LOCUS       NM_010266               5417 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus guanine deaminase (Gda), mRNA.
ACCESSION   NM_010266
VERSION     NM_010266.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5417)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5417)
  AUTHORS   Morarach,K., Mikhailova,A., Knoflach,V., Memic,F., Kumar,R., Li,W.,
            Ernfors,P. and Marklund,U.
  TITLE     Diversification of molecularly defined myenteric neuron classes
            revealed by single-cell RNA sequencing
  JOURNAL   Nat Neurosci 24 (1), 34-46 (2021)
   PUBMED   33288908
REFERENCE   3  (bases 1 to 5417)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5417)
  AUTHORS   Li,J., Zhang,W., Yang,H., Howrigan,D.P., Wilkinson,B., Souaiaia,T.,
            Evgrafov,O.V., Genovese,G., Clementel,V.A., Tudor,J.C., Abel,T.,
            Knowles,J.A., Neale,B.M., Wang,K., Sun,F. and Coba,M.P.
  TITLE     Spatiotemporal profile of postsynaptic interactomes integrates
            components of complex brain disorders
  JOURNAL   Nat Neurosci 20 (8), 1150-1161 (2017)
   PUBMED   28671696
REFERENCE   5  (bases 1 to 5417)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 5417)
  AUTHORS   Giese,R.D. and Snyder,F.F.
  TITLE     cDNA sequence of five mouse guanine deaminase (Gda) alleles and
            mapping to mouse chromosome 19
  JOURNAL   Genome 45 (2), 276-281 (2002)
   PUBMED   11962625
REFERENCE   7  (bases 1 to 5417)
  AUTHORS   Yuan,G., Bin,J.C., McKay,D.J. and Snyder,F.F.
  TITLE     Cloning and characterization of human guanine deaminase.
            Purification and partial amino acid sequence of the mouse protein
  JOURNAL   J Biol Chem 274 (12), 8175-8180 (1999)
   PUBMED   10075721
REFERENCE   8  (bases 1 to 5417)
  AUTHORS   Alexiou,M. and Leese,H.J.
  TITLE     Enzymes of purine salvage and catabolism in the mouse
            preimplantation embryo measured by high performance liquid
            chromatography
  JOURNAL   J Reprod Fertil 101 (1), 151-158 (1994)
   PUBMED   8064675
REFERENCE   9  (bases 1 to 5417)
  AUTHORS   Mohamedali,K.A., Guicherit,O.M., Kellems,R.E. and Rudolph,F.B.
  TITLE     The highest levels of purine catabolic enzymes in mice are present
            in the proximal small intestine
  JOURNAL   J Biol Chem 268 (31), 23728-23733 (1993)
   PUBMED   8226898
REFERENCE   10 (bases 1 to 5417)
  AUTHORS   Bonhomme,F., Catalan,J., Britton-Davidian,J., Chapman,V.M.,
            Moriwaki,K., Nevo,E. and Thaler,L.
  TITLE     Biochemical diversity and evolution in the genus Mus
  JOURNAL   Biochem Genet 22 (3-4), 275-303 (1984)
   PUBMED   6375655
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY250819.1, AK041056.1 and AC103947.20.
            
            On Feb 16, 2006 this sequence version replaced NM_010266.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173138.1, AK041056.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               BY250819.1         13-306
            295-2720            AK041056.1         234-2659
            2721-5417           AC103947.20        220721-223417       c
FEATURES             Location/Qualifiers
     source          1..5417
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 14.32 cM"
     gene            1..5417
                     /gene="Gda"
                     /gene_synonym="GAH"
                     /note="guanine deaminase"
                     /db_xref="GeneID:14544"
                     /db_xref="MGI:MGI:95678"
     exon            1..294
                     /gene="Gda"
                     /gene_synonym="GAH"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1536
                     /gene="Gda"
                     /gene_synonym="GAH"
                     /EC_number="3.5.4.3"
                     /note="guanase; guanine aminase; guanine aminohydrolase"
                     /codon_start=1
                     /product="guanine deaminase"
                     /protein_id="NP_034396.1"
                     /db_xref="CCDS:CCDS29698.1"
                     /db_xref="GeneID:14544"
                     /db_xref="MGI:MGI:95678"
                     /translation="MCAARTPPLALVFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVF
                     LEESSQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHAPQYAFAGSNVDLPLLEW
                     LNKYTFPTEQRFRSTDVAEEVYTRVVRRTLKNGTTTACYFGTIHTDSSLILAEITDKF
                     GQRAFVGKVCMDLNDTVPEYKETTEESVKETERFVSEMLQKNYPRVKPIVTPRFTLSC
                     TETLMSELGNIAKTHDLYIQSHISENREEIEAVKSLYPSYKNYTDVYDKNNLLTNKTV
                     MAHGCYLSEEELNIFSERGASIAHCPNSNLSLSSGLLNVLEVLKHKVKIGLGTDVAGG
                     YSYSMLDAIRRAVMVSNVLLINKVNEKNLTLKEVFRLATLGGSQALGLDSEIGNFEVG
                     KEFDALLINPRASDSPIDLFYGDFVGDISEAVIQKFLYLGDDRNIEEVYVGGKQVVPF
                     SSSV"
     exon            295..383
                     /gene="Gda"
                     /gene_synonym="GAH"
                     /inference="alignment:Splign:2.1.0"
     exon            384..555
                     /gene="Gda"
                     /gene_synonym="GAH"
                     /inference="alignment:Splign:2.1.0"
     exon            556..643
                     /gene="Gda"
                     /gene_synonym="GAH"
                     /inference="alignment:Splign:2.1.0"
     exon            644..749
                     /gene="Gda"
                     /gene_synonym="GAH"
                     /inference="alignment:Splign:2.1.0"
     exon            750..777
                     /gene="Gda"
                     /gene_synonym="GAH"
                     /inference="alignment:Splign:2.1.0"
     exon            778..885
                     /gene="Gda"
                     /gene_synonym="GAH"
                     /inference="alignment:Splign:2.1.0"
     exon            886..993
                     /gene="Gda"
                     /gene_synonym="GAH"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1091
                     /gene="Gda"
                     /gene_synonym="GAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1159
                     /gene="Gda"
                     /gene_synonym="GAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1306
                     /gene="Gda"
                     /gene_synonym="GAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1437
                     /gene="Gda"
                     /gene_synonym="GAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1465
                     /gene="Gda"
                     /gene_synonym="GAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..5417
                     /gene="Gda"
                     /gene_synonym="GAH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5394..5399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gda"
                     /gene_synonym="GAH"
                     /note="hexamer: ATTAAA"
     polyA_site      5399
                     /gene="Gda"
                     /gene_synonym="GAH"
                     /note="major polyA site"
ORIGIN      
        1 agggagccag cccctgggcg cggcctgcag ggggcaggcg atcgcctggg gaagcggggg
       61 cagaacgagc cccaagagcc agcagctccc gctccgcagc cgcaggaacc gctctgcgcc
      121 cgcccggtgc gccctccttg gccagtgaac tcgcgctgcc ctgctgcagc catgtgtgcg
      181 gctcggacgc cgccgctggc gctcgtcttc cgagggactt tcgtccactc cacctggacc
      241 tgccccatgg aggtgcttcg cgatcacctc ctcggcgtga gcgacagcgg caaaatagtg
      301 tttctagaag aatcatctca gcaagaaaaa ctggccaagg agtggtgctt caaaccatgt
      361 gagatcagag aactgagcca ccatgagttc ttcatgccag gccttgttga tacccacatc
      421 catgcccctc agtatgcctt tgctggaagc aacgttgacc tgccgctttt ggagtggctg
      481 aataagtata catttcccac agaacaaagg ttccggagca ctgatgtggc tgaagaagtc
      541 tacactagag ttgttaggag aacactgaag aacggcacca ccacggcttg ctactttgga
      601 acaattcaca ctgactcatc cctgatcctt gcggaaatta cagataaatt tgggcagcga
      661 gcatttgtgg gcaaagtatg catggatttg aatgatactg ttccagaata caaggagacc
      721 accgaggagt cagtcaagga gacagagaga tttgtgtcag aaatgctgca aaagaattat
      781 ccaagggtga aacccatagt gaccccacgc tttacccttt cttgcacgga gactctgatg
      841 agtgaacttg gcaacatcgc caagacccat gatctgtaca tccagagcca tataagtgaa
      901 aatcgtgaag aaattgaagc cgtgaaaagc ttatacccta gttacaaaaa ctacacagat
      961 gtctatgata aaaacaatct tctgacaaac aagacagtaa tggcacatgg ctgctacctt
     1021 tctgaagaag aacttaacat cttcagtgaa cgaggagcat ccattgcaca ttgtcccaac
     1081 tctaatctgt cgctgagcag tggcttactg aacgtgcttg aggtcctgaa gcataaagtg
     1141 aagatagggc tggggacaga tgtggctggt ggctactcct attccatgct tgatgccatc
     1201 agaagagcag tcatggtttc caatgtcctc ttaattaata aggtaaatga gaaaaacctc
     1261 accctcaaag aagtcttcag actagccact cttggaggaa gccaagccct ggggcttgat
     1321 agcgagattg gaaactttga agttggcaag gaatttgatg ccctcttgat caaccccaga
     1381 gcatcagact ctcccattga tctgttttat ggggattttg ttggtgatat ttctgaggct
     1441 gttatccaga agtttcttta tctaggagac gaccgaaata ttgaggaggt ttatgtgggt
     1501 ggaaagcagg tcgttccatt ctccagctca gtgtaaggac cttggacatc tgcgacattc
     1561 tcctgggaag acatgattcc gccatcttcc ttgtgcccag ggaccaatca gaaagtatat
     1621 ttacaaaaaa gtaccgtgtt ctttggatga cttctgttcc tgtgtctcct tccagtgccc
     1681 acttggtaaa ttgtttgaag ggagtgcgct gcttctccac tccagtctgg gagcattgta
     1741 atttcatgac agtgcctccc attgggctgt ttagatttgc attgtgctcg cacagaagac
     1801 attgttaaca gctggcaatg cgcttccaat agtgaagtaa aacgtttcca tatagggaaa
     1861 tacaggacga ggagatctcc ctatgtggct agacactctg tgctaatgac taagaaaatt
     1921 aggaaactcc agtatggacc aatgagcaga tttttatgag agggcacaag ctagacattg
     1981 aaaagacatt ggaaaagtca ttggttgtgc ttggaaattt aatatagaga acagtctcgt
     2041 aaaaggagaa cctactggat ttaaaacatg cttctagatc gacattgtct atggacattt
     2101 gcactttgtg aaatttgcat ttcaggatgt gttattgtta tgctttccct tcttgggatg
     2161 aatgtcagaa cctgaatgcc acacgctttt caaatatagt tctatgcttc aaagtgttcg
     2221 gcagaagttg agtattaaag atttaaagtc tcttagggat agtattcaca tagccgcaag
     2281 gcataaatag ttgtgttttt ttgtgtgtgt gtgtacttca aagtcatctt gattcctggc
     2341 tgtgaggtgt tccagttgct tctgttttat tagatgagaa acaagccctg tgtgttgctg
     2401 ctctgtagac tggagttttc ataaatcggg gaagtactat attccccgga gttggtgaca
     2461 ctgaggggac agggttcttt gcaatgctga atctacccaa cgcataatca ttgctgtaca
     2521 gttcaccctc ctatcaatgt gctagaactt aaaagccaag tgcaagtccc taaagcatta
     2581 tggataaggc tctgcaaggc cagtatactg aaagagctct gtgtgtgttt gtttgtttgt
     2641 tcgtttgttt taatttacca aattgtcatt gtaattcttg aagatttttc tggcattaaa
     2701 atcttagaat agtgaaaagg atataaaaat tccatctaat gtttatattt ctaggactta
     2761 cctgtactag acatcaagga atattaaaca aaagagggcc ttttagcttt tctaacgtat
     2821 atggtgtccc ttctcatatt agaactaaaa ccaggtcata accacgtggc agagctttag
     2881 gaaacagtga tgtgtattct acttaaatac tacatttttc ttaattaatt ccacctccta
     2941 taaacaagca agggccagga acaggtttta ttaacatata tttcactcct agggtttagg
     3001 tgagtttcca ttgtatctta taacagagaa acccattagg cagtagttag ttctcacatc
     3061 taagaacaca cagttcttct gttctctatg ctaactcagc agtaacttgt ccagatctat
     3121 tttcctggta gaagcacttt tagatctggt gtgtatacat tatatctcaa gatggtacac
     3181 atttaggtcg tactttgttt tattttgaga gagaaagaga gagagagaga gagagagaga
     3241 gagagagaga gagagagaga gagagagaga gagagagaat ttgttttgtg ggatatcggt
     3301 gagtaaatcc aacccctggc tttagtctgc atgtccagca ttgctagcac atcagaaata
     3361 tcaaaatgag ctgccagatt cccctctccc atttctctct gaggctggca actgtttagg
     3421 ctgtctgttt tgactcttgc caaagggttt acagacccca cacttgtcct cttgaagggt
     3481 gtgcattttg atgttgaaca tcagctttta tttaaactta agactcacat gcagtaatat
     3541 aggcaaatgt aattctggaa gcaggaatag cagtggtaat gtaacaccat cctgttgaga
     3601 ttcagattag tcctgataat gtgctgccag ttgaattact tctaataaaa ataaggtgtt
     3661 gaagtgttta catgtacttt gagtactttg atctccctgc acttatatgt gttttagttc
     3721 cccaagtgaa gtgttcatga atgttaccta tgcttgtttg agtgtcccac acatagggcc
     3781 agatatcctg cacttggaaa tgctgcgctc acctaataac gtaggttgac tttcctaatt
     3841 atggataggc actgttccaa gcctatccca gttgtcactt tatgtttgaa tggtttgctc
     3901 tctgtagaag aaaggaaaag agaaacagag agagagggga tgggagggag ggagagagga
     3961 agggggagaa ggaaggaagg aaggaaggaa ggaaggaagg aaggaaggaa ggaaggaagg
     4021 ttgtcctgcc tattccatac catttgaata atttctttag agtttttgat ggacttcatt
     4081 gtaaaaggtt agaaggcatt aaaagttatc atgtgtgtta tatttataac atattcttgc
     4141 agccaaaaca caaaagtaga ctaaccaagt tgaatttgat ttaaaaaaac aaaaaggcag
     4201 ggagggatca ggggcattaa aaataagagg ttagaaccta agaagtcatc cttatctaca
     4261 gggccaaagg ggctggattc ctctgttgtg ttatcttacc tggttcttta cttacactgt
     4321 caaagacttc acagtcccag agggtatgcc aggagggggc ctttctaaat gaatcctgtg
     4381 aacactgcat ttctttgctt ctttagtgaa aaacatttca agacaaatga aaggaaatga
     4441 taaaaaaaaa aaaaaaacct cttcattgct ttgctgattt tgaggtatgc cctcaaatat
     4501 cccccaaagc aaacagaggc aacatgagtg ccagatctgg caatatgttc taaatcttca
     4561 ctctctacca gataatttct atttttaagc tctttccctt tggaagcaga cacatgagaa
     4621 gccttccagg cacactggga tgcacattgt acccgttcca tcagtgtgca tatgtggaag
     4681 atacccagaa ctccgtgctt ctgcagccta gtggacatct tttaaggttg ctgttgctgg
     4741 actattcaaa tatttgaaaa gagtcatctt agctgttaac aggtagaagg agacatgtat
     4801 cctgggcaat gactcaaaat aaatcttaaa ttacagggac tctatgatac attaaaaaaa
     4861 attaaaagac caaaaagaga tgtttgccat ttctaatctc ctagctgctg catgtatgat
     4921 tttgcacaat acactttata atgtcgtggg aagaagcaga caggggagag gtcactgaga
     4981 gaaaactctt gatattcgtt accacgcatg ttttaaagtc taccccacct tcctgcccat
     5041 ctccagcact gagatgcagt gttgtgggcc tagtccatgt ttagtgaaat gcaatgtcaa
     5101 gaaagtcaat gaggaaatta aatgtaaatt ctgagcagcc atttactggg ttacttgagc
     5161 aaccaatcat tatgaatttc tgttatttgg cagtgactta tctgtctatt tcttacccaa
     5221 aaagcccatc agaaggtgtc ccttacatta ttgctaacct tctgattgct gttcttaagg
     5281 atagagacat atatgtgtat gtagtcaagg ggacatcctt cccctcggta tctgtatgat
     5341 tttgcttatt gttaatgtac tgggtgagct cctttgtgca tcaggaaaaa aaaattaaat
     5401 gagattttgt gtttcca
//
