LOCUS       NM_010272               5833 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus growth differentiation factor 11 (Gdf11), mRNA.
ACCESSION   NM_010272 XM_125935 XM_979136 XM_991698
VERSION     NM_010272.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5833)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (bases 1 to 5833)
  AUTHORS   Wu,Z., Xi,Q., Zhao,Q. and Zhu,S.
  TITLE     GDF11 OVEREXPRESSION ALLEVIATES SEPSIS-INDUCED LUNG MICROVASCULAR
            ENDOTHELIAL BARRIER DAMAGE BY ACTIVATING SIRT1/NOX4 SIGNALING TO
            INHIBIT FERROPTOSIS
  JOURNAL   Shock 62 (2), 245-254 (2024)
   PUBMED   38920138
  REMARK    GeneRIF: GDF11 OVEREXPRESSION ALLEVIATES SEPSIS-INDUCED LUNG
            MICROVASCULAR ENDOTHELIAL BARRIER DAMAGE BY ACTIVATING SIRT1/NOX4
            SIGNALING TO INHIBIT FERROPTOSIS.
REFERENCE   3  (bases 1 to 5833)
  AUTHORS   Saito,S., Kanazawa,U., Tatsumi,A., Iida,A., Takemoto,T. and
            Suzuki,T.
  TITLE     Functional analysis of a first hindlimb positioning enhancer via
            Gdf11 expression
  JOURNAL   Front Cell Dev Biol 12, 1302141 (2024)
   PUBMED   38559809
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5833)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 5833)
  AUTHORS   Shao,Y., Li,M., Wang,Y., Qu,Y., Gong,M., Yu,Q., Yang,X., Liu,D.,
            Li,H., Wang,Y., Sun,H., Zhang,Y., Zhang,X., Liu,T., Liu,J.,
            Gong,T., Sun,Y., Du,Z., Jiao,L. and Zhang,Y.
  TITLE     GDF11 mitigates high glucose-induced cardiomyocytes apoptosis by
            inhibiting the ALKBH5-FOXO3-CDR1as/Hippo signaling pathway
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (3), 119656 (2024)
   PUBMED   38182060
  REMARK    GeneRIF: GDF11 mitigates high glucose-induced cardiomyocytes
            apoptosis by inhibiting the ALKBH5-FOXO3-CDR1as/Hippo signaling
            pathway.
REFERENCE   6  (bases 1 to 5833)
  AUTHORS   Essalmani,R., Zaid,A., Marcinkiewicz,J., Chamberland,A.,
            Pasquato,A., Seidah,N.G. and Prat,A.
  TITLE     In vivo functions of the proprotein convertase PC5/6 during mouse
            development: Gdf11 is a likely substrate
  JOURNAL   Proc Natl Acad Sci U S A 105 (15), 5750-5755 (2008)
   PUBMED   18378898
  REMARK    GeneRIF: the selectivity of PC5/6 for Gdf11 essentially resides in
            the presence of a P1' Asn in the RSRR downward arrowN cleavage
            motif
REFERENCE   7  (bases 1 to 5833)
  AUTHORS   Gad,J.M. and Tam,P.P.
  TITLE     Axis development: the mouse becomes a dachshund
  JOURNAL   Curr Biol 9 (20), R783-R786 (1999)
   PUBMED   10531023
  REMARK    Review article
REFERENCE   8  (bases 1 to 5833)
  AUTHORS   McPherron,A.C., Lawler,A.M. and Lee,S.J.
  TITLE     Regulation of anterior/posterior patterning of the axial skeleton
            by growth/differentiation factor 11
  JOURNAL   Nat Genet 22 (3), 260-264 (1999)
   PUBMED   10391213
REFERENCE   9  (bases 1 to 5833)
  AUTHORS   Gamer,L.W., Wolfman,N.M., Celeste,A.J., Hattersley,G., Hewick,R.
            and Rosen,V.
  TITLE     A novel BMP expressed in developing mouse limb, spinal cord, and
            tail bud is a potent mesoderm inducer in Xenopus embryos
  JOURNAL   Dev Biol 208 (1), 222-232 (1999)
   PUBMED   10075854
REFERENCE   10 (bases 1 to 5833)
  AUTHORS   Nakashima,M., Toyono,T., Akamine,A. and Joyner,A.
  TITLE     Expression of growth/differentiation factor 11, a new member of the
            BMP/TGFbeta superfamily during mouse embryogenesis
  JOURNAL   Mech Dev 80 (2), 185-189 (1999)
   PUBMED   10072786
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC122380.4.
            
            On Sep 1, 2016 this sequence version replaced NM_010272.1.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein plays a role in the
            development of the nervous and other organ systems, and may
            regulate aging. Mice lacking a functional copy of this gene exhibit
            impaired anteroposterior patterning and other developmental
            defects. [provided by RefSeq, Aug 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.319138.1, AF092734.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849388,
                                           SAMN01164131 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-472               AC122380.4         48883-49354         c
            473-870             AC122380.4         43784-44181         c
            871-5833            AC122380.4         38160-43122         c
FEATURES             Location/Qualifiers
     source          1..5833
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 77.18 cM"
     gene            1..5833
                     /gene="Gdf11"
                     /gene_synonym="BMP-11; Bmp11"
                     /note="growth differentiation factor 11"
                     /db_xref="GeneID:14561"
                     /db_xref="MGI:MGI:1338027"
     exon            1..472
                     /gene="Gdf11"
                     /gene_synonym="BMP-11; Bmp11"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1251
                     /gene="Gdf11"
                     /gene_synonym="BMP-11; Bmp11"
                     /note="GDF-11; bone morphogenetic protein 11"
                     /codon_start=1
                     /product="growth/differentiation factor 11 preproprotein"
                     /protein_id="NP_034402.1"
                     /db_xref="CCDS:CCDS24296.1"
                     /db_xref="GeneID:14561"
                     /db_xref="MGI:MGI:1338027"
                     /translation="MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAGVGGE
                     RSSRPAPSAPPEPDGCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLL
                     PKAPPLQQILDLHDFQGDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCC
                     HFHFSPKVMFTKVLKAQLWVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIR
                     IRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGA
                     EGLHPFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRY
                     KANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYG
                     KIPGMVVDRCGCS"
     exon            473..870
                     /gene="Gdf11"
                     /gene_synonym="BMP-11; Bmp11"
                     /inference="alignment:Splign:2.1.0"
     exon            871..5833
                     /gene="Gdf11"
                     /gene_synonym="BMP-11; Bmp11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2985..2990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gdf11"
                     /gene_synonym="BMP-11; Bmp11"
                     /note="hexamer: ATTAAA"
     polyA_site      3006
                     /gene="Gdf11"
                     /gene_synonym="BMP-11; Bmp11"
                     /note="major polyA site"
     regulatory      3632..3637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gdf11"
                     /gene_synonym="BMP-11; Bmp11"
                     /note="hexamer: AATATA"
     polyA_site      3649
                     /gene="Gdf11"
                     /gene_synonym="BMP-11; Bmp11"
     regulatory      4039..4044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gdf11"
                     /gene_synonym="BMP-11; Bmp11"
                     /note="hexamer: AATAAA"
     polyA_site      4062
                     /gene="Gdf11"
                     /gene_synonym="BMP-11; Bmp11"
     regulatory      4298..4303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gdf11"
                     /gene_synonym="BMP-11; Bmp11"
                     /note="hexamer: AATGAA"
     polyA_site      4320
                     /gene="Gdf11"
                     /gene_synonym="BMP-11; Bmp11"
     regulatory      5394..5399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gdf11"
                     /gene_synonym="BMP-11; Bmp11"
                     /note="hexamer: TATAAA"
     polyA_site      5418
                     /gene="Gdf11"
                     /gene_synonym="BMP-11; Bmp11"
ORIGIN      
        1 tccccgcccc ccagtcctcc cctcccctgc agcatggtgc tcgcggcccc gctgctgctg
       61 ggcttcctgc tcctcgccct ggagctgcgg ccccgggggg aggcggccga gggccccgcg
      121 gcggcggcgg cggcagcggc ggcggcggcc ggggtcgggg gggagcgctc gagccggccg
      181 gccccgtccg ctccgccgga gccggacggc tgccccgtgt gcgtgtggcg gcagcacagc
      241 cgcgagctgc gcctagagag catcaagtcg cagatcctga gcaaactgcg gctcaaggag
      301 gcgcccaaca tcagccggga ggtagtgaag cagctgctgc ccaaggcgcc gccgctgcag
      361 cagatcctgg atctgcacga cttccaaggc gacgcgctgc agcctgagga cttcttggaa
      421 gaggacgagt accacgctac caccgagacg gtcataagca tggcccagga gacggaccct
      481 gcagtgcaga cagatggcag ccctctctgc tgtcatttcc acttcagccc caaggtgatg
      541 ttcaccaagg tactgaaggc ccaactgtgg gtgtaccttc ggcctgtgcc ccgcccagcc
      601 acagtctacc tgcagatctt acgactgaaa cccctaactg gggaagggac cgcaggggga
      661 gggggtggag gccggcgtca catccgtatc cgttcactaa agattgagct acactcacgt
      721 tccggccact ggcagagcat cgacttcaag caagtgctac acagctggtt tcgccagcca
      781 cagagcaact ggggaatcga gatcaacgcc tttgatccca gcggcacaga cctggctgtc
      841 acctccctgg ggccaggagc tgaggggctg catcctttca tggagcttcg agtcctagag
      901 aacacgaaaa ggtcccggcg gaacctaggc ctggactgcg atgaacactc gagtgagtcc
      961 cgctgctgcc gatatcctct cacagtggac tttgaggctt ttggctggga ctggatcatc
     1021 gcacctaagc gctacaaggc caactactgc tccggccagt gcgaatacat gttcatgcaa
     1081 aagtatccac acacccactt ggtgcaacag gccaacccaa gaggctctgc tgggccctgc
     1141 tgcaccccta ccaagatgtc cccaatcaac atgctctact tcaatgacaa gcagcagatt
     1201 atctacggca agatccctgg catggtggtg gatcgatgtg gctgctccta agttgtgggc
     1261 tacagtggat gcctccctca gaccctaccc caagaacccc agccctggtc cccattcctc
     1321 aagccctaga gtgctcctcc cccacctctt cccatgaaca tcacaccttg ttccctgacc
     1381 aagcagtgtg caatacaaca gagggaggca ggtggggatg gaggggggag gggttgggag
     1441 aagagaaggg cagtcagggt gggatgtatc tgagatttgc aggtgagaag gtttggcaag
     1501 aagacagatg tagggacaga ggaagaagat ggatggatag agacaagagg acagacagaa
     1561 cactgagaaa gcaaaggaac agagaggcaa aaagattaga gactaagcag acaagtagag
     1621 agattgaaat gggagtaagc agagagccct gccccaagcc tgtttttcca cagcaaggtg
     1681 agaggcttgg tatagtttgg gggagttccc ctgacaactc agtaggagta agtcagagtc
     1741 cattcttagc tttttccctc tctccttcca gtagcagccg gaagtggacc gaggatgggg
     1801 caaagtaagg acctgggagg gttttttttt taatttattt atttattgtg actttttgtt
     1861 ttttggtatt tggctttact ggaatgggag ggaccttgcc cactgtgccc cattggtccc
     1921 ttattcccca aaccctgctc ttccccaata ccaatctact taagcacttg tattaagcct
     1981 ccagggttgg gaatgggggt aaagggcaag agggctgaca catggaggtt tctaacccat
     2041 aatcaccctg accaacgttc tcgaggcaaa cgggttgaac tgagtggtca tggaaacaga
     2101 agttcagact ttaaagctgg gggtggggtg gggggtgacc tcaacatccg ggatctatga
     2161 gagctactaa actacccctc aggcctacct tattcgtggc attatttagc cagagggtat
     2221 atagcctact tatccccaaa ttcccctcag ccaagagacc aaagagcctg tggaatgccc
     2281 ctgctctcag cctctatctt caggtcaata aaaattagaa atcccagagt cccccaggtc
     2341 tgggaagggt taagggtcaa gaaaatagta aagaggctga aggttacggg gcatttgaat
     2401 ccaaatcact gctctaggct agggaataca gccagcagac caaggtggaa gggattctga
     2461 aggggggcat tttagtcccc ctaacccaaa gctcagggtg gaagaaggga gaacaaggga
     2521 gcagagtgtc tataattttt accttatttt tggaatatag cagtacctgg atgcacaagg
     2581 ggacagtaca atagggaaag gcatgtgaca aggccagtga cagcagagga cgggagaggg
     2641 tggagactcc ttggtttgga aggcttggga agcaggcaag atattagttg ccacttcaag
     2701 tcacccattc attcctccca caatcctgac cccgcttcct ctggactcac tgtgcctcag
     2761 tttcttcccc ttgatggaac gagaagcagc agcacccgcc acagccaaga gatgaattct
     2821 gagcacttac cacgggcact ttatggacat aaaatacctc tcgctgtgga actagataac
     2881 cagggcacaa cggtggtgaa gagatgtgag gcttaaagga gtcacaggct tcagagtaca
     2941 agtacccctc tgcttctcag ctggacaatg cctgaagcca aggaattaaa aatctccaca
     3001 ccctaaccat acctcagcag tggcctcttg gctctagaca agagtcttaa gaggatgggg
     3061 gggagaaggg gagatcacag caaatgatta ctaatagaac cagcagttat ggtctggtag
     3121 aaacaggact gaactgaagc ctgaccggga aggtctatac ttcctaagag cacgtttctc
     3181 tcacttgggc cagaccatag aaaggacaaa ggtatgtgac tatccttagc cctaactcct
     3241 attctcatag tgaggaaagg agatgagagg aacagacaag ggttcttaag cctttccacc
     3301 cacttcccat tagtagcagc tagtcccaag cctctcctct ctggccattc ctcatccttt
     3361 tttttttttt ttttttccta ccccatctta aagaacaaga cacatttgac catcaacatc
     3421 aatcatgcta tcttggtgta ggagaggaac agaaaagcaa agaggattgc tttcttgcct
     3481 ccaaagtcaa atgcctcttg atcttggaaa gggtaagggt tggacaatta ggtatcaggt
     3541 aaatttctcc atagtttaga gagctggggc attacacttc aattattgcc tctttattaa
     3601 taccaagtat gggggaaggg gttgtcttat gaatatacac ctgagttaag ccccccgttt
     3661 cctggtcttt tctatcccct aagaggcttg aggatatggc ccagcgctgg cacctcttcc
     3721 cacactacct gtgtggactg gccagtgctc ctctgaacat attattagtg taattcttta
     3781 ctttgtgtat ttgttacatc atgtgtgtga ttgcctttgt ttgttaaggg tgtctgagga
     3841 gtatgggctg acaggggaac tggaatgcca ggaaagggac ttcttcaatg aaatcaaggt
     3901 ttccaggaag gaaccattgc aaaaaggcca tcaggcagtt ttcaagttat gtgacagagg
     3961 gcaaagatgg ccaaagggtg ctctgagttt tgggacggtc acatgacaca atccagcact
     4021 tgaacctgaa aaaagaaaaa taaaagcagt caaagagttc aatagttcca tggtgagctc
     4081 ttccccccta ccgagcgcca cgtccatacc agggagtcca agagctcagg aggctggctc
     4141 taaagtcaaa ggactgagat gaggagcagt caggcgtggg ggtaatggcc aggacttgga
     4201 gctgcaggat ggactgaggt tgtgaaacag ggtgtttaga actcacagag ctgggtataa
     4261 caaagtccca aagactacaa gaacacagcc cccacgaaat gaaaagtcta cacattgaaa
     4321 tgatccagcc agagttttat tttatagcac tctaatctgg ggtgcctcaa ccgtattacc
     4381 aaaatcaaac tggtagctcc ccattgtagt taaatgtttc aaacagagtc cactatgagg
     4441 aaaaaaaaaa aaaaaaaaaa agcttcccat atgcctacag cacaactcac aaggcagagc
     4501 caggggtagc aagaaatctt gagtcacagg attcaatgta tcaccaggcc ttctctgtgc
     4561 cattagttct accaaagctt tcctagcagc aagcctaaga ggcacctggg catctcagaa
     4621 aaaagcccaa ccacataagc agtgaacttg tacatagaaa ggcccagatt tctccactca
     4681 ccaccccacc cccatcctca ggctagaacc tatttgccag agtatgttgg agggatgtcc
     4741 ccacttatcc tcgacctcaa tcgaagccac aaaaagacta tgagaactac atagggatgt
     4801 gtgctgtgat gtgccactca gttttcatag caatagggtt actactgata gagtctagaa
     4861 agccacagag caatcaagta atttgtccag tgagaattca gaggttgtta ggtagaacaa
     4921 ggaatcaaac ctaaatagct atcatacaat attatgtttt aatctaatgt aatctgttgt
     4981 taaaagataa atgtagaaaa ctgaatttat accacggaaa gtgagaaagt tgagaagcaa
     5041 cttggattca aagggctggt atagtatgga accttttcca atgtctttga agagaagaac
     5101 aagatagagg ttagggatgt ggacgtagca gaactggtaa gagtacttgc ctagcataca
     5161 tggaatttct gcccaccacc aaaaaccagg catgctgtca cgggcctgta atcccagcac
     5221 gagggtggca gaaacaaaat ccagaaattt aaggccatcc tcagctacat ttgaggccag
     5281 cctgggctac aaagagacct tgcctcagga agagaaattg tttaaaaaaa aaagtttaat
     5341 tttgaaggga ttaacaatca gaaaacaagt gccattgtct gtcagaggcc tcatataaaa
     5401 tggtttagaa aaaagctatc ctgtctcaac tatccaaatt ccctcctcct tatttcatgt
     5461 ctgacaacaa gtctcaaaga ctcaagctgg cagagcaaac aagcacttta gggtgatgac
     5521 aggaaaaaaa attagtccta gaaaaaccat aaaaaggaga tttacagctg aggagtatag
     5581 ttccagctgc agcttacaga ctgggtggta aagaggggca tcttggtacc tgggtcccag
     5641 agagagaagt caaacaaaat gaaaacatgt agatcttcta agctgttcac actgctgagg
     5701 agtgactaca atgagacaga agagggctca gtaggagtta gaagaacttc tgaccaatat
     5761 atgaacaact ggaaagatgg aacaaagggc tattaaaaga agagaaagga gagagaggag
     5821 agggagaggg aga
//
