaggggca gcagcagcag cggcagtagc
      301 agcagtagca atagtagagg tagtggtagc ggctgctgtg gtgaaggagg aggagcagag
      361 cggacgctgg taccaaggcc tgatcatgga tgaggaatac gatgtgattg tgctggggac
      421 aggtcttacc gaatgcatcc tgtctggcat catgtctgtg aatggaaaga aggtgctgca
      481 catggaccga aacccctact atgggggtga gagctcttcc atcacacccc tggaggagct
      541 atataagcgc tttcagatac tggaagggcc ccctgaatca atgggccggg gccgagactg
      601 gaatgttgac ttgatcccca aattcctcat ggccaatggt cagctggtaa agatgctact
      661 atatacagaa gtgactcgat atctggactt caaggtggta gagggcagct ttgtatataa
      721 ggggggcaag atctacaaag tgccatccac cgagactgag gccttggctt ctaatctgat
      781 gggcatgttt gaaaaacgac gcttccgaaa atttttggtg tttgtggcaa actttgatga
      841 gaatgacccc aaaacctttg agggtgttga tccccagaac accagcatgc gtgatgtcta
      901 ccggaagttt gacctgggtc aagatgtcat agatttcact ggccatgcct tggcgctcta
      961 ccgcactgat gactacctgg atcagccctg tcttgagact attaaccgca tcaagttgta
     1021 cagcgagtcc ctggcccggt atggcaagag cccctattta tacccactgt atggcctggg
     1081 tgagctgccc cagggctttg ccagattgag tgccatctat gggggaacat acatgctgaa
     1141 caaaccagtg gatgacatca tcatggaaaa tggcaaggtg gtgggtgtca aatctgaggg
     1201 agaggtggcc cgctgcaagc agctgatctg tgatcccagt tacatcccag accgtgtgca
     1261 aaaggctggc caggttattc gcatcatctg tatcctcagc caccccatca agaataccaa
     1321 tgatgccaat tcctgccaaa ttatcatccc tcagaaccag gtcaacagga agtcagacat
     1381 ctatgtgtgc atgatctcct atgcgcacaa cgtggccgca cagggcaaat acatcgccat
     1441 tgccagcacc actgtagaga ctgcagaacc agaaaaggaa gttgagcctg cattggagct
     1501 gttggaaccc attgaccaga agtttgtggc tatcagtgat ttatatgagc ccattgatga
     1561 tggttcagag agtcaggtgt tctgttcctg ctcctatgat gctaccacac actttgagac
     1621 aacctgcaat gacatcaaag atatctacaa acgcatggct ggttctgcct ttgattttga
     1681 gaacatgaag cgcaaacaga atgatgtctt tggagaagct gatcagtgat tgctgactcc
     1741 cctcctccag cccctgttcc cctctcccca acttgtatgt ccttctctag ggcaggggag
     1801 atggtatggc taggcatcct tgtttccagc atcttctgct tcccctacca cattccaatc
     1861 acccacctta ttgattttat tcactgacca tatccttaac cttagggatg gtttgggaga
     1921 tgggagttgg atagtatcct ctttcttggt ctgtccttgt tctagggaaa gagaactttg
     1981 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgcgcgcgcg cgtgcgtgtg tgtacgtgtg
     2041 tgtacgtacg tgtgtgtgcg tgtgtacatg tgtgtgcatg tgtgtgtgca tcgtgcaccc
     2101 ccaattttgc tgtttgggaa ggagtggagg aaaagctgac ccccaccccc actgctctta
     2161 gtcccaaatg tagtggcctt tggagatacc catctcctcc cccaactctt aggtgttgga
     2221 gagaagggac cctcccagca caaaattgca ttcctcctcc tcctcctcct ccttataatt
     2281 tattctaatt tattaacttt ggagtaattg tctgagccct cagcctttct gtgcagccta
     2341 gggctgtaga gtgagctgcc ctggcctctc ccagtgctgg caaagcctgg gatgggagaa
     2401 gatttaggtg tgaccccctc tggaggttga tctgttttga atttcttttg tgttgtgttc
     2461 actgagaaaa agtaatgtga gcaaagcaga aggaggtagg aaagtggatc caaaccccag
     2521 tgtaccctgc cccatgcctt ttcctttagt ggtgggaaac ccttaccttg caaagtgaat
     2581 gtgtcccctt ccccaagctc tagtatattt cacagaaaac aaaaacctcc caataaaact
     2641 attgaaactt aagcctg
//
