LOCUS       NM_019506               2988 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus growth differentiation factor 2 (Gdf2), mRNA.
ACCESSION   NM_019506 XM_978916
VERSION     NM_019506.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2988)
  AUTHORS   Chen,L., Wang,R., Lv,X., Kan,M., Zhang,H., Qiu,W., Chen,S.,
            Zhao,J., Wen,X., Meng,X., Wang,H. and Zang,H.
  TITLE     Hepatic-derived BMP9 is involved in hepatic fibrosis-induced kidney
            injury through inhibition of renal VEGFA
  JOURNAL   Biochem Pharmacol 226, 116371 (2024)
   PUBMED   38885771
  REMARK    GeneRIF: Hepatic-derived BMP9 is involved in hepatic
            fibrosis-induced kidney injury through inhibition of renal VEGFA.
REFERENCE   2  (bases 1 to 2988)
  AUTHORS   Desroches-Castan,A., Koca,D., Liu,H., Roelants,C., Resmini,L.,
            Ricard,N., Bouvard,C., Chaumontel,N., Tharaux,P.L., Tillet,E.,
            Battail,C., Lenoir,O. and Bailly,S.
  TITLE     BMP9 is a key player in endothelial identity and its loss is
            sufficient to induce arteriovenous malformations
  JOURNAL   Cardiovasc Res 120 (7), 782-795 (2024)
   PUBMED   38502919
  REMARK    GeneRIF: BMP9 is a key player in endothelial identity and its loss
            is sufficient to induce arteriovenous malformations.
REFERENCE   3  (bases 1 to 2988)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2988)
  AUTHORS   Zhang,J., Ye,F., Ye,A. and He,B.
  TITLE     Lysyl oxidase inhibits BMP9-induced osteoblastic differentiation
            through reducing Wnt/beta-catenin via HIF-1a repression in 3T3-L1
            cells
  JOURNAL   J Orthop Surg Res 18 (1), 911 (2023)
   PUBMED   38031108
  REMARK    GeneRIF: Lysyl oxidase inhibits BMP9-induced osteoblastic
            differentiation through reducing Wnt/beta-catenin via HIF-1a
            repression in 3T3-L1 cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2988)
  AUTHORS   Bhave,S., Esposito,M., Swain,L., Qiao,X., Martin,G., Wadhwa,S.,
            Everett,K. and Kapur,N.K.
  TITLE     Loss of Bone Morphogenetic Protein-9 Reduces Survival and Increases
            MMP Activity After Myocardial Infarction
  JOURNAL   JACC Basic Transl Sci 8 (10), 1318-1330 (2023)
   PUBMED   38094696
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2988)
  AUTHORS   Oxburgh,L., Chu,G.C., Michael,S.K. and Robertson,E.J.
  TITLE     TGFbeta superfamily signals are required for morphogenesis of the
            kidney mesenchyme progenitor population
  JOURNAL   Development 131 (18), 4593-4605 (2004)
   PUBMED   15342483
REFERENCE   7  (bases 1 to 2988)
  AUTHORS   Peng,Y., Kang,Q., Luo,Q., Jiang,W., Si,W., Liu,B.A., Luu,H.H.,
            Park,J.K., Li,X., Luo,J., Montag,A.G., Haydon,R.C. and He,T.C.
  TITLE     Inhibitor of DNA binding/differentiation helix-loop-helix proteins
            mediate bone morphogenetic protein-induced osteoblast
            differentiation of mesenchymal stem cells
  JOURNAL   J Biol Chem 279 (31), 32941-32949 (2004)
   PUBMED   15161906
REFERENCE   8  (bases 1 to 2988)
  AUTHORS   Mori,T., Yuxing,Z., Takaki,H., Takeuchi,M., Iseki,K., Hagino,S.,
            Kitanaka,J., Takemura,M., Misawa,H., Ikawa,M., Okabe,M. and
            Wanaka,A.
  TITLE     The LIM homeobox gene, L3/Lhx8, is necessary for proper development
            of basal forebrain cholinergic neurons
  JOURNAL   Eur J Neurosci 19 (12), 3129-3141 (2004)
   PUBMED   15217369
REFERENCE   9  (bases 1 to 2988)
  AUTHORS   Lopez-Coviella,I., Berse,B., Krauss,R., Thies,R.S. and
            Blusztajn,J.K.
  TITLE     Induction and maintenance of the neuronal cholinergic phenotype in
            the central nervous system by BMP-9
  JOURNAL   Science 289 (5477), 313-316 (2000)
   PUBMED   10894782
REFERENCE   10 (bases 1 to 2988)
  AUTHORS   Song,J.J., Celeste,A.J., Kong,F.M., Jirtle,R.L., Rosen,V. and
            Thies,R.S.
  TITLE     Bone morphogenetic protein-9 binds to liver cells and stimulates
            proliferation
  JOURNAL   Endocrinology 136 (10), 4293-4297 (1995)
   PUBMED   7664647
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC166828.3.
            
            On Nov 17, 2006 this sequence version replaced NM_019506.3.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein regulates cartilage and
            bone development, angiogenesis and differentiation of cholinergic
            central nervous system neurons. Homozygous null mice exhibit
            malformations of the vasculature and skeleton. [provided by RefSeq,
            Jul 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147029.1, AF156890.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-455               AC166828.3         177738-178192
            456-2988            AC166828.3         181365-183897
FEATURES             Location/Qualifiers
     source          1..2988
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 20.8 cM"
     gene            1..2988
                     /gene="Gdf2"
                     /gene_synonym="Bmp9"
                     /note="growth differentiation factor 2"
                     /db_xref="GeneID:12165"
                     /db_xref="MGI:MGI:1321394"
     exon            1..455
                     /gene="Gdf2"
                     /gene_synonym="Bmp9"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1399
                     /gene="Gdf2"
                     /gene_synonym="Bmp9"
                     /note="bone morphogenetic protein 9"
                     /codon_start=1
                     /product="growth/differentiation factor 2 preproprotein"
                     /protein_id="NP_062379.3"
                     /db_xref="CCDS:CCDS26928.1"
                     /db_xref="GeneID:12165"
                     /db_xref="MGI:MGI:1321394"
                     /translation="MSPGAFRVALLPLFLLVCVTQQKPLQNWEQASPGENAHSSLGLS
                     GAGEEGVFDLQMFLENMKVDFLRSLNLSGIPSQDKTRAEPPQYMIDLYNRYTTDKSST
                     PASNIVRSFSVEDAISTAATEDFPFQKHILIFNISIPRHEQITRAELRLYVSCQNDVD
                     STHGLEGSMVVYDVLEDSETWDQATGTKTFLVSQDIRDEGWETLEVSSAVKRWVRADS
                     TTNKNKLEVTVQSHRESCDTLDISVPPGSKNLPFFVVFSNDRSNGTKETRLELKEMIG
                     HEQETMLVKTAKNAYQVAGESQEEEGLDGYTAVGPLLARRKRSTGASSHCQKTSLRVN
                     FEDIGWDSWIIAPKEYDAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACC
                     VPTKLSPISILYKDDMGVPTLKYHYEGMSVAECGCR"
     exon            456..2988
                     /gene="Gdf2"
                     /gene_synonym="Bmp9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaagtcttg gctaagcagt cagcaggaca atgtgggcct attcctcccg ggctcctcgt
       61 tgcaccaagt gatagaccac agcagcccct caggccccct tcagggccca agatgtcccc
      121 tggggccttc cgggtggccc tgctcccgct gttcctgctg gtctgtgtca cacagcagaa
      181 gccgctgcag aactgggaac aagcatcccc tggggaaaat gcccacagct ccctgggatt
      241 gtctggagct ggagaggagg gtgtctttga cctgcagatg ttcctggaga acatgaaggt
      301 ggatttccta cgcagcctta acctcagcgg cattccctcc caggacaaaa ccagagcgga
      361 gccaccccag tacatgatcg acttgtacaa cagatacaca acggacaaat cgtctacgcc
      421 tgcctccaac atcgtgcgga gcttcagcgt ggaagatgct atatcgacag ctgccacgga
      481 ggacttcccc tttcagaagc acatcctgat cttcaacatc tccatcccga ggcacgagca
      541 gatcaccagg gctgagctcc gactctatgt ctcctgccaa aatgatgtgg actccactca
      601 tgggctggaa ggaagcatgg tcgtttatga tgttctggag gacagtgaga cttgggacca
      661 ggccacgggg accaagacct tcttggtatc ccaggacatt cgggacgaag gatgggagac
      721 tttagaagta tcgagtgccg tgaagcggtg ggtcagggca gactccacaa caaacaaaaa
      781 taagctcgag gtgacagtgc agagccacag ggagagctgt gacacactgg acatcagtgt
      841 ccctccaggt tccaaaaacc tgcccttctt tgttgtcttc tccaatgacc gcagcaatgg
      901 gaccaaggag accagactgg agctgaagga gatgatcggc catgagcagg agaccatgct
      961 tgtgaagaca gccaaaaatg cttaccaggt ggcaggtgag agccaagagg aggagggtct
     1021 agatggatac acagctgtgg gaccactttt agctagaagg aagaggagca ccggagccag
     1081 cagccactgc cagaagactt ctctcagggt gaactttgag gacatcggct gggacagctg
     1141 gatcattgca cccaaggaat atgacgccta tgagtgtaaa gggggttgct tcttcccatt
     1201 ggctgatgac gtgacaccca ccaaacatgc catcgtgcag accctggtgc atctcaagtt
     1261 ccccacaaag gtgggcaaag cctgctgcgt tcccaccaaa ctgagtccca tctccatcct
     1321 ctacaaggat gacatggggg tgccaaccct caagtaccac tatgagggga tgagtgtggc
     1381 tgagtgtggg tgtaggtagt ccctgcagcc acccagggtg gggatacagg acatggaaga
     1441 ggttctggta cggtcctgca tcctcctgcg catggtatgc ctaagttgat cagaaaccat
     1501 ccttgagaag aaaaggagtt agttgccctt cttgtgtctg gtgggtccct ctgctgaagt
     1561 gacaatgact ggggtatgcg ggcctgtggg cagagcagga gaccctggaa gggttagtgg
     1621 gtagaaagat gtcaaaaagg aagctgtggg tagatgatct gggaacggca ggaaaccagg
     1681 cagaaactag cagaagatac aggtgatgtg cagagagctg cacgggactc acagggtcta
     1741 ggaagctgag actcattctg acaacataag gtgtgaagga aggagtgaac tccagctgct
     1801 gcttcctgtc actgccacac tccactgaga tgtgcgtcgt gacctctgac tgtcagttgt
     1861 agaaaccaaa actcagcaag ccaatgacta tgactcagca gaggattcta ccccaggtct
     1921 gttgggcccc aaattgtgac accttcccaa gtgtcacatg tggtttagca gatcagtgtg
     1981 tattgatgga gtcactagat attgaaggcc cctcttgagg ccaggtaggg ctgagccagg
     2041 tccacaccca ccacgatgaa taggctgctt gctgtgctcc aacacgatct gcttgctccc
     2101 tgcgcatgct cactctgtgg ccatgtgact tatgataaaa cccctcccct gaagaaatat
     2161 ccccaaacaa ccacagaagg gagacagttc aggacctcag ccctctgacg tgcactgtga
     2221 cccttgggag tttcaggagt catgcaaggc cacttgcaat cctttattga ttcggtgacc
     2281 atctgggaga gactgcctac ggcttgggcc tctgaaatta tctactctgt ctggccaaat
     2341 ccacaggcag gagcatctcc tgccttacgg actccacaga ggacaaggct ggggtctaaa
     2401 tttgttggga tctaatgtgc ctctagttaa ctatgaaact taactatttt ccttccctgg
     2461 tgacctgcac tccagtgatt agaagtccag ccttacctgt gagagagctc ctggcatcta
     2521 agagaactct gcttcctcat catccccacc gacttgttct tccttgggag tgtgtcctca
     2581 gggagaacag cattgctgtt cctgtgcctc aagctcccag ctgactctcc tgtggctcat
     2641 aggactgaat ggggtgagga agagcctgat gccctctggc aatcagagcc cgaaggactt
     2701 caaaacatct ggacaactct cattgactga tgctccaaca taatttttaa aaagacctgc
     2761 attaaatgtt tccatgtaac aatgaccaac tttaacacaa aatacaatgg agcattggtg
     2821 tttagttggt agagctggag aaaagataaa tccctaaaac atgccagcca gcgtagcatg
     2881 gcagtgctgt ccacagatgg tggtgggtgg tgacgtcttc ttcaggtccc agtgacgtgt
     2941 ctgtgtgtga gggagagttt tacttagaaa taaagtctaa tgcctggt
//
