LOCUS       NM_001312876            1423 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus growth differentiation factor 7 (Gdf7), transcript
            variant 1, mRNA.
ACCESSION   NM_001312876 XM_006515079
VERSION     NM_001312876.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1423)
  AUTHORS   Cai,S., Si,N., Wang,Y. and Yin,N.
  TITLE     Transcriptomic analysis of the upper lip and primary palate
            development in mice
  JOURNAL   Front Genet 13, 1039850 (2023)
   PUBMED   36685938
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1423)
  AUTHORS   Li,Q., Han,Z., Singh,N., Terre,B., Fame,R.M., Arif,U., Page,T.D.,
            Zahran,T., Abdeltawab,A., Huang,Y., Cao,P., Wang,J., Lu,H.,
            Lidov,H.G.W., Surendran,K., Wu,L., Virga,J.Q., Zhao,Y.T.,
            Schuller,U., Wechsler-Reya,R.J., Lehtinen,M.K., Roy,S., Liu,Z.,
            Stracker,T.H. and Zhao,H.
  TITLE     Disruption of GMNC-MCIDAS multiciliogenesis program is critical in
            choroid plexus carcinoma development
  JOURNAL   Cell Death Differ 29 (8), 1596-1610 (2022)
   PUBMED   35322202
REFERENCE   3  (bases 1 to 1423)
  AUTHORS   Ofek,S., Wiszniak,S., Kagan,S., Tondl,M., Schwarz,Q. and
            Kalcheim,C.
  TITLE     Notch signaling is a critical initiator of roof plate formation as
            revealed by the use of RNA profiling of the dorsal neural tube
  JOURNAL   BMC Biol 19 (1), 84 (2021)
   PUBMED   33892704
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1423)
  AUTHORS   Casoni,F., Croci,L., Vincenti,F., Podini,P., Riba,M., Massimino,L.,
            Cremona,O. and Consalez,G.G.
  TITLE     ZFP423 regulates early patterning and multiciliogenesis in the
            hindbrain choroid plexus
  JOURNAL   Development 147 (22) (2020)
   PUBMED   33046507
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1423)
  AUTHORS   Qin,L., Ahn,K.J., Wine Lee,L., de Charleroy,C. Jr. and
            Crenshaw,E.B. 3rd.
  TITLE     Analyses with double knockouts of the Bmpr1a and Bmpr1b genes
            demonstrate that BMP signaling is involved in the formation of
            precerebellar mossy fiber nuclei derived from the rhombic lip
  JOURNAL   PLoS One 14 (12), e0226602 (2019)
   PUBMED   31869353
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1423)
  AUTHORS   Rowitch,D.H., S-Jacques,B., Lee,S.M., Flax,J.D., Snyder,E.Y. and
            McMahon,A.P.
  TITLE     Sonic hedgehog regulates proliferation and inhibits differentiation
            of CNS precursor cells
  JOURNAL   J Neurosci 19 (20), 8954-8965 (1999)
   PUBMED   10516314
REFERENCE   7  (bases 1 to 1423)
  AUTHORS   Davidson,A.J., Postlethwait,J.H., Yan,Y.L., Beier,D.R., van
            Doren,C., Foernzler,D., Celeste,A.J., Crosier,K.E. and Crosier,P.S.
  TITLE     Isolation of zebrafish gdf7 and comparative genetic mapping of
            genes belonging to the growth/differentiation factor 5, 6, 7
            subgroup of the TGF-beta superfamily
  JOURNAL   Genome Res 9 (2), 121-129 (1999)
   PUBMED   10022976
REFERENCE   8  (bases 1 to 1423)
  AUTHORS   Lee,K.J., Mendelsohn,M. and Jessell,T.M.
  TITLE     Neuronal patterning by BMPs: a requirement for GDF7 in the
            generation of a discrete class of commissural interneurons in the
            mouse spinal cord
  JOURNAL   Genes Dev 12 (21), 3394-3407 (1998)
   PUBMED   9808626
REFERENCE   9  (bases 1 to 1423)
  AUTHORS   Li,W., Cogswell,C.A. and LoTurco,J.J.
  TITLE     Neuronal differentiation of precursors in the neocortical
            ventricular zone is triggered by BMP
  JOURNAL   J Neurosci 18 (21), 8853-8862 (1998)
   PUBMED   9786991
REFERENCE   10 (bases 1 to 1423)
  AUTHORS   Storm,E.E., Huynh,T.V., Copeland,N.G., Jenkins,N.A., Kingsley,D.M.
            and Lee,S.J.
  TITLE     Limb alterations in brachypodism mice due to mutations in a new
            member of the TGF beta-superfamily
  JOURNAL   Nature 368 (6472), 639-643 (1994)
   PUBMED   8145850
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC122860.5.
            
            On Aug 20, 2015 this sequence version replaced XM_006515079.2.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein may play a role in the
            differentiation of tendon cells and spinal cord interneurons. Mice
            lacking a functional copy of this gene exhibit absence of some
            spinal dopaminergic neurons and brain defects, male sterility, and
            premature death. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-388               AC122860.5         162120-162507       c
            389-1423            AC122860.5         158471-159505       c
FEATURES             Location/Qualifiers
     source          1..1423
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 3.85 cM"
     gene            1..1423
                     /gene="Gdf7"
                     /gene_synonym="BMP12"
                     /note="growth differentiation factor 7"
                     /db_xref="GeneID:238057"
                     /db_xref="MGI:MGI:95690"
     exon            1..388
                     /gene="Gdf7"
                     /gene_synonym="BMP12"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1407
                     /gene="Gdf7"
                     /gene_synonym="BMP12"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; GDF-7"
                     /codon_start=1
                     /product="growth/differentiation factor 7 isoform 1
                     preproprotein"
                     /protein_id="NP_001299805.1"
                     /db_xref="CCDS:CCDS83954.1"
                     /db_xref="GeneID:238057"
                     /db_xref="MGI:MGI:95690"
                     /translation="MDLSAAAALCLWLLSACRPRDGLEAAAVLRAAGAGPAWSPGGGG
                     GGRTLARAPGPSALQAAAVPGPRAVRRAAGSGFRNGSVVPHHFMMSLYRSLAGRAPVA
                     AASGHGRVDTITGFTDQATQDETAAAEPGQSFLFDVSSLSEADEVVNAELRVLRRRSP
                     EPDRDSATLLPRLLLSTCPDEAGTAHLLHSRAAEPLGGARWEAFDVTDAVQSHRRWPR
                     ASRKFCLVLRAVTASESSPLALRRLGFGWPGGGDGGGTAAEERALLVISSRTQRKESL
                     FREIRAQARALRAAAEPPPDPGPGAGSRKANLGGRRRRRTALAGTRGAQGSGGGGGGG
                     GGGGGGGGGGGGGAGRGHGRRGRSRCSRKSLHVDFKELGWDDWIIAPLDYEAYHCEGV
                     CDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAANNVVYKQY
                     EDMVVEACGCR"
     exon            389..1423
                     /gene="Gdf7"
                     /gene_synonym="BMP12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggccggc ccaaggagcc catggacctg agcgctgccg ccgcgctgtg tctctggctg
       61 ctgagcgctt gccgtccccg cgacgggcta gaagctgccg cggtgctccg agcggcgggg
      121 gctggaccag cctggagccc cgggggcggc ggcggcgggc ggaccctcgc ccgggctcca
      181 ggcccttcag ctctccaggc cgctgcggtt ccgggtcccc gagctgtgcg ccgcgctgcg
      241 ggttctggct tcaggaacgg ctcggtggtg ccacaccact tcatgatgtc gctttacagg
      301 agcctggcgg ggagggctcc ggtcgcggca gcttcagggc acgggcgtgt ggacacaatc
      361 accggcttca cagaccaagc aactcaagac gaaacggcgg cggccgagcc aggccagagc
      421 ttcctgttcg acgtatccag cctctccgaa gccgatgagg tggtgaatgc ggagctgcgc
      481 gtgctgcgcc ggaggtctcc ggaaccagac agggacagtg cgaccctcct tccgcggctg
      541 ctgctgtcca cgtgcccgga cgaggctggc acagctcacc tgctgcactc ccgggccgcc
      601 gagcccctgg gcggcgcgcg ctgggaagcg ttcgacgtga cggacgcggt gcagagccac
      661 cgccgctggc cgcgagcctc ccgcaagttc tgcctggtgc tgcgcgcggt gacggcctcg
      721 gagagcagcc cgctggccct gagacgactg ggcttcggct ggccgggcgg tggcgacggc
      781 ggcggcactg cggccgagga gcgcgcgctg ttggtgatct cctcccgtac gcaaaggaaa
      841 gagagtctgt tccgggagat ccgagcccag gcccgtgctc tccgggccgc tgcagagccg
      901 ccaccggatc caggaccagg cgctgggtca cgcaaagcca acctgggcgg tcgcaggcgg
      961 cggcggactg cgctggctgg gactcgggga gcgcagggaa gcggtggtgg cggcggtggc
     1021 ggtggcggcg gcggcggcgg cggcggcggc ggcggcggcg gcgcaggcag gggccacggg
     1081 cgcagaggcc ggagccgctg cagtcgcaag tcactgcacg tggactttaa ggagctgggc
     1141 tgggacgact ggatcatcgc gccattagac tacgaggcat accactgcga gggcgtttgc
     1201 gactttcctc tgcgctcgca cctggagcct accaaccacg ccatcattca gacgctgctc
     1261 aactccatgg cgcccgacgc tgcgccagcc tcctgctgcg tgcccgcaag gctcagtccc
     1321 atcagcattc tctacatcga tgccgccaac aacgtggtct acaagcagta cgaagacatg
     1381 gtggtggagg cctgcggctg caggtagcat gcggtctggg gag
//
