LOCUS       NM_008110               1805 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus growth differentiation factor 9 (Gdf9), transcript
            variant 1, mRNA.
ACCESSION   NM_008110
VERSION     NM_008110.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1805)
  AUTHORS   Song,C., Qin,Y., Li,Y., Yang,B., Guo,T., Ma,W., Xu,D., Xu,K.,
            Fu,F., Jin,L., Wu,Y., Tang,S., Chen,X. and Zhang,F.
  TITLE     Deleterious variants in RNF111 impair female fertility and induce
            premature ovarian insufficiency in humans and mice
  JOURNAL   Sci China Life Sci 67 (7), 1325-1337 (2024)
   PUBMED   38874713
REFERENCE   2  (bases 1 to 1805)
  AUTHORS   Hughes,C.H.K., Smith,O.E., Meinsohn,M.C., Brunelle,M., Gevry,N. and
            Murphy,B.D.
  TITLE     Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the
            ovarian reserve
  JOURNAL   Proc Natl Acad Sci U S A 120 (32), e2220849120 (2023)
   PUBMED   37494420
REFERENCE   3  (bases 1 to 1805)
  AUTHORS   Ito,H., Emori,C., Kobayashi,M., Maruyama,N., Fujii,W., Naito,K. and
            Sugiura,K.
  TITLE     Cooperative effects of oocytes and estrogen on the forkhead box L2
            expression in mural granulosa cells in mice
  JOURNAL   Sci Rep 12 (1), 20158 (2022)
   PUBMED   36424497
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1805)
  AUTHORS   Gindi,N., Grossman,H., Bar-Joseph,H., Miller,I., Nemerovsky,L.,
            Hadas,R., Nevo,N., Galiani,D., Dekel,N. and Shalgi,R.
  TITLE     Fyn and argonaute 2 participate in maternal-mRNA degradation during
            mouse oocyte maturation
  JOURNAL   Cell Cycle 21 (8), 792-804 (2022)
   PUBMED   35104175
REFERENCE   5  (bases 1 to 1805)
  AUTHORS   Prokopuk,L., Jarred,E.G., Blucher,R.O., McLaughlin,E.A.,
            Stringer,J.M. and Western,P.S.
  TITLE     An essential role for Polycomb Repressive Complex 2 in the mouse
            ovary
  JOURNAL   Reproduction 163 (3), 167-182 (2022)
   PUBMED   35084365
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1805)
  AUTHORS   Watkins-Chow,D.E., Buckwalter,M.S., Newhouse,M.M., Lossie,A.C.,
            Brinkmeier,M.L. and Camper,S.A.
  TITLE     Genetic mapping of 21 genes on mouse chromosome 11 reveals
            disruptions in linkage conservation with human chromosome 5
  JOURNAL   Genomics 40 (1), 114-122 (1997)
   PUBMED   9070927
REFERENCE   7  (bases 1 to 1805)
  AUTHORS   Dong,J., Albertini,D.F., Nishimori,K., Kumar,T.R., Lu,N. and
            Matzuk,M.M.
  TITLE     Growth differentiation factor-9 is required during early ovarian
            folliculogenesis
  JOURNAL   Nature 383 (6600), 531-535 (1996)
   PUBMED   8849725
REFERENCE   8  (bases 1 to 1805)
  AUTHORS   McGrath,S.A., Esquela,A.F. and Lee,S.J.
  TITLE     Oocyte-specific expression of growth/differentiation factor-9
  JOURNAL   Mol Endocrinol 9 (1), 131-136 (1995)
   PUBMED   7760846
REFERENCE   9  (bases 1 to 1805)
  AUTHORS   Incerti,B., Dong,J., Borsani,G. and Matzuk,M.M.
  TITLE     Structure of the mouse growth/differentiation factor 9 gene
  JOURNAL   Biochim Biophys Acta 1222 (1), 125-128 (1994)
   PUBMED   8186260
REFERENCE   10 (bases 1 to 1805)
  AUTHORS   McPherron,A.C. and Lee,S.J.
  TITLE     GDF-3 and GDF-9: two new members of the transforming growth
            factor-beta superfamily containing a novel pattern of cysteines
  JOURNAL   J Biol Chem 268 (5), 3444-3449 (1993)
   PUBMED   8429021
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CA559167.1, AK136145.1 and
            BC052667.1.
            
            On Nov 14, 2007 this sequence version replaced NM_008110.1.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein regulates ovarian
            function. Female mice that are homozygous null for this gene are
            sterile with impaired folliculogenesis. [provided by RefSeq, Jul
            2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052667.1, AK136145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                CA559167.1         1-62
            63-1773             AK136145.1         3-1713
            1774-1805           BC052667.1         1704-1735
FEATURES             Location/Qualifiers
     source          1..1805
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.94 cM"
     gene            1..1805
                     /gene="Gdf9"
                     /gene_synonym="Gdf-9"
                     /note="growth differentiation factor 9"
                     /db_xref="GeneID:14566"
                     /db_xref="MGI:MGI:95692"
     exon            1..517
                     /gene="Gdf9"
                     /gene_synonym="Gdf-9"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1446
                     /gene="Gdf9"
                     /gene_synonym="Gdf-9"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="growth/differentiation factor 9 isoform 1
                     precursor"
                     /protein_id="NP_032136.2"
                     /db_xref="CCDS:CCDS24679.1"
                     /db_xref="GeneID:14566"
                     /db_xref="MGI:MGI:95692"
                     /translation="MALPSNFLLGVCCFAWLCFLSSLSSQASTEESQSGASENVESEA
                     DPWSLLLPVDGTDRSGLLPPLFKVLSDRRGETPKLQPDSRALYYMKKLYKTYATKEGV
                     PKPSRSHLYNTVRLFSPCAQQEQAPSNQVTGPLPMVDLLFNLDRVTAMEHLLKSVLLY
                     TLNNSASSSSTVTCMCDLVVKEAMSSGRAPPRAPYSFTLKKHRWIEIDVTSLLQPLVT
                     SSERSIHLSVNFTCTKDQVPEDGVFSMPLSVPPSLILYLNDTSTQAYHSWQSLQSTWR
                     PLQHPGQAGVAARPVKEEAIEVERSPRRRRGQKAIRSEAKGPLLTASFNLSEYFKQFL
                     FPQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVRHRYGSPVHTMVQNI
                     IYEKLDPSVPRPSCVPGKYSPLSVLTIEPDGSIAYKEYEDMIATRCTCR"
     exon            518..1805
                     /gene="Gdf9"
                     /gene_synonym="Gdf-9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1784..1789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gdf9"
                     /gene_synonym="Gdf-9"
                     /note="hexamer: AATAAA"
     polyA_site      1805
                     /gene="Gdf9"
                     /gene_synonym="Gdf-9"
                     /note="major polyA site"
ORIGIN      
        1 acagaagtga agtcagtctt ccacacctag attttattta aggaccacgc cagggcctcc
       61 ccgaccttta gaaagaagac tggcacgagg agatgcgttc cttcttagtt ctcccaagtc
      121 atggcacttc ccagcaactt cctgttgggg gtttgctgct ttgcctggct gtgttttctt
      181 agtagcctta gctctcaggc ttctactgaa gaatcccaga gtggagccag tgaaaatgtg
      241 gagtctgagg cagacccctg gtccttgctg ctgcctgtag atgggactga caggtctggc
      301 ctcttgcccc ccctctttaa ggttctatct gataggcgag gtgagacccc taagctgcag
      361 cctgactcca gagcactcta ctacatgaaa aagctctata agacgtatgc taccaaagag
      421 ggggttccca aacccagcag aagtcacctc tacaataccg tccggctctt cagtccctgt
      481 gcccagcaag agcaggcacc cagcaaccag gtgacaggac cgctgccgat ggtggacctg
      541 ctgtttaacc tggaccgggt gactgccatg gaacacttgc tcaaatcggt cttgctatac
      601 actctgaaca actctgcctc ttcctcctcc actgtgacct gtatgtgtga ccttgtggta
      661 aaggaggcca tgtcttctgg cagggcaccc ccaagagcac cgtactcatt caccctgaag
      721 aaacacagat ggattgagat tgatgtgacc tccctccttc agcccctagt gacctccagc
      781 gagaggagca ttcacctgtc tgtcaatttt acatgcacaa aagaccaggt gccagaggac
      841 ggagtgttta gcatgcctct ctcagtgcct ccttccctca tcttgtatct caacgacaca
      901 agcacccagg cctaccactc ttggcagtct cttcagtcca cctggaggcc tttacagcat
      961 cccggccagg ccggtgtggc tgcccgtccc gtgaaagagg aagctattga ggtggaaaga
     1021 tctccccggc gccgtcgagg gcagaaagcc atccgctccg aagcgaaggg gccacttctt
     1081 acagcatcct tcaacctcag cgaatacttc aaacagtttc ttttccccca aaacgagtgt
     1141 gaactccatg acttcagact gagttttagt cagctcaaat gggacaactg gatcgtggcc
     1201 ccgcacaggt acaaccctag gtactgtaaa ggggactgtc ctagggcggt caggcatcgg
     1261 tacggctctc ctgtgcacac catggtccag aatataatct atgagaagct ggacccttca
     1321 gtgccaaggc cttcgtgtgt gccgggcaag tacagccccc tgagtgtgtt gaccattgaa
     1381 cccgacggct ccatcgctta caaagagtac gaagacatga tagctacgag gtgcacctgt
     1441 cgttagcatg ggggccactt caacaagcct gcctggcaga gcaatgctgt gggccttaga
     1501 gtgcctgggc agagagcttc ctgtgaccag tctctccgtg ctgctcagtg cacactgtgt
     1561 gagcggggga agtgtgtgtg tggatgagca catcgagtgc agtgtccgta ggtgtaaagg
     1621 gcacactcac tggtcgttgc cataaaccaa gtgaaatgta actcatttgg agagctcttt
     1681 ctccccacga gtgtagtttt cagtggacag atttgttagc ataagtctcg agtagaatgt
     1741 agctgtgaac atgtcagagt gctgtggttt tatgtgacgg aagaataaac tgttgatggc
     1801 ataaa
//
