LOCUS       NM_010267               3954 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Mus musculus ganglioside-induced differentiation-associated-protein
            1 (Gdap1), mRNA.
ACCESSION   NM_010267
VERSION     NM_010267.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3954)
  AUTHORS   Nuevo-Tapioles C, Santacatterina F, Sanchez-Garrido B, de Arenas
            CN, Robledo-Bergamo A, Martinez-Valero P, Cantarero L, Pardo B,
            Hoenicka J, Murphy MP, Satrustegui J, Palau F and Cuezva JM.
  TITLE     Effective therapeutic strategies in a preclinical mouse model of
            Charcot-Marie-Tooth disease
  JOURNAL   Hum Mol Genet 30 (24), 2441-2455 (2021)
   PUBMED   34274972
REFERENCE   2  (bases 1 to 3954)
  AUTHORS   Civera-Tregon A, Dominguez L, Martinez-Valero P, Serrano C,
            Vallmitjana A, Benitez R, Hoenicka J, Satrustegui J and Palau F.
  TITLE     Mitochondria and calcium defects correlate with axonal dysfunction
            in GDAP1-related Charcot-Marie-Tooth mouse model
  JOURNAL   Neurobiol Dis 152, 105300 (2021)
   PUBMED   33582224
REFERENCE   3  (bases 1 to 3954)
  AUTHORS   Cantarero L, Juarez-Escoto E, Civera-Tregon A, Rodriguez-Sanz M,
            Roldan M, Benitez R, Hoenicka J and Palau F.
  TITLE     Mitochondria-lysosome membrane contacts are defective in
            GDAP1-related Charcot-Marie-Tooth disease
  JOURNAL   Hum Mol Genet 29 (22), 3589-3605 (2021)
   PUBMED   33372681
  REMARK    GeneRIF: Mitochondria-lysosome membrane contacts are defective in
            GDAP1-related Charcot-Marie-Tooth disease.
REFERENCE   4  (bases 1 to 3954)
  AUTHORS   Fernandez-Lizarbe S, Civera-Tregon A, Cantarero L, Herrer I, Juarez
            P, Hoenicka J and Palau F.
  TITLE     Neuroinflammation in the pathogenesis of axonal Charcot-Marie-Tooth
            disease caused by lack of GDAP1
  JOURNAL   Exp Neurol 320, 113004 (2019)
   PUBMED   31271761
REFERENCE   5  (bases 1 to 3954)
  AUTHORS   Kiyama T, Chen CK, Wang SW, Pan P, Ju Z, Wang J, Takada S, Klein WH
            and Mao CA.
  TITLE     Essential roles of mitochondrial biogenesis regulator Nrf1 in
            retinal development and homeostasis
  JOURNAL   Mol Neurodegener 13 (1), 56 (2018)
   PUBMED   30333037
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3954)
  AUTHORS   Niemann A, Huber N, Wagner KM, Somandin C, Horn M, Lebrun-Julien F,
            Angst B, Pereira JA, Halfter H, Welzl H, Feltri ML, Wrabetz L,
            Young P, Wessig C, Toyka KV and Suter U.
  TITLE     The Gdap1 knockout mouse mechanistically links redox control to
            Charcot-Marie-Tooth disease
  JOURNAL   Brain 137 (Pt 3), 668-682 (2014)
   PUBMED   24480485
  REMARK    GeneRIF: Members of the GDAP1 family are responsive and protective
            against stress associated with increased levels of oxidized
            glutathione.
REFERENCE   7  (bases 1 to 3954)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 3954)
  AUTHORS   Coulpier F, Le Crom S, Maro GS, Manent J, Giovannini M, Maciorowski
            Z, Fischer A, Gessler M, Charnay P and Topilko P.
  TITLE     Novel features of boundary cap cells revealed by the analysis of
            newly identified molecular markers
  JOURNAL   Glia 57 (13), 1450-1457 (2009)
   PUBMED   19243017
REFERENCE   9  (bases 1 to 3954)
  AUTHORS   Pedrola L, Espert A, Valdes-Sanchez T, Sanchez-Piris M, Sirkowski
            EE, Scherer SS, Farinas I and Palau F.
  TITLE     Cell expression of GDAP1 in the nervous system and pathogenesis of
            Charcot-Marie-Tooth type 4A disease
  JOURNAL   J Cell Mol Med 12 (2), 679-689 (2008)
   PUBMED   18021315
  REMARK    GeneRIF: Cell expression of Gdap1 in the nervous system and
            pathogenesis of Charcot-Marie-Tooth type 4A disease are reported.
REFERENCE   10 (bases 1 to 3954)
  AUTHORS   Liu H, Nakagawa T, Kanematsu T, Uchida T and Tsuji S.
  TITLE     Isolation of 10 differentially expressed cDNAs in differentiated
            Neuro2a cells induced through controlled expression of the GD3
            synthase gene
  JOURNAL   J Neurochem 72 (5), 1781-1790 (1999)
   PUBMED   10217254
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK083814.1 and BC048177.1.
            
            [WARNING] On Apr 26, 2023 this sequence was replaced by
            NM_010267.4.
            
            On Apr 29, 2009 this sequence version replaced NM_010267.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048177.1, SRR1660821.120841.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2884              AK083814.1         2-2885
            2885-3150           BC048177.1         2861-3126
            3151-3954           BC048177.1         3131-3934
FEATURES             Location/Qualifiers
     source          1..3954
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..3954
                     /gene="Gdap1"
                     /note="ganglioside-induced
                     differentiation-associated-protein 1"
                     /db_xref="GeneID:14545"
                     /db_xref="MGI:MGI:1338002"
     exon            1..216
                     /gene="Gdap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1176
                     /gene="Gdap1"
                     /codon_start=1
                     /product="ganglioside-induced differentiation-associated
                     protein 1"
                     /protein_id="NP_034397.1"
                     /db_xref="CCDS:CCDS14834.1"
                     /db_xref="GeneID:14545"
                     /db_xref="MGI:MGI:1338002"
                     /translation="MARRQDEARAGVPLRVEGPPDKEVHLILYHWTHSFSSQKVRLVI
                     AEKALKCEEHDVSLPLSEHNEPWFMRLNSAGEVPVLVHGENIICEATQIIDYLEQTFL
                     DERTPRLMPDEGSMYYPRVQHYRELLDSLPMDAYTHGCILHPELTVDSMIPAYATTRI
                     RSQIGNTESELKKLAEENPDLQEAYIAKQKRLKSKLLDHDNVKYLKKILDELEKVLDQ
                     VETELQRRNEETPEEGNQPWLCGESFTLADVSLAVTLHRLKFLGFARRNWGHGKRPNL
                     ETYYERVLKRKTFNKVLGHVNNILISAVLPTAFRVAKKRAPKVLGSTLVVGLLVGMGY
                     FAFMLFRRRLGSMILALRPRPNYF"
     exon            217..409
                     /gene="Gdap1"
                     /inference="alignment:Splign:2.1.0"
     exon            410..583
                     /gene="Gdap1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..678
                     /gene="Gdap1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..793
                     /gene="Gdap1"
                     /inference="alignment:Splign:2.1.0"
     exon            794..3938
                     /gene="Gdap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgcaacagg gggccttgag aaaccaagga tgcttgctgc agcaagtgtc tgcagagagc
       61 aggccaaccc ataaagctgc ctgagtcctt tcatgcgaaa tggctcggag gcaggacgag
      121 gcgcgggccg gtgtgcccct gagggttgaa ggcccgccgg acaaggaggt ccacctcatt
      181 ctgtaccact ggacgcactc cttcagctct caaaaggtgc gcttggtaat tgctgaaaag
      241 gcactgaagt gcgaggaaca cgatgtaagt ctgcccctga gtgagcacaa tgagccttgg
      301 tttatgcgct tgaactcagc tggagaagta ccggtccttg tccacgggga gaacataatc
      361 tgtgaggcca ctcagatcat tgattatctt gagcagactt tcctggatga aagaacaccc
      421 aggttaatgc ccgatgaagg aagcatgtat tacccacggg tgcagcatta ccgagagctt
      481 cttgactcct tgccaatgga tgcttacaca catggctgca ttttgcatcc tgagctcact
      541 gtggattcca tgatccccgc ttatgcaacc acaaggattc gcagccagat tggtaacaca
      601 gagtctgaac taaagaaact tgctgaagaa aaccctgact tacaagaggc atacattgcc
      661 aaacagaagc gacttaagtc aaagctgctt gatcatgaca atgtcaaata cttgaagaaa
      721 attcttgatg agttggagaa ggtcttggat caggtggaaa ctgaattaca aagaagaaat
      781 gaggaaactc cagaggaggg caaccagcct tggctctgtg gagaatcctt tacactggca
      841 gatgtctcac tggctgtcac attgcatcgg ctgaagttcc tggggtttgc aagacgaaac
      901 tggggacatg gaaagagacc gaacttggaa acctattatg agcgtgtctt gaagagaaaa
      961 acatttaaca aggttttagg acatgtcaac aatatattaa tctctgcggt gctgccaaca
     1021 gcattccggg tggccaaaaa aagggcccca aaagttcttg gcagcaccct tgtggttggt
     1081 ttgcttgtag gaatgggata ttttgcattt atgcttttca gaaggagact tggcagcatg
     1141 atattagcac ttagacccag accaaattat ttctaggttt gttgggatct gtggtagcag
     1201 cacacggaat cactccacta gaccctcatc cacttgtcca gacccagtga agatttagcc
     1261 ttggcaatta gtagagagca tactttatat aattcacggg gagctcatgt gggagaagga
     1321 gctaatgata tgtttttttc ttctttctct ctgtctcttt ctctttcttc ctttcttttt
     1381 ttgtagacaa catgacttac ttctaatcta tccctaaagg ccagtataac tgctgacaga
     1441 ttggggggag ggaacctttg atggagattg ttagttcatg tatgttctca ggtatttttt
     1501 gagaggttgt aattaggagc agacagtaat aacaacccat gattgctcat agtgcctcac
     1561 ctgagagtga ctgcaggtct gggtgttgaa cagttatagg attcctctgg gactcagagg
     1621 catctttgtt atactagaca gagttcagac acaaacaaga cattgtactg attcatcttt
     1681 cactagcagc tttaggcata agtaaaggag aaaatgagaa aggggagaaa gaaaatgaga
     1741 gaatgaagta catccagaac agagcagtag atgctaacct ccagtggcct tcattgctgc
     1801 ccatggttgc ctctctcttt ggggaatttc acatatacct acttgtggtc atgtaccctc
     1861 cttaactcag aacttttagg gaggagaggg ctgggaagtt agtggggata gtatactggg
     1921 gagaaaccta tgcactgcat agaaaacact tcatttgacc ttaattatga gttacacttg
     1981 ttaatttaat aagattaagt tattatgcac ttgaatgaga tgcccattga aacatatgtc
     2041 tagcactttt atgaatgtct aaaaggatag tagggtagtc ttcatggctc ccatggccac
     2101 gtgaggtgct catcctgtat atgattgtct tcagtcctgg gaaccttggc ctcgacagcc
     2161 ctatttatgc atacaagtaa tatatagatg aatgtctcaa gtaaatatgg cttatggatg
     2221 gtagtggata atttgatgag aactaaatat gcttagtttt atttggagag actagtacat
     2281 tcatgcacaa actgttggcc aggctttgta tttgtttatg attattgaca gagctttaca
     2341 ttaaagaaaa aagtaaaagc tagcattaga tattgacagc taatttggga aaggtaaaat
     2401 atatagctag ctagatgtcc acccatactc atccatgtgt gtttaaatat ttgggggata
     2461 tatcagtcca tatggaagag acggttcatg gatgacctag gaatagccat cagactataa
     2521 tgcatgattt ttgctcagga caagcctcct attaaagcag ggaggcagtt ttcctggagc
     2581 tggctgtcaa agccttagga gaagcttcaa gaatctgatg ggaagcttgt ccacagactg
     2641 tgagtaaaga gaaagtctgc ttggatgacc tcaggtgaac tatgcacatg gccaaaaaat
     2701 gtactgacgt ttattaatag gaaaatgtca caaccagcaa gcaatggctt tctgatgata
     2761 aaaacaattc tataattcct ttttgattct attattccat ttcataagct agatgtactt
     2821 aaaaaaagaa cccatatgag caggatgtgt cctgtttgta aaaaacaagc aaaacagcaa
     2881 catcaaaaca aaaaacccta acacccccat gtgaactcag atctatgatg aggaaatgca
     2941 cgcagctttt gtgccatctt cctctgccca tcaatgtgtc atgcagagtg tctgaatctg
     3001 cttattgcta ggacattgct gtcattgtat ttatacaaca gtcataaaat taactgacta
     3061 gtgattcaga atttcttaca atgttctgat agaaataaaa agtgaggcac aaagaagtaa
     3121 caatgggaat tttgtaaaaa aaaaaaaaaa tctacaaaag gtacttattt acttgtgaaa
     3181 ggattgttaa agagtgaatt ttctttcagt atatgttatg atggagtcag aaaatcacca
     3241 ggaaattatg attttcatct gtaatttatt tggaggtaga tgtgtgccag tgttcaaggc
     3301 gaggcatcca agcctcttca atgttttata ggtaggtatt cttgacatta gtgctttaaa
     3361 aatatttgtc tagtgataaa accctgacca ctagatgtcg ctgttcaccc agtagtctaa
     3421 gactgttcca tttggtttgg catgtgtgag aggtttcaag tgacgataaa acattaatga
     3481 ccttagtttc tgagggaatc ttcattaaga ttagccacct gtgaaaaagt ttgggacaaa
     3541 tgtagtattg atttcttatg cgttgcgagt gatgtcagca ccgtatgata aggaggtgca
     3601 cagccactgt tagccagaga ggcactttaa tgcatcttct ttttaggatc atggtaactg
     3661 gtcaatatgc ttctcatgtg aaaaaaaaaa gtataaatgc cacagctaga aaatgcccaa
     3721 ggcattaaca ggttatgttg cctatttctt aacatacatg cacactattt tattggtact
     3781 gccattatat gccttttgat tctcaagact ggtgaactgc ttgctcgttt tagtaatcat
     3841 tgctattgat atcaaagttg taatgtattg ttgattgtca tgggaaatta aagatattat
     3901 tctgatggta agatcaataa aaataatttg aaaataaaaa aaaaaaaaaa aaaa
//
