LOCUS       NM_008109               2237 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus growth differentiation factor 5 (Gdf5), mRNA.
ACCESSION   NM_008109
VERSION     NM_008109.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2237)
  AUTHORS   Song,C., Sawall,J.K., Ji,X., Song,F., Liao,X., Peng,R., Ren,H.,
            Koyama,E., Pacifici,M. and Long,F.
  TITLE     Tgfbeta signaling stimulates glycolysis to promote the genesis of
            synovial joint interzone in developing mouse embryonic limbs
  JOURNAL   Sci Adv 11 (2), eadq4991 (2025)
   PUBMED   39772668
REFERENCE   2  (bases 1 to 2237)
  AUTHORS   Sorsby,M., Almardini,S., Alayyat,A., Hughes,A., Venkat,S.,
            Rahman,M., Baker,J., Rana,R., Rosen,V. and Liu,E.S.
  TITLE     The role of GDF5 in regulating enthesopathy development in the Hyp
            mouse model of XLH
  JOURNAL   J Bone Miner Res 39 (8), 1162-1173 (2024)
   PUBMED   38836497
  REMARK    GeneRIF: The role of GDF5 in regulating enthesopathy development in
            the Hyp mouse model of XLH.
REFERENCE   3  (bases 1 to 2237)
  AUTHORS   Leung,A.O.W., Poon,A.C.H., Wang,X., Feng,C., Chen,P., Zheng,Z.,
            To,M.K., Chan,W.C.W., Cheung,M. and Chan,D.
  TITLE     Suppression of apoptosis impairs phalangeal joint formation in the
            pathogenesis of brachydactyly type A1
  JOURNAL   Nat Commun 15 (1), 2229 (2024)
   PUBMED   38472182
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2237)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2237)
  AUTHORS   Grall,E., Feregrino,C., Fischer,S., De Courten,A., Sacher,F.,
            Hiscock,T.W. and Tschopp,P.
  TITLE     Self-organized BMP signaling dynamics underlie the development and
            evolution of digit segmentation patterns in birds and mammals
  JOURNAL   Proc Natl Acad Sci U S A 121 (2), e2304470121 (2024)
   PUBMED   38175868
REFERENCE   6  (bases 1 to 2237)
  AUTHORS   Kwasigroch,T.E., Curtis,S.K., Knudsen,T.B., Barrach,H.J. and
            Elmer,W.A.
  TITLE     Morphological analysis of abnormal digital chondrogenesis in the
            brachypod (bpH) mouse limb in organ culture
  JOURNAL   Anat Embryol (Berl) 185 (4), 307-315 (1992)
   PUBMED   1609959
REFERENCE   7  (bases 1 to 2237)
  AUTHORS   Davisson,M.T. and Cattanach,B.M.
  TITLE     The mouse mutation ulnaless on chromosome 2
  JOURNAL   J Hered 81 (2), 151-153 (1990)
   PUBMED   2338491
REFERENCE   8  (bases 1 to 2237)
  AUTHORS   Duke,J. and Elmer,W.A.
  TITLE     Cell adhesion and chondrogenesis in brachypod mouse limb
            mesenchyme: fragment fusion studies
  JOURNAL   J Embryol Exp Morphol 48, 161-168 (1978)
   PUBMED   744946
REFERENCE   9  (bases 1 to 2237)
  AUTHORS   Goto,N., Imamura,K. and Sakamoto,K.
  TITLE     [Inheritance and growth of mouse mutation brachypodism (brp)
            (author's transl)]
  JOURNAL   Jikken Dobutsu 26 (3), 231-238 (1977)
   PUBMED   908358
REFERENCE   10 (bases 1 to 2237)
  AUTHORS   Rhodes,R.K. and Elmer,W.A.
  TITLE     Aberrant metabolism of matrix components in neonatal fibular
            cartilage of brachypod (bpH) mice
  JOURNAL   Dev Biol 46 (1), 14-27 (1975)
   PUBMED   125666
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845445.14.
            
            On Dec 21, 2021 this sequence version replaced NM_008109.3.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein regulates the development
            of numerous tissue and cell types, including cartilage, joints,
            brown fat, teeth, and the growth of neuronal axons and dendrites.
            Mice with a mutation in this gene exhibit enhanced tooth enamel
            formation. [provided by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034546.1, U08337.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-842               AL845445.14        119791-120632       c
            843-2237            AL845445.14        116371-117765       c
FEATURES             Location/Qualifiers
     source          1..2237
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.26 cM"
     gene            1..2237
                     /gene="Gdf5"
                     /gene_synonym="BMP-14; bp; brp; Cdmp-1"
                     /note="growth differentiation factor 5"
                     /db_xref="GeneID:14563"
                     /db_xref="MGI:MGI:95688"
     exon            1..842
                     /gene="Gdf5"
                     /gene_synonym="BMP-14; bp; brp; Cdmp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..2237
                     /gene="Gdf5"
                     /gene_synonym="BMP-14; bp; brp; Cdmp-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2210..2215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gdf5"
                     /gene_synonym="BMP-14; bp; brp; Cdmp-1"
                     /note="hexamer: CATAAA"
     polyA_site      2237
                     /gene="Gdf5"
                     /gene_synonym="BMP-14; bp; brp; Cdmp-1"
                     /note="major polyA site"
ORIGIN      
        1 ggagacggtg cacgtctgga cacgggagca cttccactat gggactggat acagacacac
       61 gcccggcgga cttcaagaca ctcagactga ggagaaagcc ctgcctgctg ctgctgctgc
      121 caccgctgcc tctgaagacc cactcctttc atggtttttc ctgccaagcc agaggcacct
      181 tcgctgctac ggcctttctc tgtggtgtca ttcagcggct ggccagagga tgagactccc
      241 caaactcctc actcttttgc tgtggcacct ggcttggctg gacctggaac tcatctgcac
      301 tgtgctgggt gcccctgact taggacagag aaccccaggg gccaagccag ggttgaccaa
      361 agcggaggcc aaggagaggc cacccctggc caggaatgtc tttaggccag ggggtcatat
      421 ctatggtgtg ggggccacca atgccagggc caagggaagc tctgggcaga cacaggccaa
      481 gaaggatgaa cccagaaaga tgccccccag atccggtggc cctgaaacca agccaggacc
      541 ctcttcccag actagacagg ctgcagcccg gactgtaacc ccaaaaggac agcttcctgg
      601 gggcaaagca tcttcaaaag caggatctgc ccccagctcc ttcctgctga agaagaccag
      661 ggagcctggg acccctcgag agcccaagga gccgttccgc ccgcccccca tcacacccca
      721 cgaatacatg ctctccctgt acaggacgct gtccgatgct gacagaaagg gaggtaacag
      781 cagcgtgaag ttggaggctg gcctggccaa caccatcacc agctttattg acaaagggca
      841 agatgaccga ggccctgcgg tcaggaagca gaggtacgtg tttgacatca gtgccttgga
      901 gaaggatggg ctgttggggg ctgaactgcg gatcttacgg aagaagccct tggacgtggc
      961 caagccagcg gtccccagta gcgggcgggt tgcccaactg aagctgtcca gctgccccag
     1021 cggccggcag ccggcagcct tgctggatgt gcgctccgtg ccaggcctgg atggatctgg
     1081 ctgggaggtg ttcgacatct ggaagctctt ccgaaatttt aagaactcag cgcagctgtg
     1141 cctggagctg gaggcctggg aacggggccg ggccgtggac ctccgtggcc tgggctttga
     1201 acgcactgcc cgacaggtcc acgagaaagc cttgttccta gtgtttggtc gtaccaagaa
     1261 acgggacctg ttctttaatg agattaaggc ccgctctggc caggatgaca agactgtgta
     1321 tgaatatttg ttcagccagc ggcggaaacg ccgggcccca ttggccaatc gccagggcaa
     1381 gcgacccagc aagaacctca aggctcgctg cagtcgcaag gccttgcatg tcaacttcaa
     1441 ggacatgggc tgggacgact ggatcatcgc acctcttgag tatgaggcct tccactgcga
     1501 aggactgtgt gagttcccct tgcgctccca cttggagccc acaaaccacg cagtcattca
     1561 gaccctaatg aactctatgg accctgaatc cacaccaccc acttgttgtg tgcctacacg
     1621 gctgagtcct attagcatcc tcttcatcga ctctgccaac aacgtggtgt ataaacagta
     1681 cgaggacatg gtcgtggaat cttgtggctg caggtagcag cactggccca cctgtcttcc
     1741 agggtggcac atccagagac taccccctcc acaggttcct ggagtaacag agagcctgtg
     1801 aagctgctgc ccgaagtttc ctggcagcct gcaggaaaga gttctcagca ggcttactct
     1861 ctggatgtga tctggactaa agagatcacc ttctgaagat tcctgcccaa ggaacagact
     1921 ctgagtgggc ctggggctca ggaaaggtgt tcttaatgag actcagttca ccatctctcc
     1981 tgcccggggc ctcttcattt ctctccagac tctccagaga agttgtagct atatcctaag
     2041 ctctttaagg gagagctgtc tcctccttga atcacctttg tgcctggtga ctttctgcca
     2101 agagatgttc attacagggg ctgggcaaag aaggggaaag ggcttgggca ggggtgaaga
     2161 gaagagtatg agcctaatta gactgttaga ttaaaatgta catcgatgac ataaaagctg
     2221 aatcttcatg gctaaaa
//
