LOCUS       NM_008108               2125 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus growth differentiation factor 3 (Gdf3), mRNA.
ACCESSION   NM_008108
VERSION     NM_008108.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2125)
  AUTHORS   Masurkar,N., Bouvet,M., Logeart,D., Jouve,C., Drame,F., Claude,O.,
            Roux,M., Delacroix,C., Bergerot,D., Mercadier,J.J., Sirol,M.,
            Gellen,B., Livrozet,M., Fayol,A., Robidel,E., Tregouet,D.A.,
            Marazzi,G., Sassoon,D., Valente,M. and Hulot,J.S.
  TITLE     Novel Cardiokine GDF3 Predicts Adverse Fibrotic Remodeling After
            Myocardial Infarction
  JOURNAL   Circulation 147 (6), 498-511 (2023)
   PUBMED   36484260
  REMARK    GeneRIF: Novel Cardiokine GDF3 Predicts Adverse Fibrotic Remodeling
            After Myocardial Infarction.
REFERENCE   2  (bases 1 to 2125)
  AUTHORS   Allegre,N., Chauveau,S., Dennis,C., Renaud,Y., Meistermann,D.,
            Estrella,L.V., Pouchin,P., Cohen-Tannoudji,M., David,L. and
            Chazaud,C.
  TITLE     NANOG initiates epiblast fate through the coordination of
            pluripotency genes expression
  JOURNAL   Nat Commun 13 (1), 3550 (2022)
   PUBMED   35729116
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2125)
  AUTHORS   Hu,X., Dong,X., Li,G., Chen,Y., Chen,J., He,X., Sun,H., Kim,D.H.,
            Kemper,J.K. and Chen,L.F.
  TITLE     Brd4 modulates diet-induced obesity via PPARgamma-dependent Gdf3
            expression in adipose tissue macrophages
  JOURNAL   JCI Insight 6 (7), 143379 (2021)
   PUBMED   33830083
  REMARK    GeneRIF: Brd4 modulates diet-induced obesity via
            PPARgamma-dependent Gdf3 expression in adipose tissue macrophages.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2125)
  AUTHORS   Wang,L., Li,Y., Wang,X., Wang,P., Essandoh,K., Cui,S., Huang,W.,
            Mu,X., Liu,Z., Wang,Y., Peng,T. and Fan,G.C.
  TITLE     GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and
            Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype
  JOURNAL   Cells 9 (1), 120 (2020)
   PUBMED   31947892
  REMARK    GeneRIF: GDF3 Protects Mice against Sepsis-Induced Cardiac
            Dysfunction and Mortality by Suppression of Macrophage
            Pro-Inflammatory Phenotype.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2125)
  AUTHORS   Senft,A.D., Bikoff,E.K., Robertson,E.J. and Costello,I.
  TITLE     Genetic dissection of Nodal and Bmp signalling requirements during
            primordial germ cell development in mouse
  JOURNAL   Nat Commun 10 (1), 1089 (2019)
   PUBMED   30842446
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2125)
  AUTHORS   Oxburgh,L., Chu,G.C., Michael,S.K. and Robertson,E.J.
  TITLE     TGFbeta superfamily signals are required for morphogenesis of the
            kidney mesenchyme progenitor population
  JOURNAL   Development 131 (18), 4593-4605 (2004)
   PUBMED   15342483
REFERENCE   7  (bases 1 to 2125)
  AUTHORS   Mitsui,K., Tokuzawa,Y., Itoh,H., Segawa,K., Murakami,M.,
            Takahashi,K., Maruyama,M., Maeda,M. and Yamanaka,S.
  TITLE     The homeoprotein Nanog is required for maintenance of pluripotency
            in mouse epiblast and ES cells
  JOURNAL   Cell 113 (5), 631-642 (2003)
   PUBMED   12787504
REFERENCE   8  (bases 1 to 2125)
  AUTHORS   Drake,T.A., Hannani,K., Kabo,J.M., Villa,V., Krass,K. and
            Lusis,A.J.
  TITLE     Genetic loci influencing natural variations in femoral bone
            morphometry in mice
  JOURNAL   J Orthop Res 19 (4), 511-517 (2001)
   PUBMED   11518254
REFERENCE   9  (bases 1 to 2125)
  AUTHORS   McPherron,A.C. and Lee,S.J.
  TITLE     GDF-3 and GDF-9: two new members of the transforming growth
            factor-beta superfamily containing a novel pattern of cysteines
  JOURNAL   J Biol Chem 268 (5), 3444-3449 (1993)
   PUBMED   8429021
REFERENCE   10 (bases 1 to 2125)
  AUTHORS   Jones,C.M., Simon-Chazottes,D., Guenet,J.L. and Hogan,B.L.
  TITLE     Isolation of Vgr-2, a novel member of the transforming growth
            factor-beta-related gene family
  JOURNAL   Mol Endocrinol 6 (11), 1961-1968 (1992)
   PUBMED   1480182
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC158651.12 and AK152457.1.
            
            On Sep 1, 2016 this sequence version replaced NM_008108.4.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein is important in
            embryogenesis and likely plays a role ocular and skeletal
            development. Mice lacking a functional copy of this gene exhibit
            defects in early embryonic development resulting in embryonic
            lethality. [provided by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152457.1, L06443.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC158651.12        118780-118795       c
            17-1068             AK152457.1         2-1053
            1069-1069           AC158651.12        115167-115167       c
            1070-1616           AK152457.1         1055-1601
            1617-1617           AC158651.12        114619-114619       c
            1618-2125           AK152457.1         1603-2110
FEATURES             Location/Qualifiers
     source          1..2125
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.7 cM"
     gene            1..2125
                     /gene="Gdf3"
                     /gene_synonym="ecat9; Gdf-3; Vgr-2; Vgr2"
                     /note="growth differentiation factor 3"
                     /db_xref="GeneID:14562"
                     /db_xref="MGI:MGI:95686"
     exon            1..392
                     /gene="Gdf3"
                     /gene_synonym="ecat9; Gdf-3; Vgr-2; Vgr2"
                     /inference="alignment:Splign:2.1.0"
     exon            393..2125
                     /gene="Gdf3"
                     /gene_synonym="ecat9; Gdf-3; Vgr-2; Vgr2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1264..1269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gdf3"
                     /gene_synonym="ecat9; Gdf-3; Vgr-2; Vgr2"
                     /note="hexamer: AATAAA"
     polyA_site      1281
                     /gene="Gdf3"
                     /gene_synonym="ecat9; Gdf-3; Vgr-2; Vgr2"
                     /note="major polyA site"
     regulatory      1734..1739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gdf3"
                     /gene_synonym="ecat9; Gdf-3; Vgr-2; Vgr2"
                     /note="hexamer: AATATA"
     polyA_site      1769
                     /gene="Gdf3"
                     /gene_synonym="ecat9; Gdf-3; Vgr-2; Vgr2"
     regulatory      2098..2103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gdf3"
                     /gene_synonym="ecat9; Gdf-3; Vgr-2; Vgr2"
                     /note="hexamer: AATAAA"
     polyA_site      2118
                     /gene="Gdf3"
                     /gene_synonym="ecat9; Gdf-3; Vgr-2; Vgr2"
ORIGIN      
        1 tgaggggctg agaagagagc aattcacact tgattagctc ccaggctcct gaattgagca
       61 gaggaggcta gaccgctgag ctgcgcaccc cagaggctgc tctaccctgg ctcagacgac
      121 catgcagcct tatcaacggc ttctggcgct tggcttcctt ctgttaaccc tgccctgggg
      181 ccagacatcc gagtttcaag actctgacct tttgcagttt ctgggattag agaaagcgcc
      241 ttcacctcac aggttccaac ctgtgcctcg cgtcttaagg aaaatcatcc gggctcgaga
      301 agccgctgca gccagtgggg cctcgcagga cttatgctac gtgaaggagc tgggtgttcg
      361 tgggaacctg cttcagcttc tcccagacca gggttttttc cttaatacac agaaaccttt
      421 ccaagatggc tcctgtctcc agaaggtcct ctattttaac ttgtctgcca tcaaagaaaa
      481 ggcaaagttg accatggccc agctgactct agacttgggg cccaggtcct actataacct
      541 gcgaccagag ctggtggttg ctctgtctgt ggttcaggac cggggcgtgt gggggcgatc
      601 ccaccctaag gtgggcagat tgctttttct gcggtctgtc cctgggcctc aaggtcagct
      661 ccagttcaac ctgcagggtg cgcttaagga ttggagcagc aaccgactga agaacttgga
      721 cttacactta gagattctgg tcaaagagga cagatactcc agggtaactg tccagcccga
      781 gaacccctgt gaccggctgc tccgctctct ccatgcctcg ctgctggtgg taaccctcaa
      841 tcctaaacac tgtcatcctt cttccagaaa aaggagggcg gccatctctg tccccaaggg
      901 tttctgtagg aacttctgcc accgtcatca gctgttcatc aacttccagg acctgggttg
      961 gcacaagtgg gtcatcgccc ctaaggggtt catggcaaat tactgtcatg gagagtgccc
     1021 cttctcaatg accacgtatt taaatagttc caattatgct ttcatgcagg ctctgatgca
     1081 tatggctgac cccaaggtcc ccaaggctgt ctgtgtcccc accaagctct cgcccatctc
     1141 catgctctat caggatagtg ataagaacgt cattctccga cattatgaag acatggtagt
     1201 cgatgagtgt gggtgtgggt agtctcggga ctaggctagg agtgtgctta gggtaaatcc
     1261 tttaataaaa ctaccacccc acctttggct tatgctctct tgaatcggac atgtctgtca
     1321 tcatggttca tgagccccac aattacacac atttgtgtat gactatggac cccttggtga
     1381 gcttacttaa tttgtgctca ttatgcatag tagctgggct tcttgttctt gtttgaaaca
     1441 aggtcttatt atacatcttt gctggccttg aactcatggc aattctcttt cctctacctc
     1501 ctgtgtgctg ggattacagc tgtgtgccac caggaccaaa aaaaaaattt ttttttttga
     1561 aacaggaaac atggtctcta taccaggctg tcctataact atgtagacca ggctaacctc
     1621 aaacgcacaa gagatcaaac tgcctctgct tcctgaatcc tagaattaaa ggcctgccct
     1681 gtaccatatt atatccaatt gtatatctta agattttaaa attattttga gaaaatataa
     1741 catagaaaaa tttacgtgag ctttaaaaat gttcacttgt ttgttttatg tgtgggtgct
     1801 tgtgtaagtg cacggtgtac atgcaggaac ccgtggcggc cagaagaggg agtcagatcc
     1861 cctgaagtta caggtgatca tgcgtctcct ccatgtggat gctcaagtgg gtcctgcaca
     1921 agagcaggca gcgctcttac tgctgagcca gttctttttt ctgtgtaatc ctggcagtcc
     1981 tggaactcac tccgtagacc aggctggcct cgaactcaga aatctgcctg cctctgcctc
     2041 ccaagtgctg ggattaaagg tgtgcgccac caccgtctgg cttcctgggg ttttcttaat
     2101 aaatttactt caactgaatt attac
//
