LOCUS       NM_013526               3532 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus growth differentiation factor 6 (Gdf6), mRNA.
ACCESSION   NM_013526 XM_143637
VERSION     NM_013526.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3532)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3532)
  AUTHORS   Yu,T., Li,G., Wang,C., Li,N., Yao,R. and Wang,J.
  TITLE     Defective Joint Development and Maintenance in GDF6-Related
            Multiple Synostoses Syndrome
  JOURNAL   J Bone Miner Res 38 (4), 568-577 (2023)
   PUBMED   36744814
  REMARK    GeneRIF: Defective Joint Development and Maintenance in
            GDF6-Related Multiple Synostoses Syndrome.
REFERENCE   3  (bases 1 to 3532)
  AUTHORS   Peschl,V., Seitz,T., Sommer,J., Thasler,W., Bosserhoff,A. and
            Hellerbrand,C.
  TITLE     Bone morphogenetic protein 13 in hepatic stellate cells and hepatic
            fibrosis
  JOURNAL   J Cell Biochem 123 (10), 1544-1552 (2022)
   PUBMED   35442524
  REMARK    GeneRIF: Bone morphogenetic protein 13 in hepatic stellate cells
            and hepatic fibrosis.
REFERENCE   4  (bases 1 to 3532)
  AUTHORS   Kaiser,M., Wojahn,I., Rudat,C., Ludtke,T.H., Christoffels,V.M.,
            Moon,A., Kispert,A. and Trowe,M.O.
  TITLE     Regulation of otocyst patterning by Tbx2 and Tbx3 is required for
            inner ear morphogenesis in the mouse
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33795231
REFERENCE   5  (bases 1 to 3532)
  AUTHORS   Yan,S., Thienthanasit,R., Chen,D., Engelen,E., Bruhl,J.,
            Crossman,D.K., Kesterson,R., Wang,Q., Bouazoune,K. and Jiao,K.
  TITLE     CHD7 regulates cardiovascular development through ATP-dependent and
            -independent activities
  JOURNAL   Proc Natl Acad Sci U S A 117 (46), 28847-28858 (2020)
   PUBMED   33127760
REFERENCE   6  (bases 1 to 3532)
  AUTHORS   Settle,S.H. Jr., Rountree,R.B., Sinha,A., Thacker,A., Higgins,K.
            and Kingsley,D.M.
  TITLE     Multiple joint and skeletal patterning defects caused by single and
            double mutations in the mouse Gdf6 and Gdf5 genes
  JOURNAL   Dev Biol 254 (1), 116-130 (2003)
   PUBMED   12606286
  REMARK    GeneRIF: role of single and double mutations in the mouse Gdf6 and
            Gdf5 genes in multiple joint and skeletal patterning defects
REFERENCE   7  (bases 1 to 3532)
  AUTHORS   Davidson,A.J., Postlethwait,J.H., Yan,Y.L., Beier,D.R., van
            Doren,C., Foernzler,D., Celeste,A.J., Crosier,K.E. and Crosier,P.S.
  TITLE     Isolation of zebrafish gdf7 and comparative genetic mapping of
            genes belonging to the growth/differentiation factor 5, 6, 7
            subgroup of the TGF-beta superfamily
  JOURNAL   Genome Res 9 (2), 121-129 (1999)
   PUBMED   10022976
REFERENCE   8  (bases 1 to 3532)
  AUTHORS   Lee,K.J., Mendelsohn,M. and Jessell,T.M.
  TITLE     Neuronal patterning by BMPs: a requirement for GDF7 in the
            generation of a discrete class of commissural interneurons in the
            mouse spinal cord
  JOURNAL   Genes Dev 12 (21), 3394-3407 (1998)
   PUBMED   9808626
REFERENCE   9  (bases 1 to 3532)
  AUTHORS   Li,W., Cogswell,C.A. and LoTurco,J.J.
  TITLE     Neuronal differentiation of precursors in the neocortical
            ventricular zone is triggered by BMP
  JOURNAL   J Neurosci 18 (21), 8853-8862 (1998)
   PUBMED   9786991
REFERENCE   10 (bases 1 to 3532)
  AUTHORS   Storm,E.E., Huynh,T.V., Copeland,N.G., Jenkins,N.A., Kingsley,D.M.
            and Lee,S.J.
  TITLE     Limb alterations in brachypodism mice due to mutations in a new
            member of the TGF beta-superfamily
  JOURNAL   Nature 368 (6472), 639-643 (1994)
   PUBMED   8145850
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL732476.12 and BC141339.1.
            
            On Feb 3, 2004 this sequence version replaced XM_143637.2.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein is required for normal
            formation of some bones and joints in the limbs, skull, and axial
            skeleton. Mice lacking a functional copy of this gene exhibit joint
            and skeletal defects. [provided by RefSeq, Sep 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ537425.1, BC141340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AL732476.12        25932-26017
            87-1930             BC141339.1         1-1844
            1931-3532           AL732476.12        42304-43905
FEATURES             Location/Qualifiers
     source          1..3532
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 4.35 cM"
     gene            1..3532
                     /gene="Gdf6"
                     /gene_synonym="BMP-13; BMP13; GDF16"
                     /note="growth differentiation factor 6"
                     /db_xref="GeneID:242316"
                     /db_xref="MGI:MGI:95689"
     exon            1..521
                     /gene="Gdf6"
                     /gene_synonym="BMP-13; BMP13; GDF16"
                     /inference="alignment:Splign:2.1.0"
     exon            522..3532
                     /gene="Gdf6"
                     /gene_synonym="BMP-13; BMP13; GDF16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggagcgcg gcccccgccg ctgtccagcc gctccgtgcc tttcgcgccc ggcgcagccg
       61 ctgctgtcgc cgccgcctct ccgagtaact tagccactcg ctcgccatgg acactcctag
      121 ggtccttctc tgggcgatct tcctcattag cttcctctgg gatttgccgg gtttccagca
      181 ggcttccatc tcctcgtcct cctcctcctc caccgaattg gactccacca aagacgtggg
      241 gaaccgcaaa gaagggaaga tgcagcgaac tccacaagag agtgccgagg gccggacgcc
      301 cccggagcac gggctgcggc agaaggacct ccggcggcgg ccgcccggac aacatcaggg
      361 gcaggagccg ccgggcaggg ggctgcgcgt ggtgcctcac gagtacatgc tgtcaatcta
      421 caagacttac tccattgccg agaagctggg catcaatgcc agctttttcc agtcttccaa
      481 gtcagctaat acgatcacta gctttgtaga cagaggactg gacgatctct cgcacactcc
      541 tctccggaga cagaagtatt tgtttgatgt gtccacactc tcagacaaag aagagctggt
      601 gggcgcagag ctaaggcttt atcgccaggc gcccccaacg ccctgggggc taccggcccg
      661 accgctgcac ttgcagctct tcccttgttt atccccattg ctactggacg ccaggaccct
      721 ggatcctcag ggaccaaccc aggccggctg ggaagtcttc gacgtgtggc agggcctgcg
      781 ccctcagcct tggaagcagc tgtgcctgga gttgcgggca gcctggggtg agctggacgc
      841 cggggatacg ggggcgcgcg cgaggggtcc ccagcagcca ccgcctctgg acctgcggag
      901 tctgggcttc ggtcggaggg tgaggccgcc ccaggagcgc gccctgcttg tagtgttcac
      961 cagatcgcag cgcaagaacc tgttcactga gatgcatgag cagctgggct ctgcagaggc
     1021 tgcgggagcc gaggggtcat ggccagcgcc gtcgggctcc ccagacgccg ggtcttggct
     1081 gccctcgccc ggccgccggc ggcgacgcac cgccttcgcc agccgtcacg gcaagcgaca
     1141 tggcaagaag tccaggctgc gctgcagcag aaagcctctg cacgtgaatt ttaaggagtt
     1201 aggctgggac gactggatta tcgcgcccct agagtacgag gcctatcact gcgagggcgt
     1261 gtgcgacttt ccgctgcgct cgcaccttga gcccactaac catgccatca ttcagacgct
     1321 gatgaactcc atggacccgg gctccacccc gcctagctgc tgcgttccca ccaaactgac
     1381 tcccattagc atcctgtaca tcgacgcggg caataatgta gtctacaagc agtatgagga
     1441 catggtggtg gagtcctgcg gctgtaggta gcggtgctgt cccgccacct gggccaggga
     1501 ccatggaggg aggcctgact gccgagaaag gagcaggagc tggcttggaa gaggccacag
     1561 gtgggggaca gcctgaaagt aggagcacag taagaagcag cccagccttc ccagaacctt
     1621 ccaaccccca acccagaagc agctaagggt ttcacacttt gccttgccag cctggaaaga
     1681 ctagacaaga aggattcttt cttttattat ggctttggtt ctttgtttgt tttgttttgt
     1741 tttatctcct tggttttgat aggacgtgga aggaggggaa atgcttatct gttcacaagt
     1801 gttctgtgga ttgggggagg agggaataag agaaataacc tattactttt gtccgcatct
     1861 cagattggtt gtttctacct gtgtaagaaa gtgaggcctt tgggtctttc tagccaagtc
     1921 tcagctggcg tccttgacct cacaggaagt atttgaccaa aggaataagt gagtcaggaa
     1981 gggtcttacc cttagagaag cccaagctgc ctccttctct gctctgtgca tccccacgaa
     2041 tttatcagtc tgtcctggtc tctcccagcg gagggaacag ggagttgcca ccgctgtggg
     2101 ctcagacctc cagatgcctt ttctgttggt ggtggggggg gggggggcag aaggatttgg
     2161 tatggatgga atgacaagaa ttagtccgtg tggaaccccg tgaaggataa tgagaaacca
     2221 caaggcctac ctctgaccgg gtgacacaga ggcgcattac ccaaggctgg ggtagcccac
     2281 ccaaaagctc ttggtcatgg atgtttctca gtggcttctt taaacagaat ttgccaaaat
     2341 cccagcatct ccttctaagg caattttttt ccctccttaa atggagaggg gtggaaactc
     2401 tataattaag gtaagaaggg aagaggagga ggaggaaaag acctgaaagg tggaagggct
     2461 acatcaggag gggagatgcg ggccccacaa gaggatggag ataaagggcc aggccccaag
     2521 catggaagga ggatgaaagg gccaggagtc tctgcctctg aagtttctta aaatttaagt
     2581 cccctctcct ctttctgaca ttcctgagag attaccagcc agcaatagcc cagggctccc
     2641 cctagagaaa cattttagat cgtaattacc agttaggtgc tgtttttaaa ccttagtaat
     2701 gaggagctgt gagtcgaggg ttacattgag tttggggtgg aaactggggt acaggggcac
     2761 caggaaagaa accagaagga agtaagagac agaacacggg aaatacctgt agtactccaa
     2821 atctccatcc tttcccacag tctgtaccat gattattttc aaacatcgcc tagacagagt
     2881 ctctttgaga agtaagcttc ctcatgtttg tccatggaac ggtttaaact gaggaccctg
     2941 agtgagtgat tacagactga tctgggttcc cccaactggt ttgctctctc tccccgctga
     3001 aatctgtttc ttgtctggtt cagagaagac aaactgtcaa ggaaacggtc ggaatgctaa
     3061 tactggtaat ataaactggt aagggagaaa agacaagact tggccaggag aaataactta
     3121 aatgcacatt tgctttggat gcactgctgt tctgttgagg ctgtatatat ttgtttattt
     3181 aagatgactg aaagtgcaaa gagaaaacat gcaattcatc ttaacgtaca aaacgttata
     3241 tgcactcaaa tgttataatt tctaatattt ttaaagttta tattcgagtt gtacaaagtt
     3301 aagcattaat cagatatttc attctttcat aatgttatca ttttcttaaa tattattaca
     3361 aaattttaag tgtgtctaat ggagagtttt ttttttgaaa ctgtctacct cactataata
     3421 cagattttga caacactaaa gttactggag gtcgattgat atacaaaaca tttttacagt
     3481 ataccttctt ggacgataag gaatctggtt aattctgtct tattaaactc at
//
