LOCUS       NM_019580               1529 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus glycerophosphodiester phosphodiesterase 1 (Gde1),
            mRNA.
ACCESSION   NM_019580 XM_356011
VERSION     NM_019580.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1529)
  AUTHORS   Aisyah,R., Ohshima,N., Watanabe,D., Nakagawa,Y., Sakuma,T.,
            Nitschke,F., Nakamura,M., Sato,K., Nakahata,K., Yokoyama,C.,
            Marchioni,C.R., Kumrungsee,T., Shimizu,T., Sotomaru,Y., Takeo,T.,
            Nakagata,N., Izumi,T., Miura,S., Minassian,B.A., Yamamoto,T.,
            Wada,M. and Yanaka,N.
  TITLE     GDE5/Gpcpd1 activity determines phosphatidylcholine composition in
            skeletal muscle and regulates contractile force in mice
  JOURNAL   Commun Biol 7 (1), 604 (2024)
   PUBMED   38769369
  REMARK    GeneRIF: GDE5/Gpcpd1 activity determines phosphatidylcholine
            composition in skeletal muscle and regulates contractile force in
            mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1529)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1529)
  AUTHORS   Hui,S.T., Parks,B.W., Org,E., Norheim,F., Che,N., Pan,C.,
            Castellani,L.W., Charugundla,S., Dirks,D.L., Psychogios,N.,
            Neuhaus,I., Gerszten,R.E., Kirchgessner,T., Gargalovic,P.S. and
            Lusis,A.J.
  TITLE     The genetic architecture of NAFLD among inbred strains of mice
  JOURNAL   Elife 4, e05607 (2015)
   PUBMED   26067236
  REMARK    GeneRIF: The authors confirmed the role of Gde1 in NAFLD by in vivo
            hepatic over-expression and shRNA knockdown studies.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1529)
  AUTHORS   Tsuboi,K., Okamoto,Y., Rahman,I.A., Uyama,T., Inoue,T., Tokumura,A.
            and Ueda,N.
  TITLE     Glycerophosphodiesterase GDE4 as a novel lysophospholipase D: a
            possible involvement in bioactive N-acylethanolamine biosynthesis
  JOURNAL   Biochim Biophys Acta 1851 (5), 537-548 (2015)
   PUBMED   25596343
REFERENCE   5  (bases 1 to 1529)
  AUTHORS   Ueda,N., Tsuboi,K. and Uyama,T.
  TITLE     Metabolism of endocannabinoids and related N-acylethanolamines:
            canonical and alternative pathways
  JOURNAL   FEBS J 280 (9), 1874-1894 (2013)
   PUBMED   23425575
  REMARK    Review article
REFERENCE   6  (bases 1 to 1529)
  AUTHORS   Kopp,F., Komatsu,T., Nomura,D.K., Trauger,S.A., Thomas,J.R.,
            Siuzdak,G., Simon,G.M. and Cravatt,B.F.
  TITLE     The glycerophospho metabolome and its influence on amino acid
            homeostasis revealed by brain metabolomics of GDE1(-/-) mice
  JOURNAL   Chem Biol 17 (8), 831-840 (2010)
   PUBMED   20797612
  REMARK    GeneRIF: findings designate GroPSer as a previously unappreciated
            reservoir for free serine in the nervous system and suggest that
            GDE1, through recycling serine from GroPSer, may impact
            D-serine-dependent neural signaling processes in vivo
REFERENCE   7  (bases 1 to 1529)
  AUTHORS   Simon,G.M. and Cravatt,B.F.
  TITLE     Characterization of mice lacking candidate N-acyl ethanolamine
            biosynthetic enzymes provides evidence for multiple pathways that
            contribute to endocannabinoid production in vivo
  JOURNAL   Mol Biosyst 6 (8), 1411-1418 (2010)
   PUBMED   20393650
  REMARK    GeneRIF: Characterization of mice lacking N-acyl ethanolamine
            biosynthetic enzymes.
REFERENCE   8  (bases 1 to 1529)
  AUTHORS   Simon,G.M. and Cravatt,B.F.
  TITLE     Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and
            detection of glycerophospho-N-acyl ethanolamine precursors in mouse
            brain
  JOURNAL   J Biol Chem 283 (14), 9341-9349 (2008)
   PUBMED   18227059
  REMARK    GeneRIF: a multistep pathway for the production of anandamide in
            the nervous system by the sequential actions of Abh4 and GDE1.
REFERENCE   9  (bases 1 to 1529)
  AUTHORS   Zheng,B., Berrie,C.P., Corda,D. and Farquhar,M.G.
  TITLE     GDE1/MIR16 is a glycerophosphoinositol phosphodiesterase regulated
            by stimulation of G protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 100 (4), 1745-1750 (2003)
   PUBMED   12576545
  REMARK    GeneRIF: regulation by by stimulation of G protein-coupled
            receptors
REFERENCE   10 (bases 1 to 1529)
  AUTHORS   Zheng,B., Chen,D. and Farquhar,M.G.
  TITLE     MIR16, a putative membrane glycerophosphodiester phosphodiesterase,
            interacts with RGS16
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 3999-4004 (2000)
   PUBMED   10760272
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK005361.1.
            
            On Apr 5, 2007 this sequence version replaced NM_019580.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005361.1, AK150807.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1529              AK005361.1         2-1530
FEATURES             Location/Qualifiers
     source          1..1529
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 63.52 cM"
     gene            1..1529
                     /gene="Gde1"
                     /gene_synonym="1200003M13Rik; Mir16; RGS16"
                     /note="glycerophosphodiester phosphodiesterase 1"
                     /db_xref="GeneID:56209"
                     /db_xref="MGI:MGI:1891827"
     exon            1..349
                     /gene="Gde1"
                     /gene_synonym="1200003M13Rik; Mir16; RGS16"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1084
                     /gene="Gde1"
                     /gene_synonym="1200003M13Rik; Mir16; RGS16"
                     /EC_number="3.1.4.44"
                     /note="membrane interacting protein of RGS16;
                     lysophospholipase D GDE1; glycerophosphoinositol
                     glycerophosphodiesterase GDE1"
                     /codon_start=1
                     /product="glycerophosphodiester phosphodiesterase 1"
                     /protein_id="NP_062526.1"
                     /db_xref="CCDS:CCDS21774.1"
                     /db_xref="GeneID:56209"
                     /db_xref="MGI:MGI:1891827"
                     /translation="MWLWEDQGGLLGPFSFVLVLLLVVTRSPFNACVLTGSLYILLRF
                     FSFEPVPSRRALQVLKPRDRVSAIAHRGGSHDAPENTLAAIRQAAKNGATGVELDIEF
                     TSDGVPVLMHDNTVDRTTDGSGRLCDLTFEQVRKLNPAANHRLRNEFPDERIPTLKEA
                     VTECLRHNLTIFFDVKGHADMASAALKNIYTEFPQLYNNSMVCSFLPEVIYKMRQTDQ
                     KVITALTHRPWSLSHTGDGKPRYSVFWKQSVFVVLDILLDWSMHNVLWYLCGISAFLM
                     QKDFVSPDYLKKWSAKGIQVVSWTVNTFDEKNYYESHLGSSYITDSMLEDCAPHF"
     exon            350..525
                     /gene="Gde1"
                     /gene_synonym="1200003M13Rik; Mir16; RGS16"
                     /inference="alignment:Splign:2.1.0"
     exon            526..631
                     /gene="Gde1"
                     /gene_synonym="1200003M13Rik; Mir16; RGS16"
                     /inference="alignment:Splign:2.1.0"
     exon            632..724
                     /gene="Gde1"
                     /gene_synonym="1200003M13Rik; Mir16; RGS16"
                     /inference="alignment:Splign:2.1.0"
     exon            725..936
                     /gene="Gde1"
                     /gene_synonym="1200003M13Rik; Mir16; RGS16"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1529
                     /gene="Gde1"
                     /gene_synonym="1200003M13Rik; Mir16; RGS16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagggttcc ggctgtggcc agtacctcgg cgtctacgcg tcgcccggca ggtccggggc
       61 tccggtccgt gccggtgcag gcgccggcat gtggctgtgg gaggaccagg gcggcctcct
      121 gggccccttc tccttcgtgc tggtgctgct gctggtggtg acacgcagcc ccttcaacgc
      181 ctgcgtgctc accggcagcc tctacatcct gctgcggttc ttcagcttcg agccggtgcc
      241 gtcccgccgg gccctgcagg tgctcaagcc ccgtgaccgc gtgtccgcca tcgcccatcg
      301 cggcggcagc cacgacgcgc ccgagaacac gctggcggcc atccggcagg cagctaagaa
      361 tggagcaaca ggtgtggagc tggacatcga gtttacttct gatggagttc ctgtcttgat
      421 gcacgataac acagtagata ggacaacaga cgggtctggc cgactatgtg atctgacatt
      481 tgaacaagtt aggaaactta accctgcagc aaatcacaga ctcagaaacg agttccctga
      541 tgaaaggatc cctaccctga aggaagctgt cacagagtgc ctccgccata acctcaccat
      601 cttctttgat gtcaaaggcc atgcagatat ggcttctgct gctctaaaga atatatacac
      661 ggaatttcca cagctgtaca ataacagtat ggtctgctca ttcttgccgg aagtcatcta
      721 taaaatgaga caaacggatc agaaggtaat cacagcccta actcacaggc cttggagcct
      781 gagccacact ggagatggga agcctcgcta cagcgtcttt tggaagcagt ctgtgtttgt
      841 ggtgttggac atcttgctgg actggagcat gcacaatgtc ttgtggtacc tgtgtgggat
      901 ttcagccttc ctcatgcaga aggattttgt ctccccggac tatttgaaga agtggtcagc
      961 taaaggaatc caggttgtga gttggactgt caataccttt gatgaaaaga attactacga
     1021 gtcccacctt gggtccagct acatcactga cagcatgcta gaagactgtg cacctcactt
     1081 ctagactccc caggaggaaa cacagttgcg aaactgcctg gaggcctctt gcagggacat
     1141 gagaacactc tgttagcaca agccctgggg accctgtggc tcatactagc aatagtcaca
     1201 gtgtcacccc aacaagcaga aaccaggcat ggtgaccatg ctccaaggaa ggctccacac
     1261 ttgcccttaa aattctggat ctgcaaaaag gcagggtggc cccaccctga ccccgctgag
     1321 ggtacagagc cacgaggatg agcagagtgg gtcctgcaat tagggcgcag gcaccaatgc
     1381 atggggcttg catgatcact ccaagttgac attttaaatc ttgccgtact tcagtaattc
     1441 acttatttcc aatatttgtc gtcagctttg ttaatggcga cctgtaggtg tcaaacttgt
     1501 gaccacacta ataaaatcat tgaaaggtg
//
