LOCUS       NM_145741               3741 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus growth differentiation factor 10 (Gdf10), mRNA.
ACCESSION   NM_145741
VERSION     NM_145741.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3741)
  AUTHORS   Coren,L., Zaffryar-Eilot,S., Odeh,A., Kaganovsky,A. and Hasson,P.
  TITLE     Fibroblast diversification is an embryonic process dependent on
            muscle contraction
  JOURNAL   Cell Rep 43 (12), 115034 (2024)
   PUBMED   39636726
REFERENCE   2  (bases 1 to 3741)
  AUTHORS   Platko,K., Gyulay,G., Lebeau,P.F., MacDonald,M.E., Lynn,E.G.,
            Byun,J.H., Igdoura,S.A., Holden,R.M., Roubtsova,A., Seidah,N.G.,
            Krepinsky,J.C. and Austin,R.C.
  TITLE     GDF10 is a negative regulator of vascular calcification
  JOURNAL   J Biol Chem 300 (11), 107805 (2024)
   PUBMED   39307303
REFERENCE   3  (bases 1 to 3741)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3741)
  AUTHORS   Zhang,S., Mo,X., Jin,Y., Niu,Z., Yao,M., Zhang,Y., Li,L., Hu,G. and
            Ning,W.
  TITLE     Single-cell transcriptome analysis reveals cellular heterogeneity
            and highlights Fstl1-regulated alveolar myofibroblasts in mouse
            lung at birth
  JOURNAL   Genomics 115 (5), 110677 (2023)
   PUBMED   37406975
REFERENCE   5  (bases 1 to 3741)
  AUTHORS   Marti-Pamies,I., Thoonen,R., Morley,M., Graves,L., Tamez,J.,
            Caplan,A., McDaid,K., Yao,V., Hindle,A., Gerszten,R.E.,
            Farrell,L.A., Li,L., Tseng,Y.H., Profeta,G., Buys,E.S., Bloch,D.B.
            and Scherrer-Crosbie,M.
  TITLE     Brown Adipose Tissue and BMP3b Decrease Injury in Cardiac
            Ischemia-Reperfusion
  JOURNAL   Circ Res 133 (4), 353-365 (2023)
   PUBMED   37462036
  REMARK    GeneRIF: Brown Adipose Tissue and BMP3b Decrease Injury in Cardiac
            Ischemia-Reperfusion.
REFERENCE   6  (bases 1 to 3741)
  AUTHORS   Oxburgh,L., Chu,G.C., Michael,S.K. and Robertson,E.J.
  TITLE     TGFbeta superfamily signals are required for morphogenesis of the
            kidney mesenchyme progenitor population
  JOURNAL   Development 131 (18), 4593-4605 (2004)
   PUBMED   15342483
REFERENCE   7  (bases 1 to 3741)
  AUTHORS   Gold,D.A., Baek,S.H., Schork,N.J., Rose,D.W., Larsen,D.D.,
            Sachs,B.D., Rosenfeld,M.G. and Hamilton,B.A.
  TITLE     RORalpha coordinates reciprocal signaling in cerebellar development
            through sonic hedgehog and calcium-dependent pathways
  JOURNAL   Neuron 40 (6), 1119-1131 (2003)
   PUBMED   14687547
  REMARK    GeneRIF: Gdf10 is expressed in Bergmann glia and is reduced in
            staggerer mice.
REFERENCE   8  (bases 1 to 3741)
  AUTHORS   Scott,I.C., Steiglitz,B.M., Clark,T.G., Pappano,W.N. and
            Greenspan,D.S.
  TITLE     Spatiotemporal expression patterns of mammalian chordin during
            postgastrulation embryogenesis and in postnatal brain
  JOURNAL   Dev Dyn 217 (4), 449-456 (2000)
   PUBMED   10767089
REFERENCE   9  (bases 1 to 3741)
  AUTHORS   Zhao,R., Lawler,A.M. and Lee,S.J.
  TITLE     Characterization of GDF-10 expression patterns and null mice
  JOURNAL   Dev Biol 212 (1), 68-79 (1999)
   PUBMED   10419686
REFERENCE   10 (bases 1 to 3741)
  AUTHORS   Cunningham,N.S., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.,
            Reddi,A.H. and Lee,S.J.
  TITLE     Growth/differentiation factor-10: a new member of the transforming
            growth factor-beta superfamily related to bone morphogenetic
            protein-3
  JOURNAL   Growth Factors 12 (2), 99-109 (1995)
   PUBMED   8679252
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC058358.1, AC166828.3 and
            AK042684.1.
            
            On Jul 30, 2016 this sequence version replaced NM_145741.2.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein has been shown to promote
            neural repair after stroke and may act as a tumor suppressor.
            [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042684.1, BC058358.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2512              BC058358.1         1-2512
            2513-2516           AC166828.3         171985-171988
            2517-3731           AK042684.1         2508-3722
            3732-3741           AK042684.1         3724-3733
FEATURES             Location/Qualifiers
     source          1..3741
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 20.8 cM"
     gene            1..3741
                     /gene="Gdf10"
                     /gene_synonym="Bmp3b"
                     /note="growth differentiation factor 10"
                     /db_xref="GeneID:14560"
                     /db_xref="MGI:MGI:95684"
     exon            1..616
                     /gene="Gdf10"
                     /gene_synonym="Bmp3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..1740
                     /gene="Gdf10"
                     /gene_synonym="Bmp3b"
                     /note="bone morphogenetic protein 3b"
                     /codon_start=1
                     /product="growth/differentiation factor 10 preproprotein"
                     /protein_id="NP_665684.2"
                     /db_xref="CCDS:CCDS26927.1"
                     /db_xref="GeneID:14560"
                     /db_xref="MGI:MGI:95684"
                     /translation="MAPGPARISLGSQLLPMVPLLLLLRGAGCGHRGPSWSSLPSAAA
                     GLQGDRDSQQSPGDAAAALGPGAQDMVAIHMLRLYEKYNRRGAPPGGGNTVRSFRARL
                     EMIDQKPVYFFNLTSMQDSEMILTAAFHFYSEPPRWPRAREVFCKPRAKNASCRLLTP
                     GLPARLHLIFRSLSQNTATQGLLRGAMALTPPPRGLWQAKDISSIIKAARRDGELLLS
                     AQLDTGEKDPGVPRPSSHMPYILVYANDLAISEPNSVAVSLQRYDPFPAGDFEPGAAP
                     NSSADPRVRRAAQVSKPLQDNELPGLDERPAPALHAQNFHKHEFWSSPFRALKPRTGR
                     KDRKKKDQDTFTAASSQVLDFDEKTMQKARRRQWDEPRVCSRRYLKVDFADIGWNEWI
                     ISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIVPGIPEPCCVPDKMNSLG
                     VLFLDENRNAVLKVYPNMSVETCACR"
     exon            617..1548
                     /gene="Gdf10"
                     /gene_synonym="Bmp3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..3741
                     /gene="Gdf10"
                     /gene_synonym="Bmp3b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2485..2490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gdf10"
                     /gene_synonym="Bmp3b"
                     /note="hexamer: ATTAAA"
     polyA_site      2512
                     /gene="Gdf10"
                     /gene_synonym="Bmp3b"
                     /note="major polyA site"
ORIGIN      
        1 cgaactcgcc agtcccggcg ccgctccgtg ggctgcaaag tttgcagcgc gaggccgtca
       61 agggagcgcg ccggcgcggg ctcggctgag ctccacgcgg ctcaggatag ccgtggtcgc
      121 tggcccggcg gcgcggatgc tcggcgcaca gcgctgctac agagagccaa tcccgatacc
      181 tcgagtgggg tcatccgggc tgtccgagtc ccacagggac actccagccg cggacgaggt
      241 gcacagccaa cactgagccc tccttgtctg ttctcctggg ctcagaccct tcaccaccgt
      301 tactcagcca tggctccagg tcctgctcgg atcagcttgg ggtcccagct gctgcccatg
      361 gtgccgctgc tcctgctgct gcggggcgca ggctgcggcc acaggggccc ctcatggtcc
      421 tcattgccct cggcagctgc cggtctgcag ggggacaggg actcccagca gtcacccggg
      481 gacgcagcag ccgctctggg cccaggcgcc caggacatgg tcgctatcca catgctcagg
      541 ctctatgaga agtacaaccg aagaggtgct ccaccgggag gaggcaacac cgtccgaagc
      601 ttccgtgccc ggctggaaat gatcgaccaa aagcctgtgt atttcttcaa cttgacttcc
      661 atgcaagact cagaaatgat cctcacagcc gccttccact tctactcaga acctccacgg
      721 tggccccggg ctcgtgaggt attctgcaag ccccgagcta agaacgcatc ctgccgcctc
      781 ctgaccccag ggctgcctgc acgcttgcac ctaatcttcc gcagtctttc ccagaacacc
      841 gccactcagg ggctgctccg cggggccatg gccctgacgc ctccaccacg tggcctgtgg
      901 caggccaagg acatctcctc aatcatcaag gctgcccgaa gggatggaga gctgcttctc
      961 tctgctcagc tggatactgg ggagaaggac cccggagtgc cacggcccag ttcccacatg
     1021 ccctatatcc ttgtctacgc caatgacctg gccatctccg aacccaacag tgtagcagtg
     1081 tcgctacaga gatacgaccc atttccagct ggagactttg agcctggagc agcccccaac
     1141 agctcagctg atccccgcgt gcgcagggcg gctcaggtgt caaaacccct gcaagacaat
     1201 gaactgccgg ggctggatga aagaccagcg cctgccctgc atgcccagaa tttccacaag
     1261 cacgagttct ggtccagtcc tttccgggca ctgaaacccc gcacggggcg caaagaccgc
     1321 aagaagaagg accaggacac attcaccgcc gcctcctctc aggtgctgga ctttgacgag
     1381 aagacgatgc agaaagccag gaggcggcag tgggatgagc cccgggtctg ctccaggagg
     1441 tacctgaagg tggattttgc agacatcggg tggaatgaat ggatcatctc tcccaaatcc
     1501 tttgacgcct actactgtgc tggggcctgc gagttcccca tgcccaagat tgtccgccca
     1561 tccaaccatg ccaccatcca gagcatcgtc agagctgtgg gcattgtccc tggcatccca
     1621 gagccatgct gtgttccaga caagatgaac tcccttggag tccttttcct ggatgaaaat
     1681 cggaatgcgg ttctgaaggt gtaccccaat atgtccgtag agacctgtgc ctgtcggtaa
     1741 gatggcttca agatagaaga cagacctgct tcatccctgc cctgcagagt ggcaatcttg
     1801 gagccagggc ttgactcggg gaggttccag gtgctagaca gagcttacag gcagccctgc
     1861 tgggaccaag aaagatctgc ccaccacatc gcaattcttc agttcttccg tgctggtggt
     1921 agctctgtaa agacgtgttg agttcctgga agaaatctgg aattaactgt ggtctgcaat
     1981 ttgcccatca tccctgccca cacttttcaa ggcctagaaa taacgtgtgt cctcaaatgt
     2041 caactccagg catttgtcct ctcaaaacct agaaagacta tgcaaatctt ggggtactcc
     2101 cccccccatg gcagtttaaa tgctgtttta aaaccctcag gctgcattct agaaacaggg
     2161 cctaacccat ggcacgagtg agtattttct cttacgtttc actacacgtg cttttataca
     2221 tgcagtatgc acatgtaatc acggttgatt tcttctttta atatatgtat ttctatttca
     2281 aagcaaaacg gagagagtcg atcccatccc ctgcagaggt aataatgcaa gttaggtgtg
     2341 ggttgtctaa gcatgtgtat ggaaataata catacagtaa tatgctggaa tactaaaaaa
     2401 gtaaccaaga ttttatattt ttgtaaatta tactttgtat actgtagatt gtgagtgttc
     2461 tgtgttttta tggaaagcta ataaattaaa ggtgcggagg tatctggaaa aactgaatgt
     2521 caccattcca caatatcaat tattcccttc tccagcctgt aagtccctac cctgggctag
     2581 cattaaaatg gaatatggtt ccaggatggc acagatactg tcctagagct tcctcatatc
     2641 cctaacctag ttgattggca agtgtctgtg tcacctttgg tattaagtga caggagcagg
     2701 tcagtgtgat aaaagcagaa ggagatttga catatgcagc taggaaatat ctcaggagct
     2761 ccacagttca ataggaactg gaagggccag acgatctccc agaatccctg tccccaaagg
     2821 tgaccccaat gactctacta tgaacagcat tggtgtgatg ctggctttcc ttacagtgat
     2881 tattccagaa gccctgggtt gggcaattgt caaggagaaa agaggtgcag cctgagacag
     2941 acgcaccaca atcccttcag ccagggatag gggcacaaca ttggccaggg acctcagcac
     3001 agagacctac agctgccaag gcttgctaag gagggaggga gggagctgag aagcagctgg
     3061 ggctgccgaa ttcaatgctc tctaaggtag tgttccagga aatgcaggtg aggcgaggaa
     3121 ggagacaagg aactgtgcac accaaccctc acccaaccac cacatccatt tgggctgggc
     3181 gctgctctgc tgtttgcaaa acccttcact gagtccggct ttagggaagg gagatggaac
     3241 gtctgtttcc agcctgcccc ttcatgaaat gctacctccc aattcctggg ccttctgctc
     3301 aggaggcccc agtggcgtgg gaagcctggg cagcctcgga ggaaggctgc aatgaccgaa
     3361 ttgtggtctt ggtgaactgc aagagcatcc agaacaggta agtgggagag acataaacgg
     3421 gacttgatga agtctgtcca catcctcaca tcccatcccc tgagatgctc catgtgccct
     3481 aggacatctg cagacacaga tacccgcgcc cgttagccag gcaaggaggg actatgacct
     3541 gcctgcagca cgtgacacct tagtccccta tccccgaagg aatgcacagg aagctaaatg
     3601 agtccttcca agcttttaca gatggtgtgg gagtctcaag ctgacctgca gacttggcgc
     3661 ttcgcttgcc gtgtcacaca cggttggaac atggtggaat ataattatgt gaatagcaaa
     3721 ataaattaat accagggctt g
//
