LOCUS       NM_001163282            2728 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus growth differentiation factor 1 (Gdf1), transcript
            variant 1, mRNA.
ACCESSION   NM_001163282
VERSION     NM_001163282.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2728)
  AUTHORS   Pan,L., Li,C., Meng,L., Zhang,G., Zou,L., Tian,Y., Chen,S., Sun,Y.,
            Su,D., Zhang,X., Xiong,M., Xiao,T., Xia,D., Hong,Z. and Zhang,Z.
  TITLE     GDF1 ameliorates cognitive impairment induced by hearing loss
  JOURNAL   Nat Aging 4 (4), 568-583 (2024)
   PUBMED   38491289
  REMARK    GeneRIF: GDF1 ameliorates cognitive impairment induced by hearing
            loss.
REFERENCE   2  (bases 1 to 2728)
  AUTHORS   Cheng,W., Li,H.L., Xi,S.Y., Zhang,X.F., Zhu,Y., Le,Xing., Mo,Y.X.,
            Li,M.M., Kong,F.E., Zhu,W.J., Chen,X.G., Cui,H.Q., Cao,Z.M.,
            Gong,Y.F., Tang,Y.Q., Zhang,Y., Guan,X.Y., Ma,N.F. and Liu,M.
  TITLE     Growth differentiation factor 1-induced tumour plasticity provides
            a therapeutic window for immunotherapy in hepatocellular carcinoma
  JOURNAL   Nat Commun 12 (1), 7142 (2021)
   PUBMED   34880251
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2728)
  AUTHORS   Gongrich,C., Krapacher,F.A., Munguba,H., Fernandez-Suarez,D.,
            Andersson,A., Hjerling-Leffler,J. and Ibanez,C.F.
  TITLE     ALK4 coordinates extracellular and intrinsic signals to regulate
            development of cortical somatostatin interneurons
  JOURNAL   J Cell Biol 219 (1) (2020)
   PUBMED   31676717
REFERENCE   4  (bases 1 to 2728)
  AUTHORS   Concepcion,D., Hamada,H. and Papaioannou,V.E.
  TITLE     Tbx6 controls left-right asymmetry through regulation of Gdf1
  JOURNAL   Biol Open 7 (5) (2018)
   PUBMED   29650695
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2728)
  AUTHORS   Yang,W., Mok,M.T., Li,M.S., Kang,W., Wang,H., Chan,A.W., Chou,J.L.,
            Chen,J., Ng,E.K., To,K.F., Yu,J., Chan,M.W., Chan,F.K., Sung,J.J.
            and Cheng,A.S.
  TITLE     Epigenetic silencing of GDF1 disrupts SMAD signaling to reinforce
            gastric cancer development
  JOURNAL   Oncogene 35 (16), 2133-2144 (2016)
   PUBMED   26212015
  REMARK    GeneRIF: Epigenetic silencing of GDF1 abrogates the
            growth-inhibitory SMAD signaling and renders proliferation
            advantage to gastric epithelial cells during carcinogenesis
REFERENCE   6  (bases 1 to 2728)
  AUTHORS   Wall,N.A., Craig,E.J., Labosky,P.A. and Kessler,D.S.
  TITLE     Mesendoderm induction and reversal of left-right pattern by mouse
            Gdf1, a Vg1-related gene
  JOURNAL   Dev Biol 227 (2), 495-509 (2000)
   PUBMED   11071769
REFERENCE   7  (bases 1 to 2728)
  AUTHORS   Rankin,C.T., Bunton,T., Lawler,A.M. and Lee,S.J.
  TITLE     Regulation of left-right patterning in mice by
            growth/differentiation factor-1
  JOURNAL   Nat Genet 24 (3), 262-265 (2000)
   PUBMED   10700179
REFERENCE   8  (bases 1 to 2728)
  AUTHORS   Ozkaynak,E., Schnegelsberg,P.N., Jin,D.F., Clifford,G.M.,
            Warren,F.D., Drier,E.A. and Oppermann,H.
  TITLE     Osteogenic protein-2. A new member of the transforming growth
            factor-beta superfamily expressed early in embryogenesis
  JOURNAL   J Biol Chem 267 (35), 25220-25227 (1992)
   PUBMED   1460021
REFERENCE   9  (bases 1 to 2728)
  AUTHORS   Lee,S.J.
  TITLE     Expression of growth/differentiation factor 1 in the nervous
            system: conservation of a bicistronic structure
  JOURNAL   Proc Natl Acad Sci U S A 88 (10), 4250-4254 (1991)
   PUBMED   2034669
REFERENCE   10 (bases 1 to 2728)
  AUTHORS   Lee,S.J.
  TITLE     Identification of a novel member (GDF-1) of the transforming growth
            factor-beta superfamily
  JOURNAL   Mol Endocrinol 4 (7), 1034-1040 (1990)
   PUBMED   1704486
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC158553.13, AK162823.1,
            BC132318.1, BC079555.1 and BB183489.1.
            
            On Dec 20, 2011 this sequence version replaced NM_001163282.1.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein is involved in the
            establishment of left-right asymmetry in early embryogenesis and in
            neural development in later embryogenesis. This protein is
            translated from a monocistronic mRNA early in development, and from
            a bicistronic mRNA in later stages that also encodes ceramide
            synthase 1. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longer,
            bicistronic transcript that is expressed after embryonic stage E9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M62301.1, AK162823.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            bicistronic transcript :: PMID: 2034669, 18615710
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC158553.13        148852-148869       c
            19-1163             AK162823.1         2-1146
            1164-1471           BC132318.1         1109-1416
            1472-2702           BC079555.1         401-1631
            2703-2728           BB183489.1         155-180
FEATURES             Location/Qualifiers
     source          1..2728
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..2728
                     /gene="Gdf1"
                     /gene_synonym="Gdf-1"
                     /note="growth differentiation factor 1"
                     /db_xref="GeneID:14559"
                     /db_xref="MGI:MGI:95683"
     exon            1..334
                     /gene="Gdf1"
                     /gene_synonym="Gdf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            335..494
                     /gene="Gdf1"
                     /gene_synonym="Gdf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..675
                     /gene="Gdf1"
                     /gene_synonym="Gdf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            676..837
                     /gene="Gdf1"
                     /gene_synonym="Gdf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            838..985
                     /gene="Gdf1"
                     /gene_synonym="Gdf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1095
                     /gene="Gdf1"
                     /gene_synonym="Gdf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1834
                     /gene="Gdf1"
                     /gene_synonym="Gdf-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1540..2613
                     /gene="Gdf1"
                     /gene_synonym="Gdf-1"
                     /note="embryonic growth/differentiation factor 1"
                     /codon_start=1
                     /product="embryonic growth/differentiation factor 1
                     precursor"
                     /protein_id="NP_001156754.1"
                     /db_xref="CCDS:CCDS52571.1"
                     /db_xref="GeneID:14559"
                     /db_xref="MGI:MGI:95683"
                     /translation="MLPVCHRFCDHLLLLLLLPSTTLAPAPASMGPAAALLQVLGLPE
                     APRSVPTHRPVPPVMWRLFRRRDPQEARVGRPLRPCHVEELGVAGNIVRHIPDSGLSS
                     RPAQPARTSGLCPEWTVVFDLSNVEPTERPTRARLELRLEAESEDTGGWELSVALWAD
                     AEHPGPELLRVPAPPGVLLRADLLGTAVAANASVPCTVRLALSLHPGATAACGRLAEA
                     SLLLVTLDPRLCPLPRLRRHTEPRVEVGPVGTCRTRRLHVSFREVGWHRWVIAPRGFL
                     ANFCQGTCALPETLRGPGGPPALNHAVLRALMHAAAPTPGAGSPCCVPERLSPISVLF
                     FDNSDNVVLRHYEDMVVDECGCR"
     exon            1835..2728
                     /gene="Gdf1"
                     /gene_synonym="Gdf-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2697..2702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gdf1"
                     /gene_synonym="Gdf-1"
                     /note="hexamer: AACAAA"
     polyA_site      2702
                     /gene="Gdf1"
                     /gene_synonym="Gdf-1"
     polyA_site      2714
                     /gene="Gdf1"
                     /gene_synonym="Gdf-1"
                     /note="major polyA site"
ORIGIN      
        1 tgcctggctg cggcgcgtga cgcgagggcg cgcggcgact cggaccggtg caggcaacag
       61 cggagacagc ggagaattgg atagcatggc tgctgccgcg gcgaccccca ggctcgaggc
      121 gccagagccc atgccgagtt atgcgcagat gttgcaacga agctgggcct cggcgctggc
      181 ggcggctcag ggctgcgggg actgcggctg gggactggcg cgccgcggcc tggcggagca
      241 cgcgcacctg gctgcacccg agctgctgct ggccgtgctc tgcgctctgg ggtggacagc
      301 gttgcgctgg gcagccacca cacacatctt tcggcccctg gccaagcggt gtcgtctgca
      361 gcctagagat gctgccaggt tacctgagag cgcctggaag cttctgttct acttggcctg
      421 ttggagctac tgcgcttacc tgctcctggg caccagttat cctttcttcc atgacccgcc
      481 ctctgtcttc tatgactgga ggtcaggcat ggcagtgccc tgggacatcg cggtggccta
      541 tttgctgcag gggagtttct actgccactc catctatgcc accgtgtaca tggacagctg
      601 gcgtaaggac tcggtggtca tgctggtgca tcacgtggtc accctgctcc tcattgcctc
      661 ttcctacgcc ttccggtacc acaacgtagg cctcctcgtg ttcttcctgc atgacgtcag
      721 cgatgtgcag ctggagttca caaaactcaa catctacttt aaggctaggg gtggtgccta
      781 ccatcgcttg catgggctgg tggccaacct gggctgcctc agcttctgtt tctgctggtt
      841 ctggttccgc ctctactggt tcccgctcaa ggttctgtac gccacttgcc actgcagcct
      901 gcagtctgtg cctgacattc cgtactactt cttcttcaac attctgctgt tgctcctgat
      961 ggtcatgaac atctattggt tcctgtacat tgtggctttc gcagccaagg tgctgactgg
     1021 tcagatgcgt gaactggaag acttgaggga gtacgacact ctggaagctc agacagccaa
     1081 gccctgcaaa gccgagaagc cactgaggaa tggcctggtg aaggacaagc tcttctgagt
     1141 ctcttgtcct caacttcagc catccaggac tctatcccat cctacctggg atactgactc
     1201 cgcccctgga gactcgaccc agtccctgga ggtctgctcc cacccctgga ggcccggtcc
     1261 cgcctttggc ggcatggcct cgcccctagg acaatagccc cgccctaaga ttcaggatgc
     1321 tacccttctc cagggactct ggctgccagc agctccgcct ttcagatcaa ttctcgacca
     1381 cccaccttgg gactgccgcc cagtcctgcc ctctggatca gtggggtcca gacacgcccc
     1441 ctccaggacc tcaaagcacc cccgacctaa ggtcaccagc ccactggccc cagacgcagt
     1501 gggctccgct gactctcttg gacacctcct gggaggaaaa tgctccctgt ctgccatcgt
     1561 ttttgcgacc acctcctcct cctgctcttg ctgccctcga cgaccctggc ccccgcgcca
     1621 gcatccatgg gccccgctgc cgccctgctc caggttcttg ggcttcccga agcgccccgg
     1681 agcgtcccca cacaccgacc tgtgcctcct gtcatgtggc gcctattccg tcgccgcgac
     1741 ccccaggagg ccagagtggg acgccctctg cggccatgcc acgtggagga actaggggtc
     1801 gccggaaaca ttgtgcgcca catccccgac agcggtctgt cctccaggcc cgcacaaccc
     1861 gccaggacct cggggctgtg ccccgagtgg acagtcgtct ttgacctgtc gaatgtggag
     1921 cccacagagc gcccaacacg cgcgcgctta gagttgcggc tggaggctga gagtgaagat
     1981 acaggggggt gggagctaag cgtggcactg tgggccgacg cagagcatcc agggcctgag
     2041 ctgctgcgcg tgccggcgcc accaggggtg ctcctgcgcg cagacctact ggggactgca
     2101 gtagccgcca acgcatcagt gccctgtact gtgcgcctgg cgctgtcact gcaccctggg
     2161 gccactgcag cctgtgggcg cctggctgag gcctccctgc tgctggtgac gctggaccca
     2221 cgcctgtgtc ccttgccgcg attgcggcgc cacacggagc ccagggtaga agttggtcca
     2281 gtgggcactt gtcgtacccg acggttgcat gtgagcttcc gtgaggtggg ctggcaccgt
     2341 tgggtgatcg cgccgcgtgg cttcctagcc aacttctgcc agggcacgtg cgcactaccc
     2401 gaaacgctga ggggacccgg cgggccgcct gcactcaacc acgctgtgct gcgcgcgctc
     2461 atgcacgcag ctgctcccac cccgggtgca ggctcgccct gctgcgtgcc agagcgtcta
     2521 tcacccatct ccgtgctctt cttcgacaat agtgacaacg tggtcctgcg acactacgaa
     2581 gacatggtgg tggatgagtg tggctgccgt tgaccacccg ggacaccctt tcagggaccg
     2641 ccccacgcaa aagcagggac tgtttgttca tgttttattg gtgacaaaaa gcttaaaaca
     2701 aatttgacta aaaattaagt tccattgc
//
